LOCUS       NM_001384785            5322 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 46, mRNA.
ACCESSION   NM_001384785
VERSION     NM_001384785.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5322)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 5322)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5322)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5322)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5322)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 5322)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 5322)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 5322)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 5322)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 5322)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-387             AC124916.3         2661-2729           c
            388-510             AC139667.5         48903-49025
            511-624             AC139667.5         55375-55488
            625-747             AC139667.5         58412-58534
            748-1971            AC139667.5         60079-61302
            1972-2094           AC139667.5         62314-62436
            2095-2201           AC139667.5         99730-99836
            2202-2385           AC139667.5         105153-105336
            2386-2445           AC139667.5         105967-106026
            2446-2693           AC139667.5         106148-106395
            2694-2775           AC139667.5         119741-119822
            2776-2888           AC139667.5         121893-122005
            2889-3078           AC139667.5         123901-124090
            3079-5322           AC139667.5         124315-126558
FEATURES             Location/Qualifiers
     source          1..5322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5322
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3083
                     /gene="MAP4"
                     /note="isoform 116 is encoded by transcript variant 46;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 116"
                     /protein_id="NP_001371714.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTE
                     FLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATA
                     DTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAV
                     PLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAK
                     DMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNV
                     VLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAP
                     SKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDM
                     TLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSP
                     LSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTL
                     ANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMIS
                     PETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTG
                     NDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTT
                     AAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMK
                     KTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTS
                     APDLKNVRSKVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAK
                     VGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGH
                     PTLSGGGDQREAQTLDSQIQETN"
     exon            319..387
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..510
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..624
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            625..747
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1971
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2094
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2201
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2385
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2445
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2693
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2775
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2888
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3078
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..5322
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4440..4445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4459
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      5298..5303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5322
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaagat actccatctt ctaaaccaac actcctagcc aatggtggtc
      361 atggagtaga agggagcgat actacagggt ctccaactga attccttgaa gagaaaatgg
      421 cctaccagga atacccaaat agccagaact ggccagaaga taccaacttt tgtttccaac
      481 ctgagcaagt ggtcgatcct atccagactg atccctttaa gatgtaccat gatgatgacc
      541 tggcagattt ggtctttccc tccagtgcga cagctgatac ttcaatattt gcaggacaaa
      601 atgatccctt gaaagacagt tacggtatgt ctccctgcaa cacagctgtt gtacctcagg
      661 ggtggtctgt ggaagcctta aactctccac actcagagtc ctttgtttcc ccagaggctg
      721 ttgcagaacc tcctcagcca acggcagttc ccttagagct agccaaggag atagaaatgg
      781 catcagaaga gaggccacca gcacaagcat tggaaataat gatgggactg aagactactg
      841 acatggcacc atctaaagaa acagagatgg ccctcgccaa ggacatggca ctagctacaa
      901 aaaccgaggt ggcattggct aaagatatgg aatcacccac caaattagat gtgacactgg
      961 ccaaggacat gcagccatcc atggaatcag atatggccct agtcaaggac atggaactac
     1021 ccacagaaaa agaagtggcc ctggttaagg atgtcagatg gcccacagaa acagatgtat
     1081 cttcagccaa gaatgtggta ctgcccacag aaacagaggt agccccagcc aaggatgtga
     1141 cactgttgaa agaaacagag agggcatctc ctataaaaat ggacttagcc ccttccaagg
     1201 acatgggacc acccaaagaa aacaagaaag aaacagagag ggcatctcct ataaaaatgg
     1261 acttggctcc ttccaaggac atgggaccac ccaaagaaaa caagatagtc ccagccaagg
     1321 atttggtatt actctcagaa atagaggtgg cacaggctaa tgacattata tcatccacag
     1381 aaatatcctc tgctgagaag gtggctttgt cctcagaaac agaggtagcc ctggccaggg
     1441 acatgacact gcccccggaa accaacgtga tcttgaccaa ggataaagca ctacctttag
     1501 aagcagaggt ggccccagtc aaggacatgg ctcaactccc agaaacagaa atagccccgg
     1561 ccaaggatgt ggctccgtcc acagtaaaag aagtgggctt gttgaaggac atgtctccac
     1621 tatcagaaac agaaatggct ctgggcaagg atgtgactcc acctccagaa acagaagtag
     1681 ttctcatcaa gaacgtatgt ctgcctccag aaatggaggt ggccctgact gaggatcagg
     1741 tcccagccct caaaacagaa gcacccctgg ctaaggatgg ggttctgacc ctggccaaca
     1801 atgtgactcc agccaaagat gttccaccac tctcagaaac agaggcaaca ccagttccaa
     1861 ttaaagacat ggaaattgca caaacacaaa aaggaataag tgaggattcc catttagaat
     1921 ctctgcagga tgtggggcag tcagctgcac ctactttcat gatttcacca gaaaccgtca
     1981 caggaacggg gaaaaagtgc agcttgccgg ccgaggagga ttctgtgtta gaaaaactag
     2041 gggaaaggaa accatgcaac agtcaacctt ctgagctttc ttcagagacc tcaggaatag
     2101 ccaggccaga agaaggaagg cctgtggtga gtgggacagg aaatgacatc accaccccac
     2161 cgaacaagga gctcccacca agcccagaga agaaaacaaa gcccattgca gatgcaaagg
     2221 ctcctgagaa gcgggcctca ccatccaagc cagcttctgc cccagcctcc agatctgggt
     2281 ccaagagcac tcagactgtt gcaaaaacca caacagctgc tgctgttgcc tcaactggcc
     2341 caagcagtag gagcccctcc acgctcctgc ccaagaagcc cactgccatt aagactgagg
     2401 gaaaacctgc agaagtcaag aagatgactg caaagtctgt accagctgac ttgagtcgcc
     2461 caaagagcac ctccaccagt tccatgaaga aaaccaccac tctcagtggg acagcccccg
     2521 ctgcaggggt ggttcccagc cgagtcaagg ccacacccat gccctcccgg ccctccacaa
     2581 ctcctttcat agacaagaag cccacctcgg ccaaacccag ctccaccacc ccccggctca
     2641 gccgcctggc caccaatact tctgctcctg atctgaagaa tgtccgctcc aaggttcaga
     2701 ttcagaacaa gaaagtggac atctctaagg tctcctccaa gtgtgggtct aaggctaaca
     2761 tcaagcacaa gcctggtgga ggagatgtca agattgaaag tcagaagttg aacttcaagg
     2821 agaaggccca ggccaaggtg ggatccctcg ataatgtggg ccacctacct gcaggaggtg
     2881 ctgtgaagac tgagggcggt ggcagcgagg ctcctctgtg tccgggtccc cctgctgggg
     2941 aggagccggc catctctgag gcagcgcctg aagctggcgc ccccacttca gccagtggcc
     3001 tcaatggcca ccccaccctg tcagggggtg gtgaccaaag ggaggcccag accttggaca
     3061 gccagatcca ggagacaaat tgagacctac aggctgacgt tccgggcaaa tgccagggcc
     3121 cgcaccgacc acggggccga cattgtctcc cgccccccac acttccctgg cggccccaac
     3181 tcgggctccc gggtccttgg ccccctttcc cgggctgtcc actagaccag tgagcgcttg
     3241 ggcgccgtgc tgggcagccc gctaggctcg ccttccctcc tgctttgcgt gcccggggca
     3301 gcagcagccc tgccccacac ctcctctcac tccccagcct gggcccatct ccctgctttg
     3361 gtcttgcccc atcactgcgc cactgctccg tggaggaggt tgggaggggg ttggggtggt
     3421 tgaggctaag ttgggatcta ggagaggaga accagattct atcctcatct ttttttggtt
     3481 ctttggtcca aacccaaaag aaactgacat gccctccctt ctccctggat ctacctggag
     3541 ggaagagtgg aggtggattc cgagtggtga caggacgctg accgtggagc ttaagccact
     3601 gcctctccct ctggtcccac aaatgggcgc ccccccctcc ccatgcaggt ggtgtcgggc
     3661 ccttcttgct gccctgcccc aagttggggg tcagtgctgc ctgtccccat gcttaacata
     3721 cccgcctagc tgctgtcaca tttttcttgt tttgtccttt tatttttttc taataaccta
     3781 aaaactggca aaatagttct gcaggttgaa gccatgtcta catgaaagtc ctcagtaagt
     3841 gttagaggga acagggcgga gatatcctta tgccaccccc gctggaggat gtgggcagct
     3901 tagggccctg gaggcggtgc ggcagggaag aggggtgcag aggctgtggc tggtgagccg
     3961 gtcaggcaca caaggggccc ttggagcgtg gactggttgg ttttgccatt ttgttgtgtg
     4021 tatgctgctt ttcttttcta accaagaggc tggttttggc atctctgtcc cattccctgg
     4081 gatctggtgg tcagccctag gataaaaagc cagggctgga gaacaagaaa gggccaggag
     4141 atggaattcc ttcaggccgg cacccacacc ctaggacatg taagccctca tgtccaaggg
     4201 agcctcatgc agatagtagg aaatcaggtc tggaaattta aaaataaaag gcatgagact
     4261 aaggctatct gcttccctta tgccctgact ggagagggga gggaggagag gcaaggccca
     4321 cagagggcat cccagctagg ccttgggatg gctgcagtga ggagaaatcc cgggaactgt
     4381 attgacacaa agattcttat tgcacttgta ttttttgtat taaagtttgc atggtttcta
     4441 ataaaggatt caaacataag tttgtagtga aatggcctgg gagattccaa gggcttctct
     4501 ggagggggat tggctgcagt gtagatttgc ctctgaggag gctgccccag acttggcctc
     4561 ctcatgcccc ctcctgacct ctgcccttct ctggtcctgg catccctgga gaaggtaggg
     4621 gtcttgacct aagtttagat ttgatctcca tgtgcaggga ggctgtcctg ggcctgacag
     4681 gtcctccccc tttctgaggt agcagtgcct tgtggaggtt tgacaccatg tccctagctc
     4741 cccaagcaca caccaggaaa ctgcaggggc tcacggagga agtgctgcct gggccagggg
     4801 gaccagcttt cctccgtaga gaccatgtgc agaacacttc tgctgtgcca agaacatgag
     4861 ggagccagtg ttttgtcagc aggaagaaag ggcctgctgg gatgaaagtg ggaaggaaac
     4921 agggttgcgt agtcaggaga cacctcaggg gcaacagcac aggcccagag tacctgctgc
     4981 ctccactgcg tctgtcctgg ggtcatgagg atgctgaggt tgacgacagg ttccaggtcc
     5041 tttcactcct ttggccaaag gttgggggta ggtggcccaa gtggcgtgct ctctaggtag
     5101 acaacaggag tggtcagagt tccctcaaag gatcctccac tccagagcac ctgagaaggc
     5161 cgggaccaga ggccctgtgt gatgtgtact ccgcagctgt ttggggtggg acatttctgt
     5221 acttctcgat ttgcttatgg ctcagccatt acctgtgtca gtccatgatt ctgttgtaac
     5281 agttttaaga gtaaataaat aaagctgcct gatgtcccat ca
//
