LOCUS       XM_047436084            4655 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens mitogen-activated protein kinase kinase
            kinase 3 (MAP3K3), transcript variant X2, mRNA.
ACCESSION   XM_047436084
VERSION     XM_047436084.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..4655
                     /gene="MAP3K3"
                     /gene_synonym="MAPKKK3; MEKK3"
                     /note="mitogen-activated protein kinase kinase kinase 3;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 1 mRNA, 40 ESTs, 528 long SRA reads, and
                     100% coverage of the annotated genomic feature by RNAseq
                     alignments, including 94 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4215"
                     /db_xref="HGNC:HGNC:6855"
                     /db_xref="MIM:602539"
     CDS             344..1930
                     /gene="MAP3K3"
                     /gene_synonym="MAPKKK3; MEKK3"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase 3
                     isoform X2"
                     /protein_id="XP_047292040.1"
                     /db_xref="GeneID:4215"
                     /db_xref="HGNC:HGNC:6855"
                     /db_xref="MIM:602539"
                     /translation="MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKK
                     HNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFSRPVKYEDVEH
                     KVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNS
                     SSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPGYVPERQQ
                     HIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDSPSFRKSRMSRAQ
                     SFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFT
                     LVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPINWRRG
                     KLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHER
                     IVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLH
                     SNMIVHRDIKGAWAALWWRC"
ORIGIN      
        1 gtttttcgga gcgttcctga ggtggagaac ggtggccgga cggagagact gcgggtctga
       61 gggactggcg ggcgggcggg ccgagcggcg ccgccgaggc cgggctgggc cgagcccagg
      121 agcgcccggg atgtagcggg ccaccctgcc gatgccacag cgcccggccg cgggcggagc
      181 cggagccgga gcctggggag gcggcggggg cccagagcgc agcccgcgcc ccccgcgcgg
      241 agccaggccc gctgccgtcc ccgccgcccg ggcccccggc atgcagcccc ggctgcggag
      301 gtgacactca cggaccttag ccaccgccgc cgccatcgcc accatggacg aacaggaggc
      361 attgaactca atcatgaacg atctggtggc cctccagatg aaccgacgtc accggatgcc
      421 tggatatgag accatgaaga acaaagacac aggtcactca aataggcaga aaaaacacaa
      481 cagcagcagc tcagcccttc tgaacagccc cacagtaaca acaagctcat gtgcaggggc
      541 cagtgagaaa aagaaatttt tgagtgacgt cagaatcaag ttcgagcaca acggggagag
      601 gcgaattata gcgttcagcc ggcctgtgaa atatgaagat gtggagcaca aggtgacaac
      661 agtatttgga caacctcttg atctacatta catgaacaat gagctctcca tcctgctgaa
      721 aaaccaagat gatcttgata aagcaattga cattttagat agaagctcaa gcatgaaaag
      781 ccttaggata ttgctgttgt cccaggacag aaaccataac agttcctctc cccactctgg
      841 ggtgtccaga caggtgcgga tcaaggcttc ccagtccgca ggggatataa atactatcta
      901 ccagcccccc gagcccagaa gcaggcacct ctctgtcagc tcccagaacc ctggccgaag
      961 ctcacctccc cctggctatg ttcctgagcg gcagcagcac attgcccggc aggggtccta
     1021 caccagcatc aacagtgagg gggagttcat cccagagacc agcgagcagt gcatgctgga
     1081 tcccctgagc agtgcagaaa attccttgtc tggaagctgc caatccttgg acagcccatc
     1141 cttccggaaa tcacgaatgt cccgtgccca gagcttccct gacaacagac aggaatactc
     1201 agatcgggaa actcagcttt atgacaaagg ggtcaaaggt ggaacctacc cccggcgcta
     1261 ccacgtgtct gtgcaccaca aggactacag tgatggcaga agaacatttc cccgaatacg
     1321 gcgtcatcaa ggcaacttgt tcaccctggt gccctccagc cgctccctga gcacaaatgg
     1381 cgagaacatg ggtctggctg tgcaatacct ggacccccgt gggcgcctgc ggagtgcgga
     1441 cagcgagaat gccctctctg tgcaggagag gaatgtgcca accaagtctc ccagtgcccc
     1501 catcaactgg cgccggggaa agctcctggg ccagggtgcc ttcggcaggg tctatttgtg
     1561 ctatgacgtg gacacgggac gtgaacttgc ttccaagcag gtccaatttg atccagacag
     1621 tcctgagaca agcaaggagg tgagtgctct ggagtgcgag atccagttgc taaagaactt
     1681 gcagcatgag cgcatcgtgc agtactatgg ctgtctgcgg gaccgcgctg agaagaccct
     1741 gaccatcttc atggagtaca tgccaggggg ctcggtgaaa gaccagttga aggcttacgg
     1801 tgctctgaca gagagcgtga cccgaaagta cacgcggcag atcctggagg gcatgtccta
     1861 cctgcacagc aacatgattg ttcaccggga cattaaggga gcctgggctg cactgtggtg
     1921 gagatgctga cagagaaacc accgtgggca gagtatgaag ctatggccgc catcttcaag
     1981 attgccaccc agcccaccaa tcctcagctg ccctcccaca tctctgaaca tggccgggac
     2041 ttcctgaggc gcatttttgt ggaggctcgc cagagacctt cagctgagga gctgctcaca
     2101 caccactttg cacagctcat gtactgagct ctcacggcca cacagctgcc ggtcgccctt
     2161 tgctgcatgg cagggggctg ctgctgggct cagtgaagtt gctgcttctc ccaggcaagg
     2221 ctgtggacca tggagtggca gcccagccag cgtcggtctg tgccccttcc gccactgggg
     2281 ctcagagccg gggtggggtg gctgcagcct caggactggg agcccccagc ctgtcagatc
     2341 caggagctcc agtgtcctga gctcagcgtg gaggggtagg ggctgggaac agtgtgcaag
     2401 gcagccgtgg gccccaccct cggggatgtg tcctgacact gcaattggca ccgaagccca
     2461 gagggtctgg gggcacaaga ctgacgccag ggtatgaaga gtgttatttt cattcaaagt
     2521 gttattttgt ttttccttcc aatgtctgga gaccaccagg gcatctctgg gctggatgag
     2581 ctcccacaag cctgagggaa aggccagcac tcgctagcag tggcaggcag aggcccaggc
     2641 tgccgtcccc tagagtccca ggttggctct gccagtcctg tcctttacca aagatgaatg
     2701 aagcaaatgt catgctgcct tattcaggga aggaggagcc tgtcctgcct gtggccatga
     2761 ccctgcctct cccaggcagg ggcccgcgat gtggaactgc tgccactgag gggggatcca
     2821 gttttgtcaa tgcagttgtc tctgttttac aagttggagt cactcttatg ctgtacccag
     2881 tttctaaact ggagactgtg tgtgccctct gggctctgag tacccctgct ttgggcttgg
     2941 gcctaggctg cattgaaaag agctgaaggt tgtggccttt gcgctcctgg cccagccttt
     3001 gttccccact ggagcagaag gggagatgga cgacacggtc ggggcatctg gcctggccag
     3061 tgccctgatc ccagagagcc cgaggaggtg tctcaggctg cctgagtcgt gacctgctag
     3121 gccagagccc actccatctg gtagaaggga aagcccatat gctaccacca gctgtgtcca
     3181 aaaccgccag ctctgttctt cctcagccag cctcgcccat ccccttgagg tctcagcccc
     3241 tttcccttgt agctcctccc ctggaggggg aatggcagca ggggttgggg aaacagcatc
     3301 tccaagcagc ttagagttgg ccatatttac ctcagcctgg gcgctggtcc tttcttccgg
     3361 cccctcccct ccaaaatgtg cctattgcta gagctcctcc ctctcaacac ccagtttcct
     3421 tgggagttgt cattaaagga aaaaaaaaaa aaaaaaagcc agtgcccagg gatgggcatc
     3481 tccagggagc tggggattag tgccaggcag ccctgccagc catgcctaca tccccatggg
     3541 cacagaacaa gccaaagcct tcgttgtatg ttgacgatgc acttttatga atgtagtttc
     3601 tatcgctgtt tttagccttt tcacatcatg taatgtgagg ccttgtactt gttaatttat
     3661 atctcagatc atatttgatg gtttttatat atatcaattc tagactgtta caggtgacgg
     3721 acgcctcaag agagagaaga gaaaatgaaa gcagctggtt ttgcagaagt gtgtgtcgca
     3781 tgcgccagtt gggcctggac cctcctgtgt ccatccctgt tcccccaggg gctctatcag
     3841 cccctgtacc ccacactgcc ctctgaagac aacacaggct cctgcttcca cctcggccct
     3901 tgcccagggt ggggcctggc cctcatcttg accaaagctg ctgtgtggca gctcggcctc
     3961 tctacgaccc catcttggtg gctgcacact cttcctggcc cgcaccccca tccccagtcc
     4021 ctgttcccca agaggataca gagcacggtg ctggctgact caactgtgcg tcccaggttc
     4081 agggtcttac agagctccac cccctggggt cttacctcac tgggaatgtg ttttgaaaat
     4141 gaatttgaag acaagccaac aaaccctgca ctccaaaaaa gcaaaacaga ccctaatttt
     4201 tttgtgccaa aaactgtgga catgctggct cagcatcctc aggaccaagt tgttgcttaa
     4261 tttattgttt tttaataact aatccagata aaaagttgtg gggcttcagg gtgacctggg
     4321 cccaaaggtt ctgaagggca gttcctggca gccccaggct tgctgtggga aggggccgtg
     4381 ccgtcacttt ctcatcattc catggggtgt gtctgcctgg gccaactctg catggagagg
     4441 ccagggctgg ggacagtccg cactctgcca ccctcctgcc ccttccaccc accccagctc
     4501 tatgtctgtg tctgaattgt ggatcgtgca gccatggtta ttgtggaact gtggaacctg
     4561 cagccatagt tatttgacta tatcttgacc gagggcttgc agtgcaaagc caggccagtg
     4621 ttgcgcatta cttacaataa aagggatcat ttata
//
