LOCUS       NM_006575               4270 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase kinase
            5 (MAP4K5), transcript variant 1, mRNA.
ACCESSION   NM_006575
VERSION     NM_006575.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4270)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   2  (bases 1 to 4270)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4270)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 4270)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4270)
  AUTHORS   Wang,O.H., Azizian,N., Guo,M., Capello,M., Deng,D., Zang,F.,
            Fry,J., Katz,M.H., Fleming,J.B., Lee,J.E., Wolff,R.A., Hanash,S.,
            Wang,H. and Maitra,A.
  TITLE     Prognostic and Functional Significance of MAP4K5 in Pancreatic
            Cancer
  JOURNAL   PLoS One 11 (3), e0152300 (2016)
   PUBMED   27023625
  REMARK    GeneRIF: MAP4K5 expression is decreased or lost in majority of
            pancreatic ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4270)
  AUTHORS   Shi,C.S., Leonardi,A., Kyriakis,J., Siebenlist,U. and Kehrl,J.H.
  TITLE     TNF-mediated activation of the stress-activated protein kinase
            pathway: TNF receptor-associated factor 2 recruits and activates
            germinal center kinase related
  JOURNAL   J Immunol 163 (6), 3279-3285 (1999)
   PUBMED   10477597
REFERENCE   7  (bases 1 to 4270)
  AUTHORS   Shi,C.S., Tuscano,J.M., Witte,O.N. and Kehrl,J.H.
  TITLE     GCKR links the Bcr-Abl oncogene and Ras to the stress-activated
            protein kinase pathway
  JOURNAL   Blood 93 (4), 1338-1345 (1999)
   PUBMED   9949177
REFERENCE   8  (bases 1 to 4270)
  AUTHORS   Oehrl,W., Kardinal,C., Ruf,S., Adermann,K., Groffen,J., Feng,G.S.,
            Blenis,J., Tan,T.H. and Feller,S.M.
  TITLE     The germinal center kinase (GCK)-related protein kinases HPK1 and
            KHS are candidates for highly selective signal transducers of Crk
            family adapter proteins
  JOURNAL   Oncogene 17 (15), 1893-1901 (1998)
   PUBMED   9788432
REFERENCE   9  (bases 1 to 4270)
  AUTHORS   Tung,R.M. and Blenis,J.
  TITLE     A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal
            kinase
  JOURNAL   Oncogene 14 (6), 653-659 (1997)
   PUBMED   9038372
REFERENCE   10 (bases 1 to 4270)
  AUTHORS   Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of 21 novel human protein kinases, including 3
            members of a family related to the cell cycle regulator nimA of
            Aspergillus nidulans
  JOURNAL   Cell Growth Differ 4 (10), 821-830 (1993)
   PUBMED   8274451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN343360.1, BC036013.1 and
            AK124738.1.
            
            On Aug 13, 2020 this sequence version replaced NM_006575.5.
            
            Summary: This gene encodes a member of the serine/threonine protein
            kinase family, that is highly similar to yeast SPS1/STE20 kinase.
            Yeast SPS1/STE20 functions near the beginning of the MAP kinase
            signal cascades that is essential for yeast pheromone response.
            This kinase was shown to activate Jun kinase in mammalian cells,
            which suggested a role in stress response. Two alternatively
            spliced transcript variants encoding the same protein have been
            described for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 2. Variants 1 and 2 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U77129.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682126.1/ ENSP00000507200.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-635               CN343360.1         23-657
            636-4266            BC036013.1         663-4293
            4267-4270           AK124738.1         4779-4782
FEATURES             Location/Qualifiers
     source          1..4270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.1"
     gene            1..4270
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 5"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
     exon            1..122
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            123..339
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2772
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /EC_number="2.7.11.1"
                     /note="germinal center kinase-related; kinase homologous
                     to SPS1/STE20; MEKKK 5; MEK kinase kinase 5; MAPK/ERK
                     kinase kinase kinase 5"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 5"
                     /protein_id="NP_006566.2"
                     /db_xref="CCDS:CCDS91875.1"
                     /db_xref="GeneID:11183"
                     /db_xref="HGNC:HGNC:6867"
                     /db_xref="MIM:604923"
                     /translation="MEAPLRPAADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGE
                     LAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSL
                     QDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFG
                     VAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPM
                     FDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF
                     VAQPGLSRALAVELLDKVNNPDNHAHYTEADDDDFEPHAIIRHTIRSTNRNARAERTA
                     SEINFDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVDGANTGKSTSKRAIPPPL
                     PPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGPVAETSSIGNGD
                     GISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDGCPLK
                     INCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMS
                     LSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRFPDRILPRKFALTTKIPDTKGCHK
                     CCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPSPLNVFEMLVIPE
                     QEYPMVCVAISKGTESNQVVQFETINLNSASSWFTEIGAGSQQLDSIHVTQLERDTVL
                     VCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSFKSD
                     EVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHSNLYILAGHENSY"
     exon            340..397
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            398..488
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            489..553
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            554..609
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            610..657
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            658..700
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            701..773
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            774..905
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            906..968
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1050
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1167
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1246
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1305
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1373
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1416
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1570
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1668
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1710
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1795
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1875
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1936
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..1939
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2054
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2113
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2217
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2395
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..2464
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2557
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2628
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2684
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..4270
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4248..4253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /note="hexamer: AATAAA"
     polyA_site      4270
                     /gene="MAP4K5"
                     /gene_synonym="GCKR; KHS; KHS1; MAPKKKK5"
                     /note="major polyA site"
ORIGIN      
        1 gtacgcgcct ccgccgcccc cgagaggacg cgccgtgcag cggctgagtg gcggcggcgg
       61 cgacggcaaa cccggagctg ccggccggcg cgcgggagga ggacgcgggt gcggtctagg
      121 aaacggagct gcgggcggag gctccatgtt gggaagcggc gccgttcgtg cttgttagcg
      181 ggaatccggg agccgcgggg tgagctggcg ggggccgggc cctaagtgaa gatggaggcc
      241 ccgctgcggc ctgccgcgga catcctgagg cggaacccgc agcaggacta cgaactcgtc
      301 cagagggtcg gcagcggcac ctacggggac gtctataagg ccagaaatgt acacacagga
      361 gagctggctg cagtaaaaat cattaaattg gagcctggag atgatttttc tttgattcaa
      421 caagaaatat ttatggttaa agaatgtaaa cattgtaaca tcgttgccta ctttgggagt
      481 tatcttagtc gggaaaaact atggatttgt atggaatact gtggtggcgg atcacttcaa
      541 gatatttacc atgttactgg accattatca gaattgcaaa tagcctatgt atgcagagaa
      601 accttacagg gtcttgccta tttgcatact aaaggcaaaa tgcatagaga tatcaaaggt
      661 gctaatattt tattgacaga ccatggcgat gtaaaattag ctgactttgg tgtggctgca
      721 aaaataacag ctaccattgc aaaacgaaaa tctttcattg gcacccctta ctggatggcc
      781 ccagaagttg cagcagtaga gaagaatggt ggctacaacc aactctgtga tatctgggca
      841 gtaggaataa cagcaattga acttggagaa cttcagccac ctatgtttga tctccaccca
      901 atgagggctc tcttcttaat gtcaaaaagt aattttcagc ctccaaaact aaaggacaaa
      961 acaaaatggt catcaacatt ccataatttt gtcaaaatag cactaaccaa aaacccaaaa
     1021 aaaagaccaa ctgctgaaag acttctgact cacacttttg ttgcacagcc aggtctctct
     1081 agagccctag cagttgaact gttagacaaa gtgaacaatc cagataacca cgcacattac
     1141 actgaagcag atgacgatga ctttgagccc catgcaatca ttcgtcatac cattagatct
     1201 acaaacagga atgccagagc tgaacggaca gcttcagaaa taaattttga caaattacaa
     1261 tttgaacctc ctctgagaaa agaaacagaa gcacgagatg aaatgggatt gtcatcagac
     1321 ccaaatttca tgttacagtg gaatcctttt gttgatggtg caaatactgg caaatcaacc
     1381 tcaaaacgtg caataccacc tcccctacct cctaagccaa ggataagcag ttaccctgaa
     1441 gacaactttc cggatgaaga aaaagcatca accataaaac attgtcctga ttcagaaagc
     1501 agagctcccc aaattctcag aagacagagt agcccaagtt gtgggcctgt ggcagagact
     1561 tcttctattg gaaatggtga tggtatttca aaactgatga gtgaaaatac agaaggatca
     1621 gcacaagcac cacagttacc acgaaaaaag gacaaacgag acttccctaa accagccatc
     1681 aatggccttc cacccacccc aaaagttctg atgggagcat gcttttcaaa agtttttgat
     1741 ggctgtcctt tgaaaattaa ttgtgcaaca tcctggatac atcctgatac aaaagatcag
     1801 tacattattt ttggaactga agatggtatt tacacactga atctcaatga gctacatgag
     1861 gcaacgatgg aacagttatt tccacggaag tgtacttggc tgtatgttat caataatact
     1921 ttaatgtcat tatcagaagg aaaaaccttt cagctctact ctcacaatct tatagctttg
     1981 tttgaacatg ccaaaaaacc aggattagct gcccatattc aaactcacag gtttccagac
     2041 cgaatactac caagaaaatt cgctttaaca acaaagattc ctgatacaaa aggctgccac
     2101 aaatgttgca tagtcagaaa cccttacacg ggacataaat acctctgtgg agctttacag
     2161 tctggaattg ttttacttca gtggtatgag ccaatgcaga aattcatgtt gataaagcac
     2221 tttgattttc ctttgccaag tcctttgaat gtttttgaaa tgctggtgat acctgaacag
     2281 gaatacccta tggtctgtgt agctattagc aaaggcactg aatcgaatca ggtagttcag
     2341 tttgagacaa tcaatttgaa ctctgcatct tcatggttta cagaaattgg tgcaggcagc
     2401 cagcagttag attccattca tgtaacacag ttggagagag ataccgtttt agtgtgttta
     2461 gacaaatttg tgaaaattgt aaatctacaa ggaaaattaa aatcaagtaa gaaactggcc
     2521 tctgagttaa gttttgattt tcgcattgaa tctgtagtat gccttcaaga cagtgtgttg
     2581 gctttctgga aacatgggat gcagggtaaa agcttcaagt cagatgaggt tacccaggag
     2641 atttcagatg aaacaagagt tttccgctta ttaggatcag acagggttgt cgttttggaa
     2701 agtaggccaa cagaaaatcc tactgcacac agcaatctct acatcttggc tggacatgaa
     2761 aatagttact aagcaacaga aactgatctc aaatgacagg aaaatgaata tactccattg
     2821 aaaggaaaaa taaggaaatt caatacaaac tgcactatga tttgctttaa ctattatggg
     2881 ttatattgca aatgatctgt actttagggt agaattcaat attttctgca gctggaaaca
     2941 gctagtctat ctcttgccac tgtgtggtgg ttatatcaag tttgcttaat aaaagctatg
     3001 agacaaatag tcctctagtt ccaggaaaca cagtcttttt ttaaaaaaaa caatgtttgt
     3061 aacaagggtg ccatggtatt tttagataac tcgtgattat cttaagagag gtaaatttag
     3121 tgatcatttt atatcatgtc ttattccttc ttaatgaaca taatttgtta aattctcaag
     3181 caaggttttc acttttatat tggccattct gtatgttttt gtaaaacaga atatttaatc
     3241 cttatttatt aatctcttgc tggagtggtg taatgtatct aacttttagc aaaggagggt
     3301 tgcagagcag cttaaatttt ttttataatg tataagaatt ttgtttatct tttaagagta
     3361 gtaaagtact ttgagtgttt gggggttcaa cacacacatg caattttgct taacaaaagt
     3421 attttataat acagtttcat acagaattac cttaaaaggg agtcttatgt tttcaactac
     3481 agatagttgt aagggatcat acagaagata ttgatgatag ttgaaatatt cttagaaggg
     3541 gtgtgtatgt ctagctgtgt ctaccatgtg tatgtattct tgacaagcag tataaaatac
     3601 ctgtgatttt tctttacatt agggataatg cataaggaat taatcttcat atatattatc
     3661 atccctaatg tagcaggggg aagtatttaa ttgcccatga tatgtatttt acttatacta
     3721 tgccagagag gaaactataa agtaattaca catgtaatct tgggtttttc acatatgtag
     3781 gtattcattt tgagtaggtt gaagaagaaa aaaaatattt aaatgaattg aattcctgat
     3841 gggatagtat caataagtat ttaaaagcca gtattctaaa aataataaag ggtagggtca
     3901 tttttgagtt tgtttttctt ttgctattgt taatattcaa aattaaagtg ttacattggt
     3961 acctgttgtc ttaatgcatt tattgagaac agcattgaga tgatgaacaa ggggttagca
     4021 atagcaaact ctataattat tttgactaat tacttaagag gaaaacagta taagtatctc
     4081 attcagtatt tagcaattct gtaaaataag tattatctct atttttcaga tgaggaagta
     4141 agggtttagc aaggttaaga gatctatcca atttacacag caagttagta gttgagcctg
     4201 accatgagtc ttctgactct gttcttttca ctatgcaata cgcaaacaat aaaatgttat
     4261 acaaatggaa
//
