LOCUS       NM_024597               4385 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MAP7 domain containing 3 (MAP7D3), transcript variant
            1, mRNA.
ACCESSION   NM_024597 XM_932166 XM_942816
VERSION     NM_024597.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4385)
  AUTHORS   Hooikaas,P.J., Martin,M., Muhlethaler,T., Kuijntjes,G.J.,
            Peeters,C.A.E., Katrukha,E.A., Ferrari,L., Stucchi,R.,
            Verhagen,D.G.F., van Riel,W.E., Grigoriev,I., Altelaar,A.F.M.,
            Hoogenraad,C.C., Rudiger,S.G.D., Steinmetz,M.O., Kapitein,L.C. and
            Akhmanova,A.
  TITLE     MAP7 family proteins regulate kinesin-1 recruitment and activation
  JOURNAL   J Cell Biol 218 (4), 1298-1318 (2019)
   PUBMED   30770434
  REMARK    GeneRIF: MAP7 proteins are microtubule-tethered kinesin-1
            activators, with which the motor transiently interacts as it moves
            along microtubules.
REFERENCE   2  (bases 1 to 4385)
  AUTHORS   Kwon,H.J., Park,J.E., Song,H. and Jang,C.Y.
  TITLE     DDA3 and Mdp3 modulate Kif2a recruitment onto the mitotic spindle
            to control minus-end spindle dynamics
  JOURNAL   J Cell Sci 129 (14), 2719-2725 (2016)
   PUBMED   27284004
  REMARK    GeneRIF: Mdp3 (also known as MAP7D3) forms a complex with DDA3
            (also known as PSRC1) and controls spindle dynamics at the minus
            end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment
            to the spindle.
REFERENCE   3  (bases 1 to 4385)
  AUTHORS   Tala, Xie,S., Sun,X., Sun,X., Ran,J., Zhang,L., Li,D., Liu,M.,
            Bao,G. and Zhou,J.
  TITLE     Microtubule-associated protein Mdp3 promotes breast cancer growth
            and metastasis
  JOURNAL   Theranostics 4 (10), 1052-1061 (2014)
   PUBMED   25161703
  REMARK    GeneRIF: A critical role for Mdp3 in the growth and metastasis of
            breast cancer.
            Erratum:[Theranostics. 2020 Apr 12;10(12):5527. doi:
            10.7150/thno.45566.. PMID: 32373226]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4385)
  AUTHORS   Yadav,S., Verma,P.J. and Panda,D.
  TITLE     C-terminal region of MAP7 domain containing protein 3 (MAP7D3)
            promotes microtubule polymerization by binding at the C-terminal
            tail of tubulin
  JOURNAL   PLoS One 9 (6), e99539 (2014)
   PUBMED   24927501
  REMARK    GeneRIF: Results have identified a new microtubule binding region
            in MAP7D3, formed by the conserved MAP7 domain and the C-terminal
            tail, which can bind to microtubules and promote their assembly and
            stability.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4385)
  AUTHORS   Tala, Sun,X., Chen,J., Zhang,L., Liu,N., Zhou,J., Li,D. and Liu,M.
  TITLE     Microtubule stabilization by Mdp3 is partially attributed to its
            modulation of HDAC6 in addition to its association with tubulin and
            microtubules
  JOURNAL   PLoS One 9 (3), e90932 (2014)
   PUBMED   24614595
  REMARK    GeneRIF: the amino-terminal region mediated the interaction of Mdp3
            with histone deacetylase 6 (HDAC6), in addition to its association
            with tubulin and microtubules.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4385)
  AUTHORS   Sun,X., Shi,X., Liu,M., Li,D., Zhang,L., Liu,X. and Zhou,J.
  TITLE     Mdp3 is a novel microtubule-binding protein that regulates
            microtubule assembly and stability
  JOURNAL   Cell Cycle 10 (22), 3929-3937 (2011)
   PUBMED   22142902
  REMARK    GeneRIF: Mdp3 is a novel microtubule-binding protein that regulates
            microtubule assembly and stability.
REFERENCE   7  (bases 1 to 4385)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB454674.1, BC040518.1,
            AL832120.1, AK301478.1, AL078638.9 and AW139720.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024597.3.
            
            Summary: The protein encoded by this gene belongs to the MAP7
            (microtubule-associated protein 7) family. Alternatively spliced
            transcript variants encoding different isoforms have been found.
            [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040518.1, SRR1660807.168226.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316077.14/ ENSP00000318086.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               DB454674.1         180-425
            247-1383            BC040518.1         290-1426
            1384-1909           AL832120.1         1250-1775
            1910-2784           AK301478.1         1978-2852
            2785-3779           AL078638.9         76115-77109         c
            3780-4385           AW139720.1         12-617              c
FEATURES             Location/Qualifiers
     source          1..4385
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..4385
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /note="MAP7 domain containing 3"
                     /db_xref="GeneID:79649"
                     /db_xref="HGNC:HGNC:25742"
                     /db_xref="MIM:300930"
     exon            1..112
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..2673
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /note="isoform 1 is encoded by transcript variant 1; MAP7
                     domain-containing protein 3"
                     /codon_start=1
                     /product="MAP7 domain-containing protein 3 isoform 1"
                     /protein_id="NP_078873.2"
                     /db_xref="CCDS:CCDS44004.1"
                     /db_xref="GeneID:79649"
                     /db_xref="HGNC:HGNC:25742"
                     /db_xref="MIM:300930"
                     /translation="MMADGAAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVA
                     THSSNIRSTFKPVIDGSMLKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQY
                     EKQMEERQRKLKERKEKEEQRRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQ
                     QKRWSWGGSAMANSESKTANKRSASTEKLEQGTSALIRQMPLSSAGLQNSVAKRKTDK
                     ERSSSLNRRDSNLHSSTDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPM
                     STMKIPPQTKVEESPLEKVETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVS
                     TDSFPVVSVDVSPVVSTYDSEMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEA
                     PPEVSLEALPEVSVEAAPEGSLEAPPKGSAEVAPKESVKGSPKESMEASPEAMVKASP
                     KTSLEASMEASPKAKARDAPKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLP
                     SPISTNRQIQKNCPPSPLPLISKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVS
                     KTTNRCEALSQRHMIYEESGNKSTAGIMNAEAATKILTELRRLAREQREKEEEERQRE
                     EMQQRVIKKSKDMAKEAVGGQAEDHLKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDA
                     KIKAQEEADKRKKEHERIMLQNLQERLERKKRIEEIMKRTRKTDVNASKVTETSSHDI
                     YEEAEADNEESDKDSLNEMFPSAILNGTGSPTKFKMPFNNAKKMTHKLVFLEDGTSQV
                     RKEPKTYFNGDLKNFRQKSMKDTSIQEVVSRPSSKRMTSHTTKTRKADETNTTSRSSA
                     QTKSEGFHDILPKSSDTFRQ"
     exon            113..211
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            212..295
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            296..459
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..577
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            578..682
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            683..778
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1455
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1583
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1792
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1928
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2076
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2181
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2235
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2329
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2528
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2607
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2705
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..4385
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2922..2927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /note="hexamer: AGTAAA"
     polyA_site      2953
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /note="major polyA site"
     regulatory      4366..4371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
                     /note="hexamer: AATAAA"
     polyA_site      4385
                     /gene="MAP7D3"
                     /gene_synonym="MDP3"
ORIGIN      
        1 aatgtatgcg gagagccacc accgcctccg gtcccgactc cgatgatggc ggacggcgcc
       61 gcagctggcg ctggcggcag cccatccttg agagagctgc gggcacggat ggttgctgca
      121 gcaaacgaga ttgctaagga aaggaggaag caagatgtgg ttaatcgtgt tgcaacccat
      181 tcctcaaata taagatcgac atttaaacca gtaatcgatg gatccatgct taaaaatgac
      241 ataaaacaaa gattagcaag agagcgcaga gaggagaaaa ggagacagca agacgccaat
      301 aaagaaacac aactacttga aaaagaaaga aagaccaagc tccaatatga aaaacagatg
      361 gaggaaagac agagaaagct gaaggagcga aaagagaaag aagaacaacg gagaatagct
      421 gcagaagaaa aaagacacca gaaggatgaa gcacaaaagg aaaaatttac agccattctt
      481 tatcgtactt tggaacggag gagacttgct gatgattatc agcaaaaaag atggtcatgg
      541 ggaggctctg caatggcgaa ttctgagagc aaaactgcca ataaacgatc tgcatctact
      601 gaaaaacttg aacagggtac ttctgcttta atcagacaaa tgcctttgtc atctgcaggc
      661 cttcaaaatt ccgttgccaa aaggaaaaca gacaaggaga gaagctcatc tttaaataga
      721 agagatagta acctacattc gtctactgat aaagaacaag ccgaaaggaa gccacgtgtt
      781 acaggcgtca ccaattatgt aatgcagtat gtcactgtac ccttgcgtaa atgtactagc
      841 gacgaattga gggctgttat gtttcccatg tcgacaatga aaatacctcc tcaaacaaaa
      901 gtagaagagt ctcccttgga gaaagtagag acacctccca aggcaagtgt ggatgcaccc
      961 ccccaggtga atgtggaagt attctgcaac acaagcatgg aagcgtcccc caaggcaggt
     1021 gtgggcatgg cccctgaggt gagcacggac tcattccctg tggtgagcgt ggacgtgtcg
     1081 cctgtggtga gcacatatga ttctgagatg agcatggacg catcccccga gttgagcata
     1141 gaagcactcc cgaaggtgga cctggaaaca gttcccaagg tgagcatagt agcatccccg
     1201 gaggcgagcc tggaagcacc cccggaagtg agtctggaag cactgccaga ggtgagcgtg
     1261 gaagcagccc cagaggggag cctggaagca cctcccaagg ggagcgcaga agtagccccc
     1321 aaggagagtg tgaaagggtc acccaaggag agcatggagg catctcctga ggcgatggtg
     1381 aaagcatccc ccaagacatc ccttgaagca agcatggaag catctcccaa ggcaaaagcg
     1441 agagacgctc caaagaaatc agaaatggac aaacaggcct taatccctat tgccaagaag
     1501 cgtctatcat catacactga gtgttataaa tggtcatcat ctcctgaaaa tgcttgtggt
     1561 ctgccgtctc ccatcagcac taacaggcaa atccaaaaga actgccctcc atcaccatta
     1621 ccacttattt caaaacagtc accacagact tcttttcctt ataaaataat gcctattcaa
     1681 cacaccctgt ctgtgcaaag tgcatcaagt actgtcaaaa agaaaaaaga aacagtttct
     1741 aaaaccacta acagatgtga ggctttgagc caaaggcata tgatctatga agagtctggt
     1801 aataagagta ctgcaggtat tatgaatgcc gaggcggcaa caaaaatttt gacagaattg
     1861 cgccgccttg ctcgtgaaca aagagaaaaa gaggaagaag aaagacaacg ggaagaaatg
     1921 cagcaaaggg tcattaagaa atcaaaagac atggcaaagg aagcagttgg aggccaagca
     1981 gaagaccact tgaaactcaa agatgggcag caacaaaatg agactaaaaa gaagaaagga
     2041 tggctggatc aggaagacca ggaagcacca ctgcagaaag gggacgccaa aataaaagct
     2101 caagaggaag ctgacaaacg caagaaagaa cacgagagaa ttatgttaca aaatttacaa
     2161 gaacggttag aaaggaaaaa gagaatagaa gaaattatga agcggacaag aaagacagat
     2221 gtgaatgcct caaaggtcac agaaacatcc agccatgaca tatatgaaga ggctgaggct
     2281 gacaacgaag aaagcgacaa ggactcattg aatgaaatgt ttccatcagc cattctaaat
     2341 ggcacaggct cacctaccaa atttaaaatg ccgttcaaca atgccaagaa aatgacacac
     2401 aagctggtat ttctagaaga tggtaccagc caggtccgta aagagccaaa aacatatttt
     2461 aatggcgatt tgaaaaactt cagacaaaaa agcatgaaag acacttcaat acaggaagta
     2521 gtttcaagac catcttccaa aagaatgacc agtcacacaa cgaaaaccag aaaggcggat
     2581 gaaaccaaca ccaccagcag atcctctgca caaacaaaat ctgaaggatt ccatgacatc
     2641 ttgccaaagt cctcagacac ctttagacaa taagagaaga agcaaacctg tttctcctca
     2701 tttggatatg taaaccttac tcagcctggg agatgaatac atcttccact ctggataact
     2761 caactcctgg gcccatcagt cctcaaattt ttctgcttct gacttgaacc tggtaaagga
     2821 agtgacaccg aaaaattgaa agaaactgtc aaaaggccac tttgatgtat atctcagatg
     2881 ttaaagtcat cttattctct tgtgtctaag caagagttct aagtaaagag tggtttttgt
     2941 tttctttgga aaatcatcat tgtctctcat tcttgtgttg tcccaccaat gtgtttgctg
     3001 gagtgagtgc atcaaggatg ctttcctgaa actgtaactg tggagtttct agaagaatct
     3061 gattgcagaa ctaattctct ttcagtatat atttgaaatc ttaaagtaat gctttttctt
     3121 tttctttttc tttttttttt ttttgagacg gagtcttgcc ctgtcgccca ggctgcagtg
     3181 cagtggcaca atctcggctc actgcaacct ccgcctcctc atctcaagca attctcctgt
     3241 ctcagcctcc ccagtagctg ggattacagg catgtgccac cacacctggc taattttttt
     3301 gtattttagt agagataggg ttttaccatg ttcaccaggc tagtctcgaa atcctggcct
     3361 caagagatcc acccgtcttg gcctcccaaa gtgttgggat tacaggtgtg agccactgca
     3421 cccagccaag taatgctttt tctgtgtacc agtgacaatt ttgacagcta aaaactcaca
     3481 gttgatcttg tagagaacag aatagattat gcaagggccg caggatcgct cacaagagct
     3541 gtcagattgt ttctaatata aaaataccaa aggttgcaaa atccagcaaa ttgtatttta
     3601 ctgtgatata tgtatatttt taactctacc catctgtgcc agtgagtaca caggcactaa
     3661 taacctgaaa tgctgggagt cctgtaaagc cccatcttgg aacagtcagc acctttcatg
     3721 ctcttgtcag tgtttccttt tgaaggacat attggtgttt atctacagaa acatatatta
     3781 tttttattgt gtacataaag gagtatatgg ctgttgtccc gtggggtatg tttaattcct
     3841 ctaaatgttt aaagtacttt tctgcctgta ctctccagtt ctgtcgttga gtatacactc
     3901 aggcttgaga tacaaccaaa atttgcttgc ctttctctag ccactggctg ccagtgagtt
     3961 cgtgtgatgg gcacacagaa atgcacacag atgtacatac acgtatgtat gcacacacag
     4021 tatatgattc cataaaattc aaatgcagat taattctcct aatgagtttt cagtgttgaa
     4081 tcgtaaatag tctgaagcag gccagtgttc cttttggctg ccagtcttgg attagtaaaa
     4141 ggaggtaatt ctttcagatt ccctggttct ttgccactca gagtattgta cttttgatat
     4201 agaatagaga aggttacctt tggtttaaaa actattttta tatactagct ctttcatgta
     4261 taaaacagag acaatcatcc taacaaaaga gttcctgtta tttttctgca caaatgtctt
     4321 gtgttgaaac actgttacag ttccatataa atgtgtgcta tataaaataa actttggaga
     4381 taaaa
//
