LOCUS       NM_001384812            4169 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 71, mRNA.
ACCESSION   NM_001384812
VERSION     NM_001384812.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4169)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 4169)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4169)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4169)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 4169)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 4169)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 4169)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 4169)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 4169)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 4169)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-387             AC124916.3         2661-2729           c
            388-510             AC139667.5         48903-49025
            511-624             AC139667.5         55375-55488
            625-731             AC139667.5         99730-99836
            732-947             AC139667.5         101353-101568
            948-1131            AC139667.5         105153-105336
            1132-1191           AC139667.5         105967-106026
            1192-1439           AC139667.5         106148-106395
            1440-1521           AC139667.5         119741-119822
            1522-1634           AC139667.5         121893-122005
            1635-1824           AC139667.5         123901-124090
            1825-4169           AC139667.5         124214-126558
FEATURES             Location/Qualifiers
     source          1..4169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4169
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1832
                     /gene="MAP4"
                     /note="isoform 133 is encoded by transcript variant 71;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 133"
                     /protein_id="NP_001371741.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTE
                     FLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATA
                     DTSIFAGQNDPLKDSYGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQ
                     PAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSIL
                     PSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSR
                     SPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAA
                     GVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVQ
                     IQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPA
                     GGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREA
                     QTLDSQIQETSI"
     exon            319..387
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..510
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..624
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            625..731
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            732..947
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1131
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1191
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1439
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1521
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1634
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1824
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..4169
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3287..3292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      3306
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      4145..4150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4169
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaagat actccatctt ctaaaccaac actcctagcc aatggtggtc
      361 atggagtaga agggagcgat actacagggt ctccaactga attccttgaa gagaaaatgg
      421 cctaccagga atacccaaat agccagaact ggccagaaga taccaacttt tgtttccaac
      481 ctgagcaagt ggtcgatcct atccagactg atccctttaa gatgtaccat gatgatgacc
      541 tggcagattt ggtctttccc tccagtgcga cagctgatac ttcaatattt gcaggacaaa
      601 atgatccctt gaaagacagt tacggaatag ccaggccaga agaaggaagg cctgtggtga
      661 gtgggacagg aaatgacatc accaccccac cgaacaagga gctcccacca agcccagaga
      721 agaaaacaaa gcctttggcc accactcaac ctgcaaagac ttcaacatcg aaagccaaaa
      781 cacagcccac ttctctccct aagcagccag ctcccaccac cattggtggg ttgaataaaa
      841 aacccatgag ccttgcttca ggcttagtgc cagctgcccc acccaaacgc cctgccgtcg
      901 cctctgccag gccttccatc ttaccttcaa aagacgtgaa gccaaagccc attgcagatg
      961 caaaggctcc tgagaagcgg gcctcaccat ccaagccagc ttctgcccca gcctccagat
     1021 ctgggtccaa gagcactcag actgttgcaa aaaccacaac agctgctgct gttgcctcaa
     1081 ctggcccaag cagtaggagc ccctccacgc tcctgcccaa gaagcccact gccattaaga
     1141 ctgagggaaa acctgcagaa gtcaagaaga tgactgcaaa gtctgtacca gctgacttga
     1201 gtcgcccaaa gagcacctcc accagttcca tgaagaaaac caccactctc agtgggacag
     1261 cccccgctgc aggggtggtt cccagccgag tcaaggccac acccatgccc tcccggccct
     1321 ccacaactcc tttcatagac aagaagccca cctcggccaa acccagctcc accacccccc
     1381 ggctcagccg cctggccacc aatacttctg ctcctgatct gaagaatgtc cgctccaagg
     1441 ttcagattca gaacaagaaa gtggacatct ctaaggtctc ctccaagtgt gggtctaagg
     1501 ctaacatcaa gcacaagcct ggtggaggag atgtcaagat tgaaagtcag aagttgaact
     1561 tcaaggagaa ggcccaggcc aaggtgggat ccctcgataa tgtgggccac ctacctgcag
     1621 gaggtgctgt gaagactgag ggcggtggca gcgaggctcc tctgtgtccg ggtccccctg
     1681 ctggggagga gccggccatc tctgaggcag cgcctgaagc tggcgccccc acttcagcca
     1741 gtggcctcaa tggccacccc accctgtcag ggggtggtga ccaaagggag gcccagacct
     1801 tggacagcca gatccaggag acaagcatct aatgatgaca ttctggtctc gtcttccgtc
     1861 tcccccgtgt tcccctcttg tctcccctgt tcccctctcc cttccctcct cccatgtcac
     1921 tgcagattga gacctacagg ctgacgttcc gggcaaatgc cagggcccgc accgaccacg
     1981 gggccgacat tgtctcccgc cccccacact tccctggcgg ccccaactcg ggctcccggg
     2041 tccttggccc cctttcccgg gctgtccact agaccagtga gcgcttgggc gccgtgctgg
     2101 gcagcccgct aggctcgcct tccctcctgc tttgcgtgcc cggggcagca gcagccctgc
     2161 cccacacctc ctctcactcc ccagcctggg cccatctccc tgctttggtc ttgccccatc
     2221 actgcgccac tgctccgtgg aggaggttgg gagggggttg gggtggttga ggctaagttg
     2281 ggatctagga gaggagaacc agattctatc ctcatctttt tttggttctt tggtccaaac
     2341 ccaaaagaaa ctgacatgcc ctcccttctc cctggatcta cctggaggga agagtggagg
     2401 tggattccga gtggtgacag gacgctgacc gtggagctta agccactgcc tctccctctg
     2461 gtcccacaaa tgggcgcccc cccctcccca tgcaggtggt gtcgggccct tcttgctgcc
     2521 ctgccccaag ttgggggtca gtgctgcctg tccccatgct taacataccc gcctagctgc
     2581 tgtcacattt ttcttgtttt gtccttttat ttttttctaa taacctaaaa actggcaaaa
     2641 tagttctgca ggttgaagcc atgtctacat gaaagtcctc agtaagtgtt agagggaaca
     2701 gggcggagat atccttatgc cacccccgct ggaggatgtg ggcagcttag ggccctggag
     2761 gcggtgcggc agggaagagg ggtgcagagg ctgtggctgg tgagccggtc aggcacacaa
     2821 ggggcccttg gagcgtggac tggttggttt tgccattttg ttgtgtgtat gctgcttttc
     2881 ttttctaacc aagaggctgg ttttggcatc tctgtcccat tccctgggat ctggtggtca
     2941 gccctaggat aaaaagccag ggctggagaa caagaaaggg ccaggagatg gaattccttc
     3001 aggccggcac ccacacccta ggacatgtaa gccctcatgt ccaagggagc ctcatgcaga
     3061 tagtaggaaa tcaggtctgg aaatttaaaa ataaaaggca tgagactaag gctatctgct
     3121 tcccttatgc cctgactgga gaggggaggg aggagaggca aggcccacag agggcatccc
     3181 agctaggcct tgggatggct gcagtgagga gaaatcccgg gaactgtatt gacacaaaga
     3241 ttcttattgc acttgtattt tttgtattaa agtttgcatg gtttctaata aaggattcaa
     3301 acataagttt gtagtgaaat ggcctgggag attccaaggg cttctctgga gggggattgg
     3361 ctgcagtgta gatttgcctc tgaggaggct gccccagact tggcctcctc atgccccctc
     3421 ctgacctctg cccttctctg gtcctggcat ccctggagaa ggtaggggtc ttgacctaag
     3481 tttagatttg atctccatgt gcagggaggc tgtcctgggc ctgacaggtc ctcccccttt
     3541 ctgaggtagc agtgccttgt ggaggtttga caccatgtcc ctagctcccc aagcacacac
     3601 caggaaactg caggggctca cggaggaagt gctgcctggg ccagggggac cagctttcct
     3661 ccgtagagac catgtgcaga acacttctgc tgtgccaaga acatgaggga gccagtgttt
     3721 tgtcagcagg aagaaagggc ctgctgggat gaaagtggga aggaaacagg gttgcgtagt
     3781 caggagacac ctcaggggca acagcacagg cccagagtac ctgctgcctc cactgcgtct
     3841 gtcctggggt catgaggatg ctgaggttga cgacaggttc caggtccttt cactcctttg
     3901 gccaaaggtt gggggtaggt ggcccaagtg gcgtgctctc taggtagaca acaggagtgg
     3961 tcagagttcc ctcaaaggat cctccactcc agagcacctg agaaggccgg gaccagaggc
     4021 cctgtgtgat gtgtactccg cagctgtttg gggtgggaca tttctgtact tctcgatttg
     4081 cttatggctc agccattacc tgtgtcagtc catgattctg ttgtaacagt tttaagagta
     4141 aataaataaa gctgcctgat gtcccatca
//
