LOCUS       NM_003980               3758 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens microtubule associated protein 7 (MAP7), transcript
            variant 4, mRNA.
ACCESSION   NM_003980
VERSION     NM_003980.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3758)
  AUTHORS   Adler,A., Bangera,M., Beugelink,J.W., Bahri,S., van Ingen,H.,
            Moores,C.A. and Baldus,M.
  TITLE     A structural and dynamic visualization of the interaction between
            MAP7 and microtubules
  JOURNAL   Nat Commun 15 (1), 1948 (2024)
   PUBMED   38431715
  REMARK    GeneRIF: A structural and dynamic visualization of the interaction
            between MAP7 and microtubules.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3758)
  AUTHORS   Wang,R., Xie,S., He,Y., Zheng,R., Zhang,M., Jin,J. and Wang,M.
  TITLE     MAP7 Promotes Breast Cancer Cell Migration and Invasion by
            Regulating the NF-B Pathway
  JOURNAL   Ann Clin Lab Sci 52 (5), 721-730 (2022)
   PUBMED   36261182
  REMARK    GeneRIF: MAP7 Promotes Breast Cancer Cell Migration and Invasion by
            Regulating the NF-B Pathway.
REFERENCE   3  (bases 1 to 3758)
  AUTHORS   Nabawy,S.M., Refaat,L.A., Naser-Aldin,H.M. and Rashed,R.A.
  TITLE     Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid
            Leukemia Patients
  JOURNAL   Asian Pac J Cancer Prev 23 (5), 1619-1626 (2022)
   PUBMED   35633546
  REMARK    GeneRIF: Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute
            Myeloid Leukemia Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3758)
  AUTHORS   Ferro,L.S., Fang,Q., Eshun-Wilson,L., Fernandes,J., Jack,A.,
            Farrell,D.P., Golcuk,M., Huijben,T., Costa,K., Gur,M., DiMaio,F.,
            Nogales,E. and Yildiz,A.
  TITLE     Structural and functional insight into regulation of kinesin-1 by
            microtubule-associated protein MAP7
  JOURNAL   Science 375 (6578), 326-331 (2022)
   PUBMED   35050657
  REMARK    GeneRIF: Structural and functional insight into regulation of
            kinesin-1 by microtubule-associated protein MAP7.
REFERENCE   5  (bases 1 to 3758)
  AUTHORS   Yu,L., Xie,J., Liu,X., Yu,Y. and Wang,S.
  TITLE     Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric
            Cancer via miR-409-3p/MAP7 Axis
  JOURNAL   Dig Dis Sci 66 (12), 4274-4289 (2021)
   PUBMED   33449227
  REMARK    GeneRIF: Plasma Exosomal CircNEK9 Accelerates the Progression of
            Gastric Cancer via miR-409-3p/MAP7 Axis.
REFERENCE   6  (bases 1 to 3758)
  AUTHORS   Penttila,T.L., Parvinen,M. and Paranko,J.
  TITLE     Microtubule-associated epithelial protein E-MAP-115 is localized in
            the spermatid manchette
  JOURNAL   Int J Androl 26 (3), 166-174 (2003)
   PUBMED   12755995
REFERENCE   7  (bases 1 to 3758)
  AUTHORS   Bulinski,J.C., Odde,D.J., Howell,B.J., Salmon,T.D. and
            Waterman-Storer,C.M.
  TITLE     Rapid dynamics of the microtubule binding of ensconsin in vivo
  JOURNAL   J Cell Sci 114 (Pt 21), 3885-3897 (2001)
   PUBMED   11719555
REFERENCE   8  (bases 1 to 3758)
  AUTHORS   Fabre-Jonca,N., Viard,I., French,L.E. and Masson,D.
  TITLE     Upregulation and redistribution of E-MAP-115 (epithelial
            microtubule-associated protein of 115 kDa) in terminally
            differentiating keratinocytes is coincident with the formation of
            intercellular contacts
  JOURNAL   J Invest Dermatol 112 (2), 216-225 (1999)
   PUBMED   9989799
REFERENCE   9  (bases 1 to 3758)
  AUTHORS   Masson,D. and Kreis,T.E.
  TITLE     Binding of E-MAP-115 to microtubules is regulated by cell
            cycle-dependent phosphorylation
  JOURNAL   J Cell Biol 131 (4), 1015-1024 (1995)
   PUBMED   7490279
REFERENCE   10 (bases 1 to 3758)
  AUTHORS   Masson,D. and Kreis,T.E.
  TITLE     Identification and molecular characterization of E-MAP-115, a novel
            microtubule-associated protein predominantly expressed in
            epithelial cells
  JOURNAL   J Cell Biol 123 (2), 357-371 (1993)
   PUBMED   8408219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL024508.1 and AL023284.1.
            
            On Oct 26, 2020 this sequence version replaced NM_003980.5.
            
            Summary: The product of this gene is a microtubule-associated
            protein that is predominantly expressed in cells of epithelial
            origin. Microtubule-associated proteins are thought to be involved
            in microtubule dynamics, which is essential for cell polarization
            and differentiation. This protein has been shown to be able to
            stabilize microtubules, and may serve to modulate microtubule
            functions. Studies of the related mouse protein also suggested an
            essential role in microtubule function required for
            spermatogenesis. Multiple alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X73882.1, AK312789.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354570.8/ ENSP00000346581.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AL024508.1         20985-21065         c
            82-180              AL023284.1         111424-111522       c
            181-258             AL023284.1         101343-101420       c
            259-422             AL023284.1         79077-79240         c
            423-540             AL023284.1         78116-78233         c
            541-651             AL023284.1         73394-73504         c
            652-765             AL023284.1         67478-67591         c
            766-890             AL023284.1         62224-62348         c
            891-1003            AL023284.1         56050-56162         c
            1004-1287           AL023284.1         55458-55741         c
            1288-1540           AL023284.1         52173-52425         c
            1541-1715           AL023284.1         50728-50902         c
            1716-1817           AL023284.1         50420-50521         c
            1818-1868           AL023284.1         49704-49754         c
            1869-1926           AL023284.1         49543-49600         c
            1927-2029           AL023284.1         46415-46517         c
            2030-2253           AL023284.1         35579-35802         c
            2254-3758           AL023284.1         32457-33961         c
FEATURES             Location/Qualifiers
     source          1..3758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..3758
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="microtubule associated protein 7"
                     /db_xref="GeneID:9053"
                     /db_xref="HGNC:HGNC:6869"
                     /db_xref="MIM:604108"
     exon            1..81
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2264
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="isoform 3 is encoded by transcript variant 4;
                     ensconsin; dJ325F22.2 (microtubule-associated protein 7
                     (EMAP115, E-MAP-115)); epithelial microtubule-associated
                     protein of 115 kDa"
                     /codon_start=1
                     /product="ensconsin isoform 3"
                     /protein_id="NP_003971.1"
                     /db_xref="CCDS:CCDS5178.1"
                     /db_xref="GeneID:9053"
                     /db_xref="HGNC:HGNC:6869"
                     /db_xref="MIM:604108"
                     /translation="MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAIS
                     GQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH
                     LEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW
                     SWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQL
                     SPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFV
                     TPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSK
                     SLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKV
                     ANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPT
                     PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELE
                     RQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQR
                     QKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR
                     NGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNE
                     NGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLNPILAFDDEGTLGPLPQVDGV
                     QTQQTAEVI"
     exon            82..180
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            181..258
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            259..422
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            423..540
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            541..651
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            652..765
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            766..890
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1003
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1287
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1540
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1715
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1817
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1868
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1926
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2029
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2253
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..3758
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2397..2402
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="hexamer: ATTAAA"
     polyA_site      2417
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="major polyA site"
     regulatory      3502..3507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="hexamer: ATTAAA"
     polyA_site      3529
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
     regulatory      3735..3740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="hexamer: AATAAA"
     polyA_site      3758
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="major polyA site"
ORIGIN      
        1 gtcatcggag caccatggcg gagctaggag ctggcggcga cggccacagg ggcggcgacg
       61 gcgcagtgcg aagcgaaaca gcacccgaca gctacaaagt gcaagataag aaaaatgcct
      121 ccagccgccc tgcctctgca atttcaggac aaaataacaa ccactcagga aataaaccag
      181 accctccgcc tgtgttacgt gttgatgacc ggcagcggct ggcccgggag cgacgtgagg
      241 aacgggagaa acagctagct gcaagagaaa tagtgtggtt agaaagagaa gagcgagcca
      301 ggcagcacta cgagaagcac ctggaagagc ggaagaagag gttggaggag cagaggcaga
      361 aggaggagcg gaggagggct gctgtggagg agaagcggag gcagagactt gaggaggaca
      421 aagaacgcca cgaagctgtt gtacggcgca caatggaaag gagccagaag ccaaaacaga
      481 agcataaccg ttggtcgtgg ggaggctctc tccatgggag ccctagcatc cacagtgcag
      541 atccagacag gcggtcagtt tccaccatga atctttcgaa atatgttgat cccgtcatta
      601 gcaagcggct ctcctcttca tctgcaactt tactaaattc tccagataga gctcgccgcc
      661 tgcagctcag cccatgggag agcagcgttg ttaacagact cctgacgccc acacattcgt
      721 tcctggccag aagtaaaagc acagctgcct tgtctggaga agcagcatct tgcagcccca
      781 tcatcatgcc ctacaaagct gcacactcta gaaattcgat ggatcgacca aaactctttg
      841 taacaccacc tgagggctct tctcgcagga ggatcattca tggcacagcg agctataaaa
      901 aagaaagaga gagagaaaat gtactcttcc tcacatctgg cacccgaagg gctgtatctc
      961 catctaatcc caaagcaaga caaccagctc gctcccgact ttggcttccg tccaagtctc
     1021 ttcctcattt gcctggcaca cccagaccga catcctcctt gccacccggc tcagtcaaag
     1081 ctgctcctgc tcaggtccgg cccccatccc ccggcaacat ccgccctgtc aagagggaag
     1141 tcaaagtgga gcctgagaag aaagatcctg agaaggaacc tcagaaagtt gccaatgagc
     1201 cctcactaaa gggcagagca cctttagtga aggtagaaga agccacagtt gaagagcgga
     1261 cacctgctga accagaagtt ggccctgctg ctccagccat ggccccagct ccagcctcgg
     1321 ccccagctcc agcctcggcc ccagctccag ccccggtccc caccccagcc atggtctcag
     1381 ccccgtcatc cactgtgaat gccagtgctt ctgttaagac ttctgcaggc accaccgacc
     1441 cagaggaggc cacaaggctt ctagctgaga agaggcggct ggcccgagag cagagagaaa
     1501 aggaagaaag ggagaggagg gagcaggaag agcttgaaag acaaaagaga gaggaattgg
     1561 ctcaacgtgt ggctgaagag aggacgactc gccgtgagga ggagtcgcgc aggctggaag
     1621 ccgagcaggc ccgggagaag gaggagcagc tgcagcggca ggcggaggag cgggcgctgc
     1681 gcgagcggga ggaggcagag cgcgcccaga ggcagaaaga agaagaagct cgcgttcgtg
     1741 aagaagcaga gagggtccgg caggaacgag agaagcattt ccagagagaa gagcaagagc
     1801 gcctggagag aaagaagcga cttgaggaga ttatgaaaag aaccaggaga acagaagcta
     1861 cagataagaa aaccagtgat cagagaaacg gtgatatagc caagggagct ctcactggag
     1921 gaacagaggt gtctgcactt ccatgtacaa caaacgctcc gggaaatgga aagccagttg
     1981 gcagcccaca tgtggttacc tcacaccagt caaaagtgac agtggagagc actcccgatt
     2041 tggaaaaaca accaaatgaa aatggtgtat ctgttcagaa tgaaaatttt gaagaaatta
     2101 taaacttacc cattggatct aaaccatcca gattagatgt caccaacagt gagagcccag
     2161 aaattccttt gaatccaatt ttggcctttg atgatgaagg gacacttggg cccctgcctc
     2221 aggtagatgg tgttcagaca cagcagactg cagaagttat atgagtgttt cttctgaaga
     2281 accaaagctg aaatttaatg agaatttcta caattaatgg aattcctttc ctgctataaa
     2341 ggagcatccc ctccacccgt tttctagagt tcttgaccat cattttgaaa agatttatta
     2401 aaactagcta aagacaacag actggatagc ttttctaata attttcatca ataggaaaaa
     2461 agaaatacgt ctcattcttc aatactttaa aatggctttt tccagtgtgc tccttcttag
     2521 caatcaatat ttttctgcat tctttaaaag acaagagaat ttggttataa aagaaatggg
     2581 ctgactaggc atgatttttt tggtcttaaa agcttaacat gtaaaattgg caaaaaaaat
     2641 tttttacctt ttataatact tgaaaaataa gtacctcttt gttctacaag tagaatgaat
     2701 aggagaagag tttaagcctg tttttttaaa atattattgc aaagagctct atttgtagaa
     2761 gcaaattata ggcagattac caggttctta taaatacagc ttgtacatgg acattctgca
     2821 aacccagctg tcacattttt cttgcaactc cttttgcaaa agcagactaa aatgttttaa
     2881 aatgtgaaaa aacattattt tttcaaagca agaaaataat ttactgccct cttacataat
     2941 gtatttataa agtttttcca gataaactaa tcaaataaat tagaataatg tgacaacatt
     3001 acaaatttaa tttgttagct gcattccttc tgatgttacc acgatagaat gttactgatg
     3061 attcagggct atttctgaag tctgtatgtt gctgctgtcc ccagtgatgg tggacttatc
     3121 tttgccttac ctgatcacaa attatgttgg ggaaaataaa gatttaatat ttctttaaat
     3181 agaaaaagaa tttggttttg ctcgtttaag agcaatgaga aaatgatgga atgttgactg
     3241 tgtttggcac acaggacacg gaccttcatg gaagtccttg ctctgcgtgg catctgtcag
     3301 cttttcacct ttcattctta ttcttcactt ttgctgctga gcctagctgt acaaacttgc
     3361 actttcattt gctaatataa attcagtttt attttaccat tttagagact actaatgatt
     3421 aaatgtagaa ggagagggtg cacatgtttt tatgtggagt gtttaaaaga taaatttata
     3481 ccactgtaat gtgcagcttt tattaaaaga gaaattggtt gaactgctag gttgaatgag
     3541 agacttcatc tattggacta ttttttttaa tccaggcata tggtctttag taatggcttg
     3601 taatttgtga aaacattaat ttgggggttt tccctgtttt cagttgtcca tgtacacata
     3661 gtcattatat tagaaaagaa atctgttcaa caaacttgtt taatttgttt aaatcaacat
     3721 agcatgaaac accaaataaa atgtttgaca tagtttta
//
