LOCUS       NM_001168465            4062 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens MAP7 domain containing 2 (MAP7D2), transcript variant
            1, mRNA.
ACCESSION   NM_001168465
VERSION     NM_001168465.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4062)
  AUTHORS   Pan,X., Cao,Y., Stucchi,R., Hooikaas,P.J., Portegies,S., Will,L.,
            Martin,M., Akhmanova,A., Harterink,M. and Hoogenraad,C.C.
  TITLE     MAP7D2 Localizes to the Proximal Axon and Locally Promotes
            Kinesin-1-Mediated Cargo Transport into the Axon
  JOURNAL   Cell Rep 26 (8), 1988-1999 (2019)
   PUBMED   30784582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC136379.1, BC089400.1, AW138738.1 and R45976.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001168465.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089400.1, SRR7346977.1396630.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379643.10/ ENSP00000368964.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               BC136379.1         7-579
            574-3908            BC089400.1         584-3918
            3909-3911           AW138738.1         17-19               c
            3912-4062           R45976.1           8-158               c
FEATURES             Location/Qualifiers
     source          1..4062
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.12"
     gene            1..4062
                     /gene="MAP7D2"
                     /note="MAP7 domain containing 2"
                     /db_xref="GeneID:256714"
                     /db_xref="HGNC:HGNC:25899"
                     /db_xref="MIM:301121"
     exon            1..158
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2350
                     /gene="MAP7D2"
                     /note="isoform 1 is encoded by transcript variant 1; MAP7
                     domain containing 2 protein varaint 1; MAP7 domain
                     containing 2 protein varaint 2; MAP7 domain containing 2
                     brain"
                     /codon_start=1
                     /product="MAP7 domain-containing protein 2 isoform 1"
                     /protein_id="NP_001161937.1"
                     /db_xref="CCDS:CCDS55386.1"
                     /db_xref="GeneID:256714"
                     /db_xref="HGNC:HGNC:25899"
                     /db_xref="MIM:301121"
                     /translation="MERGGGGSGTGSRPEGTARGTSLPGKIAEPGAVRTSQPNYRPQG
                     MEGFLKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQR
                     QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKKYSWGAPLAIGPGGH
                     DACDKLSTSTMSLPKPTEPPMNKRLSSSTVAISYSPDRAHHMHLSPMEAILVSRLLTP
                     TQSSLARSRASVMLSGQANDSVFHVCPRLAPLGPLNPSYKSSPTRNIEKKKATSTSTS
                     GAGDVGKEALSGGEASLVEKVKRGQRTATSLPVVNFGSPLRRCEFSGGIPKRPSSPVI
                     SKTATKAYPQSPKTTKPPYPGSPVKYRLPALSGQDMPKRKAEKEKSNKEREGTLAQQA
                     AGPQGEEALEKHVVDKHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRR
                     QARLQKEQEEQERLEKEEQDRLEREELKRKAEEERLRLEEEARKQEEERKRQEEEKKK
                     QEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREVAEQMRLE
                     REQIMLQIEQERLERKKRIDEIMKRTRKSDVSPQVKKEDPKVGVQPAVCVEKKTKLVV
                     PNKMEINGLNTCQEVNGVDHAAPETYPQDIFSNGLKPAGGLIHLDALDGKSNSLDDST
                     EEVQSMDVSPVSKEELISIPEFSPVSEMIPGVSLDQNGTGNARALQDLLDFTGPPTFP
                     KRSSENLSLDDCNKNLIEGFNSPGQETPLNTFC"
     exon            159..236
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            237..400
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            401..512
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..623
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..746
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..907
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1035
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1307
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1440
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1672
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1777
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1834
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1913
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2100
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2376
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..4062
                     /gene="MAP7D2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3441..3446
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7D2"
                     /note="hexamer: ATTAAA"
     polyA_site      3467
                     /gene="MAP7D2"
     regulatory      3887..3892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7D2"
                     /note="hexamer: AATACA"
     polyA_site      3908
                     /gene="MAP7D2"
                     /note="major polyA site"
     regulatory      4034..4039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7D2"
                     /note="hexamer: ATTAAA"
     polyA_site      4062
                     /gene="MAP7D2"
ORIGIN      
        1 agtgcgcctg tgcggccggc gcatcccgat ggagcgcggc ggcggcggct ccgggacggg
       61 atcccggcct gaggggactg cgcggggaac ctctctccca gggaagatcg cagaaccggg
      121 cgcggtgcgg acctctcagc ccaactaccg gcctcaaggc atggagggat ttttgaaatc
      181 agatgagagg cagagattgg ccaaagaaag acgagaagaa agagaaaaat gtctggctgc
      241 tcgggagcaa cagatcctgg agaaacagaa aagagccagg ctgcagtacg aaaagcaaat
      301 ggaggagcga tggcgaaaac tggaagagca gcggcagcgg gaggaccaaa agagagctgc
      361 tgtggaagag aaaaggaaac agaagctccg ggaggaggag gaacggctgg aggcgatgat
      421 gcgccggtcc ctggagcgca cacagcagct ggagctgaaa aagaagtatt cgtggggagc
      481 accactggcc attggacccg gaggacatga tgcatgtgac aaactttcaa catcaactat
      541 gagtttgcca aagccaacgg agcctcccat gaataaacgc ctgtcttcat ccaccgtggc
      601 aatatcctat tccccagacc gagctcatca catgcacctt agtccaatgg aagccattct
      661 tgtttcgcga ctgttgacac ccacacagtc ttctttagcc agaagcagag cttcagtcat
      721 gctctctggg caggccaatg attcagtatt ccatgtctgt cctcgtttag ctcctcttgg
      781 ccctcttaac ccttcttaca agtcttcacc cactcgaaac attgagaaga agaaagctac
      841 atctacgtct acatctggtg caggagatgt tgggaaagaa gccctttcag gaggagaggc
      901 ctctctggtg gagaaggtga agcgggggca acgaacagca acttctcttc ctgttgtgaa
      961 cttcgggtcc cctctgagaa gatgtgagtt ttctggaggc attcctaaga gaccatcttc
     1021 tcctgtgata tccaagacag ctactaaagc ttatccacag tctccaaaga caacgaaacc
     1081 tccctaccca gggtctcctg tgaagtaccg cttacctgcc ctttctggcc aagacatgcc
     1141 caagaggaaa gcggagaaag agaagagcaa caaggaaagg gaaggtacct tggctcagca
     1201 ggctgctggc ccgcaaggag aggaagccct agagaagcat gtagtggaca agcatgccag
     1261 cgagaagcat gctgctgccg caggagggaa agccgaaaac agcgcagcct tggggaagcc
     1321 cacagcaggc accactgatg caggagaggc tgcgaagatc ttggctgaaa agagaagaca
     1381 ggcccggctg cagaaggaac aggaggagca agaacgactg gagaaggaag aacaagatag
     1441 gctggagaga gaggaattga aaagaaaggc agaggaggaa aggcttcgcc tagaagagga
     1501 agcccgaaag caggaagaag aaaggaagcg gcaggaagag gaaaagaaaa aacaggaagg
     1561 ggaagagaaa agaaaggcag gcgaggaggc caagcggaag gctgaggagg agctgttgtt
     1621 gaaagaaaag caagaacaag aaaaacaaga gaaagccatg attgaaaagc agaaagaagc
     1681 agcagaaaca aaggcccggg aggtagctga acagatgcgt ctcgagagag aacagattat
     1741 gctgcagatt gagcaggaga gactggagag aaagaagaga atagatgaaa tcatgaagag
     1801 aacaaggaaa agtgatgtgt ctccacaagt gaagaaagaa gaccccaaag tgggggtcca
     1861 gcctgctgtg tgtgtggaaa agaagacaaa actggttgtc cccaacaaaa tggaaatcaa
     1921 tggattgaac acctgccagg aagttaatgg tgtggatcac gctgccccag aaacttatcc
     1981 ccaagacatt ttctctaatg ggcttaagcc agctggggga ctcattcatc tggatgccct
     2041 tgatgggaaa tcaaatagcc tggatgattc aactgaagaa gttcagtcta tggatgtgag
     2101 tcctgtttca aaagaagagc ttatctctat cccggaattt tcaccagtga gtgaaatgat
     2161 tcctggggtg tctctggacc aaaatggaac tggtaatgcc cgagcacttc aagatctctt
     2221 agatttcact ggtcccccga cattccccaa gagatccagt gaaaatctca gcctggacga
     2281 ctgtaacaaa aaccttatcg aaggatttaa cagtcctggc caagaaactc ctctcaacac
     2341 cttctgttga caaatacagc atccctttaa taaaaggtgt ttggagaacc cgtaaagctg
     2401 ctgatagtca aatccgagct actagctgct tgaagaagct tctgtcaccc ttaccgctgg
     2461 atcccaaatt attagctcgg aatgtaactg tattcctagg tagtatgtca aacactggcc
     2521 actcttggta gaaaccttga aactttcacc ttgctgggct ttagcaaagt ttccttttac
     2581 agttctgttt atgagcttca gctactgata aagcacttcc tgaacttctc tattatcata
     2641 gtgaccctct gaataacctg agtgactggc tcggcaattc gctttataac cattcttatt
     2701 cccaaagttg gagcacataa acatttagat gtcttttcct gtaaaatatt ctagacattt
     2761 acccaaactc tagttcaaca tatactcaac ttgcactgta tatctccctg tcttttttga
     2821 gacagagaag aaattcagga ggttccccat ctccagagtt tctctgttgg aaagcagtat
     2881 caagaagcct ttaaaaaatt gttgttaagc tttgccacct gcagaaatgc attgccccac
     2941 attattcttc tggggttaaa gtagtaagtt tggttgagga aggaagtcaa aacagtcagt
     3001 aatgatttct gttctcttat gcatattcgt gtatacatgg gcaactgaat ctagcaagga
     3061 ctctttcgtg tcacacctta aaatcttcat gctgtagtca ctccagacca tggagtggct
     3121 ttccagctga atgaatccta tgtctcgcgt gcaggtggtt ggttttcaat gttcttgcta
     3181 attttttttc tattggatct tgggagtttt ctttgtttgc tcctgtgttt gcccagcttt
     3241 aataaaacca ggcgcaaaca aaaaccatag cattctgaaa caataggggg cccacattgg
     3301 acccagtatg tcactttaat ggacttcaag aaaaaatctg aatgggaaaa atgacactag
     3361 aatgtatact ccacacattt tatgccatat aatggtgtgt tttcttaatt ttgtttcttg
     3421 tggcgaaatg tggctttcaa attaaaatga ccttttcttc tttgaaactt tttgttttga
     3481 cttgtataat taagggtttg gaaagattca taattctgag agaggtttgc aaccaggaga
     3541 tacaaagaag tctcagtagt aatcttgttc atgtgctttt acagccagct acatttaaga
     3601 atgtattagt tacagaaatt atatgtctgt gtatgtgtct ctactcaata aagtacatgc
     3661 ctccacataa tgcggtgctg tccatctcgg caaatactgg ccaagtccct ttatgacagg
     3721 cacacagaaa ccatagcatg gtctggcttt cagaaaatgc ctctcatctt tcctggaacc
     3781 ttattttgct aaatgtctgt tttcttgtga tttgttgtac ctcacagcac cattgtgacc
     3841 atggtgatgc ctcatttgca tgatatgtac cttgtgttta atgtgaaata cattttcatt
     3901 gaagagtctg atgacttgct agcgttttat tttttctgta agctcaatgt gctgaaacca
     3961 aaccaggctt ttaaaaacct gtgtagaaga aaaccaaaaa atcctgtgtg ggtgtccttt
     4021 ccctgtcaaa ctcattaaaa attcctttgt tgccagtgcc aa
//
