LOCUS       NM_001384893            5516 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 127, mRNA.
ACCESSION   NM_001384893
VERSION     NM_001384893.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5516)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 5516)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5516)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5516)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5516)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 5516)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 5516)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 5516)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 5516)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 5516)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.2738626.1,
                                           SRR14038196.3156222.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-387             AC124916.3         2661-2729           c
            388-510             AC139667.5         48903-49025
            511-624             AC139667.5         55375-55488
            625-1848            AC139667.5         60079-61302
            1849-1971           AC139667.5         62314-62436
            1972-2078           AC139667.5         99730-99836
            2079-2294           AC139667.5         101353-101568
            2295-2478           AC139667.5         105153-105336
            2479-2538           AC139667.5         105967-106026
            2539-2786           AC139667.5         106148-106395
            2787-2868           AC139667.5         119741-119822
            2869-2981           AC139667.5         121893-122005
            2982-3171           AC139667.5         123901-124090
            3172-5516           AC139667.5         124214-126558
FEATURES             Location/Qualifiers
     source          1..5516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5516
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3179
                     /gene="MAP4"
                     /note="isoform 103 is encoded by transcript variant 127;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 103"
                     /protein_id="NP_001371822.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTE
                     FLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATA
                     DTSIFAGQNDPLKDSYVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMA
                     LAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALV
                     KDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKE
                     NKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSA
                     EKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKD
                     VAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQV
                     PALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHL
                     ESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSET
                     SGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTS
                     LPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKA
                     PEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKT
                     EGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSR
                     PSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVQIQNKKVDISKVSSKC
                     GSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPL
                     CPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI"
     exon            319..387
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..510
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..624
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            625..1848
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1971
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2078
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2294
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2478
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2538
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2786
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2868
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2981
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3171
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3172..5516
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4634..4639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4653
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      5492..5497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5516
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaagat actccatctt ctaaaccaac actcctagcc aatggtggtc
      361 atggagtaga agggagcgat actacagggt ctccaactga attccttgaa gagaaaatgg
      421 cctaccagga atacccaaat agccagaact ggccagaaga taccaacttt tgtttccaac
      481 ctgagcaagt ggtcgatcct atccagactg atccctttaa gatgtaccat gatgatgacc
      541 tggcagattt ggtctttccc tccagtgcga cagctgatac ttcaatattt gcaggacaaa
      601 atgatccctt gaaagacagt tacgttccct tagagctagc caaggagata gaaatggcat
      661 cagaagagag gccaccagca caagcattgg aaataatgat gggactgaag actactgaca
      721 tggcaccatc taaagaaaca gagatggccc tcgccaagga catggcacta gctacaaaaa
      781 ccgaggtggc attggctaaa gatatggaat cacccaccaa attagatgtg acactggcca
      841 aggacatgca gccatccatg gaatcagata tggccctagt caaggacatg gaactaccca
      901 cagaaaaaga agtggccctg gttaaggatg tcagatggcc cacagaaaca gatgtatctt
      961 cagccaagaa tgtggtactg cccacagaaa cagaggtagc cccagccaag gatgtgacac
     1021 tgttgaaaga aacagagagg gcatctccta taaaaatgga cttagcccct tccaaggaca
     1081 tgggaccacc caaagaaaac aagaaagaaa cagagagggc atctcctata aaaatggact
     1141 tggctccttc caaggacatg ggaccaccca aagaaaacaa gatagtccca gccaaggatt
     1201 tggtattact ctcagaaata gaggtggcac aggctaatga cattatatca tccacagaaa
     1261 tatcctctgc tgagaaggtg gctttgtcct cagaaacaga ggtagccctg gccagggaca
     1321 tgacactgcc cccggaaacc aacgtgatct tgaccaagga taaagcacta cctttagaag
     1381 cagaggtggc cccagtcaag gacatggctc aactcccaga aacagaaata gccccggcca
     1441 aggatgtggc tccgtccaca gtaaaagaag tgggcttgtt gaaggacatg tctccactat
     1501 cagaaacaga aatggctctg ggcaaggatg tgactccacc tccagaaaca gaagtagttc
     1561 tcatcaagaa cgtatgtctg cctccagaaa tggaggtggc cctgactgag gatcaggtcc
     1621 cagccctcaa aacagaagca cccctggcta aggatggggt tctgaccctg gccaacaatg
     1681 tgactccagc caaagatgtt ccaccactct cagaaacaga ggcaacacca gttccaatta
     1741 aagacatgga aattgcacaa acacaaaaag gaataagtga ggattcccat ttagaatctc
     1801 tgcaggatgt ggggcagtca gctgcaccta ctttcatgat ttcaccagaa accgtcacag
     1861 gaacggggaa aaagtgcagc ttgccggccg aggaggattc tgtgttagaa aaactagggg
     1921 aaaggaaacc atgcaacagt caaccttctg agctttcttc agagacctca ggaatagcca
     1981 ggccagaaga aggaaggcct gtggtgagtg ggacaggaaa tgacatcacc accccaccga
     2041 acaaggagct cccaccaagc ccagagaaga aaacaaagcc tttggccacc actcaacctg
     2101 caaagacttc aacatcgaaa gccaaaacac agcccacttc tctccctaag cagccagctc
     2161 ccaccaccat tggtgggttg aataaaaaac ccatgagcct tgcttcaggc ttagtgccag
     2221 ctgccccacc caaacgccct gccgtcgcct ctgccaggcc ttccatctta ccttcaaaag
     2281 acgtgaagcc aaagcccatt gcagatgcaa aggctcctga gaagcgggcc tcaccatcca
     2341 agccagcttc tgccccagcc tccagatctg ggtccaagag cactcagact gttgcaaaaa
     2401 ccacaacagc tgctgctgtt gcctcaactg gcccaagcag taggagcccc tccacgctcc
     2461 tgcccaagaa gcccactgcc attaagactg agggaaaacc tgcagaagtc aagaagatga
     2521 ctgcaaagtc tgtaccagct gacttgagtc gcccaaagag cacctccacc agttccatga
     2581 agaaaaccac cactctcagt gggacagccc ccgctgcagg ggtggttccc agccgagtca
     2641 aggccacacc catgccctcc cggccctcca caactccttt catagacaag aagcccacct
     2701 cggccaaacc cagctccacc accccccggc tcagccgcct ggccaccaat acttctgctc
     2761 ctgatctgaa gaatgtccgc tccaaggttc agattcagaa caagaaagtg gacatctcta
     2821 aggtctcctc caagtgtggg tctaaggcta acatcaagca caagcctggt ggaggagatg
     2881 tcaagattga aagtcagaag ttgaacttca aggagaaggc ccaggccaag gtgggatccc
     2941 tcgataatgt gggccaccta cctgcaggag gtgctgtgaa gactgagggc ggtggcagcg
     3001 aggctcctct gtgtccgggt ccccctgctg gggaggagcc ggccatctct gaggcagcgc
     3061 ctgaagctgg cgcccccact tcagccagtg gcctcaatgg ccaccccacc ctgtcagggg
     3121 gtggtgacca aagggaggcc cagaccttgg acagccagat ccaggagaca agcatctaat
     3181 gatgacattc tggtctcgtc ttccgtctcc cccgtgttcc cctcttgtct cccctgttcc
     3241 cctctccctt ccctcctccc atgtcactgc agattgagac ctacaggctg acgttccggg
     3301 caaatgccag ggcccgcacc gaccacgggg ccgacattgt ctcccgcccc ccacacttcc
     3361 ctggcggccc caactcgggc tcccgggtcc ttggccccct ttcccgggct gtccactaga
     3421 ccagtgagcg cttgggcgcc gtgctgggca gcccgctagg ctcgccttcc ctcctgcttt
     3481 gcgtgcccgg ggcagcagca gccctgcccc acacctcctc tcactcccca gcctgggccc
     3541 atctccctgc tttggtcttg ccccatcact gcgccactgc tccgtggagg aggttgggag
     3601 ggggttgggg tggttgaggc taagttggga tctaggagag gagaaccaga ttctatcctc
     3661 atcttttttt ggttctttgg tccaaaccca aaagaaactg acatgccctc ccttctccct
     3721 ggatctacct ggagggaaga gtggaggtgg attccgagtg gtgacaggac gctgaccgtg
     3781 gagcttaagc cactgcctct ccctctggtc ccacaaatgg gcgccccccc ctccccatgc
     3841 aggtggtgtc gggcccttct tgctgccctg ccccaagttg ggggtcagtg ctgcctgtcc
     3901 ccatgcttaa catacccgcc tagctgctgt cacatttttc ttgttttgtc cttttatttt
     3961 tttctaataa cctaaaaact ggcaaaatag ttctgcaggt tgaagccatg tctacatgaa
     4021 agtcctcagt aagtgttaga gggaacaggg cggagatatc cttatgccac ccccgctgga
     4081 ggatgtgggc agcttagggc cctggaggcg gtgcggcagg gaagaggggt gcagaggctg
     4141 tggctggtga gccggtcagg cacacaaggg gcccttggag cgtggactgg ttggttttgc
     4201 cattttgttg tgtgtatgct gcttttcttt tctaaccaag aggctggttt tggcatctct
     4261 gtcccattcc ctgggatctg gtggtcagcc ctaggataaa aagccagggc tggagaacaa
     4321 gaaagggcca ggagatggaa ttccttcagg ccggcaccca caccctagga catgtaagcc
     4381 ctcatgtcca agggagcctc atgcagatag taggaaatca ggtctggaaa tttaaaaata
     4441 aaaggcatga gactaaggct atctgcttcc cttatgccct gactggagag gggagggagg
     4501 agaggcaagg cccacagagg gcatcccagc taggccttgg gatggctgca gtgaggagaa
     4561 atcccgggaa ctgtattgac acaaagattc ttattgcact tgtatttttt gtattaaagt
     4621 ttgcatggtt tctaataaag gattcaaaca taagtttgta gtgaaatggc ctgggagatt
     4681 ccaagggctt ctctggaggg ggattggctg cagtgtagat ttgcctctga ggaggctgcc
     4741 ccagacttgg cctcctcatg ccccctcctg acctctgccc ttctctggtc ctggcatccc
     4801 tggagaaggt aggggtcttg acctaagttt agatttgatc tccatgtgca gggaggctgt
     4861 cctgggcctg acaggtcctc cccctttctg aggtagcagt gccttgtgga ggtttgacac
     4921 catgtcccta gctccccaag cacacaccag gaaactgcag gggctcacgg aggaagtgct
     4981 gcctgggcca gggggaccag ctttcctccg tagagaccat gtgcagaaca cttctgctgt
     5041 gccaagaaca tgagggagcc agtgttttgt cagcaggaag aaagggcctg ctgggatgaa
     5101 agtgggaagg aaacagggtt gcgtagtcag gagacacctc aggggcaaca gcacaggccc
     5161 agagtacctg ctgcctccac tgcgtctgtc ctggggtcat gaggatgctg aggttgacga
     5221 caggttccag gtcctttcac tcctttggcc aaaggttggg ggtaggtggc ccaagtggcg
     5281 tgctctctag gtagacaaca ggagtggtca gagttccctc aaaggatcct ccactccaga
     5341 gcacctgaga aggccgggac cagaggccct gtgtgatgtg tactccgcag ctgtttgggg
     5401 tgggacattt ctgtacttct cgatttgctt atggctcagc cattacctgt gtcagtccat
     5461 gattctgttg taacagtttt aagagtaaat aaataaagct gcctgatgtc ccatca
//
