LOCUS       NM_002419               3543 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 11
            (MAP3K11), mRNA.
ACCESSION   NM_002419
VERSION     NM_002419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3543)
  AUTHORS   Ke,R., Viswakarma,N., Menhart,M., Singh,S.K., Kumar,S.,
            Srivastava,P., Vishnoi,K., Kashyap,T., Srivastava,D., Nair,R.S.,
            Maienschein-Cline,M., Wang,X., Rana,A. and Rana,B.
  TITLE     MLK3 promotes prooncogenic signaling in hepatocellular carcinoma
            via TGFbeta pathway
  JOURNAL   Oncogene 43 (30), 2307-2324 (2024)
   PUBMED   38858590
  REMARK    GeneRIF: MLK3 promotes prooncogenic signaling in hepatocellular
            carcinoma via TGFbeta pathway.
REFERENCE   2  (bases 1 to 3543)
  AUTHORS   Jiang,Y., Wang,B.X., Xie,Y., Meng,L., Li,M. and Du,C.P.
  TITLE     MLK3 localizes mainly to the cytoplasm and promotes oxidative
            stress injury via a positive feedback loop
  JOURNAL   Cell Biochem Biophys 81 (3), 469-479 (2023)
   PUBMED   37550525
  REMARK    GeneRIF: MLK3 localizes mainly to the cytoplasm and promotes
            oxidative stress injury via a positive feedback loop.
REFERENCE   3  (bases 1 to 3543)
  AUTHORS   Liu,P.F., Chen,C.F., Ger,L.P., Tsai,W.L., Tseng,H.H., Lee,C.H.,
            Yang,W.H. and Shu,C.W.
  TITLE     MAP3K11 facilitates autophagy activity and is correlated with
            malignancy of oral squamous cell carcinoma
  JOURNAL   J Cell Physiol 237 (11), 4275-4291 (2022)
   PUBMED   36103355
  REMARK    GeneRIF: MAP3K11 facilitates autophagy activity and is correlated
            with malignancy of oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 3543)
  AUTHORS   Ramachandraiah,K. and Thylur Puttalingaiah,R.
  TITLE     The role of mixed lineage kinase 3 (MLK3) in cancers
  JOURNAL   Pharmacol Ther 238, 108269 (2022)
   PUBMED   36038020
  REMARK    GeneRIF: The role of mixed lineage kinase 3 (MLK3) in cancers.
            Review article
REFERENCE   5  (bases 1 to 3543)
  AUTHORS   Ha,A.T., Cho,J.Y. and Kim,D.
  TITLE     MLK3 Regulates Inflammatory Response via Activation of AP-1 Pathway
            in HEK293 and RAW264.7 Cells
  JOURNAL   Int J Mol Sci 23 (18), 10874 (2022)
   PUBMED   36142785
  REMARK    GeneRIF: MLK3 Regulates Inflammatory Response via Activation of
            AP-1 Pathway in HEK293 and RAW264.7 Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3543)
  AUTHORS   Nagata,Ki., Puls,A., Futter,C., Aspenstrom,P., Schaefer,E.,
            Nakata,T., Hirokawa,N. and Hall,A.
  TITLE     The MAP kinase kinase kinase MLK2 co-localizes with activated JNK
            along microtubules and associates with kinesin superfamily motor
            KIF3
  JOURNAL   EMBO J 17 (1), 149-158 (1998)
   PUBMED   9427749
REFERENCE   7  (bases 1 to 3543)
  AUTHORS   Smith,C.M., Ma,N.S., Nowak,N.J., Shows,T.B. and Gerhard,D.S.
  TITLE     A 3-Mb contig from D11S987 to MLK3, a gene-rich region in 11q13
  JOURNAL   Genome Res 7 (8), 835-842 (1997)
   PUBMED   9267807
REFERENCE   8  (bases 1 to 3543)
  AUTHORS   Kiefer,F., Tibbles,L.A., Anafi,M., Janssen,A., Zanke,B.W.,
            Lassam,N., Pawson,T., Woodgett,J.R. and Iscove,N.N.
  TITLE     HPK1, a hematopoietic protein kinase activating the SAPK/JNK
            pathway
  JOURNAL   EMBO J 15 (24), 7013-7025 (1996)
   PUBMED   9003777
REFERENCE   9  (bases 1 to 3543)
  AUTHORS   Ing,Y.L., Leung,I.W., Heng,H.H., Tsui,L.C. and Lassam,N.J.
  TITLE     MLK-3: identification of a widely-expressed protein kinase bearing
            an SH3 domain and a leucine zipper-basic region domain
  JOURNAL   Oncogene 9 (6), 1745-1750 (1994)
   PUBMED   8183572
REFERENCE   10 (bases 1 to 3543)
  AUTHORS   Gallo,K.A., Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q. and
            Godowski,P.J.
  TITLE     Identification and characterization of SPRK, a novel src-homology 3
            domain-containing proline-rich kinase with serine/threonine kinase
            activity
  JOURNAL   J Biol Chem 269 (21), 15092-15100 (1994)
   PUBMED   8195146
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from L32976.1 and U07747.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002419.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine kinase family. This kinase contains a SH3 domain
            and a leucine zipper-basic motif. This kinase preferentially
            activates MAPK8/JNK kinase, and functions as a positive regulator
            of JNK signaling pathway. This kinase can directly phosphorylate,
            and activates IkappaB kinase alpha and beta, and is found to be
            involved in the transcription activity of NF-kappaB mediated by Rho
            family GTPases and CDC42. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011263.2, AK222781.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309100.8/ ENSP00000309597.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3542              L32976.1           17-3558
            3543-3543           U07747.1           3528-3528
FEATURES             Location/Qualifiers
     source          1..3543
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3543
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /note="mitogen-activated protein kinase kinase kinase 11"
                     /db_xref="GeneID:4296"
                     /db_xref="HGNC:HGNC:6850"
                     /db_xref="MIM:600050"
     exon            1..1204
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1385
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1534
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1710
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1954
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2068
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2204
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2296
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2671
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..3543
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /note="hexamer: AATAAA"
     polyA_site      3543
                     /gene="MAP3K11"
                     /gene_synonym="MEKK11; MLK-3; MLK3; PTK1; SPRK"
                     /note="major polyA site"
ORIGIN      
        1 gtcggagccg tcggggccaa aggagacggg gccaggaaca ggcagtctcg gcccaactgc
       61 ggacgctccc tccaccccct gcgcaaaaag acccaaccgg agttgaggcg ctgcccctga
      121 aggccccacc ttacacttgg cgggggccgg agccaggctc ccaggactgc tccagaaccg
      181 agggaagctc gggtccctcc aagctagcca tggtgaggcg ccggaggccc cggggcccca
      241 cccccccggc ctgaccacac tgccctgggt gccctcctcc agaagcccga gatgcggggg
      301 gccgggagac aacactcctg gctccccaga gaggcgtggg tctggggctg agggccaggg
      361 cccggatgcc caggttccgg gactagggcc ttggcagcca gcgggggtgg ggaccacggg
      421 cacccagaga aggtcctcca cacatcccag cgccggctcc cggccatgga gcccttgaag
      481 agcctcttcc tcaagagccc tctagggtca tggaatggca gtggcagcgg gggtggtggg
      541 ggcggtggag gaggccggcc tgaggggtct ccaaaggcag cgggttatgc caacccggtg
      601 tggacagccc tgttcgacta cgagcccagt gggcaggatg agctggccct gaggaagggt
      661 gaccgtgtgg aggtgctgtc ccgggacgca gccatctcag gagacgaggg ctggtgggcg
      721 ggccaggtgg gtggccaggt gggcatcttc ccgtccaact atgtgtctcg gggtggcggc
      781 ccgcccccct gcgaggtggc cagcttccag gagctgcggc tggaggaggt gatcggcatt
      841 ggaggctttg gcaaggtgta caggggcagc tggcgaggtg agctggtggc tgtgaaggca
      901 gctcgccagg accccgatga ggacatcagt gtgacagccg agagcgttcg ccaggaggcc
      961 cggctcttcg ccatgctggc acaccccaac atcattgccc tcaaggctgt gtgcctggag
     1021 gagcccaacc tgtgcctggt gatggagtat gcagccggtg ggcccctcag ccgagctctg
     1081 gccgggcggc gcgtgcctcc ccatgtgctg gtcaactggg ctgtgcagat tgcccgtggg
     1141 atgcactacc tgcactgcga ggccctggtg cccgtcatcc accgtgatct caagtccaac
     1201 aacattttgc tgctgcagcc cattgagagt gacgacatgg agcacaagac cctgaagatc
     1261 accgactttg gcctggcccg agagtggcac aaaaccacac aaatgagtgc cgcgggcacc
     1321 tacgcctgga tggctcctga ggttatcaag gcctccacct tctctaaggg cagtgacgtc
     1381 tggagttttg gggtgctgct gtgggaactg ctgaccgggg aggtgccata ccgtggcatt
     1441 gactgccttg ctgtggccta tggcgtagct gttaacaagc tcacactgcc catcccatcc
     1501 acctgccccg agcccttcgc acagcttatg gccgactgct gggcgcagga cccccaccgc
     1561 aggcccgact tcgcctccat cctgcagcag ttggaggcgc tggaggcaca ggtcctacgg
     1621 gaaatgccgc gggactcctt ccattccatg caggaaggct ggaagcgcga gatccagggt
     1681 ctcttcgacg agctgcgagc caaggaaaag gaactactga gccgcgagga ggagctgacg
     1741 cgagcggcgc gcgagcagcg gtcacaggcg gagcagctgc ggcggcgcga gcacctgctg
     1801 gcccagtggg agctagaggt gttcgagcgc gagctgacgc tgctgctgca gcaggtggac
     1861 cgcgagcgac cgcacgtgcg ccgccgccgc gggacattca agcgcagcaa gctccgggcg
     1921 cgcgacggcg gcgagcgtat cagcatgcca ctcgacttca agcaccgcat caccgtgcag
     1981 gcctcacccg gccttgaccg gaggagaaac gtcttcgagg tcgggcctgg ggattcgccc
     2041 acctttcccc ggttccgagc catccagttg gagcctgcag agccaggcca ggcatggggc
     2101 cgccagtccc cccgacgtct ggaggactca agcaatggag agcggcgagc atgctgggct
     2161 tggggtccca gttcccccaa gcctggggaa gcccagaatg ggaggagaag gtcccgcatg
     2221 gacgaagcca catggtacct ggattcagat gactcatccc ccttaggatc tccttccaca
     2281 cccccagcac tcaatggtaa ccccccgcgg cctagcctgg agcccgagga gcccaagagg
     2341 cctgtccccg cagagcgcgg tagcagctct gggacgccca agctgatcca gcgggcgctg
     2401 ctgcgcggca ccgccctgct cgcctcgctg ggccttggcc gcgacctgca gccgccggga
     2461 ggcccaggac gcgagcgcgg ggagtccccg acaacacccc ccacgccaac gcccgcgccc
     2521 tgcccgaccg agccgccccc ttccccgctc atctgcttct cgctcaagac gcccgactcc
     2581 ccgcccactc ctgcacccct gttgctggac ctgggtatcc ctgtgggcca gcggtcagcc
     2641 aagagccccc gacgtgagga ggagccccgc ggaggcactg tctcaccccc accggggaca
     2701 tcacgctctg ctcctggcac cccaggcacc ccacgttcac cacccctggg cctcatcagc
     2761 cgacctcggc cctcgcccct tcgcagccgc attgatccct ggagctttgt gtcagctggg
     2821 ccacggcctt ctcccctgcc atcaccacag cctgcacccc gccgagcacc ctggaccttg
     2881 ttcccggact cagacccctt ctgggactcc ccacctgcca accccttcca ggggggcccc
     2941 caggactgca gggcacagac caaagacatg ggtgcccagg ccccgtgggt gccggaagcg
     3001 gggccttgag tgggccaggc cactcccccg agctccagct gccttaggag gagtcacagc
     3061 atacactgga acaggagctg ggtcagcctc tgcagctgcc tcagtttccc cagggacccc
     3121 accccccttt gggggtcagg aacactacac tgcacaggaa gccttcacac tggaaggggg
     3181 acctgcgccc ccacatctga aacctgtagg tccccccagc tcacctgccc tactggggcc
     3241 caacactgta cccagctggt tgggaggacc agagcctgtc tcagggaatt gcctgctggg
     3301 gtgatgcagg gaggagggga ggtgcaggga agaggggccg gcctcagctg tcaccagcac
     3361 ttttgaccaa gtcctgctac tgcggcccct gccctagggc ttagagcatg gacctcctgc
     3421 cctgggggtc atctggggcc agggctctct ggatgccttc ctgctgcccc agccagggtt
     3481 ggagtcttag cctcgggatc cagtgaagcc agaagccaaa taaactcaaa agctgtctcc
     3541 cca
//
