LOCUS       NM_001242314            9810 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 13
            (MAP3K13), transcript variant 2, mRNA.
ACCESSION   NM_001242314
VERSION     NM_001242314.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9810)
  AUTHORS   Liu,Z., Zhou,X., Zheng,P., Bu,C., Yan,X., Yu,H. and Xu,Y.
  TITLE     Clinical significance of mitogen-activated protein kinase kinase
            kinases in hepatitis B virus -related hepatocellular carcinoma and
            underlying mechanism exploration
  JOURNAL   Bioengineered 13 (3), 6819-6838 (2022)
   PUBMED   35311629
  REMARK    GeneRIF: Clinical significance of mitogen-activated protein kinase
            kinase kinases in hepatitis B virus -related hepatocellular
            carcinoma and underlying mechanism exploration.
REFERENCE   2  (bases 1 to 9810)
  AUTHORS   Zhang,Q., Li,X., Cui,K., Liu,C., Wu,M., Prochownik,E.V. and Li,Y.
  TITLE     The MAP3K13-TRIM25-FBXW7alpha axis affects c-Myc protein stability
            and tumor development
  JOURNAL   Cell Death Differ 27 (2), 420-433 (2020)
   PUBMED   31186535
  REMARK    GeneRIF: The MAP3K13-TRIM25-FBXW7alpha axis affects c-Myc protein
            stability and tumor development.
REFERENCE   3  (bases 1 to 9810)
  AUTHORS   Welsbie,D.S., Mitchell,K.L., Jaskula-Ranga,V., Sluch,V.M., Yang,Z.,
            Kim,J., Buehler,E., Patel,A., Martin,S.E., Zhang,P.W., Ge,Y.,
            Duan,Y., Fuller,J., Kim,B.J., Hamed,E., Chamling,X., Lei,L.,
            Fraser,I.D.C., Ronai,Z.A., Berlinicke,C.A. and Zack,D.J.
  TITLE     Enhanced Functional Genomic Screening Identifies Novel Mediators of
            Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons
  JOURNAL   Neuron 94 (6), 1142-1154 (2017)
   PUBMED   28641113
  REMARK    GeneRIF: LZK cooperates with DLK to promote retinal ganglion cell
            death in response to axon injury.
REFERENCE   4  (bases 1 to 9810)
  AUTHORS   Han,H., Chen,Y., Cheng,L., Prochownik,E.V. and Li,Y.
  TITLE     microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal
            manner by directly inhibiting MAP3K13
  JOURNAL   Oncotarget 7 (13), 16409-16419 (2016)
   PUBMED   26918941
  REMARK    GeneRIF: Data indicate that miR-206's effect on Myc was mediated
            through MAP3K13.
REFERENCE   5  (bases 1 to 9810)
  AUTHORS   Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
            Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
            Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
            Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
            Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
            Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
            Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
            Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
            Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
            Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
            Rotter,J.I., Soler Artigas,M., Starr,J.M., Uitterlinden,A.G.,
            Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
            Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
            Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
            Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
            and Stricker,B.H.
  TITLE     Genome-wide association studies identify CHRNA5/3 and HTR4 in the
            development of airflow obstruction
  JOURNAL   Am J Respir Crit Care Med 186 (7), 622-632 (2012)
   PUBMED   22837378
REFERENCE   6  (bases 1 to 9810)
  AUTHORS   Ikeda,A., Sakuma,H., Masaki,M., Kozutsumi,Y., Oka,S., Inazawa,J.
            and Kawasaki,T.
  TITLE     Genomic organization and fine-mapping of the human leucine
            zipper-bearing kinase (LZK) gene
  JOURNAL   J Biochem Mol Biol Biophys 6 (2), 113-117 (2002)
   PUBMED   12186766
  REMARK    GeneRIF: Chromosomal localization studies involving FISH mapping
            demonstrated that the human LZK gene is located at 3q27.
REFERENCE   7  (bases 1 to 9810)
  AUTHORS   Ikeda,A., Hasegawa,K., Masaki,M., Moriguchi,T., Nishida,E.,
            Kozutsumi,Y., Oka,S. and Kawasaki,T.
  TITLE     Mixed lineage kinase LZK forms a functional signaling complex with
            JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase
            pathway
  JOURNAL   J Biochem 130 (6), 773-781 (2001)
   PUBMED   11726277
REFERENCE   8  (bases 1 to 9810)
  AUTHORS   Ikeda,A., Masaki,M., Kozutsumi,Y., Oka,S. and Kawasaki,T.
  TITLE     Identification and characterization of functional domains in a
            mixed lineage kinase LZK
  JOURNAL   FEBS Lett 488 (3), 190-195 (2001)
   PUBMED   11163770
REFERENCE   9  (bases 1 to 9810)
  AUTHORS   Sakuma,H., Ikeda,A., Oka,S., Kozutsumi,Y., Zanetta,J.P. and
            Kawasaki,T.
  TITLE     Molecular cloning and functional expression of a cDNA encoding a
            new member of mixed lineage protein kinase from human brain
  JOURNAL   J Biol Chem 272 (45), 28622-28629 (1997)
   PUBMED   9353328
REFERENCE   10 (bases 1 to 9810)
  AUTHORS   Schultz,S.J. and Nigg,E.A.
  TITLE     Identification of 21 novel human protein kinases, including 3
            members of a family related to the cell cycle regulator nimA of
            Aspergillus nidulans
  JOURNAL   Cell Growth Differ 4 (10), 821-830 (1993)
   PUBMED   8274451
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ432918.1, AK312714.1 and
            AC099661.11.
            
            On May 31, 2019 this sequence version replaced NM_001242314.1.
            
            Summary: The protein encoded by this gene is a member of
            serine/threonine protein kinase family. This kinase contains a dual
            leucine-zipper motif, and has been shown to form dimers/oligomers
            through its leucine-zipper motif. This kinase can phosphorylate and
            activate MAPK8/JNK, MAP2K7/MKK7, which suggests a role in the JNK
            signaling pathway. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BQ432918.1         24-39
            17-3172             AK312714.1         2-3157
            3173-9810           AC099661.11        70713-77350
FEATURES             Location/Qualifiers
     source          1..9810
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..9810
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /note="mitogen-activated protein kinase kinase kinase 13"
                     /db_xref="GeneID:9175"
                     /db_xref="HGNC:HGNC:6852"
                     /db_xref="MIM:604915"
     exon            1..67
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            68..186
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            187..746
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..3172
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /EC_number="2.7.11.25"
                     /note="isoform 1 is encoded by transcript variant 2;
                     leucine zipper-bearing kinase; mixed lineage kinase"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     13 isoform 1"
                     /protein_id="NP_001229243.1"
                     /db_xref="CCDS:CCDS3270.1"
                     /db_xref="GeneID:9175"
                     /db_xref="HGNC:HGNC:6852"
                     /db_xref="MIM:604915"
                     /translation="MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLE
                     DQQEKGMVRTELIESVHSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNS
                     NTVDGESTSGTEDIKIQFSRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDT
                     WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIA
                     FKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKII
                     HRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKV
                     DIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQS
                     KPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRL
                     DEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVE
                     KKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTA
                     SPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQA
                     QSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSP
                     LSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQY
                     GSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTP
                     PALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVS
                     DGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVR
                     RVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKHYSSATW"
     exon            747..930
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1122
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1281
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1440
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1549
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1659
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1776
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1914
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2701
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2772
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..3070
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..9810
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5856..5861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /note="hexamer: AATAAA"
     polyA_site      5888
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
     regulatory      9789..9794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /note="hexamer: ATTAAA"
     polyA_site      9810
                     /gene="MAP3K13"
                     /gene_synonym="LZK; MEKK13; MLK"
                     /note="major polyA site"
ORIGIN      
        1 gtggagggtg acgccatggg tggggcggag cgtctgggat gcgctgggag cctaggatcc
       61 ccgacagaac actgaaatct atggactcta aaatggactt catttaaaga aacccacgga
      121 ccattaatgg acaaaaacat gagtcaatat gtattgtggc attcaaatcc tagcactctg
      181 ggagaggttt tggagccctc tcttaagtca gaactctgtc ccaaaaatct tctgagtgtc
      241 atctcaggac tttggttata ctcatggcac gatggccaac tttcaggagc acctgagctg
      301 ctcctcttct ccacacttac ccttcagtga aagcaaaacc ttcaatggac tacaagatga
      361 gctcacagct atggggaacc acccttctcc caagctgctc gaggaccagc aggaaaaggg
      421 gatggtacga acagagctaa tcgagagcgt gcacagcccc gtcaccacaa cagtgttgac
      481 gagcgtaagt gaggattcca gggaccagtt tgagaacagc gttcttcagc taagggaaca
      541 cgatgaatca gagacggcgg tgtctcaggg gaacagcaac acggtggacg gagagagcac
      601 aagcggaact gaagacataa agattcagtt cagcaggtca ggcagtggca gtggtgggtt
      661 tcttgaagga ctatttggat gcttaaggcc tgtatggaat atcattggga aggcatattc
      721 cactgattac aaattgcagc agcaagatac ttgggaagtg ccatttgagg agatctcaga
      781 gctgcagtgg ctgggtagtg gagcccaagg agcggtcttc ttgggcaagt tccgggcgga
      841 agaggtggcc atcaagaaag tgagagaaca gaatgagacg gatatcaagc atttgaggaa
      901 gttgaagcac cctaacatca tcgcattcaa gggtgtttgt actcaggccc catgttattg
      961 tattatcatg gaatactgtg cccatggaca actctacgag gtcttacgag ctggcaggaa
     1021 gatcacacct cgattgctag tagactggtc cacaggaatt gcaagtggaa tgaattattt
     1081 gcacctccat aaaattattc atcgtgatct caaatcacct aatgttttag tgacccacac
     1141 agatgcggta aaaatttcag attttggtac atctaaggaa ctcagtgaca aaagtaccaa
     1201 gatgtcattt gctggcacgg tcgcatggat ggcgccagag gtgatacgga atgaacctgt
     1261 ctctgaaaaa gttgatatat ggtcttttgg agtggtgctt tgggagctgc tgacaggaga
     1321 gatcccttac aaagatgtag attcttcagc cattatctgg ggtgttggaa gcaacagcct
     1381 ccaccttcca gttccttcca cttgccctga tggattcaaa atccttatga aacagacgtg
     1441 gcagagtaaa cctcgaaacc gaccttcttt tcggcagaca ctcatgcatt tagacattgc
     1501 ctctgcagat gtacttgcca ccccacaaga aacttacttc aagtctcagg ctgaatggag
     1561 agaagaagtg aaaaaacatt ttgagaagat caaaagtgaa ggaacttgta tacaccggtt
     1621 agatgaagaa ctgattcgaa ggcgcagaga agagctcagg catgcgctgg atattcgtga
     1681 acactatgag cggaagcttg agcgggcgaa taatttatac atggaattga gtgccatcat
     1741 gctgcagcta gaaatgcggg agaaggagct cattaagcgt gagcaagcag tggaaaagaa
     1801 gtatcctggg acctacaaac gacaccctgt tcgtcctatc atccatccca atgccatgga
     1861 gaaactcatg aaaaggaaag gagtgcctca caaatctggg atgcagacca aacggccaga
     1921 cttgttgaga tcagaaggga tccccaccac agaagtggct cccactgcat cccctttgtc
     1981 cggaagtccc aaaatgtcca cttctagcag caagagccga tatcgaagca aaccacgcca
     2041 ccgccgaggg aatagcagag gcagccatag tgactttgcc gcaatcttga aaaaccagcc
     2101 agcccaggaa aattcacccc atcccactta cctgcaccaa gctcaatccc aatacccttc
     2161 tcttcatcac cataattctc tgcagcagca ataccagcag ccccctcctg ccatgtccca
     2221 gagtcaccat cccagactca atatgcacgg acaggacata gcaacctgcg ccaacaacct
     2281 gaggtatttc ggcccagcag cagccctgcg gagcccactc agcaaccatg ctcagagaca
     2341 gctgcccggc tcgagccctg acctcatctc cacagccatg gctgcagact gctggagaag
     2401 ttctgagcct gacaagggcc aagctggtcc ctggggctgt tgccaggctg acgcttatga
     2461 cccctgcctt cagtgcaggc cagaacagta tgggtcctta gacataccct ctgctgagcc
     2521 agtggggagg agccctgacc tttccaagtc accagcacat aatcctctct tggaaaacgc
     2581 ccagagttct gagaaaacgg aagaaaatga attcagcggc tgtaggtctg agtcatccct
     2641 cggcacctct catctcggca cccctccagc gctacctcga aaaacaaggc ctctgcagaa
     2701 gagtggagat gactcctcag aagaggaaga aggggaagta gatagtgaag ttgaatttcc
     2761 acgaagacag aggccccatc gctgtatcag cagctgccag tcatattcaa cctttagctc
     2821 tgagaatttc tctgtgtctg atggagaaga gggaaatacc agtgaccact caaacagtcc
     2881 tgatgagtta gctgataaac ttgaagaccg cttggcagag aagctagacg acctgctgtc
     2941 ccagacgcca gagattccca ttgacatatc ctcacactcg gatgggctct ctgacaagga
     3001 gtgtgccgtg cgccgtgtga agactcagat gtctctgggc aagctgtgtg tggaggaacg
     3061 tggctatgag aaccccatgc agtttgaaga atcggactgt gactcttcag atggggagtg
     3121 ttctgatgcc acagttagga ccaataaaca ctacagctct gctacctggt aatgaaggaa
     3181 tacacatcct gaagatctcg tgactatact ggcatttcag atccacccca cccccagact
     3241 catcccactc tctcccagca ttttgtctgg gaagagagac taccccatct ttaccacccc
     3301 ctagaaatga gctgcaataa caggaacatg agacttcgca aatctctgga aaataatatc
     3361 caaatgaaat taagtctcac tgaacatttc aatcaagaat ggcagggatc tattttattg
     3421 aatattctag ctactgtaac attgatattt atttttgttt gacattttaa cactttgtac
     3481 tgcaaagagt gaactatata tgagatagag agacaataat ttcttgcaaa aaaaaaaaga
     3541 gataaaagaa agaacagaaa aaaagaaata agtggaattt aagagcaaca tccttgggaa
     3601 tttgtggggc cgggaggtat tattgctgct tgaacagggg accaggtctt ttggccataa
     3661 gtgactaaag aagagccaga gcaagacatt gaacatttta gaacacaaag aacagcaaaa
     3721 gaaaagcaat tccaggcaac ttgtgaacag accatattca cttcaaccag cttgtccagg
     3781 tggcttacgg aaatgaccta gaaaagtctg gtgaccagat acttgcaccc aatgtcttca
     3841 agggcatgtg cttcctctag gagggaaaaa cagacaaaca aacaaacaaa caaacctgtg
     3901 tatgtggaag ctggtttcat ttttaaatgt ttaagcagca gttggtagtg aggtttacag
     3961 atagtgtcaa atcttgtttt tggcaaatac gtcccttttt agtgctgtca ctgtcattac
     4021 cttggcaaat gtgctacctt gacccaacgt gttgatcttt catactcaag tgccatttcc
     4081 ttgtagctca tttcctttct gcctgctgac cacttcctgt aggaacaaag gttggggggc
     4141 agtactgagg aggagaaaag ggtgagagag gaagaacatc tacagtggtg ttaggaaaac
     4201 gaacgtggaa tttataaaac tccattctca ggatcactca gttcagctac gaggagaaga
     4261 tggaaccacc cctctctgga gccaggttgc ttgtctactt gagtcatatt gattcaagca
     4321 ggagaacaga ctttgaaggc agctaggatg tatgtgtgtc tatacaatgt ctgagcccaa
     4381 accatccctt tgtttttatt caataactca ttctatctta gaagttcttt tttttttttt
     4441 tttttttgac agagttttgc tctttttgcc caggctagag tgcaatggca caatctcagt
     4501 tcactgcaac ctccatctcc caggttcaag cgattctcct gcctcagcct cccgagtagc
     4561 tgggattaca ggcgcccgca accacgcctg gctaattttg tatttttagt agacacgggg
     4621 tttcaccatg ttggccaggc ttgtctcaaa ctcctgacct caggtgatcc gcctgcctcg
     4681 gcctcccaaa gtgctgggat tacaggcatc agccactgtg cccggcctat cttagaagtc
     4741 ttaatgactg gctaccactg tcagaataaa agcaaaaaca agcagcttgc aaaaggcaac
     4801 tcctctccca gcacaatagc atttttgttc aatgctactt gtaaaatatc ttttacttca
     4861 ctccaaatca atgcagtttt aaataactgg atttgaacat ttgtggaaag aacaagggat
     4921 gctgagcagg gataggaagg atttttacat tgccaaaagc atgaggtcct gcctgtctcc
     4981 agggtcatgg gctctgaaaa gcattccaag gtacttcatg gtgccttggc cttaaggaaa
     5041 aattttttta gaattttatg tacaaatagg tgttgaccta gtacctgtcc ctgtctccaa
     5101 gacagattac cgtcaaacaa cctctctaga ttcactggac tctttgacac tgcatcatgt
     5161 tggacgttag gaaatacttg cacagacagc tgttaaacca tttccaatgc acatgaaaat
     5221 gttgccgctc ctctgggttt tactgattgc atcagccaaa aaggaaaggc aggagggaat
     5281 ttagagttcc ttttgcttgt ttgatccatt tgtttacact ttatgttgat acattgattt
     5341 aaaatgtagt gtctgtgatt tatagctctt aggatgaagg aaaatgttta atttatacaa
     5401 agagcagtat tgtttgcatt aatttattcc attttgtaaa aattctgtag ctggactaca
     5461 tgaaagatct taagttatgg cattattatc attgttattt tattttataa tattatcatt
     5521 ctcattttct gtcgatcaga aggtgtgatt tatgatgtgg cacaatggtt gtgtttattg
     5581 ctaaccagga attattatgg attttatgat tttaatgaag gaatgaaaat ggaattccca
     5641 tttgggagct ccctggtatt gatcttagct gtgttcccta attttctgtg tacaacaatc
     5701 atctgaggac gcatgttctg ccctgaagcc caatggatac attgtgattt tgacttgatc
     5761 atgaaagctc ctgggtgggc cgatgacccc caggatgtca aatagtggat ggacatatag
     5821 ttaaaaagct gtaaactttc taaagtttct taggaaataa attcatggga ctatattaga
     5881 aataaaaaga gaatgattta atgtcctgag aggaacagac ctagagggtt tccgcacagg
     5941 gctcatggat tcgtttcaag aattgacaac atagtttgca atctccttcc tgccagaccc
     6001 ctttgttctc ccacctttat tctcctagtg gagagtagca gggagactaa aaaaagaaat
     6061 ggtatacagt agtcccctct tacccatggc ttcattttca tggtttcagt tacgctcaac
     6121 agcagtccaa aaatatttga tggaacattc cagaaataaa caattcataa attttaattg
     6181 cacagcattc tgaggagcat gatgagatct tgccccttgc tgccctggag gtgatcctcc
     6241 ctctgtccag catattcatg ctgctcatcc attagtcact tagtagcagt ctcggtgatc
     6301 agatcgactg tctcggttat cagatgactg tatcgcagtg cttgtgttca agtaccccta
     6361 tttaattaat aatagcccca aagggcaaga gtgctgtgcc taatttacaa attaaatttt
     6421 atcatagata tgtaagtata gaaaaaaaaa catagtatat atagggtttg gtactatcag
     6481 agtttttagg catccactgg gggtcttgga atgtatcccc cagaaataag ggaggactac
     6541 cgtatataca tgtagggcat gacataaaat gcctaactgt gatgtcatcc tagaacaaga
     6601 ctaaagaact ttaagaagga ggcctggtca cttagaggac caacgactgg aaaaaaattc
     6661 ttgaaaggct atattttcca tcctcttgac ttcagatctc actgtactgt aaatctctct
     6721 ggttcattat tccttggaac agagatgcta caactctatg tcttctttct atccaacata
     6781 aaacactggc agttttgtcc aattcttgcc cacctttagt ggcaacagag aaacatgagg
     6841 gtcagctttt atcttacatc tttcagtgat ggtcttccta gaaaacctac ccctgatacc
     6901 tcgtaatttt gatcagtttt ttttgaattc tcatcttgat tatctgttat gctattgtca
     6961 tcatacacct tatgtggatt aactgttatg agtatgttag ggtagtacgt agtggctgaa
     7021 tctcagtcat tcattgtata gtcgagagtt gaataaagtc catattgaac acattttttt
     7081 aagtagaatt gactagaggt ttcagaggag aataaggtcc ttagtggagg ttaaaaaggg
     7141 aaataccttc tctagcccag cctggtcctt cgctgcctgc cttgtgataa ccgggaaaat
     7201 cttgaattga tgtatgtttc tttgagaacg actccacagt catctgaaga gtgttgaatc
     7261 aagagctcag ggaagttatg agctaattct tcagtcctga caagtgtgtt acaacagtgc
     7321 ttccaggaac ctcacaagac tgtgatttca agctgcttca ttgatggaaa gtttcaccat
     7381 cttgggatga atgtccatgt tccgttagcg tctgttttta actgactgca agatgatgag
     7441 ttttaatttg ggttgcagat gagcatttgg ttctgatttt catctatttc aagatcatat
     7501 cctctggata acagttcctt ttaaaattgc tttgcagagg ggctgagaag cctgcatcta
     7561 ctttgaaatt ataatggacc ttaccaccac ttaagtttag acctgtttgc aagatggtgg
     7621 ggagctccta ctgagaaaga tgaagatgct agctctattg taaactggcg tcttcatcta
     7681 gctacttgaa gttgagatac tatattttaa aatgttggca tcaaacaaat ctatccttct
     7741 agaagtaaag acattttgag taggatttag taagtactgg acatctcctg tagagcttca
     7801 tcatgctaaa ttattcccct ctccttttct aaataataga tgtgcttggg tttgggattt
     7861 acctggcacc aacccagact ttttttgggg gggggtgagg gcgcaggatc tcactctgtc
     7921 accaggttgg agtacagtgg catgattatg gctcactgca gcctcaacct cctgggctca
     7981 agtgatcctc ccacctcagc ctcctgagta gctgggacca caggtgtgtg ccaccatgca
     8041 caacaatttt tttttttttt ttgtagagat gggcgtctcc ctgtgttgcc caggctggta
     8101 tcgaactctg ggctctagcg atcctcctgc tttggcctcc caaagtactg ggattacaaa
     8161 cgtgagctgc catgcccagc ctccagacta ttttaaatgc cctctcccac tgtggaacat
     8221 tggcatcctt taagaataaa tgcatccttt ttgatcaaat gatttactct ttttttcttc
     8281 aatgtcctca tgtctcaatt tttttttcct tttcttaaaa cagtcccact tgaacttcct
     8341 ggaactgaat tctccagaac ataatattta taatccatag aattcctgcc ctgctctgca
     8401 gtagagtgtg ctatgttttg ttttcccact gagccagaag ccgaaatatt atactaccac
     8461 ttaccaccat ctaccacctc caagaccaag accaacatta tgtattgagc atcgtatctt
     8521 tcctactgag cctagacaca gcctcagaac ctctcaacat agcacttgga gcaacaattg
     8581 ccgcttgatt ggaattgcca tttgagcttg agttagcccc aatggcagaa cgacaggctc
     8641 gcactagtgt ccacctgtgg ctgtcagggg cggtaccaca gaaaggggaa aggccacttg
     8701 cctctaccca ctgccctttt ggacaacaat tccaattgaa ggaacaccaa tcactgatgg
     8761 atcccattcc aaaatgtctc ttcattcaca tcatttaatt ctgttgaatg aatatgttcc
     8821 tccctcacct tttataaaca gaaaattaat ataagtccca gttacttgct tcttagactc
     8881 tgtgagactc atgtaccaaa acaatgtgac attcttttcg agactttgac ttgtacggtc
     8941 agtatgaatt tagtgccttt ccaggcagca aaatgtttct tctttgctga tttcatagga
     9001 caaatatcct agcatactca caccaccagt gtcccaccct cacagactgg cacattagaa
     9061 tcatattaat ctgcttgttt gcatgttaca actgatactg caaaagccta ttcaagtcgg
     9121 actgaactag gctaagcaga ggacccttgt ggaacctgga gcatttctca gggacaggtg
     9181 gctaaagagg ggagctctaa aatcactgct ctgagaaaca ggaggtgggt taaggctttt
     9241 gttaactgtc atgtggccag ggtacgatgg caggacttca cagagcagag ccctaagcag
     9301 atggcaaggc cactgtaagg aagctcccgg cagcatccca ggtctgctct ccagagccac
     9361 ttcacagcac tcagggatcg ctggctcccg gccctaggct gctgtccagt gaccaggtgg
     9421 acagggtcct ccagtgactg caggccaagg gaaccccagc cagcatgtgc aagctattag
     9481 gaagatgtcc catcttgccc atatcacccc agtggctctt caccttcaga gtgaccactt
     9541 cccagactct ggaagtggga agaccctctt tgacgcttta ttacagtaat ttgagctcct
     9601 atcgacttgg agcgaatgaa tttctctttt gtggttaggt ctccaaatga acctccttac
     9661 ctggctcccc tctggtctcc tgtactgtca gtccccagct cccagtgttg ttttctgatg
     9721 ccggctccct ctctgtattg aacggcaatg ggaacaagaa tgactatcaa agcaaacaaa
     9781 tgcatggaat taaacaaaaa gtgtacttca
//
