LOCUS       NM_001384824            5702 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 79, mRNA.
ACCESSION   NM_001384824
VERSION     NM_001384824.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5702)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 5702)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5702)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5702)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5702)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 5702)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 5702)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 5702)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 5702)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 5702)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-387             AC124916.3         2661-2729           c
            388-510             AC139667.5         48903-49025
            511-624             AC139667.5         55375-55488
            625-747             AC139667.5         58412-58534
            748-1971            AC139667.5         60079-61302
            1972-2094           AC139667.5         62314-62436
            2095-2201           AC139667.5         99730-99836
            2202-2342           AC139667.5         101428-101568
            2343-2526           AC139667.5         105153-105336
            2527-2586           AC139667.5         105967-106026
            2587-2879           AC139667.5         106148-106440
            2880-2972           AC139667.5         109915-110007
            2973-3054           AC139667.5         119741-119822
            3055-3167           AC139667.5         121893-122005
            3168-3357           AC139667.5         123901-124090
            3358-5702           AC139667.5         124214-126558
FEATURES             Location/Qualifiers
     source          1..5702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5702
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3365
                     /gene="MAP4"
                     /note="isoform 59 is encoded by transcript variant 79;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 59"
                     /protein_id="NP_001371753.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTE
                     FLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATA
                     DTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAV
                     PLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAK
                     DMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNV
                     VLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAP
                     SKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDM
                     TLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSP
                     LSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTL
                     ANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMIS
                     PETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTG
                     NDITTPPNKELPPSPEKKTKPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSI
                     LPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSS
                     RSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPA
                     AGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKV
                     GSTENIKHQPGGGRVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKV
                     SSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGS
                     EAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETS
                     I"
     exon            319..387
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..510
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..624
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            625..747
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1971
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2094
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2201
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2342
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2526
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2586
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2879
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2880..2972
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3054
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3167
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3168..3357
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..5702
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4820..4825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4839
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      5678..5683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5702
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaagat actccatctt ctaaaccaac actcctagcc aatggtggtc
      361 atggagtaga agggagcgat actacagggt ctccaactga attccttgaa gagaaaatgg
      421 cctaccagga atacccaaat agccagaact ggccagaaga taccaacttt tgtttccaac
      481 ctgagcaagt ggtcgatcct atccagactg atccctttaa gatgtaccat gatgatgacc
      541 tggcagattt ggtctttccc tccagtgcga cagctgatac ttcaatattt gcaggacaaa
      601 atgatccctt gaaagacagt tacggtatgt ctccctgcaa cacagctgtt gtacctcagg
      661 ggtggtctgt ggaagcctta aactctccac actcagagtc ctttgtttcc ccagaggctg
      721 ttgcagaacc tcctcagcca acggcagttc ccttagagct agccaaggag atagaaatgg
      781 catcagaaga gaggccacca gcacaagcat tggaaataat gatgggactg aagactactg
      841 acatggcacc atctaaagaa acagagatgg ccctcgccaa ggacatggca ctagctacaa
      901 aaaccgaggt ggcattggct aaagatatgg aatcacccac caaattagat gtgacactgg
      961 ccaaggacat gcagccatcc atggaatcag atatggccct agtcaaggac atggaactac
     1021 ccacagaaaa agaagtggcc ctggttaagg atgtcagatg gcccacagaa acagatgtat
     1081 cttcagccaa gaatgtggta ctgcccacag aaacagaggt agccccagcc aaggatgtga
     1141 cactgttgaa agaaacagag agggcatctc ctataaaaat ggacttagcc ccttccaagg
     1201 acatgggacc acccaaagaa aacaagaaag aaacagagag ggcatctcct ataaaaatgg
     1261 acttggctcc ttccaaggac atgggaccac ccaaagaaaa caagatagtc ccagccaagg
     1321 atttggtatt actctcagaa atagaggtgg cacaggctaa tgacattata tcatccacag
     1381 aaatatcctc tgctgagaag gtggctttgt cctcagaaac agaggtagcc ctggccaggg
     1441 acatgacact gcccccggaa accaacgtga tcttgaccaa ggataaagca ctacctttag
     1501 aagcagaggt ggccccagtc aaggacatgg ctcaactccc agaaacagaa atagccccgg
     1561 ccaaggatgt ggctccgtcc acagtaaaag aagtgggctt gttgaaggac atgtctccac
     1621 tatcagaaac agaaatggct ctgggcaagg atgtgactcc acctccagaa acagaagtag
     1681 ttctcatcaa gaacgtatgt ctgcctccag aaatggaggt ggccctgact gaggatcagg
     1741 tcccagccct caaaacagaa gcacccctgg ctaaggatgg ggttctgacc ctggccaaca
     1801 atgtgactcc agccaaagat gttccaccac tctcagaaac agaggcaaca ccagttccaa
     1861 ttaaagacat ggaaattgca caaacacaaa aaggaataag tgaggattcc catttagaat
     1921 ctctgcagga tgtggggcag tcagctgcac ctactttcat gatttcacca gaaaccgtca
     1981 caggaacggg gaaaaagtgc agcttgccgg ccgaggagga ttctgtgtta gaaaaactag
     2041 gggaaaggaa accatgcaac agtcaacctt ctgagctttc ttcagagacc tcaggaatag
     2101 ccaggccaga agaaggaagg cctgtggtga gtgggacagg aaatgacatc accaccccac
     2161 cgaacaagga gctcccacca agcccagaga agaaaacaaa gccagctccc accaccattg
     2221 gtgggttgaa taaaaaaccc atgagccttg cttcaggctt agtgccagct gccccaccca
     2281 aacgccctgc cgtcgcctct gccaggcctt ccatcttacc ttcaaaagac gtgaagccaa
     2341 agcccattgc agatgcaaag gctcctgaga agcgggcctc accatccaag ccagcttctg
     2401 ccccagcctc cagatctggg tccaagagca ctcagactgt tgcaaaaacc acaacagctg
     2461 ctgctgttgc ctcaactggc ccaagcagta ggagcccctc cacgctcctg cccaagaagc
     2521 ccactgccat taagactgag ggaaaacctg cagaagtcaa gaagatgact gcaaagtctg
     2581 taccagctga cttgagtcgc ccaaagagca cctccaccag ttccatgaag aaaaccacca
     2641 ctctcagtgg gacagccccc gctgcagggg tggttcccag ccgagtcaag gccacaccca
     2701 tgccctcccg gccctccaca actcctttca tagacaagaa gcccacctcg gccaaaccca
     2761 gctccaccac cccccggctc agccgcctgg ccaccaatac ttctgctcct gatctgaaga
     2821 atgtccgctc caaggttggc tccacggaaa acatcaagca tcagcctgga ggaggccggg
     2881 tccagatagt ctccaaaaaa gtgagctaca gccatattca gtccaagtgt ggttccaagg
     2941 acaatattaa gcatgtccct ggaggtggta atgttcagat tcagaacaag aaagtggaca
     3001 tctctaaggt ctcctccaag tgtgggtcta aggctaacat caagcacaag cctggtggag
     3061 gagatgtcaa gattgaaagt cagaagttga acttcaagga gaaggcccag gccaaggtgg
     3121 gatccctcga taatgtgggc cacctacctg caggaggtgc tgtgaagact gagggcggtg
     3181 gcagcgaggc tcctctgtgt ccgggtcccc ctgctgggga ggagccggcc atctctgagg
     3241 cagcgcctga agctggcgcc cccacttcag ccagtggcct caatggccac cccaccctgt
     3301 cagggggtgg tgaccaaagg gaggcccaga ccttggacag ccagatccag gagacaagca
     3361 tctaatgatg acattctggt ctcgtcttcc gtctcccccg tgttcccctc ttgtctcccc
     3421 tgttcccctc tcccttccct cctcccatgt cactgcagat tgagacctac aggctgacgt
     3481 tccgggcaaa tgccagggcc cgcaccgacc acggggccga cattgtctcc cgccccccac
     3541 acttccctgg cggccccaac tcgggctccc gggtccttgg ccccctttcc cgggctgtcc
     3601 actagaccag tgagcgcttg ggcgccgtgc tgggcagccc gctaggctcg ccttccctcc
     3661 tgctttgcgt gcccggggca gcagcagccc tgccccacac ctcctctcac tccccagcct
     3721 gggcccatct ccctgctttg gtcttgcccc atcactgcgc cactgctccg tggaggaggt
     3781 tgggaggggg ttggggtggt tgaggctaag ttgggatcta ggagaggaga accagattct
     3841 atcctcatct ttttttggtt ctttggtcca aacccaaaag aaactgacat gccctccctt
     3901 ctccctggat ctacctggag ggaagagtgg aggtggattc cgagtggtga caggacgctg
     3961 accgtggagc ttaagccact gcctctccct ctggtcccac aaatgggcgc ccccccctcc
     4021 ccatgcaggt ggtgtcgggc ccttcttgct gccctgcccc aagttggggg tcagtgctgc
     4081 ctgtccccat gcttaacata cccgcctagc tgctgtcaca tttttcttgt tttgtccttt
     4141 tatttttttc taataaccta aaaactggca aaatagttct gcaggttgaa gccatgtcta
     4201 catgaaagtc ctcagtaagt gttagaggga acagggcgga gatatcctta tgccaccccc
     4261 gctggaggat gtgggcagct tagggccctg gaggcggtgc ggcagggaag aggggtgcag
     4321 aggctgtggc tggtgagccg gtcaggcaca caaggggccc ttggagcgtg gactggttgg
     4381 ttttgccatt ttgttgtgtg tatgctgctt ttcttttcta accaagaggc tggttttggc
     4441 atctctgtcc cattccctgg gatctggtgg tcagccctag gataaaaagc cagggctgga
     4501 gaacaagaaa gggccaggag atggaattcc ttcaggccgg cacccacacc ctaggacatg
     4561 taagccctca tgtccaaggg agcctcatgc agatagtagg aaatcaggtc tggaaattta
     4621 aaaataaaag gcatgagact aaggctatct gcttccctta tgccctgact ggagagggga
     4681 gggaggagag gcaaggccca cagagggcat cccagctagg ccttgggatg gctgcagtga
     4741 ggagaaatcc cgggaactgt attgacacaa agattcttat tgcacttgta ttttttgtat
     4801 taaagtttgc atggtttcta ataaaggatt caaacataag tttgtagtga aatggcctgg
     4861 gagattccaa gggcttctct ggagggggat tggctgcagt gtagatttgc ctctgaggag
     4921 gctgccccag acttggcctc ctcatgcccc ctcctgacct ctgcccttct ctggtcctgg
     4981 catccctgga gaaggtaggg gtcttgacct aagtttagat ttgatctcca tgtgcaggga
     5041 ggctgtcctg ggcctgacag gtcctccccc tttctgaggt agcagtgcct tgtggaggtt
     5101 tgacaccatg tccctagctc cccaagcaca caccaggaaa ctgcaggggc tcacggagga
     5161 agtgctgcct gggccagggg gaccagcttt cctccgtaga gaccatgtgc agaacacttc
     5221 tgctgtgcca agaacatgag ggagccagtg ttttgtcagc aggaagaaag ggcctgctgg
     5281 gatgaaagtg ggaaggaaac agggttgcgt agtcaggaga cacctcaggg gcaacagcac
     5341 aggcccagag tacctgctgc ctccactgcg tctgtcctgg ggtcatgagg atgctgaggt
     5401 tgacgacagg ttccaggtcc tttcactcct ttggccaaag gttgggggta ggtggcccaa
     5461 gtggcgtgct ctctaggtag acaacaggag tggtcagagt tccctcaaag gatcctccac
     5521 tccagagcac ctgagaaggc cgggaccaga ggccctgtgt gatgtgtact ccgcagctgt
     5581 ttggggtggg acatttctgt acttctcgat ttgcttatgg ctcagccatt acctgtgtca
     5641 gtccatgatt ctgttgtaac agttttaaga gtaaataaat aaagctgcct gatgtcccat
     5701 ca
//
