LOCUS       NM_003954               4442 bp    mRNA    linear   PRI 22-FEB-2025
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 14
            (MAP3K14), mRNA.
ACCESSION   NM_003954
VERSION     NM_003954.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4442)
  AUTHORS   Pflug,K.M., Lee,D.W., McFadden,K., Herrera,L. and Sitcheran,R.
  TITLE     Transcriptional induction of NF-kappaB-inducing kinase by E2F4/5
            facilitates collective invasion of GBM cells
  JOURNAL   Sci Rep 13 (1), 13093 (2023)
   PUBMED   37567906
  REMARK    GeneRIF: Transcriptional induction of NF-kappaB-inducing kinase by
            E2F4/5 facilitates collective invasion of GBM cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4442)
  AUTHORS   Bilgic,S.N., Domaniku,A., Toledo,B., Agca,S., Weber,B.Z.C.,
            Arabaci,D.H., Ozornek,Z., Lause,P., Thissen,J.P., Loumaye,A. and
            Kir,S.
  TITLE     EDA2R-NIK signalling promotes muscle atrophy linked to cancer
            cachexia
  JOURNAL   Nature 617 (7962), 827-834 (2023)
   PUBMED   37165186
  REMARK    GeneRIF: EDA2R-NIK signalling promotes muscle atrophy linked to
            cancer cachexia.
REFERENCE   3  (bases 1 to 4442)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 4442)
  AUTHORS   Vesting,A.J., Jais,A., Klemm,P., Steuernagel,L., Wienand,P.,
            Fog-Tonnesen,M., Hvid,H., Schumacher,A.L., Kukat,C., Nolte,H.,
            Georgomanolis,T., Altmuller,J., Pasparakis,M., Schmidt,A.,
            Kruger,M., Supprian,M.S., Waisman,A., Straub,B.K., Raschzok,N.,
            Bernier,M., Birkenfeld,A.L., Hovelmeyer,N., Bruning,J.C. and
            Wunderlich,F.T.
  TITLE     NIK/MAP3K14 in hepatocytes orchestrates NASH to hepatocellular
            carcinoma progression via JAK2/STAT5 inhibition
  JOURNAL   Mol Metab 66, 101626 (2022)
   PUBMED   36356831
  REMARK    GeneRIF: NIK/MAP3K14 in hepatocytes orchestrates NASH to
            hepatocellular carcinoma progression via JAK2/STAT5 inhibition.
REFERENCE   5  (bases 1 to 4442)
  AUTHORS   Zhao,Y.X., Mei,H., Huang,Y.X. and Chen,J.Q.
  TITLE     Impairment of a NIK-SIX Feedback Axis Results in Dysregulation of
            Intestinal Immune Homeostasis and Promotes Early-onset Fatal
            Spontaneous Colitis
  JOURNAL   Iran J Immunol 19 (3), 263-277 (2022)
   PUBMED   36190381
  REMARK    GeneRIF: Impairment of a NIK-SIX Feedback Axis Results in
            Dysregulation of Intestinal Immune Homeostasis and Promotes
            Early-onset Fatal Spontaneous Colitis.
REFERENCE   6  (bases 1 to 4442)
  AUTHORS   Ling,L., Cao,Z. and Goeddel,D.V.
  TITLE     NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of
            Ser-176
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3792-3797 (1998)
   PUBMED   9520446
REFERENCE   7  (bases 1 to 4442)
  AUTHORS   Woronicz,J.D., Gao,X., Cao,Z., Rothe,M. and Goeddel,D.V.
  TITLE     IkappaB kinase-beta: NF-kappaB activation and complex formation
            with IkappaB kinase-alpha and NIK
  JOURNAL   Science 278 (5339), 866-869 (1997)
   PUBMED   9346485
REFERENCE   8  (bases 1 to 4442)
  AUTHORS   Song,H.Y., Regnier,C.H., Kirschning,C.J., Goeddel,D.V. and Rothe,M.
  TITLE     Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation
            of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK)
            pathways at TNF receptor-associated factor 2
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9792-9796 (1997)
   PUBMED   9275204
REFERENCE   9  (bases 1 to 4442)
  AUTHORS   Regnier,C.H., Song,H.Y., Gao,X., Goeddel,D.V., Cao,Z. and Rothe,M.
  TITLE     Identification and characterization of an IkappaB kinase
  JOURNAL   Cell 90 (2), 373-383 (1997)
   PUBMED   9244310
REFERENCE   10 (bases 1 to 4442)
  AUTHORS   Malinin,N.L., Boldin,M.P., Kovalenko,A.V. and Wallach,D.
  TITLE     MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95
            and IL-1
  JOURNAL   Nature 385 (6616), 540-544 (1997)
   PUBMED   9020361
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK290203.1, Y10256.1,
            CR749592.1 and HY287427.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 29, 2018 this sequence version replaced NM_003954.4.
            
            Summary: This gene encodes mitogen-activated protein kinase kinase
            kinase 14, which is a serine/threonine protein-kinase. This kinase
            binds to TRAF2 and stimulates NF-kappaB activity. It shares
            sequence similarity with several other MAPKK kinases. It
            participates in an NF-kappaB-inducing signalling cascade common to
            receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF)
            family and to the interleukin-1 type-I receptor. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035576.1, SRR18074969.103597.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344686.8/ ENSP00000478552.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2718              AK290203.1         21-2738
            2719-2960           Y10256.1           2870-3111
            2961-4433           CR749592.1         2434-3906
            4434-4442           HY287427.1         26-34               c
FEATURES             Location/Qualifiers
     source          1..4442
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4442
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /note="mitogen-activated protein kinase kinase kinase 14"
                     /db_xref="GeneID:9020"
                     /db_xref="HGNC:HGNC:6853"
                     /db_xref="MIM:604655"
     exon            1..61
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            62..337
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2925
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /EC_number="2.7.11.25"
                     /note="NF-kappa-beta-inducing kinase;
                     serine/threonine-protein kinase NIK"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     14"
                     /protein_id="NP_003945.2"
                     /db_xref="CCDS:CCDS74079.1"
                     /db_xref="GeneID:9020"
                     /db_xref="HGNC:HGNC:6853"
                     /db_xref="MIM:604655"
                     /translation="MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEA
                     VEKSPVFCGKWEILNDVITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFI
                     AGSKQYSQSESLDQIPNNVAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVA
                     LAKPLPRTPEQESCTIPVQEDESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLR
                     PALPRSELHKLISPLQCLNHVWKLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWK
                     PHPLESFLGKLACVDSQKPLPDPHLSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVE
                     EYLVHALQGSVSSGQAHSLTSLAKTWAARGSRSREPSPKTEDNEGVLLTEKLKPVDYE
                     YREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSP
                     RIVPLYGAVREGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHS
                     RRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKSLLTGDYIPGTETHMAPE
                     VVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAP
                     LTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPRHPPPNQANY
                     HQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPEPPEPNKSPPLTLSKEESGMW
                     EPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLNSLSQPFSLEEQEQILSCL
                     SIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSSSWNMVLARGRPTDTPS
                     YFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFSLVTKDGQPVRYDME
                     VPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP"
     exon            338..407
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            408..618
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            619..1233
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1371
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1501
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1633
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1738
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1902
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2053
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2407
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2514
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2659
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2760
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..4442
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4406..4411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /note="hexamer: AATAAA"
     polyA_site      4433
                     /gene="MAP3K14"
                     /gene_synonym="FTDCR1B; HS; HSNIK; IMD112; NIK"
                     /note="major polyA site"
ORIGIN      
        1 gggagatcgc gggcgagcgg agcgcaacac tcgcttggtt ggggagatcg gcgcttggcc
       61 ggatgagcac aagcctggga gatggcagtg atggaaatgg cctgcccagg tgcccctggc
      121 tcagcagtgg ggcagcagaa ggaactcccc aaagccaagg agaagacgcc gccactgggg
      181 aagaaacaga gctccgtcta caagcttgag gccgtggaga agagccctgt gttctgcgga
      241 aagtgggaga tcctgaatga cgtgattacc aagggcacag ccaaggaagg ctccgaggca
      301 gggccagctg ccatctctat catcgcccag gctgagtgtg agaatagcca agagttcagc
      361 cccacctttt cagaacgcat tttcatcgct gggtccaaac agtacagcca gtccgagagt
      421 cttgatcaga tccccaacaa tgtggcccat gctacagagg gcaaaatggc ccgtgtgtgt
      481 tggaagggaa agcgtcgcag caaagcccgg aagaaacgga agaagaagag ctcaaagtcc
      541 ctggctcatg caggagtggc cttggccaaa cccctcccca ggacccctga gcaggagagc
      601 tgcaccatcc cagtgcagga ggatgagtct ccactcggcg ccccatatgt tagaaacacc
      661 ccgcagttca ccaagcctct gaaggaacca ggccttgggc aactctgttt taagcagctt
      721 ggcgagggcc tacggccggc tctgcctcga tcagaactcc acaaactgat cagccccttg
      781 caatgtctga accacgtgtg gaaactgcac cacccccagg acggaggccc cctgcccctg
      841 cccacgcacc ccttccccta tagcagactg cctcatccct tcccattcca ccctctccag
      901 ccctggaaac ctcaccctct ggagtccttc ctgggcaaac tggcctgtgt agacagccag
      961 aaacccttgc ctgacccaca cctgagcaaa ctggcctgtg tagacagtcc aaagcccctg
     1021 cctggcccac acctggagcc cagctgcctg tctcgtggtg cccatgagaa gttttctgtg
     1081 gaggaatacc tagtgcatgc tctgcaaggc agcgtgagct caggccaggc ccacagcctg
     1141 accagcctgg ccaagacctg ggcagcaagg ggctccagat cccgggagcc cagccccaaa
     1201 actgaggaca acgagggtgt cctgctcact gagaaactca agccagtgga ttatgagtac
     1261 cgagaagaag tccactgggc cacgcaccag ctccgcctgg gcagaggctc cttcggagag
     1321 gtgcacagga tggaggacaa gcagactggc ttccagtgcg ctgtcaaaaa ggtgcggctg
     1381 gaagtatttc gggcagagga gctgatggca tgtgcaggat tgacctcacc cagaattgtc
     1441 cctttgtatg gagctgtgag agaagggcct tgggtcaaca tcttcatgga gctgctggaa
     1501 ggtggctccc tgggccagct ggtcaaggag cagggctgtc tcccagagga ccgggccctg
     1561 tactacctgg gccaggccct ggagggtctg gaatacctcc actcacgaag gattctgcat
     1621 ggggacgtca aagctgacaa cgtgctcctg tccagcgatg ggagccacgc agccctctgt
     1681 gactttggcc atgctgtgtg tcttcaacct gatggcctgg gaaagtcctt gctcacaggg
     1741 gactacatcc ctggcacaga gacccacatg gctccggagg tggtgctggg caggagctgc
     1801 gacgccaagg tggatgtctg gagcagctgc tgtatgatgc tgcacatgct caacggctgc
     1861 cacccctgga ctcagttctt ccgagggccg ctctgcctca agattgccag cgagcctccg
     1921 cctgtgaggg agatcccacc ctcctgcgcc cctctcacag cccaggccat ccaagagggg
     1981 ctgaggaaag agcccatcca ccgcgtgtct gcagcggagc tgggagggaa ggtgaaccgg
     2041 gcactacagc aagtgggagg tctgaagagc ccttggaggg gagaatataa agaaccaaga
     2101 catccaccgc caaatcaagc caattaccac cagaccctcc atgcccagcc gagagagctt
     2161 tcgccaaggg ccccagggcc ccggccagct gaggagacaa caggcagagc ccctaagctc
     2221 cagcctcctc tcccaccaga gcccccagag ccaaacaagt ctcctccctt gactttgagc
     2281 aaggaggagt ctgggatgtg ggaaccctta cctctgtcct ccctggagcc agcccctgcc
     2341 agaaacccca gctcaccaga gcggaaagca accgtcccgg agcaggaact gcagcagctg
     2401 gaaatagaat tattcctcaa cagcctgtcc cagccatttt ctctggagga gcaggagcaa
     2461 attctctcgt gcctcagcat cgacagcctc tccctgtcgg atgacagtga gaagaaccca
     2521 tcaaaggcct ctcaaagctc gcgggacacc ctgagctcag gcgtacactc ctggagcagc
     2581 caggccgagg ctcgaagctc cagctggaac atggtgctgg cccgggggcg gcccaccgac
     2641 accccaagct atttcaatgg tgtgaaagtc caaatacagt ctcttaatgg tgaacacctg
     2701 cacatccggg agttccaccg ggtcaaagtg ggagacatcg ccactggcat cagcagccag
     2761 atcccagctg cagccttcag cttggtcacc aaagacgggc agcctgttcg ctacgacatg
     2821 gaggtgccag actcgggcat cgacctgcag tgcacactgg cccctgatgg cagcttcgcc
     2881 tggagctgga gggtcaagca tggccagctg gagaacaggc cctaaccctg ccctccaccg
     2941 ccggctccac actgccggaa gcagccttcc tgctcggtgc acgatgctgc cctgaaacac
     3001 aggctcagcc gttcccaggg atctgccagc ccccggctca gcagtgggac cagggcctcg
     3061 cagcagcaag gtgggggcaa gcagaatgcc tcccaggatt tcacacctga gccctgcccc
     3121 accctgctga gaaaacactc cgccacgtga agagacagag gaggatggca ggagttacct
     3181 cgggaaacaa acaggatctt ctctgccctg ctccagtcga gttggcctga cccgcttgga
     3241 tcagtgacca tttgctggca gacaggggag agcagcttcc agcctgggtc agaaggggtg
     3301 ggcgagcccc tcggcccctc accctccagg ctgctgtgag agtgtcaagt gtgtaagggc
     3361 ccaaactcag gttcagtgca gaaccaggtc agcaggtatg cccgcccgta ggttaagggg
     3421 gccctctaaa ccccttgcct ggcctcacct ggccagctca ccccttttgg gtgtagggga
     3481 aaagaatgcc tgaccctggg aaggctccct ggtagaatac accacacttt tcaggttgtt
     3541 gcaacacagg tcctgagttg acctctggtt cagccaagga ccaaagaagg tgtgtaagtg
     3601 aagtggttct cagtccccag acatgtgccc ctttgctgct ggctaccact cttccccaga
     3661 gcagcaggcc ccgagcccct tcaggcccag cactgcccca gactcgctgg cactcagttc
     3721 cctcatctgt aaaggtgaag ggtgatgcag gatatgcctg acaggaacag tctgtggatg
     3781 gacatgatca gtgctaagga aagcagcaga gagagacgct ccggcgcccc agccccacta
     3841 tcagtgtcca gcgtgctggt tccccagagc acagctcagc atcacactga cactcaccct
     3901 gccctgcccc tggccagagg gtactgccga cggcactttg cactctgatg acctcaaagc
     3961 actttcatgg ctgccctctg gcagggcagg gcagggcagt gacactgtag gagcatagca
     4021 agccaggaga tggggtgaag ggacacagtc ttgagctgtc cacatgcatg tgactcctca
     4081 aacctcttcc agatttctct aagaatagca cccccttccc cattgcccca gcttagcctc
     4141 ttctcccagg ggagctactc aggactcacg tagcattaaa tcagctgtga atcgtcaggg
     4201 ggtgtctgct agcctcaacc tcctggggca ggggacgccg agactccgtg ggagaagctc
     4261 attcccacat cttgccaaga cagcctttgt ccagctgtcc acattgagtc agactgctcc
     4321 cggggagaga gccccggccc ccagcacata aagaactgca gccttggtac tgcagagtct
     4381 gggttgtaga gaactctttg taagcaataa agtttggggt gatgacaaat gtttccaggc
     4441 ca
//
