LOCUS       NM_004672               4438 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 6
            (MAP3K6), transcript variant 1, mRNA.
ACCESSION   NM_004672
VERSION     NM_004672.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4438)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 4438)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4438)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 4438)
  AUTHORS   Trevelyan,S.J., Brewster,J.L., Burgess,A.E., Crowther,J.M.,
            Cadell,A.L., Parker,B.L., Croucher,D.R., Dobson,R.C.J., Murphy,J.M.
            and Mace,P.D.
  TITLE     Structure-based mechanism of preferential complex formation by
            apoptosis signal-regulating kinases
  JOURNAL   Sci Signal 13 (622) (2020)
   PUBMED   32156783
  REMARK    GeneRIF: Structure-based mechanism of preferential complex
            formation by apoptosis signal-regulating kinases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4438)
  AUTHORS   Weren,R.D.A., van der Post,R.S., Vogelaar,I.P., van Krieken,J.H.,
            Spruijt,L., Lubinski,J., Jakubowska,A., Teodorczyk,U., Aalfs,C.M.,
            van Hest,L.P., Oliveira,C., Kamping,E.J., Schackert,H.K.,
            Ranzani,G.N., Gomez Garcia,E.B., Hes,F.J., Holinski-Feder,E.,
            Genuardi,M., Ausems,M.G.E.M., Sijmons,R.H., Wagner,A., van der
            Kolk,L.E., Cats,A., Bjornevoll,I., Hoogerbrugge,N. and
            Ligtenberg,M.J.L.
  TITLE     Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in
            gastric cancer susceptibility
  JOURNAL   J Med Genet 55 (10), 669-674 (2018)
   PUBMED   29330337
  REMARK    GeneRIF: MAP3K6 should no longer be considered a gastric cancer
            (GC) predisposition gene, whereas deleterious CTNNA1 variants are
            confirmed as an infrequent cause of GC susceptibility. Biallelic
            MYD88 germline mutations are at most a very rare cause of GC
            susceptibility.
REFERENCE   6  (bases 1 to 4438)
  AUTHORS   Iriyama,T., Takeda,K., Nakamura,H., Morimoto,Y., Kuroiwa,T.,
            Mizukami,J., Umeda,T., Noguchi,T., Naguro,I., Nishitoh,H.,
            Saegusa,K., Tobiume,K., Homma,T., Shimada,Y., Tsuda,H., Aiko,S.,
            Imoto,I., Inazawa,J., Chida,K., Kamei,Y., Kozuma,S., Taketani,Y.,
            Matsuzawa,A. and Ichijo,H.
  TITLE     ASK1 and ASK2 differentially regulate the counteracting roles of
            apoptosis and inflammation in tumorigenesis
  JOURNAL   EMBO J 28 (7), 843-853 (2009)
   PUBMED   19214184
REFERENCE   7  (bases 1 to 4438)
  AUTHORS   Arning,L., Monte,D., Hansen,W., Wieczorek,S., Jagiello,P.,
            Akkad,D.A., Andrich,J., Kraus,P.H., Saft,C. and Epplen,J.T.
  TITLE     ASK1 and MAP2K6 as modifiers of age at onset in Huntington's
            disease
  JOURNAL   J Mol Med (Berl) 86 (4), 485-490 (2008)
   PUBMED   18327563
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4438)
  AUTHORS   Ortner,E. and Moelling,K.
  TITLE     Heteromeric complex formation of ASK2 and ASK1 regulates
            stress-induced signaling
  JOURNAL   Biochem Biophys Res Commun 362 (2), 454-459 (2007)
   PUBMED   17714688
REFERENCE   9  (bases 1 to 4438)
  AUTHORS   Takeda,K., Shimozono,R., Noguchi,T., Umeda,T., Morimoto,Y.,
            Naguro,I., Tobiume,K., Saitoh,M., Matsuzawa,A. and Ichijo,H.
  TITLE     Apoptosis signal-regulating kinase (ASK) 2 functions as a
            mitogen-activated protein kinase kinase kinase in a heteromeric
            complex with ASK1
  JOURNAL   J Biol Chem 282 (10), 7522-7531 (2007)
   PUBMED   17210579
  REMARK    GeneRIF: Apoptosis signal-regulating kinase (ASK) 2 functions as a
            mitogen-activated protein kinase kinase kinase in a heteromeric
            complex with ASK1.
REFERENCE   10 (bases 1 to 4438)
  AUTHORS   Wang,X.S., Diener,K., Tan,T.H. and Yao,Z.
  TITLE     MAPKKK6, a novel mitogen-activated protein kinase kinase kinase,
            that associates with MAPKKK5
  JOURNAL   Biochem Biophys Res Commun 253 (1), 33-37 (1998)
   PUBMED   9875215
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from FO393419.1, AW771625.1,
            AB167411.1 and AF100318.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004672.4.
            
            Summary: This gene encodes a serine/threonine protein kinase that
            forms a component of protein kinase-mediated signal transduction
            cascades. The encoded kinase participates in the regulation of
            vascular endothelial growth factor (VEGF) expression. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB167411.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357582.3/ ENSP00000350195.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                FO393419.1         94282-94376
            96-364              AW771625.1         263-531             c
            365-1656            AB167411.1         1-1292
            1657-4438           AF100318.1         707-3488
FEATURES             Location/Qualifiers
     source          1..4438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..4438
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /note="mitogen-activated protein kinase kinase kinase 6"
                     /db_xref="GeneID:9064"
                     /db_xref="HGNC:HGNC:6858"
                     /db_xref="MIM:604468"
     exon            1..704
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..4231
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /EC_number="2.7.11.25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     apoptosis signal-regulating kinase 2"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase 6
                     isoform 1"
                     /protein_id="NP_004663.3"
                     /db_xref="CCDS:CCDS299.1"
                     /db_xref="GeneID:9064"
                     /db_xref="HGNC:HGNC:6858"
                     /db_xref="MIM:604468"
                     /translation="MAGPCPRSGAERAGSCWQDPLAVALSRGRQLAAPPGRGCARSRP
                     LSVVYVLTREPQPGLEPREGTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELG
                     DTAALDAFYNADVVVLEVSSSLVQPSLFYHLGVRESFSMTNNVLLCSQADLPDLQALR
                     EDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGLADGLVQAGVGTEALLTPLVG
                     RLARLLEATPTDSCGYFRETIRRDIRQARERFSGPQLRQELARLQRRLDSVELLSPDI
                     IMNLLLSYRDVQDYSAIIELVETLQALPTCDVAEQHNVCFHYTFALNRRNRPGDRAKA
                     LSVLLPLVQLEGSVAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSL
                     HSGINAAVLLIAAGQHFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQIL
                     ANDPTQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPPGGPPRRAHFWLHFL
                     LQSCQPFKTACAQGDQCLVLVLEMNKVLLPAKLEVRGTDPVSTVTLSLLEPETQDIPS
                     SWTFPVASICGVSASKRDERCCFLYALPPAQDVQLCFPSVGHCQWFCGLIQAWVTNPD
                     STAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRVRIAIKEIPER
                     DSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWGP
                     LKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLA
                     GITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQ
                     AAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQPGKRSRS
                     PSSPRHAPRPSDAPSASPTPSANSTTQSQTFPCPQAPSQHPPSPPKRCLSYGGTSQLR
                     VPEEPAAEEPASPEESSGLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQEQGAR
                     LGRNHVEELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVK
                     QILRKRQIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEELSNEGDSQQSPG
                     QQSPLPVEPEQGPAPLMVQLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEART
                     YVLAPEPPTALSTDQGLVQWLQELNVDSGTIQMLLNHSFTLHTLLTYATRDDLIYTRI
                     RGGMVCRIWRAILAQRAGSTPVTSGP"
     exon            705..844
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            845..868
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1059
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1228
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1335
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1506
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1619
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1779
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1942
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2050
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2100
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2196
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2284
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2418
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2546
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2683
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2789
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2947
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            2948..3140
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3279
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3445
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3622
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3728
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3888
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4001
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            4002..4075
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            4076..4152
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     exon            4153..4438
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4418..4423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /note="hexamer: ATTAAA"
     polyA_site      4438
                     /gene="MAP3K6"
                     /gene_synonym="ASK2; MAPKKK6; MEKK6"
                     /note="major polyA site"
ORIGIN      
        1 acaagtgaag gcagggcagc gttggcgggc gctcccttga gaagtccagg tggcgggcac
       61 ctccgagccg attcccagga tcccccaagt ggctctgagc tgccgatcac cggatgcccc
      121 agattcctgg gacccaatcc cggatttcag aacctcagga ccttgcaagt ccgagctagg
      181 atttctccct ggactttaga ttcctggaac gggacgtcag gccgtattcc ggatccctag
      241 atcccgtggg agattctccg attccgaacg gattccagat cccaagattc ctgatctgcc
      301 ggcccaggct cctgccccgc ccccggttcc cagtgcgcgg cgccccgcgc ctgagcgccc
      361 ccgcatggcg gggccgtgtc cccggtccgg ggcggagcgc gccggcagct gctggcagga
      421 cccgctggcc gtggcgctga gccggggccg gcagctcgcg gcgcccccgg gccggggctg
      481 cgcgcggagc cggccgctca gcgtggtcta cgtgctgacc cgggagccgc agcccgggct
      541 cgagcctcgg gagggaaccg aggcggagcc gctgcccctg cgctgcctgc gcgaggcttg
      601 cgcgcaggtc ccccggccgc ggccgccccc gcagctgcgc agcctgccct tcgggacgct
      661 ggagctaggc gacaccgcgg ctctggatgc cttctacaac gcggatgtgg tggtgctgga
      721 ggtgagcagc tcgctggtac agccctccct gttctaccac cttggtgtgc gtgagagctt
      781 cagcatgacc aacaatgtgc tcctctgctc ccaggccgac ctccctgacc tgcaggccct
      841 gcgggaggat gttttccaga agaactcgga ttgcgttggc agctacacac tgatccccta
      901 tgtggtgacg gccactggtc gggtgctgtg tggtgatgca ggccttctgc ggggcctggc
      961 tgatgggctg gtacaggctg gagtggggac cgaggccctg ctcactcccc tggtgggccg
     1021 gcttgcccgc ctgctggagg ccacacccac agactcttgt ggctatttcc gggagaccat
     1081 tcggcgggac atccggcagg cgcgggagcg gttcagtggg ccacagctgc ggcaggagct
     1141 ggctcgcctg cagcggagac tggacagcgt ggagctgctg agccccgaca tcatcatgaa
     1201 cttgctgctc tcctaccgcg atgtgcagga ctactcggcc atcattgagc tggtggagac
     1261 gctgcaggcc ttgcccacct gtgatgtggc cgagcagcat aatgtctgct tccactacac
     1321 ttttgccctc aaccggagga acaggcctgg ggaccgggcg aaggccctgt ctgtgctgct
     1381 gccgctggta cagcttgagg gctctgtggc gcccgatctg tactgcatgt gtggccgtat
     1441 ctacaaggac atgttcttca gctcgggttt ccaggatgct gggcaccggg agcaggccta
     1501 tcactggtat cgcaaggctt ttgacgtaga gcccagcctt cactcaggca tcaatgcagc
     1561 tgtgctcctc attgctgccg ggcagcactt tgaggattcc aaagagctcc ggctaatagg
     1621 catgaagctg ggctgcctgc tggcccgcaa aggctgcgtg gagaagatgc agtattactg
     1681 ggatgtgggt ttctacctgg gagcccagat cctcgccaat gaccccaccc aggtggtgct
     1741 ggctgcagag cagctgtata agctcaatgc ccccatatgg tacctggtgt ccgtgatgga
     1801 gaccttcctg ctctaccagc acttcaggcc cacgccagag ccccctggag ggccaccacg
     1861 ccgtgcccac ttctggctcc acttcttgct acagtcctgc caaccattca agacagcctg
     1921 tgcccagggc gaccagtgct tggtgctggt cctggagatg aacaaggtgc tgctgcctgc
     1981 aaagctcgag gttcggggta ctgacccagt aagcacagtg accctgagcc tgctggagcc
     2041 tgagacccag gacattccct ccagctggac cttcccagtc gcctccatat gcggagtcag
     2101 cgcctcaaag cgcgacgagc gctgctgctt cctctatgca ctccccccgg ctcaggacgt
     2161 ccagctgtgc ttccccagcg tagggcactg ccagtggttc tgcggcctga tccaggcctg
     2221 ggtgacgaac ccggattcca cggcgcccgc ggaggaggcg gagggcgcgg gggagatgtt
     2281 ggagtttgat tatgagtaca cggagacggg cgagcggctg gtgctgggca agggcacgta
     2341 tggggtggtg tacgcgggcc gcgatcgcca cacgagggtg cgcatcgcca tcaaggagat
     2401 cccggagcgg gacagcaggt tctctcagcc cctgcatgaa gagatcgctc ttcacagacg
     2461 cctgcgccac aagaacatag tgcgctatct gggctcagct agccagggcg gctaccttaa
     2521 gatcttcatg gaggaagtgc ctggaggcag cctgtcctcc ttgctgcggt cggtgtgggg
     2581 acccctgaag gacaacgaga gcaccatcag tttctacacc cgccagatcc tgcagggact
     2641 tggctacttg cacgacaacc acatcgtgca cagggacata aaaggggaca atgtgctgat
     2701 caacaccttc agtgggctgc tcaagatttc tgacttcggc acctccaagc ggctggcagg
     2761 catcacacct tgcactgaga ccttcacagg aactctgcag tatatggccc cagaaatcat
     2821 tgaccagggc ccacgcgggt atgggaaagc agctgacatc tggtcactgg gctgcactgt
     2881 cattgagatg gccacaggtc gccccccctt ccacgagctc gggagcccac aggctgccat
     2941 gtttcaggtg ggtatgtaca aggtccatcc gccaatgccc agctctctgt cggccgaggc
     3001 ccaagccttt ctcctccgaa cttttgagcc agacccccgc ctccgagcca gcgcccagac
     3061 actgctgggg gaccccttcc tgcagcctgg gaaaaggagc cgcagcccca gctccccacg
     3121 acatgctcca cggccctcag atgccccttc tgccagtccc actccttcag ccaactcaac
     3181 cacccagtct cagacattcc cgtgccctca ggcaccctct cagcacccac ccagcccccc
     3241 gaagcgctgc ctcagttatg ggggcaccag ccagctccgg gtgcccgagg agcctgcggc
     3301 cgaggagcct gcgtctccgg aggagagttc ggggctgagc ctgctgcacc aggagagcaa
     3361 gcgtcgggcc atgctggccg cagtattgga gcaggagctg ccagcgctgg cggagaatct
     3421 gcaccaggag cagaagcaag agcagggggc ccgtctgggc agaaaccatg tggaagagct
     3481 gctgcgctgc ctcggggcac acatccacac tcccaaccgc cggcagctcg cccaggagct
     3541 gcgggcgctg caaggacggc tgagggccca gggccttggg cctgcgcttc tgcacagacc
     3601 gctgtttgcc ttcccggatg cggtgaagca gatcctccgc aagcgccaga tccgtccaca
     3661 ctggatgttc gttctggact cactgctcag ccgtgctgtg cgggcagccc tgggtgtgct
     3721 aggaccggag gtggagaagg aggcggtctc accgaggtca gaggagctga gtaatgaagg
     3781 ggactcccag cagagcccag gccagcagag cccgcttccg gtggagcccg agcagggccc
     3841 cgctcctctg atggtgcagc tgagcctctt gagggcagag actgatcggc tgcgcgaaat
     3901 cctggcgggg aaggaacggg agtaccaggc cctggtgcag cgggctctac agcggctgaa
     3961 tgaggaagcc cggacctatg tcctggcccc agagcctcca actgctcttt caacggacca
     4021 gggcctggtg cagtggctac aggaactgaa tgtggattca ggcaccatcc aaatgctgtt
     4081 gaaccatagc ttcaccctcc acactctgct cacctatgcc actcgagatg acctcatcta
     4141 cacccgcatc aggggaggga tggtatgccg catctggagg gccatcttgg cacagcgagc
     4201 aggatccaca ccagtcacct ctggaccctg agagctgaat gagggcatca taggccagac
     4261 aggcccaagg atggatgaat ggagaggaca aaggcagctt ctgacacacc agccccagga
     4321 cctggggcga ctggaggaag ccaggcgagt ggggcccagg actggttcca gtgagagaaa
     4381 ccaaccacag gcacccaagc actaccagac aaagcgtatt aaacagaaca cttttgaa
//
