LOCUS       NM_001388490            3372 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens MAP7 domain containing 1 (MAP7D1), transcript variant
            4, mRNA.
ACCESSION   NM_001388490 XM_006710759
VERSION     NM_001388490.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3372)
  AUTHORS   Wu,S.L., Zhang,X., Chang,M., Huang,C., Qian,J., Li,Q., Yuan,F.,
            Sun,L., Yu,X., Cui,X., Jiang,J., Cui,M., Liu,Y., Wu,H.W.,
            Liang,Z.Y., Wang,X., Niu,Y., Tong,W.M. and Jin,F.
  TITLE     Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies
            MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast
            Cancer
  JOURNAL   Genomics Proteomics Bioinformatics 19 (1), 64-79 (2021)
   PUBMED   33716151
  REMARK    GeneRIF: Genome-wide 5-Hydroxymethylcytosine Profiling Analysis
            Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in
            Breast Cancer.
REFERENCE   2  (bases 1 to 3372)
  AUTHORS   Hooikaas,P.J., Martin,M., Muhlethaler,T., Kuijntjes,G.J.,
            Peeters,C.A.E., Katrukha,E.A., Ferrari,L., Stucchi,R.,
            Verhagen,D.G.F., van Riel,W.E., Grigoriev,I., Altelaar,A.F.M.,
            Hoogenraad,C.C., Rudiger,S.G.D., Steinmetz,M.O., Kapitein,L.C. and
            Akhmanova,A.
  TITLE     MAP7 family proteins regulate kinesin-1 recruitment and activation
  JOURNAL   J Cell Biol 218 (4), 1298-1318 (2019)
   PUBMED   30770434
  REMARK    GeneRIF: MAP7 proteins are microtubule-tethered kinesin-1
            activators, with which the motor transiently interacts as it moves
            along microtubules.
REFERENCE   3  (bases 1 to 3372)
  AUTHORS   Kikuchi,K., Nakamura,A., Arata,M., Shi,D., Nakagawa,M., Tanaka,T.,
            Uemura,T., Fujimori,T., Kikuchi,A., Uezu,A., Sakamoto,Y. and
            Nakanishi,H.
  TITLE     Map7/7D1 and Dvl form a feedback loop that facilitates microtubule
            remodeling and Wnt5a signaling
  JOURNAL   EMBO Rep 19 (7) (2018)
   PUBMED   29880710
  REMARK    GeneRIF: Here we show that in HeLa cells, the paralogous
            MT-associated proteins Map7 and Map7D1 (Map7/7D1) form an
            interdependent regulatory loop with Disheveled, the critical signal
            transducer in Wnt signaling
REFERENCE   4  (bases 1 to 3372)
  AUTHORS   Agrawal,P., Yu,K., Salomon,A.R. and Sedivy,J.M.
  TITLE     Proteomic profiling of Myc-associated proteins
  JOURNAL   Cell Cycle 9 (24), 4908-4921 (2010)
   PUBMED   21150319
REFERENCE   5  (bases 1 to 3372)
  AUTHORS   Sauer,G., Korner,R., Hanisch,A., Ries,A., Nigg,E.A. and Sillje,H.H.
  TITLE     Proteome analysis of the human mitotic spindle
  JOURNAL   Mol Cell Proteomics 4 (1), 35-43 (2005)
   PUBMED   15561729
REFERENCE   6  (bases 1 to 3372)
  AUTHORS   Kleiderlein,J.J., Nisson,P.E., Jessee,J., Li,W.B., Becker,K.G.,
            Derby,M.L., Ross,C.A. and Margolis,R.L.
  TITLE     CCG repeats in cDNAs from human brain
  JOURNAL   Hum Genet 103 (6), 666-673 (1998)
   PUBMED   9921901
  REMARK    Erratum:[Hum Genet 1999 Jan;104(1):113]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC114484.2.
            
            On Nov 16, 2020 this sequence version replaced XM_006710759.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.171785.1,
                                           SRR14038191.4249770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000474796.2/ ENSP00000507044.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-304               AC114484.2         72134-72437         c
            305-649             AC114484.2         57282-57626         c
            650-718             AC114484.2         57016-57084         c
            719-882             AC114484.2         55970-56133         c
            883-997             AC114484.2         55119-55233         c
            998-1108            AC114484.2         53589-53699         c
            1109-1491           AC114484.2         52016-52398         c
            1492-1637           AC114484.2         51755-51900         c
            1638-1966           AC114484.2         50396-50724         c
            1967-2144           AC114484.2         50001-50178         c
            2145-2283           AC114484.2         49774-49912         c
            2284-2388           AC114484.2         49572-49676         c
            2389-2442           AC114484.2         49282-49335         c
            2443-2485           AC114484.2         49040-49082         c
            2486-2576           AC114484.2         48841-48931         c
            2577-2770           AC114484.2         48530-48723         c
            2771-3372           AC114484.2         47748-48349         c
FEATURES             Location/Qualifiers
     source          1..3372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..3372
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /note="MAP7 domain containing 1"
                     /db_xref="GeneID:55700"
                     /db_xref="HGNC:HGNC:25514"
     exon            1..304
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..2781
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     proline arginine rich coiled coil 1; arginine/proline rich
                     coiled-coil 1; MAP7 domain-containing protein 1;
                     arginine/proline-rich coiled-coil domain-containing
                     protein 1; proline/arginine-rich coiled-coil
                     domain-containing protein 1"
                     /codon_start=1
                     /product="MAP7 domain-containing protein 1 isoform 4"
                     /protein_id="NP_001375419.1"
                     /db_xref="CCDS:CCDS90916.1"
                     /db_xref="GeneID:55700"
                     /db_xref="HGNC:HGNC:25514"
                     /translation="MESGPRAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALV
                     PDTPPDTPPAMKNATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMG
                     PRDARPPRRSSQPSPTAVPASDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVW
                     LEKEEKAKALREKQLQERRRRLEEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRS
                     VKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSAT
                     LWNSPSRNRSLQLSAWESSIVDRLMTPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGP
                     TWGRAGASLARGPQPDRTHPSAAVPVCPRSASASPLTPCSVTRSVHRCAPAGERGERR
                     KPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRAR
                     LSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRV
                     RRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAE
                     TPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQ
                     AERDKRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEAR
                     SREEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKKQDSKEANANGS
                     SPEPVKAVEARSPGLQKEAVQKEEPIPQEPQWSLPSKELPASLVNGLQPLPAHQENGF
                     STNGPSGDKSLSRTPETLLPFAEAEAFLKKAVVQSPQVTEVL"
     exon            305..649
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            650..718
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            719..882
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..997
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1108
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1491
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1637
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1966
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2144
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2283
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2388
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2442
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2485
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2486..2576
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2770
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..3372
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3352..3357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /note="hexamer: AATAAA"
     polyA_site      3372
                     /gene="MAP7D1"
                     /gene_synonym="PARCC1; RPRC1"
                     /note="major polyA site"
ORIGIN      
        1 gttgggccga ggccgggact gggccggcgc cgggcgggga acgggttcgc gaccgcagcc
       61 gagagacccc gggcgaccgg cacctccgag actcgcgggc cacctgcctc gaccttcccc
      121 ggagcgcccc cgcctccgag tcgctacttg ccgggccggg ccgggccggg cgtgatgcgc
      181 cgcgggaccc ctgtcctggc cactggccgc cgccgccgcc gccgctgaga ccccgagacc
      241 cccagtgacg ccgcagccat ggagagcggc ccgcgtgcgg agctgggggc gggcgcaccc
      301 ccagctgtgg tcgccaggac ccccccagag ccaagacctt ctccagaagg tgacccttcc
      361 cccccaccac caccaatgtc agccctggtc cccgacactc ccccggacac ccctcctgcc
      421 atgaagaatg ccactagctc taagcagctc ccactggaac cagagagccc ctcagggcag
      481 gtcgggccta ggccagcccc cccgcaggaa gagtcccctt cctctgaagc aaagagcaga
      541 ggacccaccc caccagccat gggcccacgg gatgccagac ctcctcgaag gagcagccag
      601 ccatctccaa cagcagtgcc agcctccgac agccctccca ccaagcaaga ggtgaagaag
      661 gcaggagaga gacacaagct ggcaaaggag cggcgagaag agcgggccaa gtacctggcg
      721 gccaagaagg cagtgtggct ggagaaggag gagaaggcca aggcgctgcg ggagaagcag
      781 ctccaggagc gccggcgccg gctggaggag caacgtctta aagccgagca acgccgtgca
      841 gccctggagg aacggcagcg gcagaagctc gagaaaaaca aggagcgcta tgaagcagcc
      901 atccaacggt cagtgaagaa gacgtgggcc gaaatccggc agcagcgctg gtcctgggca
      961 ggggccctgc accacagctc tccaggacat aagaccagtg ggagcaggtg ctccgtgtcg
     1021 gcagttaacc tgcccaaaca cgtggactct ataatcaaca agcggctctc aaagtcctct
     1081 gccacgctct ggaactcccc cagtagaaat cgcagcctgc agctgagcgc atgggagagc
     1141 agcatcgtgg atcgtctgat gacgcccact ctctccttcc ttgctcggag tcgcagcgcg
     1201 gtcacactgc cccgcaacgg ccgggaccag ggtaggggct gcgaccctgg gagaggcccc
     1261 acgtggggcc gggcaggggc cagcctggcg cgcgggccgc aacccgaccg cactcatccc
     1321 tctgcagccg tgccggtgtg cccgcgctcg gcctccgcca gccccctgac gccgtgcagc
     1381 gtcacccgaa gcgtgcaccg ctgcgccccc gccggtgagc gcggggagcg ccgcaagccc
     1441 aacgccgggg gcagccccgc tccggtgcgc cgccggccgg aggcctcgcc ggtgcagaaa
     1501 aaggagaaga aggacaagga gcgggaaaac gagaaggaga agagtgccct agcccgggag
     1561 cgcagcctca agaagcgcca gtcgctgccc gcctccccac gtgcccgcct ctctgccagc
     1621 accgcctctg agctcagccc caaatccaag gccaggccat cctctccctc cacatcctgg
     1681 cacaggcctg cctccccctg ccccagccca gggccaggcc acactctgcc tccaaagcca
     1741 ccgtcccccc gaggcaccac tgcatccccc aaggggcggg ttcggaggaa ggaggaggca
     1801 aaggagagcc ccagcgccgc agggcccgag gacaagagcc agagcaagcg cagggccagt
     1861 aacgagaagg agtcagcagc cccagcctca ccggcacctt cgccggcgcc ctcgcccacc
     1921 ccagccccgc cccagaagga gcagcccccc gcggagaccc ctacagacgc tgctgtcttg
     1981 acctcacccc cagcccctgc tcccccggtg acccctagca aaccaatggc cggcaccaca
     2041 gaccgagaag aagccactcg gctcttggct gagaagcggc gccaggcccg ggagcagcgg
     2101 gagcgcgagg agcaggagcg gaggctgcag gcagaaaggg acaagcgaat gcgagaggag
     2161 cagctggcac gggaggccga ggcccgggcg gagcgggagg cggaggcccg gaggcgggag
     2221 gagcaggagg cacgagagaa ggcgcaggcc gagcaggagg agcaggagcg gctgcagaag
     2281 cagaaagagg aggccgaagc tcggtcgcgg gaagaggcgg agcggcagcg tctggagcgg
     2341 gaaaagcact tccagcagca ggagcaagag cggcaagagc gcagaaagcg tctggaggag
     2401 atcatgaaga ggactcggaa gtcagaagtt tctgaaacca agaagcagga cagcaaggag
     2461 gccaacgcca acggttccag cccagagcct gtgaaagctg tggaggctcg gtccccaggg
     2521 ctgcagaagg aggctgtgca gaaagaggag cccatcccac aggagcctca gtggagtctc
     2581 ccaagcaagg agttgccagc gtccctggtg aatggcctgc agcctctccc agcacaccag
     2641 gagaatggct tctccaccaa cggaccctct ggggacaaga gtctgagccg aacaccagag
     2701 acactcctgc cctttgcaga ggcagaagcc ttcctcaaga aagctgtggt gcagtccccg
     2761 caggtcacag aagtccttta agagggtttg ccttggatcc gggcacagtt gtgagggctc
     2821 ctctgcatca cctaccagga tgtctggagg agaaaaagac agaacaaaga tggaagtggc
     2881 ctgggcccct gggggtgggt cctctctgtt gtttttaatc tgcaccttat agactgatgt
     2941 ctctttggcc ggagccagat ctgcccctca gtgcattcgt gtgctcgcac gcgcagacat
     3001 cccttctccc ccatacacac atatacactc acagcctctc tggcctcttc ccttggggag
     3061 gggccacctg tagtatttgc cttgatttgg tggggtacag tggatgtgaa tactgtaaat
     3121 agcttgtgct cagactcctc tgcgtggaga gggtgggtgc aggaggcaga ccctcccccc
     3181 aaagccccct ggggagatct tcctctctct atttaactgt aactgagggg gatcccaggt
     3241 ctggggatgg gggacacctt gggccacagg atactggttg cttcaggggt acccatgccc
     3301 cctgccctcg cctggaatca gtgttactgc atctgattaa atgtctccag aaataaagaa
     3361 taattctgcc aa
//
