LOCUS       NM_001384777            5729 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 38, mRNA.
ACCESSION   NM_001384777
VERSION     NM_001384777.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5729)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 5729)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5729)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5729)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5729)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 5729)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 5729)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 5729)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 5729)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 5729)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.106747.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-441             AC139667.5         48903-49025
            442-555             AC139667.5         55375-55488
            556-678             AC139667.5         58412-58534
            679-1902            AC139667.5         60079-61302
            1903-2025           AC139667.5         62314-62436
            2026-2132           AC139667.5         99730-99836
            2133-2348           AC139667.5         101353-101568
            2349-2532           AC139667.5         105153-105336
            2533-2592           AC139667.5         105967-106026
            2593-2885           AC139667.5         106148-106440
            2886-2999           AC139667.5         107926-108039
            3000-3081           AC139667.5         119741-119822
            3082-3194           AC139667.5         121893-122005
            3195-3384           AC139667.5         123901-124090
            3385-5729           AC139667.5         124214-126558
FEATURES             Location/Qualifiers
     source          1..5729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5729
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3392
                     /gene="MAP4"
                     /note="isoform 52 is encoded by transcript variant 38;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 52"
                     /protein_id="NP_001371706.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEGSPTEFLEEKMAYQEYPNSQNWPEDTNF
                     CFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNT
                     AVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEI
                     MMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESD
                     MALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERA
                     SPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSE
                     IEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVA
                     PVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLI
                     KNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPI
                     KDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEK
                     LGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLA
                     TTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARP
                     SILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGP
                     SSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTA
                     PAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRS
                     KVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIQ
                     NKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGG
                     AVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQT
                     LDSQIQETSI"
     exon            319..441
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            442..555
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..678
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1902
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2025
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2132
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2348
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2532
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2592
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2885
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..2999
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3081
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3194
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3384
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..5729
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4847..4852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4866
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      5705..5710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5729
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaaggg tctccaactg aattccttga agagaaaatg gcctaccagg
      361 aatacccaaa tagccagaac tggccagaag ataccaactt ttgtttccaa cctgagcaag
      421 tggtcgatcc tatccagact gatcccttta agatgtacca tgatgatgac ctggcagatt
      481 tggtctttcc ctccagtgcg acagctgata cttcaatatt tgcaggacaa aatgatccct
      541 tgaaagacag ttacggtatg tctccctgca acacagctgt tgtacctcag gggtggtctg
      601 tggaagcctt aaactctcca cactcagagt cctttgtttc cccagaggct gttgcagaac
      661 ctcctcagcc aacggcagtt cccttagagc tagccaagga gatagaaatg gcatcagaag
      721 agaggccacc agcacaagca ttggaaataa tgatgggact gaagactact gacatggcac
      781 catctaaaga aacagagatg gccctcgcca aggacatggc actagctaca aaaaccgagg
      841 tggcattggc taaagatatg gaatcaccca ccaaattaga tgtgacactg gccaaggaca
      901 tgcagccatc catggaatca gatatggccc tagtcaagga catggaacta cccacagaaa
      961 aagaagtggc cctggttaag gatgtcagat ggcccacaga aacagatgta tcttcagcca
     1021 agaatgtggt actgcccaca gaaacagagg tagccccagc caaggatgtg acactgttga
     1081 aagaaacaga gagggcatct cctataaaaa tggacttagc cccttccaag gacatgggac
     1141 cacccaaaga aaacaagaaa gaaacagaga gggcatctcc tataaaaatg gacttggctc
     1201 cttccaagga catgggacca cccaaagaaa acaagatagt cccagccaag gatttggtat
     1261 tactctcaga aatagaggtg gcacaggcta atgacattat atcatccaca gaaatatcct
     1321 ctgctgagaa ggtggctttg tcctcagaaa cagaggtagc cctggccagg gacatgacac
     1381 tgcccccgga aaccaacgtg atcttgacca aggataaagc actaccttta gaagcagagg
     1441 tggccccagt caaggacatg gctcaactcc cagaaacaga aatagccccg gccaaggatg
     1501 tggctccgtc cacagtaaaa gaagtgggct tgttgaagga catgtctcca ctatcagaaa
     1561 cagaaatggc tctgggcaag gatgtgactc cacctccaga aacagaagta gttctcatca
     1621 agaacgtatg tctgcctcca gaaatggagg tggccctgac tgaggatcag gtcccagccc
     1681 tcaaaacaga agcacccctg gctaaggatg gggttctgac cctggccaac aatgtgactc
     1741 cagccaaaga tgttccacca ctctcagaaa cagaggcaac accagttcca attaaagaca
     1801 tggaaattgc acaaacacaa aaaggaataa gtgaggattc ccatttagaa tctctgcagg
     1861 atgtggggca gtcagctgca cctactttca tgatttcacc agaaaccgtc acaggaacgg
     1921 ggaaaaagtg cagcttgccg gccgaggagg attctgtgtt agaaaaacta ggggaaagga
     1981 aaccatgcaa cagtcaacct tctgagcttt cttcagagac ctcaggaata gccaggccag
     2041 aagaaggaag gcctgtggtg agtgggacag gaaatgacat caccacccca ccgaacaagg
     2101 agctcccacc aagcccagag aagaaaacaa agcctttggc caccactcaa cctgcaaaga
     2161 cttcaacatc gaaagccaaa acacagccca cttctctccc taagcagcca gctcccacca
     2221 ccattggtgg gttgaataaa aaacccatga gccttgcttc aggcttagtg ccagctgccc
     2281 cacccaaacg ccctgccgtc gcctctgcca ggccttccat cttaccttca aaagacgtga
     2341 agccaaagcc cattgcagat gcaaaggctc ctgagaagcg ggcctcacca tccaagccag
     2401 cttctgcccc agcctccaga tctgggtcca agagcactca gactgttgca aaaaccacaa
     2461 cagctgctgc tgttgcctca actggcccaa gcagtaggag cccctccacg ctcctgccca
     2521 agaagcccac tgccattaag actgagggaa aacctgcaga agtcaagaag atgactgcaa
     2581 agtctgtacc agctgacttg agtcgcccaa agagcacctc caccagttcc atgaagaaaa
     2641 ccaccactct cagtgggaca gcccccgctg caggggtggt tcccagccga gtcaaggcca
     2701 cacccatgcc ctcccggccc tccacaactc ctttcataga caagaagccc acctcggcca
     2761 aacccagctc caccaccccc cggctcagcc gcctggccac caatacttct gctcctgatc
     2821 tgaagaatgt ccgctccaag gttggctcca cggaaaacat caagcatcag cctggaggag
     2881 gccgggccaa agtagagaaa aaaacagagg cagctgctac aacccgaaag cctgaatcta
     2941 atgcagtcac taaaacagcc ggcccaattg caagtgcaca gaaacaacct gcggggaaag
     3001 ttcagattca gaacaagaaa gtggacatct ctaaggtctc ctccaagtgt gggtctaagg
     3061 ctaacatcaa gcacaagcct ggtggaggag atgtcaagat tgaaagtcag aagttgaact
     3121 tcaaggagaa ggcccaggcc aaggtgggat ccctcgataa tgtgggccac ctacctgcag
     3181 gaggtgctgt gaagactgag ggcggtggca gcgaggctcc tctgtgtccg ggtccccctg
     3241 ctggggagga gccggccatc tctgaggcag cgcctgaagc tggcgccccc acttcagcca
     3301 gtggcctcaa tggccacccc accctgtcag ggggtggtga ccaaagggag gcccagacct
     3361 tggacagcca gatccaggag acaagcatct aatgatgaca ttctggtctc gtcttccgtc
     3421 tcccccgtgt tcccctcttg tctcccctgt tcccctctcc cttccctcct cccatgtcac
     3481 tgcagattga gacctacagg ctgacgttcc gggcaaatgc cagggcccgc accgaccacg
     3541 gggccgacat tgtctcccgc cccccacact tccctggcgg ccccaactcg ggctcccggg
     3601 tccttggccc cctttcccgg gctgtccact agaccagtga gcgcttgggc gccgtgctgg
     3661 gcagcccgct aggctcgcct tccctcctgc tttgcgtgcc cggggcagca gcagccctgc
     3721 cccacacctc ctctcactcc ccagcctggg cccatctccc tgctttggtc ttgccccatc
     3781 actgcgccac tgctccgtgg aggaggttgg gagggggttg gggtggttga ggctaagttg
     3841 ggatctagga gaggagaacc agattctatc ctcatctttt tttggttctt tggtccaaac
     3901 ccaaaagaaa ctgacatgcc ctcccttctc cctggatcta cctggaggga agagtggagg
     3961 tggattccga gtggtgacag gacgctgacc gtggagctta agccactgcc tctccctctg
     4021 gtcccacaaa tgggcgcccc cccctcccca tgcaggtggt gtcgggccct tcttgctgcc
     4081 ctgccccaag ttgggggtca gtgctgcctg tccccatgct taacataccc gcctagctgc
     4141 tgtcacattt ttcttgtttt gtccttttat ttttttctaa taacctaaaa actggcaaaa
     4201 tagttctgca ggttgaagcc atgtctacat gaaagtcctc agtaagtgtt agagggaaca
     4261 gggcggagat atccttatgc cacccccgct ggaggatgtg ggcagcttag ggccctggag
     4321 gcggtgcggc agggaagagg ggtgcagagg ctgtggctgg tgagccggtc aggcacacaa
     4381 ggggcccttg gagcgtggac tggttggttt tgccattttg ttgtgtgtat gctgcttttc
     4441 ttttctaacc aagaggctgg ttttggcatc tctgtcccat tccctgggat ctggtggtca
     4501 gccctaggat aaaaagccag ggctggagaa caagaaaggg ccaggagatg gaattccttc
     4561 aggccggcac ccacacccta ggacatgtaa gccctcatgt ccaagggagc ctcatgcaga
     4621 tagtaggaaa tcaggtctgg aaatttaaaa ataaaaggca tgagactaag gctatctgct
     4681 tcccttatgc cctgactgga gaggggaggg aggagaggca aggcccacag agggcatccc
     4741 agctaggcct tgggatggct gcagtgagga gaaatcccgg gaactgtatt gacacaaaga
     4801 ttcttattgc acttgtattt tttgtattaa agtttgcatg gtttctaata aaggattcaa
     4861 acataagttt gtagtgaaat ggcctgggag attccaaggg cttctctgga gggggattgg
     4921 ctgcagtgta gatttgcctc tgaggaggct gccccagact tggcctcctc atgccccctc
     4981 ctgacctctg cccttctctg gtcctggcat ccctggagaa ggtaggggtc ttgacctaag
     5041 tttagatttg atctccatgt gcagggaggc tgtcctgggc ctgacaggtc ctcccccttt
     5101 ctgaggtagc agtgccttgt ggaggtttga caccatgtcc ctagctcccc aagcacacac
     5161 caggaaactg caggggctca cggaggaagt gctgcctggg ccagggggac cagctttcct
     5221 ccgtagagac catgtgcaga acacttctgc tgtgccaaga acatgaggga gccagtgttt
     5281 tgtcagcagg aagaaagggc ctgctgggat gaaagtggga aggaaacagg gttgcgtagt
     5341 caggagacac ctcaggggca acagcacagg cccagagtac ctgctgcctc cactgcgtct
     5401 gtcctggggt catgaggatg ctgaggttga cgacaggttc caggtccttt cactcctttg
     5461 gccaaaggtt gggggtaggt ggcccaagtg gcgtgctctc taggtagaca acaggagtgg
     5521 tcagagttcc ctcaaaggat cctccactcc agagcacctg agaaggccgg gaccagaggc
     5581 cctgtgtgat gtgtactccg cagctgtttg gggtgggaca tttctgtact tctcgatttg
     5641 cttatggctc agccattacc tgtgtcagtc catgattctg ttgtaacagt tttaagagta
     5701 aataaataaa gctgcctgat gtcccatca
//
