LOCUS       NM_001042600            2631 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase kinase
            1 (MAP4K1), transcript variant 1, mRNA.
ACCESSION   NM_001042600
VERSION     NM_001042600.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Choi,W.S., Kwon,H.J., Yi,E., Lee,H., Kim,J.M., Park,H.J.,
            Choi,E.J., Choi,M.E., Sung,Y.H., Won,C.H., Sung,C.O. and Kim,H.S.
  TITLE     HPK1 Dysregulation-Associated NK Cell Dysfunction and Defective
            Expansion Promotes Metastatic Melanoma Progression
  JOURNAL   Adv Sci (Weinh) 11 (29), e2400920 (2024)
   PUBMED   38828677
  REMARK    GeneRIF: HPK1 Dysregulation-Associated NK Cell Dysfunction and
            Defective Expansion Promotes Metastatic Melanoma Progression.
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   Sun,J.M., Fan,H.Y., Zhu,Y., Pan,T.T., Wu,Y.P., Zhang,D.Y. and
            Hou,X.Y.
  TITLE     Glioblastoma cellular MAP4K1 facilitates tumor growth and disrupts
            T effector cell infiltration
  JOURNAL   Life Sci Alliance 6 (12), e202301966 (2023)
   PUBMED   37734869
  REMARK    GeneRIF: Glioblastoma cellular MAP4K1 facilitates tumor growth and
            disrupts T effector cell infiltration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Bader,A., Winkelmann,M., Forne,I., Walzog,B. and Maier-Begandt,D.
  TITLE     Decoding the signaling profile of hematopoietic progenitor kinase 1
            (HPK1) in innate immunity: A proteomic approach
  JOURNAL   Eur J Immunol 52 (5), 760-769 (2022)
   PUBMED   35099066
  REMARK    GeneRIF: Decoding the signaling profile of hematopoietic progenitor
            kinase 1 (HPK1) in innate immunity: A proteomic approach.
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 2631)
  AUTHORS   Zhou,G., Lee,S.C., Yao,Z. and Tan,T.H.
  TITLE     Hematopoietic progenitor kinase 1 is a component of transforming
            growth factor beta-induced c-Jun N-terminal kinase signaling
            cascade
  JOURNAL   J Biol Chem 274 (19), 13133-13138 (1999)
   PUBMED   10224067
REFERENCE   7  (bases 1 to 2631)
  AUTHORS   Ling,P., Yao,Z., Meyer,C.F., Wang,X.S., Oehrl,W., Feller,S.M. and
            Tan,T.H.
  TITLE     Interaction of hematopoietic progenitor kinase 1 with adapter
            proteins Crk and CrkL leads to synergistic activation of c-Jun
            N-terminal kinase
  JOURNAL   Mol Cell Biol 19 (2), 1359-1368 (1999)
   PUBMED   9891069
REFERENCE   8  (bases 1 to 2631)
  AUTHORS   Oehrl,W., Kardinal,C., Ruf,S., Adermann,K., Groffen,J., Feng,G.S.,
            Blenis,J., Tan,T.H. and Feller,S.M.
  TITLE     The germinal center kinase (GCK)-related protein kinases HPK1 and
            KHS are candidates for highly selective signal transducers of Crk
            family adapter proteins
  JOURNAL   Oncogene 17 (15), 1893-1901 (1998)
   PUBMED   9788432
REFERENCE   9  (bases 1 to 2631)
  AUTHORS   Anafi,M., Kiefer,F., Gish,G.D., Mbamalu,G., Iscove,N.N. and
            Pawson,T.
  TITLE     SH2/SH3 adaptor proteins can link tyrosine kinases to a
            Ste20-related protein kinase, HPK1
  JOURNAL   J Biol Chem 272 (44), 27804-27811 (1997)
   PUBMED   9346925
REFERENCE   10 (bases 1 to 2631)
  AUTHORS   Hu,M.C., Qiu,W.R., Wang,X., Meyer,C.F. and Tan,T.H.
  TITLE     Human HPK1, a novel human hematopoietic progenitor kinase that
            activates the JNK/SAPK kinase cascade
  JOURNAL   Genes Dev 10 (18), 2251-2264 (1996)
   PUBMED   8824585
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY074876.1 and U66464.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001042600.2.
            
            Transcript Variant: This variant (1) lacks an exon in the 3' coding
            region, which results in a frameshift, compared to variant 2. The
            encoded isoform (1) has a shorter and distinct C-terminus, compared
            to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.6850.1,
                                           SRR1163657.489551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396857.7/ ENSP00000380066.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                HY074876.1         84-112
            30-2454             U66464.1           26-2450
            2455-2631           U66464.1           2549-2725
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2631
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /note="mitogen-activated protein kinase kinase kinase
                     kinase 1"
                     /db_xref="GeneID:11184"
                     /db_xref="HGNC:HGNC:6863"
                     /db_xref="MIM:601983"
     exon            1..157
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2524
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     hematopoietic progenitor kinase 1; MEKKK 1; MEK kinase
                     kinase 1; MAPK/ERK kinase kinase kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     kinase 1 isoform 1"
                     /protein_id="NP_001036065.1"
                     /db_xref="CCDS:CCDS42564.1"
                     /db_xref="GeneID:11184"
                     /db_xref="HGNC:HGNC:6863"
                     /db_xref="MIM:601983"
                     /translation="MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVA
                     LKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDI
                     YQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISA
                     QIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDV
                     HPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ
                     PGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADC
                     CRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAED
                     TPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHL
                     TAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPS
                     TKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHS
                     ILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLC
                     GALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRP
                     GKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVR
                     GLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSP
                     RPVVVETRPVDDPTAPSNLYIQE"
     exon            158..215
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            216..306
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..371
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            372..427
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..475
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            476..518
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            519..591
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            592..723
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..786
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..868
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            869..985
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1064
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1123
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1167
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1215
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1258
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1421
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1504
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1589
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1666
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1727
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1836
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1895
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1999
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2174
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2237
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2327
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2398
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2454
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2631
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2608..2613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /note="hexamer: AATAAA"
     polyA_site      2631
                     /gene="MAP4K1"
                     /gene_synonym="HPK1"
                     /note="major polyA site"
ORIGIN      
        1 agttgagccc tgaggccctg ctggcccctg ggcgcaggcc cagctcaggc ccccagggat
       61 ggacgtcgtg gaccctgaca ttttcaatag agacccccgg gaccactatg acctgctaca
      121 gcggctgggt ggcggcacgt atggggaagt ctttaaggct cgagacaagg tgtcagggga
      181 cctggtggca ctgaagatgg tgaagatgga gcctgatgat gatgtctcca cccttcagaa
      241 ggaaatcctc atattgaaaa cttgccggca cgccaacatc gtggcctacc atgggagtta
      301 tctctggttg cagaaactct ggatctgcat ggaattctgt ggggctggtt ctctccagga
      361 catctaccaa gtgacaggct ccctgtcaga gctccagatt agctatgtct gccgggaagt
      421 gctccaggga ctggcctatt tgcactcaca gaagaagata cacagggaca tcaagggagc
      481 taacatcctc atcaatgatg ctggggaggt cagattggct gactttggca tctcggccca
      541 gattggggct acactggcca gacgcctctc tttcattggg acaccctact ggatggctcc
      601 ggaagtggca gctgtggccc tgaagggagg atacaatgag ctgtgtgaca tctggtccct
      661 gggcatcacg gccatcgaac tggccgagct acagccaccg ctctttgatg tgcaccctct
      721 cagagttctc ttcctcatga ccaagagtgg ctaccagcct ccccgactga aggaaaaagg
      781 caaatggtcg gctgccttcc acaacttcat caaagtcact ctgactaaga gtcccaagaa
      841 acgacccagc gccaccaaga tgctcagtca tcaactggta tcccagcctg ggctgaatcg
      901 aggcctgatc ctggatcttc ttgacaaact gaagaatccc gggaaaggac cctccattgg
      961 ggacattgag gatgaggagc ccgagctacc ccctgctatc cctcggcgga tcagatccac
     1021 ccaccgctcc agctctctgg ggatcccaga tgcagactgc tgtcggcggc acatggagtt
     1081 caggaagctc cgaggaatgg agaccagacc cccagccaac accgctcgcc tacagcctcc
     1141 tcgagacctc aggagcagca gccccaggaa gcaactgtca gagtcgtctg acgatgacta
     1201 tgacgacgtg gacatcccca cccctgcaga ggacacacct cctccacttc cccccaagcc
     1261 caagttccgt tctccatcag acgagggtcc tgggagcatg ggggatgatg ggcagctgag
     1321 cccgggggtg ctggtccggt gtgccagtgg gcccccacca aacagccccc gtcctgggcc
     1381 tcccccatcc accagcagcc cccacctcac cgcccattca gaaccctcac tctggaaccc
     1441 accctcccgg gagcttgaca agcccccact tctgcccccc aagaaggaaa agatgaagag
     1501 aaagggatgt gcccttctcg taaagttgtt caatggctgc cccctccgga tccacagcac
     1561 ggccgcctgg acacatccct ccaccaagga ccagcacctg ctcctggggg cagaggaagg
     1621 catcttcatc ctgaaccgga atgaccagga ggccacgctg gaaatgctct ttcctagccg
     1681 gactacgtgg gtgtactcca tcaacaacgt tctcatgtct ctctcaggaa agacccccca
     1741 cctgtattct catagcatcc ttggcctgct ggaacggaaa gagaccagag caggaaaccc
     1801 catcgctcac attagccccc accgcctact ggcaaggaag aacatggttt ccaccaagat
     1861 ccaggacacc aaaggctgcc gggcgtgctg tgtggcggag ggtgcgagct ctgggggccc
     1921 gttcctgtgc ggtgcattgg agacgtccgt tgtcctgctt cagtggtacc agcccatgaa
     1981 caaattcctg cttgtccggc aggtgctgtt cccactgccg acgcctctgt ccgtgttcgc
     2041 gctgctgacc gggccaggct ctgagctgcc cgctgtgtgc atcggcgtga gccccgggcg
     2101 gccggggaag tcggtgctct tccacacggt gcgctttggc gcgctctctt gctggctggg
     2161 cgagatgagc accgagcaca ggggacccgt gcaggtgacc caggtagagg aagatatggt
     2221 gatggtgttg atggatggct ctgtgaagct ggtgaccccg gaggggtccc cagtccgggg
     2281 acttcgcaca cctgagatcc ccatgaccga agcggtggag gccgtggcta tggttggagg
     2341 tcagcttcag gccttctgga agcatggagt gcaggtgtgg gctctaggct cggatcagct
     2401 gctacaggag ctgagagacc ctaccctcac tttccgtctg cttggctccc ccaggcctgt
     2461 agtggtggag acacgcccag tggatgatcc tactgctccc agcaacctct acatccagga
     2521 atgagtccct aggggggtgt caggaactag tccttgcacc ccctccccca tagacacact
     2581 agtggtcatg gcatgtcctc atctcccaat aaacatgact ttagcctctg c
//
