LOCUS       NM_033063               3252 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens microtubule associated protein 6 (MAP6), transcript
            variant 1, mRNA.
ACCESSION   NM_033063 XM_166256
VERSION     NM_033063.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3252)
  AUTHORS   Swami,U., Graf,R.P., Nussenzveig,R.H., Fisher,V., Tukachinsky,H.,
            Schrock,A.B., Li,G., Ross,J.S., Sayegh,N., Tripathi,N., Mathew
            Thomas,V., Oxnard,G.R., Antonarakis,E.S. and Agarwal,N.
  TITLE     SPOP Mutations as a Predictive Biomarker for Androgen Receptor
            Axis-Targeted Therapy in De Novo Metastatic Castration-Sensitive
            Prostate Cancer
  JOURNAL   Clin Cancer Res 28 (22), 4917-4925 (2022)
   PUBMED   36088616
  REMARK    GeneRIF: SPOP Mutations as a Predictive Biomarker for Androgen
            Receptor Axis-Targeted Therapy in De Novo Metastatic
            Castration-Sensitive Prostate Cancer.
REFERENCE   2  (bases 1 to 3252)
  AUTHORS   Wei,H., Sun,S., Li,Y. and Yu,S.
  TITLE     Reduced plasma levels of microtubule-associated STOP/MAP6 protein
            in autistic patients
  JOURNAL   Psychiatry Res 245, 116-118 (2016)
   PUBMED   27541346
  REMARK    GeneRIF: the concentration of STOP/MAP6 protein was significantly
            reduced in the plasma of autistic subjects than that in healthy
            controls.
REFERENCE   3  (bases 1 to 3252)
  AUTHORS   Lemonidis,K., Sanchez-Perez,M.C. and Chamberlain,L.H.
  TITLE     Identification of a Novel Sequence Motif Recognized by the Ankyrin
            Repeat Domain of zDHHC17/13 S-Acyltransferases
  JOURNAL   J Biol Chem 290 (36), 21939-21950 (2015)
   PUBMED   26198635
REFERENCE   4  (bases 1 to 3252)
  AUTHORS   Schwenk,B.M., Lang,C.M., Hogl,S., Tahirovic,S., Orozco,D.,
            Rentzsch,K., Lichtenthaler,S.F., Hoogenraad,C.C., Capell,A.,
            Haass,C. and Edbauer,D.
  TITLE     The FTLD risk factor TMEM106B and MAP6 control dendritic
            trafficking of lysosomes
  JOURNAL   EMBO J 33 (5), 450-467 (2014)
   PUBMED   24357581
  REMARK    GeneRIF: These data show that TMEM106B/MAP6 interaction is crucial
            for controlling dendritic trafficking of lysosomes, presumably by
            acting as a molecular brake for retrograde transport.
REFERENCE   5  (bases 1 to 3252)
  AUTHORS   Lefevre,J., Savarin,P., Gans,P., Hamon,L., Clement,M.J.,
            David,M.O., Bosc,C., Andrieux,A. and Curmi,P.A.
  TITLE     Structural basis for the association of MAP6 protein with
            microtubules and its regulation by calmodulin
  JOURNAL   J Biol Chem 288 (34), 24910-24922 (2013)
   PUBMED   23831686
  REMARK    GeneRIF: Structural basis for the association of MAP6 protein with
            microtubules and its regulation by calmodulin.
REFERENCE   6  (bases 1 to 3252)
  AUTHORS   Bosc,C., Andrieux,A. and Job,D.
  TITLE     STOP proteins
  JOURNAL   Biochemistry 42 (42), 12125-12132 (2003)
   PUBMED   14567673
REFERENCE   7  (bases 1 to 3252)
  AUTHORS   Andrieux,A., Salin,P.A., Vernet,M., Kujala,P., Baratier,J.,
            Gory-Faure,S., Bosc,C., Pointu,H., Proietto,D., Schweitzer,A.,
            Denarier,E., Klumperman,J. and Job,D.
  TITLE     The suppression of brain cold-stable microtubules in mice induces
            synaptic defects associated with neuroleptic-sensitive behavioral
            disorders
  JOURNAL   Genes Dev 16 (18), 2350-2364 (2002)
   PUBMED   12231625
REFERENCE   8  (bases 1 to 3252)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   9  (bases 1 to 3252)
  AUTHORS   Jolly,C., Denarier,E., Mongelard,F., Robert-Nicoud,M., Vourc'h,C.,
            Bosc,C. and Job,D.
  TITLE     Assignment of the STOP gene (MAP6) to human chromosome bands
            6p12-->p11 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 86 (1), 25 (1999)
   PUBMED   10516426
REFERENCE   10 (bases 1 to 3252)
  AUTHORS   Bosc,C., Cronk,J.D., Pirollet,F., Watterson,D.M., Haiech,J., Job,D.
            and Margolis,R.L.
  TITLE     Cloning, expression, and properties of the microtubule-stabilizing
            protein STOP
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 2125-2130 (1996)
   PUBMED   8700896
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001922.4, AB058781.1,
            BC063860.1 and AK123340.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 5, 2020 this sequence version replaced NM_033063.1.
            
            Summary: This gene encodes a microtubule-associated protein. The
            encoded protein is a calmodulin-binding and calmodulin-regulated
            protein that is involved in microtubule stabilization. Two
            transcript variants encoding distinct isoforms have been identified
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063860.1, ERR4352444.221115.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304771.8/ ENSP00000307093.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-604               AP001922.4         96185-96788         c
            605-1409            AB058781.1         1-805
            1410-2417           BC063860.1         472-1479
            2418-3251           AK123340.1         922-1755
            3252-3252           BC063860.1         2314-2314
FEATURES             Location/Qualifiers
     source          1..3252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.5"
     gene            1..3252
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /note="microtubule associated protein 6"
                     /db_xref="GeneID:4135"
                     /db_xref="HGNC:HGNC:6868"
                     /db_xref="MIM:601783"
     exon            1..1574
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /inference="alignment:Splign:2.1.0"
     CDS             670..3111
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     stable tubule-only polypeptide; MAP-6; CTD-2530H12.7"
                     /codon_start=1
                     /product="microtubule-associated protein 6 isoform 1"
                     /protein_id="NP_149052.1"
                     /db_xref="CCDS:CCDS31641.1"
                     /db_xref="GeneID:4135"
                     /db_xref="HGNC:HGNC:6868"
                     /db_xref="MIM:601783"
                     /translation="MAWPCITRACCIARFWNQLDKADIAVPLVFTKYSEATEHPGAPP
                     QPPPPQQQAQPALAPPSARAVAIETQPAQGELDAVARATGPAPGPTGEREPAAGPGRS
                     GPGPGLGSGSTSGPADSVMRQDYRAWKVQRPEPSCRPRSEYQPSDAPFERETQYQKDF
                     RAWPLPRRGDHPWIPKPVQISAASQASAPILGAPKRRPQSQERWPVQAAAEAREQEAA
                     PGGAGGLAAGKASGADERDTRRKAGPAWIVRRAEGLGHEQTPLPAAQAQVQATGPEAG
                     RGRAAADALNRQIREEVASAVSSSYRNEFRAWTDIKPVKPIKAKPQYKPPDDKMVHET
                     SYSAQFKGEASKPTTADNKVIDRRRIRSLYSEPFKEPPKVEKPSVQSSKPKKTSASHK
                     PTRKAKDKQAVSGQAAKKKSAEGPSTTKPDDKEQSKEMNNKLAEAKESLAQPVSDSSK
                     TQGPVATEPDKDQGSVVPGLLKGQGPMVQEPLKKQGSVVPGPPKDLGPMIPLPVKDQD
                     HTVPEPLKNESPVISAPVKDQGPSVPVPPKNQSPMVPAKVKDQGSVVPESLKDQGPRI
                     PEPVKNQAPMVPAPVKDEGPMVSASVKDQGPMVSAPVKDQGPIVPAPVKGEGPIVPAP
                     VKDEGPMVSAPIKDQDPMVPEHPKDESAMATAPIKNQGSMVSEPVKNQGLVVSGPVKD
                     QDVVVPEHAKVHDSAVVAPVKNQGPVVPESVKNQDPILPVLVKDQGPTVLQPPKNQGR
                     IVPEPLKNQVPIVPVPLKDQDPLVPVPAKDQGPAVPEPLKTQGPRDPQLPTVSPLPRV
                     MIPTAPHTEYIESSP"
     exon            1575..1788
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1985
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..3252
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3229..3234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /note="hexamer: AATAAA"
     polyA_site      3252
                     /gene="MAP6"
                     /gene_synonym="MAP6-N; MTAP6; N-STOP; STOP"
                     /note="major polyA site"
ORIGIN      
        1 agaggcagag gcggcggcgg cagcggctgc agcatcattc gcgggcagcg gcggagaccg
       61 agagctgcag aaaagggtgg ggtcgcttcc caggagaaga ggcggtggcg gcggcggctg
      121 cggcatcctc gcgggcagcg gcggaggcag caatgctcgg tctccgctgg aggtgatggc
      181 ctcccagccc tgctaggtgg ccggctgcac taggacgccg gcaggaagga gactcgagcc
      241 cggtccgcgg accctgcggc cacaccgccc ggcccctcct ctgcgccatg gcttaagcct
      301 gtagccacct ctcctcacgt cgcctcgctc gaccgaggtc tgtgcgccgc cgcagccgca
      361 gggaggggcg cgtcccagac accctcgccg gggactcggg aacgccgtgc gtctcaccct
      421 tcggcgctcg cagcagactg cgctcccaaa ggcgtttgcg accggtaatc gagggactct
      481 acagactctc ctaggacagc tctccccggg tgctcgctga gggaggaggg cgaactagct
      541 ccggctgatc gggggtagaa aacggtggga accacattgg ccggtcagga tcggaggctg
      601 aaggaagatt atagagactt gctttagaac cacaagaaga aagaggaggc cggcttttca
      661 gctagcatca tggcgtggcc gtgcatcacg agggcctgct gcatcgcccg cttctggaac
      721 cagttggaca aagcggacat cgctgtgccg ctggttttca ccaagtactc ggaggccacc
      781 gagcacccgg gcgccccgcc gcagccaccg ccgccgcagc agcaggcgca gccggcgctc
      841 gcgcccccct cggcgcgcgc ggttgccata gagacgcagc cagcccaggg cgagttggat
      901 gcagttgccc gggcaacggg gccagcgcct gggcctaccg gcgagcgcga gccggcggcg
      961 ggccccggcc ggagcgggcc gggcccgggc ctgggctccg gctccacctc cggccccgcg
     1021 gactcggtga tgcggcagga ttaccgagcc tggaaggtgc agcggcccga gcccagctgc
     1081 cggccgcgca gcgaatacca gccctccgac gctcccttcg agcgcgagac ccagtaccag
     1141 aaggacttcc gcgcctggcc gctgccgcgc cgcggggacc acccgtggat ccccaagccc
     1201 gtgcagatct ctgcggcctc ccaggcgtcg gcgcccattc tcggggcgcc caagcgccgg
     1261 ccgcagagcc aggagcgctg gccagtgcag gccgccgctg aggcccggga gcaggaggcg
     1321 gcccccggcg gagcgggtgg cctggcggcc ggaaaggcgt ccggggcgga cgagcgcgac
     1381 acgcgcagga aggccgggcc tgcctggatt gtgcgccgcg ccgagggcct ggggcacgag
     1441 cagacgccgc tgcccgcggc ccaggcccag gtccaggcca ccggccccga ggctggcagg
     1501 gggcgcgccg cggcggacgc cctcaaccgg caaatccgcg aggaggtggc gagtgcagtg
     1561 agcagctcct acaggaatga attcagggca tggacggaca tcaagcctgt gaaaccaata
     1621 aaggccaagc cccagtacaa gcccccagat gataagatgg ttcatgagac cagctacagt
     1681 gctcagttca aaggagaggc cagcaagcca acaacagctg acaataaggt cattgatcgc
     1741 agaagaatac gcagcctcta cagcgaaccc ttcaaggaac ccccaaaggt ggaaaaacct
     1801 agtgttcaga gttccaaacc aaaaaagacc tcagcgagcc ataagcccac gaggaaggcc
     1861 aaagacaagc aggcggtgtc aggccaggct gccaagaaaa agagcgcgga gggcccgagt
     1921 accaccaagc cagacgacaa ggagcaaagc aaagagatga acaataaact ggctgaggcg
     1981 aaagagagcc tggctcaacc cgtcagtgat tcaagtaaga ctcaaggtcc tgtagccaca
     2041 gagccagaca aggatcaagg ttctgtggtc ccaggccttc tgaaaggtca aggtcctatg
     2101 gtgcaagagc ctctgaagaa gcaaggttct gtggtcccag ggcctccaaa ggatctaggt
     2161 cccatgatcc cattaccagt caaggatcaa gatcacacgg tccctgagcc tttaaagaat
     2221 gaaagccctg ttatctcagc accagtcaag gaccaaggtc cctcggtccc agttcctcca
     2281 aagaatcaaa gtcctatggt tccagcaaaa gttaaggatc aaggctctgt ggtaccagag
     2341 tctctaaagg atcaaggtcc taggattcct gagcctgtga agaatcaagc tcctatggtc
     2401 ccagcacctg tcaaggatga aggtcccatg gtctcagcat ctgtcaagga tcaaggtccc
     2461 atggtctcag cacctgtcaa ggatcaaggt cccatagtcc cagcacctgt caagggtgaa
     2521 ggtcccatag tcccagcacc tgtcaaggat gaaggtccca tggtctcagc acctatcaag
     2581 gatcaagatc ccatggtccc agagcatccg aaggatgaaa gtgccatggc cacagcaccc
     2641 ataaagaatc aaggttccat ggtctctgag cctgtaaaga atcaaggttt agtggtctca
     2701 gggccagtca aggatcaaga tgttgtagtc ccagagcatg caaaggttca cgattctgca
     2761 gttgtggcac ctgtaaagaa tcaaggtcct gtggtccccg agtccgtgaa gaatcaagac
     2821 cccattctcc cagtactagt taaggatcaa ggccccacag tcctacagcc tccaaagaat
     2881 caaggtcgta tagtccctga acctctgaag aatcaagttc ctatagtccc agtgcctctg
     2941 aaggatcaag atcctctggt gccagtacca gcaaaggacc aaggtcctgc agtccctgaa
     3001 cctctgaaga ctcaaggtcc cagggaccct cagctaccta ctgtctcacc tctaccccga
     3061 gtcatgatcc caactgcccc ccatacggaa tacattgaga gctccccttg acactcaccc
     3121 cttgacacac caatgaagga gctgacagtg agagtgctcc cctcccaggg gcagtgaaga
     3181 cacatattta atctgcatga aacatgtaca gtagtcttgc tggaatctaa taaaaatggt
     3241 ccctctggct ca
//
