LOCUS       NM_145331               4932 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 7
            (MAP3K7), transcript variant B, mRNA.
ACCESSION   NM_145331
VERSION     NM_145331.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4932)
  AUTHORS   Ming,T., Liu,H., Yuan,M., Tian,J., Fang,Q., Liu,Y., Kong,Q.,
            Wang,Q., Song,X., Xia,Z. and Wu,X.
  TITLE     The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a
            protective role in sepsis-induced lung injury by targeting
            TAK1-mediated MAPK and NF-kappaB signaling
  JOURNAL   Biochem Pharmacol 227, 116418 (2024)
   PUBMED   38996928
  REMARK    GeneRIF: The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a
            protective role in sepsis-induced lung injury by targeting
            TAK1-mediated MAPK and NF-kappaB signaling.
REFERENCE   2  (bases 1 to 4932)
  AUTHORS   Damhofer,H., Tatar,T., Southgate,B., Scarneo,S., Agger,K.,
            Shlyueva,D., Uhrbom,L., Morrison,G.M., Hughes,P.F., Haystead,T.,
            Pollard,S.M. and Helin,K.
  TITLE     TAK1 inhibition leads to RIPK1-dependent apoptosis in
            immune-activated cancers
  JOURNAL   Cell Death Dis 15 (4), 273 (2024)
   PUBMED   38632238
  REMARK    GeneRIF: TAK1 inhibition leads to RIPK1-dependent apoptosis in
            immune-activated cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4932)
  AUTHORS   Zhang,H., Han,Y., Xiao,W., Gao,Y., Sui,Z., Ren,P., Meng,F., Tang,P.
            and Yu,Z.
  TITLE     USP4 promotes the proliferation, migration, and invasion of
            esophageal squamous cell carcinoma by targeting TAK1
  JOURNAL   Cell Death Dis 14 (11), 730 (2023)
   PUBMED   37949874
  REMARK    GeneRIF: USP4 promotes the proliferation, migration, and invasion
            of esophageal squamous cell carcinoma by targeting TAK1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4932)
  AUTHORS   Ma,M., Dang,Y., Chang,B., Wang,F., Xu,J., Chen,L., Su,H., Li,J.,
            Ge,B., Chen,C. and Liu,H.
  TITLE     TAK1 is an essential kinase for STING trafficking
  JOURNAL   Mol Cell 83 (21), 3885-3903 (2023)
   PUBMED   37832545
REFERENCE   5  (bases 1 to 4932)
  AUTHORS   Abd-Elmawla,M.A., Elsabagh,Y.A. and Aborehab,N.M.
  TITLE     Association of XIST/miRNA155/Gab2/TAK1 cascade with the
            pathogenesis of anti-phospholipid syndrome and its effect on cell
            adhesion molecules and inflammatory mediators
  JOURNAL   Sci Rep 13 (1), 18790 (2023)
   PUBMED   37914735
  REMARK    GeneRIF: Association of XIST/miRNA155/Gab2/TAK1 cascade with the
            pathogenesis of anti-phospholipid syndrome and its effect on cell
            adhesion molecules and inflammatory mediators.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4932)
  AUTHORS   Moriguchi,T., Kuroyanagi,N., Yamaguchi,K., Gotoh,Y., Irie,K.,
            Kano,T., Shirakabe,K., Muro,Y., Shibuya,H., Matsumoto,K.,
            Nishida,E. and Hagiwara,M.
  TITLE     A novel kinase cascade mediated by mitogen-activated protein kinase
            kinase 6 and MKK3
  JOURNAL   J Biol Chem 271 (23), 13675-13679 (1996)
   PUBMED   8663074
REFERENCE   7  (bases 1 to 4932)
  AUTHORS   Shibuya,H., Yamaguchi,K., Shirakabe,K., Tonegawa,A., Gotoh,Y.,
            Ueno,N., Irie,K., Nishida,E. and Matsumoto,K.
  TITLE     TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal
            transduction
  JOURNAL   Science 272 (5265), 1179-1182 (1996)
   PUBMED   8638164
REFERENCE   8  (bases 1 to 4932)
  AUTHORS   Yamaguchi,K., Shirakabe,K., Shibuya,H., Irie,K., Oishi,I., Ueno,N.,
            Taniguchi,T., Nishida,E. and Matsumoto,K.
  TITLE     Identification of a member of the MAPKKK family as a potential
            mediator of TGF-beta signal transduction
  JOURNAL   Science 270 (5244), 2008-2011 (1995)
   PUBMED   8533096
REFERENCE   9  (bases 1 to 4932)
  AUTHORS   Hirose,T., Fujimoto,W., Tamaai,T., Kim,K.H., Matsuura,H. and
            Jetten,A.M.
  TITLE     TAK1: molecular cloning and characterization of a new member of the
            nuclear receptor superfamily
  JOURNAL   Mol Endocrinol 8 (12), 1667-1680 (1994)
   PUBMED   7708055
REFERENCE   10 (bases 1 to 4932)
  AUTHORS   DuBridge,R.B., Tang,P., Hsia,H.C., Leong,P.M., Miller,J.H. and
            Calos,M.P.
  TITLE     Analysis of mutation in human cells by using an Epstein-Barr virus
            shuttle system
  JOURNAL   Mol Cell Biol 7 (1), 379-387 (1987)
   PUBMED   3031469
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM172351.1, AB009357.1,
            AL121964.16 and AI147171.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_145331.2.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine protein kinase family. This kinase mediates the
            signaling transduction induced by TGF beta and morphogenetic
            protein (BMP), and controls a variety of cell functions including
            transcription regulation and apoptosis. In response to IL-1, this
            protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and
            MAP3K7P2/TAB2; this complex is required for the activation of
            nuclear factor kappa B. This kinase can also activate MAPK8/JNK,
            MAP2K4/MKK4, and thus plays a role in the cell response to
            environmental stresses. Four alternatively spliced transcript
            variants encoding distinct isoforms have been reported. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (B) encodes the longest isoform
            (B).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.222071.1,
                                           SRR1660807.12235.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369329.8/ ENSP00000358335.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BM172351.1         238-264
            28-2877             AB009357.1         1-2850
            2878-4609           AL121964.16        70207-71938
            4610-4932           AI147171.1         12-334              c
FEATURES             Location/Qualifiers
     source          1..4932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..4932
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /note="mitogen-activated protein kinase kinase kinase 7"
                     /db_xref="GeneID:6885"
                     /db_xref="HGNC:HGNC:6859"
                     /db_xref="MIM:602614"
     exon            1..309
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..2010
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /EC_number="2.7.11.25"
                     /note="isoform B is encoded by transcript variant B;
                     transforming growth factor-beta-activated kinase 1;
                     TGF-beta activated kinase 1"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase 7
                     isoform B"
                     /protein_id="NP_663304.1"
                     /db_xref="CCDS:CCDS5028.1"
                     /db_xref="GeneID:6885"
                     /db_xref="HGNC:HGNC:6859"
                     /db_xref="MIM:602614"
                     /translation="MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGR
                     GAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPVCL
                     VMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPP
                     NLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGII
                     LWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKDPSQRPS
                     MEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTN
                     MEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADM
                     SEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVTGTEP
                     GQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQ
                     PLAPCPNSKESMAVFEQHCKMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSR
                     LVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQQQKRQGTS"
     exon            310..420
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            421..486
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            487..532
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            533..671
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            672..796
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            797..925
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1056
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1138
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1269
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1399
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1480
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1545
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1651
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1713
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1829
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..4932
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2796..2801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /note="hexamer: ATTAAA"
     polyA_site      2817
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /note="major polyA site"
     regulatory      4907..4912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /note="hexamer: AATAAA"
     polyA_site      4932
                     /gene="MAP3K7"
                     /gene_synonym="CSCF; FMD2; MEKK7; TAK1; TGF1a"
                     /note="major polyA site"
ORIGIN      
        1 ggcggaaaac gcagcggagc cagagccgga cacggctgtg gccgctgcct ctacccccgc
       61 cacggatcgc cgggtagtag gactgcgcgg ctccaggctg agggtcggtc cggaggcggg
      121 tgggcgcggg tctcacccgg attgtccggg tggcaccgtt cccggcccca ccgggcgccg
      181 cgagggatca tgtctacagc ctctgccgcc tcctcctcct cctcgtcttc ggccggtgag
      241 atgatcgaag ccccttccca ggtcctcaac tttgaagaga tcgactacaa ggagatcgag
      301 gtggaagagg ttgttggaag aggagccttt ggagttgttt gcaaagctaa gtggagagca
      361 aaagatgttg ctattaaaca aatagaaagt gaatctgaga ggaaagcgtt tattgtagag
      421 cttcggcagt tatcccgtgt gaaccatcct aatattgtaa agctttatgg agcctgcttg
      481 aatccagtgt gtcttgtgat ggaatatgct gaagggggct ctttatataa tgtgctgcat
      541 ggtgctgaac cattgccata ttatactgct gcccacgcaa tgagttggtg tttacagtgt
      601 tcccaaggag tggcttatct tcacagcatg caacccaaag cgctaattca cagggacctg
      661 aaaccaccaa acttactgct ggttgcaggg gggacagttc taaaaatttg tgattttggt
      721 acagcctgtg acattcagac acacatgacc aataacaagg ggagtgctgc ttggatggca
      781 cctgaagttt ttgaaggtag taattacagt gaaaaatgtg acgtcttcag ctggggtatt
      841 attctttggg aagtgataac gcgtcggaaa ccctttgatg agattggtgg cccagctttc
      901 cgaatcatgt gggctgttca taatggtact cgaccaccac tgataaaaaa tttacctaag
      961 cccattgaga gcctgatgac tcgttgttgg tctaaagatc cttcccagcg cccttcaatg
     1021 gaggaaattg tgaaaataat gactcacttg atgcggtact ttccaggagc agatgagcca
     1081 ttacagtatc cttgtcagta ttcagatgaa ggacagagca actctgccac cagtacaggc
     1141 tcattcatgg acattgcttc tacaaatacg agtaacaaaa gtgacactaa tatggagcaa
     1201 gttcctgcca caaatgatac tattaagcgc ttagaatcaa aattgttgaa aaatcaggca
     1261 aagcaacaga gtgaatctgg acgtttaagc ttgggagcct cccgtgggag cagtgtggag
     1321 agcttgcccc caacctctga gggcaagagg atgagtgctg acatgtctga aatagaagct
     1381 aggatcgccg caaccacagc ctattccaag cctaaacggg gccaccgtaa aactgcttca
     1441 tttggcaaca ttctggatgt ccctgagatc gtcatatcag gcaacggaca gccaagacgt
     1501 agatccatcc aagacttgac tgtaactgga acagaacctg gtcaggtgag cagtaggtca
     1561 tccagtccca gtgtcagaat gattactacc tcaggaccaa cctcagaaaa gccaactcga
     1621 agtcatccat ggacccctga tgattccaca gataccaatg gatcagataa ctccatccca
     1681 atggcttatc ttacactgga tcaccaacta cagcctctag caccgtgccc aaactccaaa
     1741 gaatctatgg cagtgtttga acagcattgt aaaatggcac aagaatatat gaaagttcaa
     1801 acagaaattg cattgttatt acagagaaag caagaactag ttgcagaact ggaccaggat
     1861 gaaaaggacc agcaaaatac atctcgcctg gtacaggaac ataaaaagct tttagatgaa
     1921 aacaaaagcc tttctactta ctaccagcaa tgcaaaaaac aactagaggt catcagaagt
     1981 cagcagcaga aacgacaagg cacttcatga ttctctggga ccgttacatt ttgaaatatg
     2041 caaagaaaga cttttttttt aaggaaagga aaaccttata atgacgattc atgagtgtta
     2101 gctttttggc gtgttctgaa tgccaactgc ctatatttgc tgcatttttt tcattgttta
     2161 ttttcctttt ctcatggtgg acatacaatt ttactgtttc attgcataac atggtagcat
     2221 ctgtgacttg aatgagcagc actttgcaac ttcaaaacag atgcagtgaa ctgtggctgt
     2281 atatgcatgc tcattgtgtg aaggctagcc taacagaaca ggaggtatca aactagctgc
     2341 tatgtgcaaa cagcgtccat tttttcatat tagaggtgga acctcaagaa tgactttatt
     2401 cttgtatctc atctcaaaat attaataatt tttttcccaa aagatggtat ataccaagtt
     2461 aaagacaggg tattataaat ttagagtgat tggtggtata ttacggaaat acggaacctt
     2521 tagggatagt tccgtgtaag ggctttgatg ccagcatcct tggatcagta ctgaactcag
     2581 ttccatccgt aaaatatgta aaggtaagtg gcagctgctc tatttaatga aagcagtttt
     2641 accggatttt gttagactaa aatttgattg tgatacattg aacaaaatgg aactcatttt
     2701 tttttaagga gtaaagattt ttaattctgt gattgtgtgt atgtgtgttg aaactgtaaa
     2761 gcttttatga ctctaatatt aatctcttaa atgaaattaa aaggcaaaag aacatgattg
     2821 agcttaaatg atcatttctt cctgcagtga ttcttggatt gttttctcat gtatttgaaa
     2881 aaaaaaaaat gaagaaaaat aatggaaaat ggaagtaatt actccagcta aaaaaagctt
     2941 ggacttagat ttctttttat gataccaaat gagaaataaa ccaggcaaat cagaaggaag
     3001 ttaaagaagc aaatataaat tcaacaagtg tcctaattat cctggatatt ggaatatttg
     3061 attttcctta caatcccgtt ctagaatgcc tgccgccttt caacactttc aagagaattt
     3121 caacacttac agagtattta tattgttaac agtaattttg ctaccaaaac cttcagaata
     3181 actttaataa taaaatgaca ctgaaataat agactataca aactctatat tttttcagtt
     3241 ggtgttaaaa taagtcacat tttgatacca gtacaagatg tcttttaaat aaggatgtca
     3301 tcagtctgat ttttatagca ttaatgtttt atgaagaaaa agttcaaaat gaaagcatta
     3361 attgctgtga ttattagaat tctatcatga ctgtattgta gtttttgctc tatttcagat
     3421 aagcaagatc taagaagtta tcaaaactat tctttaaaat gctaaagcag gtaacttttt
     3481 cttccattat tttttcctcc taccactgag ttttgtaatg aattccttgt gtatacaagc
     3541 aatacaggtg aatactaaac tgttattttt agcttcttca aaagctattt tagaaagctt
     3601 cctggaaata aatgtcttct gtcatttaat ttaaataaaa ggagtgttaa ttgttcccaa
     3661 atttgattac ctagctgaaa cagatattgg attcagcata gtaatagtaa aataaaattg
     3721 gcagagaaaa taactgtaga ctaggataaa gcatgactcc tccatagcat tgttgcttgt
     3781 atgtacatct gtcactccac tgaaagggac ctagtcactt taaagaggcc ttttatctca
     3841 gcacgagata tccaagcgtg aatgctaagg cttgatgttt ccattaggat ttagcattcg
     3901 agatttcaga ttttatttat agtcattgat gtgttttgct gtattataac acatttaagg
     3961 gaaattttat tatggttttt acatgtagtc atttcataaa aatatccaga taggtaaatg
     4021 gaagaaaata gtagatttta gtcatggtac caaatgcaag aggctgttga acagttgctt
     4081 gtttgtttac agtaagttcc ttgagatttt cagtactgta gttgccctgg acattgagta
     4141 cagttcagcc ttactctgtt tttaagtagt tgtgttgtca atttcatgct tttaagtcct
     4201 gatgatcctt ggagatggga gaaaaagata ccagggataa ttaaaatcca cagccagttt
     4261 catcagtttc ctcatccatc ctgcaaataa aaatgttaac aaggagccaa acttattcgt
     4321 tctggtttta caatttattt tgaccgtttt ttgggtgaaa attgcaaaca gccaagcaag
     4381 tggctggaat gccccagtct aagaaattca aaaacaatca ctgagtaagc cctaattaca
     4441 ttaattacat tttactcttg actccaggaa aagaaagcaa gcttttatct aatctagagg
     4501 gaagtattcg tgagcaataa aaatcacttt tttgagttga ataataatca gttaagaata
     4561 tttaccgcat agcaacacaa catataaaga tttgttacaa gttgtttacg gatgtttgac
     4621 tatttttgct gaagtatttt agagtattga atgtcttctc tcttcaagtt tctttcatgt
     4681 tcctaatttc agctcctgta gccagagatc acaggtcttc cctgtgaaac tttggtttct
     4741 ttctataaat gtgtgtggtt ttcagcgctc aactcctgtc ttcaaatggt agtaagttct
     4801 acttctactt ctgtcattca gaacatttta tgtcaaatga tgtaatgcag aaattcttgt
     4861 gcatatttgt aactgaagga agctttttag atttattttt gtttttaata aaattcagat
     4921 tcctattcta aa
//
