LOCUS       NM_001286620            1743 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens MAP3K7 C-terminal like (MAP3K7CL), transcript variant
            6, mRNA.
ACCESSION   NM_001286620 XM_005261010
VERSION     NM_001286620.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Bao,S., Guo,Y., Diao,Z., Guo,W. and Liu,W.
  TITLE     Genome-wide identification of lncRNAs and mRNAs differentially
            expressed in human vascular smooth muscle cells stimulated by high
            phosphorus
  JOURNAL   Ren Fail 42 (1), 437-446 (2020)
   PUBMED   32401115
  REMARK    GeneRIF: Genome-wide identification of lncRNAs and mRNAs
            differentially expressed in human vascular smooth muscle cells
            stimulated by high phosphorus.
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
            Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
            Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
            Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
            McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
  TITLE     Genome-wide association scan of dental caries in the permanent
            dentition
  JOURNAL   BMC Oral Health 12, 57 (2012)
   PUBMED   23259602
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Li,J., Ji,C., Yang,Q., Chen,J., Gu,S., Ying,K., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a novel human TGF-beta activated
            kinase-like gene
  JOURNAL   Biochem Genet 42 (3-4), 129-137 (2004)
   PUBMED   15168726
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC008567.1 and AF269161.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001286620.1.
            
            Transcript Variant: This variant (6) contains alternate 5' end
            exons that result in translation initiation from an alternate start
            codon compared to variant 1. The resulting shorter isoform (2) has
            a distinct N-terminus compared to isoform 1. Variants 3-6 encode
            the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056341.1, AF269164.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399928.6/ ENSP00000382812.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1136              BC008567.1         160-1295
            1137-1743           AF269161.1         1247-1853
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q21.3"
     gene            1..1743
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /note="MAP3K7 C-terminal like"
                     /db_xref="GeneID:56911"
                     /db_xref="HGNC:HGNC:16457"
                     /db_xref="MIM:611110"
     exon            1..280
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            281..389
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..748
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /note="isoform 2 is encoded by transcript variant 6;
                     TGF-beta activated kinase; TAK1-like protein 1; TAK1-like
                     protein 2; TAK1-like protein 4; MAP3K7 C-terminal-like
                     protein"
                     /codon_start=1
                     /product="MAP3K7 C-terminal-like protein isoform 2"
                     /protein_id="NP_001273549.1"
                     /db_xref="CCDS:CCDS68182.1"
                     /db_xref="GeneID:56911"
                     /db_xref="HGNC:HGNC:16457"
                     /db_xref="MIM:611110"
                     /translation="MISTARVPADKPVRIAFSLNDASDDTPPEDSIPLVFPELDQQLQ
                     PLPPCHDSEESMEVFKQHCQIAEEYHEVKKEITLLEQRKKELIAKLDQAEKEKVDAAE
                     LVREFEALTEENRTLRLAQSQCVEQLEKLRIQYQKRQGSS"
     exon            390..451
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            452..567
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1743
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /note="hexamer: ATTAAA"
     polyA_site      1743
                     /gene="MAP3K7CL"
                     /gene_synonym="C21orf7; HC21ORF7; TAK1L; TAKL; TAKL-1;
                     TAKL-2; TAKL-4"
                     /note="major polyA site"
ORIGIN      
        1 gacaacatcc tggctgttag agaggcaagg aaaggagaga ggggttgtga agggaagcgg
       61 aagggaaggg aagggaggtc ccgtgggacg ctggggtctg gggcagagca ggtagcagcg
      121 tgctgccctg acagctgtct ccgctcctca gattgtcagt ggctgctatg cagcaggtgc
      181 agcctggtct ctcactgagt ctctactcca caaaggcaac gactggccaa ggcagtggct
      241 ggctctgggt tacacaagtg cagacactca actaagtgag ctggaagacc caggagaagg
      301 cggaggctca ggtgcccaca tgatcagcac agccagggta cctgctgaca agcctgtacg
      361 catcgccttt agcctcaatg acgcctcaga tgatacaccc cctgaagact ccattccttt
      421 ggtctttcca gaattagacc agcagctaca gcccctgccg ccttgtcatg actccgagga
      481 atccatggag gtgttcaaac agcactgcca aatagcagaa gaataccatg aggtcaaaaa
      541 ggaaatcacc ctgcttgagc aaaggaagaa ggagctcatt gccaagttag atcaggcaga
      601 aaaggagaag gtggatgctg ctgagctggt tcgggaattc gaggctctga cggaggagaa
      661 tcggacgttg aggttggccc agtctcaatg tgtggaacaa ctggagaaac ttcgaataca
      721 gtatcagaag aggcagggct cgtcctaact ttaaattttt cagtgtgagc atacgaggct
      781 gatgactgcc ctgtgctggc caaaagattt ttattttaaa tgaatagtga gtcagatcta
      841 ttgcttctct gtattaccca catgacaact gtctataatg agtttactgc ttgccagctt
      901 ctagcttgag agaagggata ttttaaatga gatcattaac gtgaaactat tactagtata
      961 tgtttttgga gatcagaatt cttttccaaa gatatatgtt tttttctttt ttaggaagat
     1021 atgatcatgc tgtacaacag ggtagaaaat gataaaaata gactattgac tgacccagct
     1081 aagaatcgtg ggctgagcag agttaaacca tgggacaaac ccataacatg ttcaccatag
     1141 tttcacgtat gtgtattttt aaatttcatg cctttaatat ttcaaatatg ctcaaattta
     1201 aactgtcaga aacttctgtg catgtattta tatttgccag agtataaact tttatactct
     1261 gatttttatc cttcaatgat tgattatact aagaataaat ggtcacatat cctaaaagct
     1321 tcttcatgaa attattagca gaaaccatgt ttgtaaccaa agcacatttg ccaatgctaa
     1381 ctggctgttg taataataaa cagataaggc tgcatttgct tcatgccatg tgacctcaca
     1441 gtaaacatct ctgcctttgc ctgtgtgtgt tctgggggag gggggacatg gaaaaatatt
     1501 gtttggacat tacttgggtg agtgcccatg aaaacatcag tgaacttgta actattgttt
     1561 tgttttggat ttaaggagat gttttagatc agtaacagct aataggaata tgcgagtaaa
     1621 ttcagaattg aaacaatttc tccttgttct acctatcacc acattttctc aaattgaact
     1681 ctttgttata tgtccatttc tattcatgta acttcttttt cattaaacat ggatcaaaac
     1741 tga
//
