LOCUS       NM_001198608            4428 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens microtubule associated protein 7 (MAP7), transcript
            variant 1, mRNA.
ACCESSION   NM_001198608
VERSION     NM_001198608.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4428)
  AUTHORS   Adler,A., Bangera,M., Beugelink,J.W., Bahri,S., van Ingen,H.,
            Moores,C.A. and Baldus,M.
  TITLE     A structural and dynamic visualization of the interaction between
            MAP7 and microtubules
  JOURNAL   Nat Commun 15 (1), 1948 (2024)
   PUBMED   38431715
  REMARK    GeneRIF: A structural and dynamic visualization of the interaction
            between MAP7 and microtubules.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4428)
  AUTHORS   Wang,R., Xie,S., He,Y., Zheng,R., Zhang,M., Jin,J. and Wang,M.
  TITLE     MAP7 Promotes Breast Cancer Cell Migration and Invasion by
            Regulating the NF-B Pathway
  JOURNAL   Ann Clin Lab Sci 52 (5), 721-730 (2022)
   PUBMED   36261182
  REMARK    GeneRIF: MAP7 Promotes Breast Cancer Cell Migration and Invasion by
            Regulating the NF-B Pathway.
REFERENCE   3  (bases 1 to 4428)
  AUTHORS   Nabawy,S.M., Refaat,L.A., Naser-Aldin,H.M. and Rashed,R.A.
  TITLE     Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute Myeloid
            Leukemia Patients
  JOURNAL   Asian Pac J Cancer Prev 23 (5), 1619-1626 (2022)
   PUBMED   35633546
  REMARK    GeneRIF: Clinical Significance of MAP-7 and FOXC1 in Egyptian Acute
            Myeloid Leukemia Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4428)
  AUTHORS   Ferro,L.S., Fang,Q., Eshun-Wilson,L., Fernandes,J., Jack,A.,
            Farrell,D.P., Golcuk,M., Huijben,T., Costa,K., Gur,M., DiMaio,F.,
            Nogales,E. and Yildiz,A.
  TITLE     Structural and functional insight into regulation of kinesin-1 by
            microtubule-associated protein MAP7
  JOURNAL   Science 375 (6578), 326-331 (2022)
   PUBMED   35050657
  REMARK    GeneRIF: Structural and functional insight into regulation of
            kinesin-1 by microtubule-associated protein MAP7.
REFERENCE   5  (bases 1 to 4428)
  AUTHORS   Yu,L., Xie,J., Liu,X., Yu,Y. and Wang,S.
  TITLE     Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric
            Cancer via miR-409-3p/MAP7 Axis
  JOURNAL   Dig Dis Sci 66 (12), 4274-4289 (2021)
   PUBMED   33449227
  REMARK    GeneRIF: Plasma Exosomal CircNEK9 Accelerates the Progression of
            Gastric Cancer via miR-409-3p/MAP7 Axis.
REFERENCE   6  (bases 1 to 4428)
  AUTHORS   Penttila,T.L., Parvinen,M. and Paranko,J.
  TITLE     Microtubule-associated epithelial protein E-MAP-115 is localized in
            the spermatid manchette
  JOURNAL   Int J Androl 26 (3), 166-174 (2003)
   PUBMED   12755995
REFERENCE   7  (bases 1 to 4428)
  AUTHORS   Bulinski,J.C., Odde,D.J., Howell,B.J., Salmon,T.D. and
            Waterman-Storer,C.M.
  TITLE     Rapid dynamics of the microtubule binding of ensconsin in vivo
  JOURNAL   J Cell Sci 114 (Pt 21), 3885-3897 (2001)
   PUBMED   11719555
REFERENCE   8  (bases 1 to 4428)
  AUTHORS   Fabre-Jonca,N., Viard,I., French,L.E. and Masson,D.
  TITLE     Upregulation and redistribution of E-MAP-115 (epithelial
            microtubule-associated protein of 115 kDa) in terminally
            differentiating keratinocytes is coincident with the formation of
            intercellular contacts
  JOURNAL   J Invest Dermatol 112 (2), 216-225 (1999)
   PUBMED   9989799
REFERENCE   9  (bases 1 to 4428)
  AUTHORS   Masson,D. and Kreis,T.E.
  TITLE     Binding of E-MAP-115 to microtubules is regulated by cell
            cycle-dependent phosphorylation
  JOURNAL   J Cell Biol 131 (4), 1015-1024 (1995)
   PUBMED   7490279
REFERENCE   10 (bases 1 to 4428)
  AUTHORS   Masson,D. and Kreis,T.E.
  TITLE     Identification and molecular characterization of E-MAP-115, a novel
            microtubule-associated protein predominantly expressed in
            epithelial cells
  JOURNAL   J Cell Biol 123 (2), 357-371 (1993)
   PUBMED   8408219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133511.9 and AL023284.1.
            
            On Oct 26, 2020 this sequence version replaced NM_001198608.2.
            
            Summary: The product of this gene is a microtubule-associated
            protein that is predominantly expressed in cells of epithelial
            origin. Microtubule-associated proteins are thought to be involved
            in microtubule dynamics, which is essential for cell polarization
            and differentiation. This protein has been shown to be able to
            stabilize microtubules, and may serve to modulate microtubule
            functions. Studies of the related mouse protein also suggested an
            essential role in microtubule function required for
            spermatogenesis. Multiple alternatively spliced transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Oct 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296556.1, SRR14372079.1035964.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-751               AL133511.9         47964-48714         c
            752-850             AL023284.1         111424-111522       c
            851-928             AL023284.1         101343-101420       c
            929-1092            AL023284.1         79077-79240         c
            1093-1210           AL023284.1         78116-78233         c
            1211-1321           AL023284.1         73394-73504         c
            1322-1435           AL023284.1         67478-67591         c
            1436-1560           AL023284.1         62224-62348         c
            1561-1673           AL023284.1         56050-56162         c
            1674-1957           AL023284.1         55458-55741         c
            1958-2210           AL023284.1         52173-52425         c
            2211-2385           AL023284.1         50728-50902         c
            2386-2487           AL023284.1         50420-50521         c
            2488-2538           AL023284.1         49704-49754         c
            2539-2596           AL023284.1         49543-49600         c
            2597-2699           AL023284.1         46415-46517         c
            2700-2923           AL023284.1         35579-35802         c
            2924-4428           AL023284.1         32457-33961         c
FEATURES             Location/Qualifiers
     source          1..4428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..4428
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="microtubule associated protein 7"
                     /db_xref="GeneID:9053"
                     /db_xref="HGNC:HGNC:6869"
                     /db_xref="MIM:604108"
     exon            1..751
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     CDS             619..2934
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ensconsin; dJ325F22.2 (microtubule-associated protein 7
                     (EMAP115, E-MAP-115)); epithelial microtubule-associated
                     protein of 115 kDa"
                     /codon_start=1
                     /product="ensconsin isoform 1"
                     /protein_id="NP_001185537.1"
                     /db_xref="CCDS:CCDS56455.1"
                     /db_xref="GeneID:9053"
                     /db_xref="HGNC:HGNC:6869"
                     /db_xref="MIM:604108"
                     /translation="MPGSATALRHERLKKTNARPIPLGLFTINEEDEQQKNGNSRRPK
                     APDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQ
                     LAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKER
                     HEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVIS
                     KRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCS
                     PIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRR
                     AVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIR
                     PVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPA
                     MAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEK
                     RRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE
                     QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKR
                     LEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV
                     VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIP
                     LNPILAFDDEGTLGPLPQVDGVQTQQTAEVI"
     exon            752..850
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            851..928
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1092
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1210
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1321
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1435
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1560
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1673
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1957
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2210
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2385
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2487
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2538
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2596
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2699
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2923
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     exon            2924..4428
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="hexamer: ATTAAA"
     polyA_site      3087
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="major polyA site"
     regulatory      4172..4177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="hexamer: ATTAAA"
     polyA_site      4199
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
     regulatory      4405..4410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="hexamer: AATAAA"
     polyA_site      4428
                     /gene="MAP7"
                     /gene_synonym="E-MAP-115; EMAP115"
                     /note="major polyA site"
ORIGIN      
        1 agaacccagc atcctgcaag ctgccgcttc tcagctgggg agatggagcc gctctgggcc
       61 cttcttgatt aggatatgtt agggttgtca gggcaactgt taacggcagc atatcatatt
      121 ttcccctctc tgctgtgggc tgaatatttt actgtgtggt agcaggaaga agattggaaa
      181 aaggtgctgc agcaggaaga agctgggatc tgattgaaca ggttgtgcag tggtgggagg
      241 catcagaccc tgcgtgtctg tagtagggct tttctggaag gagtgtgtgt gtgtgtgtgt
      301 gtgtgcgcgc gcgtgtacgt gcatgcatga gccggagcaa tcaccagcgc atgtgcctgt
      361 cggggagtca gtgggagggg gctggtaggg gaggtgggga agctgctgct aggtgagggg
      421 aactgcaggg cctcagttgc caagtggctg gtactatctg tcagctgttt gcaaactgtt
      481 tacccatagg ggatctatta caagtgctca aatgaacagg cagcttagga actagcagct
      541 tcctgggagc tgcaattaca taagcatata tttttaatat aatcacaatt aaaaaaaaaa
      601 aaaacaagta gcagcggtat gcctggatca gctacagctc tccgacatga gagactgaag
      661 aagaccaatg caaggccaat tcctcttggt ttattcacca ttaatgagga agacgaacag
      721 caaaagaatg gaaattccag aagaccaaaa gcacccgaca gctacaaagt gcaagataag
      781 aaaaatgcct ccagccgccc tgcctctgca atttcaggac aaaataacaa ccactcagga
      841 aataaaccag accctccgcc tgtgttacgt gttgatgacc ggcagcggct ggcccgggag
      901 cgacgtgagg aacgggagaa acagctagct gcaagagaaa tagtgtggtt agaaagagaa
      961 gagcgagcca ggcagcacta cgagaagcac ctggaagagc ggaagaagag gttggaggag
     1021 cagaggcaga aggaggagcg gaggagggct gctgtggagg agaagcggag gcagagactt
     1081 gaggaggaca aagaacgcca cgaagctgtt gtacggcgca caatggaaag gagccagaag
     1141 ccaaaacaga agcataaccg ttggtcgtgg ggaggctctc tccatgggag ccctagcatc
     1201 cacagtgcag atccagacag gcggtcagtt tccaccatga atctttcgaa atatgttgat
     1261 cccgtcatta gcaagcggct ctcctcttca tctgcaactt tactaaattc tccagataga
     1321 gctcgccgcc tgcagctcag cccatgggag agcagcgttg ttaacagact cctgacgccc
     1381 acacattcgt tcctggccag aagtaaaagc acagctgcct tgtctggaga agcagcatct
     1441 tgcagcccca tcatcatgcc ctacaaagct gcacactcta gaaattcgat ggatcgacca
     1501 aaactctttg taacaccacc tgagggctct tctcgcagga ggatcattca tggcacagcg
     1561 agctataaaa aagaaagaga gagagaaaat gtactcttcc tcacatctgg cacccgaagg
     1621 gctgtatctc catctaatcc caaagcaaga caaccagctc gctcccgact ttggcttccg
     1681 tccaagtctc ttcctcattt gcctggcaca cccagaccga catcctcctt gccacccggc
     1741 tcagtcaaag ctgctcctgc tcaggtccgg cccccatccc ccggcaacat ccgccctgtc
     1801 aagagggaag tcaaagtgga gcctgagaag aaagatcctg agaaggaacc tcagaaagtt
     1861 gccaatgagc cctcactaaa gggcagagca cctttagtga aggtagaaga agccacagtt
     1921 gaagagcgga cacctgctga accagaagtt ggccctgctg ctccagccat ggccccagct
     1981 ccagcctcgg ccccagctcc agcctcggcc ccagctccag ccccggtccc caccccagcc
     2041 atggtctcag ccccgtcatc cactgtgaat gccagtgctt ctgttaagac ttctgcaggc
     2101 accaccgacc cagaggaggc cacaaggctt ctagctgaga agaggcggct ggcccgagag
     2161 cagagagaaa aggaagaaag ggagaggagg gagcaggaag agcttgaaag acaaaagaga
     2221 gaggaattgg ctcaacgtgt ggctgaagag aggacgactc gccgtgagga ggagtcgcgc
     2281 aggctggaag ccgagcaggc ccgggagaag gaggagcagc tgcagcggca ggcggaggag
     2341 cgggcgctgc gcgagcggga ggaggcagag cgcgcccaga ggcagaaaga agaagaagct
     2401 cgcgttcgtg aagaagcaga gagggtccgg caggaacgag agaagcattt ccagagagaa
     2461 gagcaagagc gcctggagag aaagaagcga cttgaggaga ttatgaaaag aaccaggaga
     2521 acagaagcta cagataagaa aaccagtgat cagagaaacg gtgatatagc caagggagct
     2581 ctcactggag gaacagaggt gtctgcactt ccatgtacaa caaacgctcc gggaaatgga
     2641 aagccagttg gcagcccaca tgtggttacc tcacaccagt caaaagtgac agtggagagc
     2701 actcccgatt tggaaaaaca accaaatgaa aatggtgtat ctgttcagaa tgaaaatttt
     2761 gaagaaatta taaacttacc cattggatct aaaccatcca gattagatgt caccaacagt
     2821 gagagcccag aaattccttt gaatccaatt ttggcctttg atgatgaagg gacacttggg
     2881 cccctgcctc aggtagatgg tgttcagaca cagcagactg cagaagttat atgagtgttt
     2941 cttctgaaga accaaagctg aaatttaatg agaatttcta caattaatgg aattcctttc
     3001 ctgctataaa ggagcatccc ctccacccgt tttctagagt tcttgaccat cattttgaaa
     3061 agatttatta aaactagcta aagacaacag actggatagc ttttctaata attttcatca
     3121 ataggaaaaa agaaatacgt ctcattcttc aatactttaa aatggctttt tccagtgtgc
     3181 tccttcttag caatcaatat ttttctgcat tctttaaaag acaagagaat ttggttataa
     3241 aagaaatggg ctgactaggc atgatttttt tggtcttaaa agcttaacat gtaaaattgg
     3301 caaaaaaaat tttttacctt ttataatact tgaaaaataa gtacctcttt gttctacaag
     3361 tagaatgaat aggagaagag tttaagcctg tttttttaaa atattattgc aaagagctct
     3421 atttgtagaa gcaaattata ggcagattac caggttctta taaatacagc ttgtacatgg
     3481 acattctgca aacccagctg tcacattttt cttgcaactc cttttgcaaa agcagactaa
     3541 aatgttttaa aatgtgaaaa aacattattt tttcaaagca agaaaataat ttactgccct
     3601 cttacataat gtatttataa agtttttcca gataaactaa tcaaataaat tagaataatg
     3661 tgacaacatt acaaatttaa tttgttagct gcattccttc tgatgttacc acgatagaat
     3721 gttactgatg attcagggct atttctgaag tctgtatgtt gctgctgtcc ccagtgatgg
     3781 tggacttatc tttgccttac ctgatcacaa attatgttgg ggaaaataaa gatttaatat
     3841 ttctttaaat agaaaaagaa tttggttttg ctcgtttaag agcaatgaga aaatgatgga
     3901 atgttgactg tgtttggcac acaggacacg gaccttcatg gaagtccttg ctctgcgtgg
     3961 catctgtcag cttttcacct ttcattctta ttcttcactt ttgctgctga gcctagctgt
     4021 acaaacttgc actttcattt gctaatataa attcagtttt attttaccat tttagagact
     4081 actaatgatt aaatgtagaa ggagagggtg cacatgtttt tatgtggagt gtttaaaaga
     4141 taaatttata ccactgtaat gtgcagcttt tattaaaaga gaaattggtt gaactgctag
     4201 gttgaatgag agacttcatc tattggacta ttttttttaa tccaggcata tggtctttag
     4261 taatggcttg taatttgtga aaacattaat ttgggggttt tccctgtttt cagttgtcca
     4321 tgtacacata gtcattatat tagaaaagaa atctgttcaa caaacttgtt taatttgttt
     4381 aaatcaacat agcatgaaac accaaataaa atgtttgaca tagtttta
//
