LOCUS       NM_025052               5032 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 19
            (MAP3K19), transcript variant 1, mRNA.
ACCESSION   NM_025052 NM_001018043 XM_017005003
VERSION     NM_025052.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5032)
  AUTHORS   Hoang,V.T., Nyswaner,K., Torres-Ayuso,P. and Brognard,J.
  TITLE     The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby
            activates ERK and JNK kinases and increases viability of
            KRAS-mutant lung cancer cells
  JOURNAL   J Biol Chem 295 (25), 8470-8479 (2020)
   PUBMED   32358059
  REMARK    GeneRIF: The protein kinase MAP3K19 phosphorylates MAP2Ks and
            thereby activates ERK and JNK kinases and increases viability of
            KRAS-mutant lung cancer cells.
REFERENCE   2  (bases 1 to 5032)
  AUTHORS   Boehme,S.A., Franz-Bacon,K., Ludka,J., DiTirro,D.N., Ly,T.W. and
            Bacon,K.B.
  TITLE     MAP3K19 Is Overexpressed in COPD and Is a Central Mediator of
            Cigarette Smoke-Induced Pulmonary Inflammation and Lower Airway
            Destruction
  JOURNAL   PLoS One 11 (12), e0167169 (2016)
   PUBMED   27935962
  REMARK    GeneRIF: Mitogen-activated protein kinase kinase kinase 19
            (MAP3K19) is overexpressed in the lungs of chronic obstructive
            pulmonary disease (COPD) patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5032)
  AUTHORS   Boehme,S.A., Franz-Bacon,K., DiTirro,D.N., Ly,T.W. and Bacon,K.B.
  TITLE     MAP3K19 Is a Novel Regulator of TGF-beta Signaling That Impacts
            Bleomycin-Induced Lung Injury and Pulmonary Fibrosis
  JOURNAL   PLoS One 11 (5), e0154874 (2016)
   PUBMED   27144281
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020602.6 and AC016725.5.
            
            On or before Sep 24, 2020 this sequence version replaced
            XM_017005003.1, NM_025052.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            CDS exon combination :: AY574901.1, BC137277.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968968,
                                    SAMEA2144333 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392915.7/ ENSP00000376647.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC020602.6         47130-47392         c
            264-403             AC020602.6         40308-40447         c
            404-592             AC020602.6         30257-30445         c
            593-708             AC020602.6         24571-24686         c
            709-824             AC020602.6         21660-21775         c
            825-921             AC020602.6         5380-5476           c
            922-1000            AC016725.5         162062-162140       c
            1001-1260           AC016725.5         160863-161122       c
            1261-1304           AC016725.5         153662-153705       c
            1305-3758           AC016725.5         147925-150378       c
            3759-3908           AC016725.5         145801-145950       c
            3909-4606           AC016725.5         142946-143643       c
            4607-5032           AC016725.5         126616-127041       c
FEATURES             Location/Qualifiers
     source          1..5032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.3"
     gene            1..5032
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /note="mitogen-activated protein kinase kinase kinase 19"
                     /db_xref="GeneID:80122"
                     /db_xref="HGNC:HGNC:26249"
     exon            1..263
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            264..403
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            404..592
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            593..708
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             687..4673
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulated in COPD kinase; SPS1/STE20-related protein
                     kinase YSK4; regulated in COPD, protein kinase; yeast
                     Sps1/Ste20-related kinase 4; YSK4 Sps1/Ste20-related
                     kinase homolog"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     19 isoform 1"
                     /protein_id="NP_079328.3"
                     /db_xref="CCDS:CCDS2176.2"
                     /db_xref="GeneID:80122"
                     /db_xref="HGNC:HGNC:26249"
                     /translation="MSSMPKPERHAESLLDICHDTNSSPTDLMTVTKNQNIILQSISR
                     SEEFDQDGDCSHSTLVNEEEDPSGGRQDWQPRTEGVEITVTFPRDVSPPQEMSQEDLK
                     EKNLINSSLQEWAQAHAVSHPNEIETVELRKKKLTMRPLVLQKEESSRELCNVNLGFL
                     LPRSCLELNISKSVTREDAPHFLKEQQRKSEEFSTSHMKYSGRSIKFLLPPLSLLPTR
                     SGVLTIPQNHKFPKEKERNIPSLTSFVPKLSVSVRQSDELSPSNEPPGALVKSLMDPT
                     LRSSDGFIWSRNMCSFPKTNHHRQCLEKEENWKSKEIEECNKIEITHFEKGQSLVSFE
                     NLKEGNIPAVREEDIDCHGSKTRKPEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPS
                     KFQETQHSEITPSQDEEMRNNKAASKRVSLHKNEAMEPNNILEECTVLKSLSSVVFDD
                     PIDKLPEGCSSMETNIKISIAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTR
                     KGTIHNNHSVNIPVHQENDKHKMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHK
                     TSIKTQIFPALGLVDPRPWQLPRFQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQ
                     KSCVPLSVQPTEPRLNYLDLKYSDMFKEINSTANGPGIYEMFGTPVYCHVRETERDEN
                     TYYREICSAPSGRRITNKCRSSHSERKSNIRTRLSQKKTHMKCPKTSFGIKQEHKVLI
                     SKEKSSKAVHSNLHDIENGDGISEPDWQIKSSGNEFLSSKDEIHPMNLAQTPEQSMKQ
                     NEFPPVSDLSIVEEVSMEESTGDRDISNNQILTTSLRDLQELEELHHQIPFIPSEDSW
                     AVPSEKNSNKYVQQEKQNTASLSKVNASRILTNDLEFDSVSDHSKTLTNFSFQAKQES
                     ASSQTYQYWVHYLDHDSLANKSITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGC
                     LAAELLALDEKDNNSCQKMANETDPENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGL
                     RIYDREEKFLISNEKKIFSENSLKSEEPILWTKGEILGKGAYGTVYCGLTSQGQLIAV
                     KQVALDTSNKLAAEKEYRKLQEEVDLLKALKHVNIVAYLGTCLQENTVSIFMEFVPGG
                     SISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGIIKLID
                     FGCARRLAWAGLNGTHSDMLKSMHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMAT
                     GKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPSALQLLK
                     HSFLERSH"
     exon            709..824
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            825..921
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1000
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1260
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1304
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..3758
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            3759..3908
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            3909..4606
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     exon            4607..5032
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5015..5020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /note="hexamer: AATAAA"
     polyA_site      5032
                     /gene="MAP3K19"
                     /gene_synonym="RCK; YSK4"
                     /note="major polyA site"
ORIGIN      
        1 agtctatttg cagctaacta aagggtttgt gcatgcagga ccagcttaat taaagacaaa
       61 atttaaaagg aaaaattatt tgggctgtac aacactgaaa aaaaaatctg aatctatgct
      121 gtttttaaat ggatccctgg ttgaagtgtg ggttacagct gtcccagaaa tcagtgccac
      181 aatgaattag gatgatgttg gctactgttt ggcttggtgt ttcttcaact gtgtgccacg
      241 tccctcagca aaacacagca cagaagtggt ttcaagaggt gatgtggaac tcatctgtga
      301 ctatattacc gaagtccaat ccatcctcgg aaaccttgac tttcagcacc cagagacgtg
      361 gaatacgcct ctcattactg cagcagagga aaatctaaca gaggttgttg gatttcttct
      421 ggaaaagtga gtagatatca ccctttgcaa ttacagcaat cgaaccgcaa ttcatgtagc
      481 taattgcaat atccaaagac aactcttggc agtcaataga atccaggctc cccaaatgca
      541 acttctacaa agttcatggc aaggtgatct tgagcaagtt caacatttac tgagatccta
      601 aactttgtga ttttagtgga aaatcagcaa tacattatgt gtcacaaata gagagttcaa
      661 agaaacagca gcttttggac attttaatga gttctatgcc aaaaccagaa agacatgctg
      721 agtcattgct tgacatttgt catgatacaa actcttctcc aactgatttg atgacagtta
      781 ccaaaaatca aaacatcatc ttgcaaagca tcagcagaag tgaggagttc gaccaagatg
      841 gtgactgcag tcattccaca ctggttaatg aagaagaaga tcccagtggt ggtagacagg
      901 actggcaacc caggacagaa ggtgttgaga tcactgtaac ttttccaaga gatgtcagtc
      961 ctccccaaga aatgagccaa gaagacttaa aagaaaagaa tctgataaac tcatcgcttc
     1021 aagaatgggc acaagcacat gcagtttctc atccaaatga aatagaaacg gtggagctca
     1081 ggaaaaagaa gctgaccatg cggcccttag ttttgcaaaa agaggaaagt tccagggagc
     1141 tctgcaatgt gaacttgggc tttttgctac caagatcttg tttagaactg aacatttcca
     1201 agtctgtaac cagagaagat gctcctcatt ttctgaagga gcagcaaaga aaatctgaag
     1261 agttttcgac ctctcatatg aagtacagtg gccgaagcat caagttcctt ctgccaccac
     1321 tgtcactctt gcccacgcga tctggtgtcc ttactatccc ccaaaatcac aagtttccaa
     1381 aagaaaaaga aagaaacatt ccaagtctca catcttttgt gcctaagctc tcagtgtctg
     1441 ttcgtcaatc tgatgagctc agcccatcaa acgagcctcc gggagcccta gttaagtcgt
     1501 tgatggatcc gactctcagg tcttctgatg gcttcatttg gtcaagaaac atgtgctctt
     1561 ttcctaagac taaccatcac aggcaatgcc tggagaagga ggaaaactgg aaatccaagg
     1621 aaatagaaga atgtaacaaa attgaaatca ctcactttga aaaagggcag tctttggtgt
     1681 cttttgagaa tttgaaggaa ggcaatattc ctgcagttag ggaagaggat attgactgcc
     1741 atggtagtaa aacgcgaaaa cctgaagaag agaactctca atatctttca tcaagaaaga
     1801 atgagagttc agtagccaaa aactatgaac aagatccaga aatagtatgt accattccaa
     1861 gcaagttcca agaaacccag cattcagaaa taactccaag ccaggatgaa gagatgagaa
     1921 ataataaagc tgcttcaaaa agagtttcat tacataaaaa tgaagcaatg gaaccaaaca
     1981 atattttaga agagtgtact gtacttaaaa gcttatccag tgtagtcttt gatgacccca
     2041 ttgataaact cccagaaggt tgtagcagca tggagacaaa cataaaaata tcaatagcag
     2101 aaagagccaa accagaaatg agtaggatgg tgcctcttat ccacatcacc ttccctgtgg
     2161 atggaagccc caaggaacca gtgatagcca aaccaagcct ccaaacaaga aagggaacca
     2221 ttcataacaa ccatagtgtc aacatacctg tacaccaaga aaatgacaag cataagatga
     2281 attcccatag gagtaagttg gattcaaaga ccaagacaag taagaagaca cctcagaatt
     2341 ttgtgatttc tactgaaggt cccattaagc ctaccatgca taaaaccagc ataaaaacac
     2401 aaattttccc ggctttggga cttgtggacc ccaggccttg gcaattgccc aggtttcaaa
     2461 agaaaatgcc acagatagca aagaagcaat caactcaccg gactcagaaa cctaaaaagc
     2521 aatcatttcc ttgcatctgt aaaaatccag gaacacagaa gtcatgtgtt cctctctctg
     2581 ttcaaccgac agagccaaga ctaaattacc tagatcttaa gtatagtgat atgttcaaag
     2641 aaatcaattc aactgctaat ggacctggaa tctatgaaat gtttgggacc cctgtttatt
     2701 gtcatgtgcg agagactgaa agggatgaaa acacgtatta ccgtgagata tgttcggctc
     2761 catcaggcag acgtatcacc aataaatgtc gatcttcaca cagtgagagg aagagcaata
     2821 tcagaacaag actttctcag aaaaaaacac atatgaaatg cccaaagact tcatttggca
     2881 ttaaacaaga gcacaaagtc ttaatttcta aagaaaagag ttccaaggct gtacatagca
     2941 acctacatga cattgaaaat ggtgatggta tttcagaacc agactggcag ataaagtctt
     3001 caggaaatga gtttctatct tccaaagatg aaattcatcc catgaacttg gctcagacac
     3061 ctgagcagtc catgaaacag aatgaattcc ctcctgtctc agatttatcc attgttgaag
     3121 aagtttctat ggaagagtct actggtgata gagacatttc taacaatcaa atactcacca
     3181 caagcctcag agatctgcaa gaacttgaag agctacatca ccagatccca tttatccctt
     3241 cagaagacag ctgggcagtg cccagtgaga agaattctaa caagtatgta cagcaagaaa
     3301 agcagaatac agcatctctt agtaaagtaa atgccagccg aattttaact aatgatctag
     3361 agtttgatag tgtttcagat cactctaaaa cacttacaaa tttctctttc caagcaaaac
     3421 aagaaagtgc atcttcccag acatatcaat attgggtaca ttatttggat catgatagtt
     3481 tagcaaataa gtcaatcaca tatcaaatgt ttggaaaaac cttaagtggc acaaattcaa
     3541 tttcccaaga aattatggac tctgtaaata atgaagaatt gacagatgaa ctattaggtt
     3601 gtctagctgc agaattatta gctcttgatg agaaagataa caactcttgc caaaaaatgg
     3661 caaatgaaac agatcctgaa aacctaaatc ttgtcctcag atggagagga agtaccccaa
     3721 aagaaatggg cagagagaca acaaaagtca aaatacagag gcatagtagt gggctcagga
     3781 tatatgacag ggaggagaaa tttctcatct caaatgaaaa gaagatattt tctgaaaata
     3841 gtttaaagtc tgaagaacct atcctatgga ccaagggtga gattcttgga aagggagcct
     3901 acggcacagt atactgtggt ctcactagtc aaggacagct aatagctgta aaacaggtgg
     3961 ctttggatac ctctaataaa ttagctgctg aaaaggaata ccggaaacta caggaagaag
     4021 tagatttgct caaagcactg aaacatgtca acattgtggc ctatttgggg acatgcttgc
     4081 aagagaacac tgtgagcatt ttcatggagt ttgttcctgg tggctcaatc tctagtatta
     4141 taaaccgttt tgggccattg cctgagatgg tgttctgtaa atatacgaaa caaatacttc
     4201 aaggtgttgc ttatctccat gagaactgtg tggtacatcg cgatatcaaa ggaaataatg
     4261 ttatgctcat gccaactgga ataataaagc tgattgactt tggctgtgcc aggcgtttgg
     4321 cctgggcagg tttaaatggc acccacagtg acatgcttaa gtccatgcat gggactccat
     4381 attggatggc cccagaagtc atcaatgagt ctggctatgg acggaaatca gatatctgga
     4441 gcattggttg tactgtgttt gagatggcta cagggaagcc tccactggct tccatggaca
     4501 ggatggccgc catgttttac atcggagcac accgagggct gatgcctcct ttaccagacc
     4561 acttctcaga aaatgcagca gactttgtgc gcatgtgcct gaccagggac cagcatgagc
     4621 gaccttctgc tctccagctc ctgaagcact ccttcttgga gagaagtcac tgaatataca
     4681 tcaagacttt cttcccagtt ccactgcaga tgctcccttg cttaattgtg gggaatgatg
     4741 gctaagggat ctttgtttcc ccactgaaaa ttcagtctaa cccagtttaa gcagatccta
     4801 tggagtcatt aactgaaagt tgcagttaca tattagcctc ctcaagtgtc agacattatt
     4861 actcatagta tcagaaaaca tgttcttaat aacaacaaaa aactatttca gtgtttacag
     4921 ttttgattgt ccaggaacta cattctctat tgttttatat gacatttctt tttatttttg
     4981 gcctgtcctg tcaattttaa tgttgttagt ttaaaataaa ttgtaaaaac aa
//
