LOCUS       NM_001384840            5460 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 92, mRNA.
ACCESSION   NM_001384840
VERSION     NM_001384840.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5460)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 5460)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5460)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5460)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5460)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 5460)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 5460)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 5460)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 5460)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 5460)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-387             AC124916.3         2661-2729           c
            388-510             AC139667.5         48903-49025
            511-624             AC139667.5         55375-55488
            625-747             AC139667.5         58412-58534
            748-1971            AC139667.5         60079-61302
            1972-2094           AC139667.5         62314-62436
            2095-2201           AC139667.5         99730-99836
            2202-2385           AC139667.5         105153-105336
            2386-2445           AC139667.5         105967-106026
            2446-2738           AC139667.5         106148-106440
            2739-2831           AC139667.5         109915-110007
            2832-2913           AC139667.5         119741-119822
            2914-3026           AC139667.5         121893-122005
            3027-3216           AC139667.5         123901-124090
            3217-5460           AC139667.5         124315-126558
FEATURES             Location/Qualifiers
     source          1..5460
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5460
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3221
                     /gene="MAP4"
                     /note="isoform 95 is encoded by transcript variant 92;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 95"
                     /protein_id="NP_001371769.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTE
                     FLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATA
                     DTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAV
                     PLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAK
                     DMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNV
                     VLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAP
                     SKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDM
                     TLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSP
                     LSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTL
                     ANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMIS
                     PETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTG
                     NDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTT
                     AAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMK
                     KTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTS
                     APDLKNVRSKVGSTENIKHQPGGGRVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQ
                     IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPA
                     GGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREA
                     QTLDSQIQETN"
     exon            319..387
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..510
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..624
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            625..747
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1971
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2094
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2201
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2385
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2445
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2738
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2831
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..2913
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..3026
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3216
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..5460
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4578..4583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4597
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      5436..5441
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5460
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaagat actccatctt ctaaaccaac actcctagcc aatggtggtc
      361 atggagtaga agggagcgat actacagggt ctccaactga attccttgaa gagaaaatgg
      421 cctaccagga atacccaaat agccagaact ggccagaaga taccaacttt tgtttccaac
      481 ctgagcaagt ggtcgatcct atccagactg atccctttaa gatgtaccat gatgatgacc
      541 tggcagattt ggtctttccc tccagtgcga cagctgatac ttcaatattt gcaggacaaa
      601 atgatccctt gaaagacagt tacggtatgt ctccctgcaa cacagctgtt gtacctcagg
      661 ggtggtctgt ggaagcctta aactctccac actcagagtc ctttgtttcc ccagaggctg
      721 ttgcagaacc tcctcagcca acggcagttc ccttagagct agccaaggag atagaaatgg
      781 catcagaaga gaggccacca gcacaagcat tggaaataat gatgggactg aagactactg
      841 acatggcacc atctaaagaa acagagatgg ccctcgccaa ggacatggca ctagctacaa
      901 aaaccgaggt ggcattggct aaagatatgg aatcacccac caaattagat gtgacactgg
      961 ccaaggacat gcagccatcc atggaatcag atatggccct agtcaaggac atggaactac
     1021 ccacagaaaa agaagtggcc ctggttaagg atgtcagatg gcccacagaa acagatgtat
     1081 cttcagccaa gaatgtggta ctgcccacag aaacagaggt agccccagcc aaggatgtga
     1141 cactgttgaa agaaacagag agggcatctc ctataaaaat ggacttagcc ccttccaagg
     1201 acatgggacc acccaaagaa aacaagaaag aaacagagag ggcatctcct ataaaaatgg
     1261 acttggctcc ttccaaggac atgggaccac ccaaagaaaa caagatagtc ccagccaagg
     1321 atttggtatt actctcagaa atagaggtgg cacaggctaa tgacattata tcatccacag
     1381 aaatatcctc tgctgagaag gtggctttgt cctcagaaac agaggtagcc ctggccaggg
     1441 acatgacact gcccccggaa accaacgtga tcttgaccaa ggataaagca ctacctttag
     1501 aagcagaggt ggccccagtc aaggacatgg ctcaactccc agaaacagaa atagccccgg
     1561 ccaaggatgt ggctccgtcc acagtaaaag aagtgggctt gttgaaggac atgtctccac
     1621 tatcagaaac agaaatggct ctgggcaagg atgtgactcc acctccagaa acagaagtag
     1681 ttctcatcaa gaacgtatgt ctgcctccag aaatggaggt ggccctgact gaggatcagg
     1741 tcccagccct caaaacagaa gcacccctgg ctaaggatgg ggttctgacc ctggccaaca
     1801 atgtgactcc agccaaagat gttccaccac tctcagaaac agaggcaaca ccagttccaa
     1861 ttaaagacat ggaaattgca caaacacaaa aaggaataag tgaggattcc catttagaat
     1921 ctctgcagga tgtggggcag tcagctgcac ctactttcat gatttcacca gaaaccgtca
     1981 caggaacggg gaaaaagtgc agcttgccgg ccgaggagga ttctgtgtta gaaaaactag
     2041 gggaaaggaa accatgcaac agtcaacctt ctgagctttc ttcagagacc tcaggaatag
     2101 ccaggccaga agaaggaagg cctgtggtga gtgggacagg aaatgacatc accaccccac
     2161 cgaacaagga gctcccacca agcccagaga agaaaacaaa gcccattgca gatgcaaagg
     2221 ctcctgagaa gcgggcctca ccatccaagc cagcttctgc cccagcctcc agatctgggt
     2281 ccaagagcac tcagactgtt gcaaaaacca caacagctgc tgctgttgcc tcaactggcc
     2341 caagcagtag gagcccctcc acgctcctgc ccaagaagcc cactgccatt aagactgagg
     2401 gaaaacctgc agaagtcaag aagatgactg caaagtctgt accagctgac ttgagtcgcc
     2461 caaagagcac ctccaccagt tccatgaaga aaaccaccac tctcagtggg acagcccccg
     2521 ctgcaggggt ggttcccagc cgagtcaagg ccacacccat gccctcccgg ccctccacaa
     2581 ctcctttcat agacaagaag cccacctcgg ccaaacccag ctccaccacc ccccggctca
     2641 gccgcctggc caccaatact tctgctcctg atctgaagaa tgtccgctcc aaggttggct
     2701 ccacggaaaa catcaagcat cagcctggag gaggccgggt ccagatagtc tccaaaaaag
     2761 tgagctacag ccatattcag tccaagtgtg gttccaagga caatattaag catgtccctg
     2821 gaggtggtaa tgttcagatt cagaacaaga aagtggacat ctctaaggtc tcctccaagt
     2881 gtgggtctaa ggctaacatc aagcacaagc ctggtggagg agatgtcaag attgaaagtc
     2941 agaagttgaa cttcaaggag aaggcccagg ccaaggtggg atccctcgat aatgtgggcc
     3001 acctacctgc aggaggtgct gtgaagactg agggcggtgg cagcgaggct cctctgtgtc
     3061 cgggtccccc tgctggggag gagccggcca tctctgaggc agcgcctgaa gctggcgccc
     3121 ccacttcagc cagtggcctc aatggccacc ccaccctgtc agggggtggt gaccaaaggg
     3181 aggcccagac cttggacagc cagatccagg agacaaattg agacctacag gctgacgttc
     3241 cgggcaaatg ccagggcccg caccgaccac ggggccgaca ttgtctcccg ccccccacac
     3301 ttccctggcg gccccaactc gggctcccgg gtccttggcc ccctttcccg ggctgtccac
     3361 tagaccagtg agcgcttggg cgccgtgctg ggcagcccgc taggctcgcc ttccctcctg
     3421 ctttgcgtgc ccggggcagc agcagccctg ccccacacct cctctcactc cccagcctgg
     3481 gcccatctcc ctgctttggt cttgccccat cactgcgcca ctgctccgtg gaggaggttg
     3541 ggagggggtt ggggtggttg aggctaagtt gggatctagg agaggagaac cagattctat
     3601 cctcatcttt ttttggttct ttggtccaaa cccaaaagaa actgacatgc cctcccttct
     3661 ccctggatct acctggaggg aagagtggag gtggattccg agtggtgaca ggacgctgac
     3721 cgtggagctt aagccactgc ctctccctct ggtcccacaa atgggcgccc ccccctcccc
     3781 atgcaggtgg tgtcgggccc ttcttgctgc cctgccccaa gttgggggtc agtgctgcct
     3841 gtccccatgc ttaacatacc cgcctagctg ctgtcacatt tttcttgttt tgtcctttta
     3901 tttttttcta ataacctaaa aactggcaaa atagttctgc aggttgaagc catgtctaca
     3961 tgaaagtcct cagtaagtgt tagagggaac agggcggaga tatccttatg ccacccccgc
     4021 tggaggatgt gggcagctta gggccctgga ggcggtgcgg cagggaagag gggtgcagag
     4081 gctgtggctg gtgagccggt caggcacaca aggggccctt ggagcgtgga ctggttggtt
     4141 ttgccatttt gttgtgtgta tgctgctttt cttttctaac caagaggctg gttttggcat
     4201 ctctgtccca ttccctggga tctggtggtc agccctagga taaaaagcca gggctggaga
     4261 acaagaaagg gccaggagat ggaattcctt caggccggca cccacaccct aggacatgta
     4321 agccctcatg tccaagggag cctcatgcag atagtaggaa atcaggtctg gaaatttaaa
     4381 aataaaaggc atgagactaa ggctatctgc ttcccttatg ccctgactgg agaggggagg
     4441 gaggagaggc aaggcccaca gagggcatcc cagctaggcc ttgggatggc tgcagtgagg
     4501 agaaatcccg ggaactgtat tgacacaaag attcttattg cacttgtatt ttttgtatta
     4561 aagtttgcat ggtttctaat aaaggattca aacataagtt tgtagtgaaa tggcctggga
     4621 gattccaagg gcttctctgg agggggattg gctgcagtgt agatttgcct ctgaggaggc
     4681 tgccccagac ttggcctcct catgccccct cctgacctct gcccttctct ggtcctggca
     4741 tccctggaga aggtaggggt cttgacctaa gtttagattt gatctccatg tgcagggagg
     4801 ctgtcctggg cctgacaggt cctccccctt tctgaggtag cagtgccttg tggaggtttg
     4861 acaccatgtc cctagctccc caagcacaca ccaggaaact gcaggggctc acggaggaag
     4921 tgctgcctgg gccaggggga ccagctttcc tccgtagaga ccatgtgcag aacacttctg
     4981 ctgtgccaag aacatgaggg agccagtgtt ttgtcagcag gaagaaaggg cctgctggga
     5041 tgaaagtggg aaggaaacag ggttgcgtag tcaggagaca cctcaggggc aacagcacag
     5101 gcccagagta cctgctgcct ccactgcgtc tgtcctgggg tcatgaggat gctgaggttg
     5161 acgacaggtt ccaggtcctt tcactccttt ggccaaaggt tgggggtagg tggcccaagt
     5221 ggcgtgctct ctaggtagac aacaggagtg gtcagagttc cctcaaagga tcctccactc
     5281 cagagcacct gagaaggccg ggaccagagg ccctgtgtga tgtgtactcc gcagctgttt
     5341 ggggtgggac atttctgtac ttctcgattt gcttatggct cagccattac ctgtgtcagt
     5401 ccatgattct gttgtaacag ttttaagagt aaataaataa agctgcctga tgtcccatca
//
