LOCUS       NM_001384758            5525 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated protein 4 (MAP4), transcript
            variant 31, mRNA.
ACCESSION   NM_001384758
VERSION     NM_001384758.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5525)
  AUTHORS   Thapa,N., Chen,M., Cryns,V.L. and Anderson,R.
  TITLE     A p85 isoform switch enhances PI3K activation on endosomes by a
            MAP4- and PI3P-dependent mechanism
  JOURNAL   Cell Rep 43 (5), 114119 (2024)
   PUBMED   38630589
  REMARK    GeneRIF: A p85 isoform switch enhances PI3K activation on endosomes
            by a MAP4- and PI3P-dependent mechanism.
REFERENCE   2  (bases 1 to 5525)
  AUTHORS   Xia,X., Ge,Y., Ge,F., Gu,P., Liu,Y., Li,P. and Xu,P.
  TITLE     MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 150 (2), 88 (2024)
   PUBMED   38341398
  REMARK    GeneRIF: MAP4 acts as an oncogene and prognostic marker and affects
            radioresistance by mediating epithelial-mesenchymal transition in
            lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5525)
  AUTHORS   Nishida,K., Matsumura,K., Tamura,M., Nakamichi,T., Shimamori,K.,
            Kuragano,M., Kabir,A.M.R., Kakugo,A., Kotani,S., Nishishita,N. and
            Tokuraku,K.
  TITLE     Effects of three microtubule-associated proteins (MAP2, MAP4, and
            Tau) on microtubules' physical properties and neurite morphology
  JOURNAL   Sci Rep 13 (1), 8870 (2023)
   PUBMED   37258650
  REMARK    GeneRIF: Effects of three microtubule-associated proteins (MAP2,
            MAP4, and Tau) on microtubules' physical properties and neurite
            morphology.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5525)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5525)
  AUTHORS   Wang,L., Paudyal,S.C., Kang,Y., Owa,M., Liang,F.X., Spektor,A.,
            Knaut,H., Sanchez,I. and Dynlacht,B.D.
  TITLE     Regulators of tubulin polyglutamylation control nuclear shape and
            cilium disassembly by balancing microtubule and actin assembly
  JOURNAL   Cell Res 32 (2), 190-209 (2022)
   PUBMED   34782749
REFERENCE   6  (bases 1 to 5525)
  AUTHORS   Ookata,K., Hisanaga,S., Bulinski,J.C., Murofushi,H., Aizawa,H.,
            Itoh,T.J., Hotani,H., Okumura,E., Tachibana,K. and Kishimoto,T.
  TITLE     Cyclin B interaction with microtubule-associated protein 4 (MAP4)
            targets p34cdc2 kinase to microtubules and is a potential regulator
            of M-phase microtubule dynamics
  JOURNAL   J Cell Biol 128 (5), 849-862 (1995)
   PUBMED   7876309
REFERENCE   7  (bases 1 to 5525)
  AUTHORS   Chapin,S.J., Lue,C.M., Yu,M.T. and Bulinski,J.C.
  TITLE     Differential expression of alternatively spliced forms of MAP4: a
            repertoire of structurally different microtubule-binding domains
  JOURNAL   Biochemistry 34 (7), 2289-2301 (1995)
   PUBMED   7857940
REFERENCE   8  (bases 1 to 5525)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Microtubule stabilization by assembly-promoting
            microtubule-associated proteins: a repeat performance
  JOURNAL   Cell Motil Cytoskeleton 23 (4), 236-243 (1992)
   PUBMED   1477887
  REMARK    Review article
REFERENCE   9  (bases 1 to 5525)
  AUTHORS   West,R.R., Tenbarge,K.M. and Olmsted,J.B.
  TITLE     A model for microtubule-associated protein 4 structure. Domains
            defined by comparisons of human, mouse, and bovine sequences
  JOURNAL   J Biol Chem 266 (32), 21886-21896 (1991)
   PUBMED   1718985
REFERENCE   10 (bases 1 to 5525)
  AUTHORS   Chapin,S.J. and Bulinski,J.C.
  TITLE     Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4)
            contains a domain homologous to the microtubule-binding domains of
            neuronal MAP2 and tau
  JOURNAL   J Cell Sci 98 (Pt 1), 27-36 (1991)
   PUBMED   1905296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124916.3 and AC139667.5.
            
            Summary: The protein encoded by this gene is a major non-neuronal
            microtubule-associated protein. This protein contains a domain
            similar to the microtubule-binding domains of neuronal
            microtubule-associated protein (MAP2) and microtubule-associated
            protein tau (MAPT/TAU). This protein promotes microtubule assembly,
            and has been shown to counteract destabilization of interphase
            microtubule catastrophe promotion. Cyclin B was found to interact
            with this protein, which targets cell division cycle 2 (CDC2)
            kinase to microtubules. The phosphorylation of this protein affects
            microtubule properties and cell cycle progression. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC124916.3         113569-113644       c
            77-318              AC124916.3         23434-23675         c
            319-387             AC124916.3         2661-2729           c
            388-510             AC139667.5         48903-49025
            511-633             AC139667.5         58412-58534
            634-1857            AC139667.5         60079-61302
            1858-1980           AC139667.5         62314-62436
            1981-2087           AC139667.5         99730-99836
            2088-2303           AC139667.5         101353-101568
            2304-2487           AC139667.5         105153-105336
            2488-2547           AC139667.5         105967-106026
            2548-2795           AC139667.5         106148-106395
            2796-2877           AC139667.5         119741-119822
            2878-2990           AC139667.5         121893-122005
            2991-3180           AC139667.5         123901-124090
            3181-5525           AC139667.5         124214-126558
FEATURES             Location/Qualifiers
     source          1..5525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..5525
                     /gene="MAP4"
                     /note="microtubule associated protein 4"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
     exon            1..76
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            77..318
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3188
                     /gene="MAP4"
                     /note="isoform 100 is encoded by transcript variant 31;
                     MAP-4"
                     /codon_start=1
                     /product="microtubule-associated protein 4 isoform 100"
                     /protein_id="NP_001371687.1"
                     /db_xref="GeneID:4134"
                     /db_xref="HGNC:HGNC:6862"
                     /db_xref="MIM:157132"
                     /translation="MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGK
                     TDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTE
                     FLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTGMSPCNTAVVPQGWSVEALNSP
                     HSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKET
                     EMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEV
                     ALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGP
                     PKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEI
                     SSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAP
                     AKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTE
                     DQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISED
                     SHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELS
                     SETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQ
                     PTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIAD
                     AKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTA
                     IKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPM
                     PSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVQIQNKKVDISKVS
                     SKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSE
                     APLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI
                     "
     exon            319..387
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            388..510
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..633
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..1857
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1980
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2087
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2303
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2487
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2547
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2795
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2877
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..2990
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3180
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..5525
                     /gene="MAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4643..4648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      4662
                     /gene="MAP4"
                     /note="major polyA site"
     regulatory      5501..5506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5525
                     /gene="MAP4"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctacc tcctcacggc tcttcccggc gctctcctgg ctcccttctg ccccagctcc
       61 gtctcggcgg cggcgggcag ttgcagtggt gcagaatggc tgacctcagt cttgcagatg
      121 cattaacaga accatctcca gacattgagg gagagataaa gcgggacttc attgccacac
      181 tagaggcaga ggcctttgat gatgttgtgg gagaaactgt tggaaaaaca gactatattc
      241 ctctcctgga tgttgatgag aaaaccggga actcagagtc aaagaagaaa ccgtgctcag
      301 aaactagcca gattgaagat actccatctt ctaaaccaac actcctagcc aatggtggtc
      361 atggagtaga agggagcgat actacagggt ctccaactga attccttgaa gagaaaatgg
      421 cctaccagga atacccaaat agccagaact ggccagaaga taccaacttt tgtttccaac
      481 ctgagcaagt ggtcgatcct atccagactg gtatgtctcc ctgcaacaca gctgttgtac
      541 ctcaggggtg gtctgtggaa gccttaaact ctccacactc agagtccttt gtttccccag
      601 aggctgttgc agaacctcct cagccaacgg cagttccctt agagctagcc aaggagatag
      661 aaatggcatc agaagagagg ccaccagcac aagcattgga aataatgatg ggactgaaga
      721 ctactgacat ggcaccatct aaagaaacag agatggccct cgccaaggac atggcactag
      781 ctacaaaaac cgaggtggca ttggctaaag atatggaatc acccaccaaa ttagatgtga
      841 cactggccaa ggacatgcag ccatccatgg aatcagatat ggccctagtc aaggacatgg
      901 aactacccac agaaaaagaa gtggccctgg ttaaggatgt cagatggccc acagaaacag
      961 atgtatcttc agccaagaat gtggtactgc ccacagaaac agaggtagcc ccagccaagg
     1021 atgtgacact gttgaaagaa acagagaggg catctcctat aaaaatggac ttagcccctt
     1081 ccaaggacat gggaccaccc aaagaaaaca agaaagaaac agagagggca tctcctataa
     1141 aaatggactt ggctccttcc aaggacatgg gaccacccaa agaaaacaag atagtcccag
     1201 ccaaggattt ggtattactc tcagaaatag aggtggcaca ggctaatgac attatatcat
     1261 ccacagaaat atcctctgct gagaaggtgg ctttgtcctc agaaacagag gtagccctgg
     1321 ccagggacat gacactgccc ccggaaacca acgtgatctt gaccaaggat aaagcactac
     1381 ctttagaagc agaggtggcc ccagtcaagg acatggctca actcccagaa acagaaatag
     1441 ccccggccaa ggatgtggct ccgtccacag taaaagaagt gggcttgttg aaggacatgt
     1501 ctccactatc agaaacagaa atggctctgg gcaaggatgt gactccacct ccagaaacag
     1561 aagtagttct catcaagaac gtatgtctgc ctccagaaat ggaggtggcc ctgactgagg
     1621 atcaggtccc agccctcaaa acagaagcac ccctggctaa ggatggggtt ctgaccctgg
     1681 ccaacaatgt gactccagcc aaagatgttc caccactctc agaaacagag gcaacaccag
     1741 ttccaattaa agacatggaa attgcacaaa cacaaaaagg aataagtgag gattcccatt
     1801 tagaatctct gcaggatgtg gggcagtcag ctgcacctac tttcatgatt tcaccagaaa
     1861 ccgtcacagg aacggggaaa aagtgcagct tgccggccga ggaggattct gtgttagaaa
     1921 aactagggga aaggaaacca tgcaacagtc aaccttctga gctttcttca gagacctcag
     1981 gaatagccag gccagaagaa ggaaggcctg tggtgagtgg gacaggaaat gacatcacca
     2041 ccccaccgaa caaggagctc ccaccaagcc cagagaagaa aacaaagcct ttggccacca
     2101 ctcaacctgc aaagacttca acatcgaaag ccaaaacaca gcccacttct ctccctaagc
     2161 agccagctcc caccaccatt ggtgggttga ataaaaaacc catgagcctt gcttcaggct
     2221 tagtgccagc tgccccaccc aaacgccctg ccgtcgcctc tgccaggcct tccatcttac
     2281 cttcaaaaga cgtgaagcca aagcccattg cagatgcaaa ggctcctgag aagcgggcct
     2341 caccatccaa gccagcttct gccccagcct ccagatctgg gtccaagagc actcagactg
     2401 ttgcaaaaac cacaacagct gctgctgttg cctcaactgg cccaagcagt aggagcccct
     2461 ccacgctcct gcccaagaag cccactgcca ttaagactga gggaaaacct gcagaagtca
     2521 agaagatgac tgcaaagtct gtaccagctg acttgagtcg cccaaagagc acctccacca
     2581 gttccatgaa gaaaaccacc actctcagtg ggacagcccc cgctgcaggg gtggttccca
     2641 gccgagtcaa ggccacaccc atgccctccc ggccctccac aactcctttc atagacaaga
     2701 agcccacctc ggccaaaccc agctccacca ccccccggct cagccgcctg gccaccaata
     2761 cttctgctcc tgatctgaag aatgtccgct ccaaggttca gattcagaac aagaaagtgg
     2821 acatctctaa ggtctcctcc aagtgtgggt ctaaggctaa catcaagcac aagcctggtg
     2881 gaggagatgt caagattgaa agtcagaagt tgaacttcaa ggagaaggcc caggccaagg
     2941 tgggatccct cgataatgtg ggccacctac ctgcaggagg tgctgtgaag actgagggcg
     3001 gtggcagcga ggctcctctg tgtccgggtc cccctgctgg ggaggagccg gccatctctg
     3061 aggcagcgcc tgaagctggc gcccccactt cagccagtgg cctcaatggc caccccaccc
     3121 tgtcaggggg tggtgaccaa agggaggccc agaccttgga cagccagatc caggagacaa
     3181 gcatctaatg atgacattct ggtctcgtct tccgtctccc ccgtgttccc ctcttgtctc
     3241 ccctgttccc ctctcccttc cctcctccca tgtcactgca gattgagacc tacaggctga
     3301 cgttccgggc aaatgccagg gcccgcaccg accacggggc cgacattgtc tcccgccccc
     3361 cacacttccc tggcggcccc aactcgggct cccgggtcct tggccccctt tcccgggctg
     3421 tccactagac cagtgagcgc ttgggcgccg tgctgggcag cccgctaggc tcgccttccc
     3481 tcctgctttg cgtgcccggg gcagcagcag ccctgcccca cacctcctct cactccccag
     3541 cctgggccca tctccctgct ttggtcttgc cccatcactg cgccactgct ccgtggagga
     3601 ggttgggagg gggttggggt ggttgaggct aagttgggat ctaggagagg agaaccagat
     3661 tctatcctca tctttttttg gttctttggt ccaaacccaa aagaaactga catgccctcc
     3721 cttctccctg gatctacctg gagggaagag tggaggtgga ttccgagtgg tgacaggacg
     3781 ctgaccgtgg agcttaagcc actgcctctc cctctggtcc cacaaatggg cgcccccccc
     3841 tccccatgca ggtggtgtcg ggcccttctt gctgccctgc cccaagttgg gggtcagtgc
     3901 tgcctgtccc catgcttaac atacccgcct agctgctgtc acatttttct tgttttgtcc
     3961 ttttattttt ttctaataac ctaaaaactg gcaaaatagt tctgcaggtt gaagccatgt
     4021 ctacatgaaa gtcctcagta agtgttagag ggaacagggc ggagatatcc ttatgccacc
     4081 cccgctggag gatgtgggca gcttagggcc ctggaggcgg tgcggcaggg aagaggggtg
     4141 cagaggctgt ggctggtgag ccggtcaggc acacaagggg cccttggagc gtggactggt
     4201 tggttttgcc attttgttgt gtgtatgctg cttttctttt ctaaccaaga ggctggtttt
     4261 ggcatctctg tcccattccc tgggatctgg tggtcagccc taggataaaa agccagggct
     4321 ggagaacaag aaagggccag gagatggaat tccttcaggc cggcacccac accctaggac
     4381 atgtaagccc tcatgtccaa gggagcctca tgcagatagt aggaaatcag gtctggaaat
     4441 ttaaaaataa aaggcatgag actaaggcta tctgcttccc ttatgccctg actggagagg
     4501 ggagggagga gaggcaaggc ccacagaggg catcccagct aggccttggg atggctgcag
     4561 tgaggagaaa tcccgggaac tgtattgaca caaagattct tattgcactt gtattttttg
     4621 tattaaagtt tgcatggttt ctaataaagg attcaaacat aagtttgtag tgaaatggcc
     4681 tgggagattc caagggcttc tctggagggg gattggctgc agtgtagatt tgcctctgag
     4741 gaggctgccc cagacttggc ctcctcatgc cccctcctga cctctgccct tctctggtcc
     4801 tggcatccct ggagaaggta ggggtcttga cctaagttta gatttgatct ccatgtgcag
     4861 ggaggctgtc ctgggcctga caggtcctcc ccctttctga ggtagcagtg ccttgtggag
     4921 gtttgacacc atgtccctag ctccccaagc acacaccagg aaactgcagg ggctcacgga
     4981 ggaagtgctg cctgggccag ggggaccagc tttcctccgt agagaccatg tgcagaacac
     5041 ttctgctgtg ccaagaacat gagggagcca gtgttttgtc agcaggaaga aagggcctgc
     5101 tgggatgaaa gtgggaagga aacagggttg cgtagtcagg agacacctca ggggcaacag
     5161 cacaggccca gagtacctgc tgcctccact gcgtctgtcc tggggtcatg aggatgctga
     5221 ggttgacgac aggttccagg tcctttcact cctttggcca aaggttgggg gtaggtggcc
     5281 caagtggcgt gctctctagg tagacaacag gagtggtcag agttccctca aaggatcctc
     5341 cactccagag cacctgagaa ggccgggacc agaggccctg tgtgatgtgt actccgcagc
     5401 tgtttggggt gggacatttc tgtacttctc gatttgctta tggctcagcc attacctgtg
     5461 tcagtccatg attctgttgt aacagtttta agagtaaata aataaagctg cctgatgtcc
     5521 catca
//
