LOCUS       NM_002446               3754 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase kinase 10
            (MAP3K10), mRNA.
ACCESSION   NM_002446
VERSION     NM_002446.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Zhao,J., Xu,T., Zhou,S., Zhang,J., Wu,Y., Zhou,C., Sun,J., Gao,X.
            and Huang,Y.
  TITLE     DNA methylation of the MAP3K10 gene may participate in the
            development of intracranial aneurysm
  JOURNAL   Gene 851, 147024 (2023)
   PUBMED   36341729
  REMARK    GeneRIF: DNA methylation of the MAP3K10 gene may participate in the
            development of intracranial aneurysm.
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Luo,W., Zhang,H., Liang,X., Xia,R., Deng,H., Yi,Q., Lv,L. and
            Qian,L.
  TITLE     DNA methylation-regulated miR-155-5p depresses sensitivity of
            esophageal carcinoma cells to radiation and multiple
            chemotherapeutic drugs via suppression of MAP3K10
  JOURNAL   Oncol Rep 43 (5), 1692-1704 (2020)
   PUBMED   32323857
  REMARK    GeneRIF: DNA methylationregulated miR1555p depresses sensitivity of
            esophageal carcinoma cells to radiation and multiple
            chemotherapeutic drugs via suppression of MAP3K10.
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Kulaberoglu,Y., Lin,K., Holder,M., Gai,Z., Gomez,M., Assefa
            Shifa,B., Mavis,M., Hoa,L., Sharif,A.A.D., Lujan,C., Smith,E.S.J.,
            Bjedov,I., Tapon,N., Wu,G. and Hergovich,A.
  TITLE     Stable MOB1 interaction with Hippo/MST is not essential for
            development and tissue growth control
  JOURNAL   Nat Commun 8 (1), 695 (2017)
   PUBMED   28947795
  REMARK    GeneRIF: MST interaction with MOB1 is not essential for development
            and tissue growth control.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Wang,C., Zhang,X., Zhang,C., Zhai,F., Li,Y. and Huang,Z.
  TITLE     MicroRNA-155 targets MAP3K10 and regulates osteosarcoma cell growth
  JOURNAL   Pathol Res Pract 213 (4), 389-393 (2017)
   PUBMED   28214207
  REMARK    GeneRIF: We identified a direct target of miR-155 as MAP3K10 in
            osteosarcoma
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Hirai,Si., Katoh,M., Terada,M., Kyriakis,J.M., Zon,L.I., Rana,A.,
            Avruch,J. and Ohno,S.
  TITLE     MST/MLK2, a member of the mixed lineage kinase family, directly
            phosphorylates and activates SEK1, an activator of c-Jun N-terminal
            kinase/stress-activated protein kinase
  JOURNAL   J Biol Chem 272 (24), 15167-15173 (1997)
   PUBMED   9182538
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Dorow,D.S., Devereux,L., Tu,G.F., Price,G., Nicholl,J.K.,
            Sutherland,G.R. and Simpson,R.J.
  TITLE     Complete nucleotide sequence, expression, and chromosomal
            localisation of human mixed-lineage kinase 2
  JOURNAL   Eur J Biochem 234 (2), 492-500 (1995)
   PUBMED   8536694
REFERENCE   8  (bases 1 to 3754)
  AUTHORS   Katoh,M., Hirai,M., Sugimura,T. and Terada,M.
  TITLE     Cloning and characterization of MST, a novel (putative)
            serine/threonine kinase with SH3 domain
  JOURNAL   Oncogene 10 (7), 1447-1451 (1995)
   PUBMED   7731697
REFERENCE   9  (bases 1 to 3754)
  AUTHORS   Gallo,K.A., Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q. and
            Godowski,P.J.
  TITLE     Identification and characterization of SPRK, a novel src-homology 3
            domain-containing proline-rich kinase with serine/threonine kinase
            activity
  JOURNAL   J Biol Chem 269 (21), 15092-15100 (1994)
   PUBMED   8195146
REFERENCE   10 (bases 1 to 3754)
  AUTHORS   Dorow,D.S., Devereux,L., Dietzsch,E. and De Kretser,T.
  TITLE     Identification of a new family of human epithelial protein kinases
            containing two leucine/isoleucine-zipper domains
  JOURNAL   Eur J Biochem 213 (2), 701-710 (1993)
   PUBMED   8477742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011496.7, X90846.1,
            BF594729.1, Z48615.1 and BU633407.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002446.3.
            
            Summary: The protein encoded by this gene is a member of the
            serine/threonine kinase family. This kinase has been shown to
            activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be
            phoshorylated, and thus activated by JNK kinases. This kinase
            functions preferentially on the JNK signaling pathway, and is
            reported to be involved in nerve growth factor (NGF) induced
            neuronal apoptosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X90846.1, Z48615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253055.8/ ENSP00000253055.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC011496.7         96100-96417
            319-410             X90846.1           1-92
            411-505             BF594729.1         303-397             c
            506-2423            X90846.1           188-2105
            2424-3587           Z48615.1           1975-3138
            3588-3754           BU633407.1         18-184              c
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3754
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /note="mitogen-activated protein kinase kinase kinase 10"
                     /db_xref="GeneID:4294"
                     /db_xref="HGNC:HGNC:6849"
                     /db_xref="MIM:600137"
     exon            1..1288
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     CDS             607..3471
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /EC_number="2.7.11.25"
                     /note="MKN28 kinase; mixed lineage kinase 2; MKN28 derived
                     nonreceptor_type serine/threonine kinase; protein kinase
                     MST"
                     /codon_start=1
                     /product="mitogen-activated protein kinase kinase kinase
                     10"
                     /protein_id="NP_002437.2"
                     /db_xref="CCDS:CCDS12549.1"
                     /db_xref="GeneID:4294"
                     /db_xref="HGNC:HGNC:6849"
                     /db_xref="MIM:600137"
                     /translation="MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQ
                     VLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEE
                     IIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIAL
                     RGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPI
                     IHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIR
                     LSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFAR
                     LLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLR
                     TKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKP
                     RVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPS
                     IIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQ
                     KERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSS
                     VPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLL
                     GAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGL
                     APSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLE
                     LESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFP
                     RLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPS
                     RPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH"
     exon            1289..1469
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..1618
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1794
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..2041
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2158
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2330
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2443
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..3148
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     exon            3149..3754
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3731..3736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /note="hexamer: ATTAAA"
     polyA_site      3754
                     /gene="MAP3K10"
                     /gene_synonym="MEKK10; MLK2; MST"
                     /note="major polyA site"
ORIGIN      
        1 gtcactcggg ccccgccggt ggcccgggga agcagcacgg gcggggggca ggggctgggg
       61 ccgaccggga ggccggtgcc aaggatgggg gccgcccggc tgccccgcgc gtgaggaggc
      121 cgaggggcgc gccaccccgg cccggggcgg ccgccccagg ggccccgcca cccccgcccg
      181 gcccggcagt cgtggcccgg gatgcggagc cgggggccgc cggtggagct gcgcggggtg
      241 agcggcgcgg ggaacgggga ctgcctgccg ccctcgccct cgtcccccac cggcggaccc
      301 cggcgggcat tcgagagccg cgcggccagg ccctcttagc cctctgccgt ttggggggca
      361 cgggtgaacc tgccgcccca ctcccacccc gccccgcccc gcccgtacag ccaaatcgga
      421 agggacgagc ctgccctttg aaagggtttt ttttcttgct cctgcggagg gcgccccagc
      481 catggccctc aggagctccc tagaccccgc agggactgcc ctccatcccg gccgccgggg
      541 cccgccctct gcatcccgcg ggcagcctgt gtgaagcggc ctcccgcagc ccccggcccc
      601 tcccccatgg aggaggagga gggggcggtg gccaaggagt ggggcacgac ccccgcgggg
      661 cccgtctgga ccgcggtgtt cgactacgag gcggcgggcg acgaggagct gaccctgcgg
      721 aggggcgatc gcgtccaggt gctttcccaa gactgtgcgg tgtccggcga cgagggctgg
      781 tggaccgggc agctccccag cggccgcgtg ggcgtcttcc ccagcaacta cgtggccccc
      841 ggcgcccccg ctgcacccgc gggcctccag ctgccccagg agatcccctt ccacgagctg
      901 cagctagagg agatcatcgg tgtggggggc tttggcaagg tctatcgggc cctgtggcgt
      961 ggcgaggagg tggcagtcaa ggccgcccgg ctggaccctg agaaggaccc ggcagtgaca
     1021 gcggagcagg tgtgccagga agcccggctc tttggagccc tgcagcaccc caacataatt
     1081 gcccttaggg gcgcctgcct caacccccca cacctctgcc tagtgatgga gtatgcccgg
     1141 ggtggtgcac tgagcagggt gctggcaggt cgccgggtgc cacctcacgt gctggtcaac
     1201 tgggctgtgc aggtggcccg gggcatgaac tacctacaca atgatgcccc tgtgcccatc
     1261 atccaccggg acctcaagtc catcaacatc ctgatcctgg aggccatcga gaaccacaac
     1321 ctcgcagaca cggtgctcaa gatcacggac ttcggcctcg cccgcgagtg gcacaagacc
     1381 accaagatga gcgctgcggg gacctacgcc tggatggcgc cggaggttat ccgtctctcc
     1441 ctcttctcca aaagcagtga tgtctggagc ttcggggtgc tgctgtggga gctgctgacg
     1501 ggggaggtcc cctaccgtga gatcgacgcc ttggccgtgg cgtatggcgt ggctatgaat
     1561 aagctgacgc tgcccattcc ctccacgtgc cccgagccct ttgcccgcct cctggaggaa
     1621 tgctgggacc cagaccccca cgggcggcca gatttcggta gcatcttgaa gcggcttgaa
     1681 gtcatcgaac agtcagccct gttccagatg ccactggagt ccttccactc gctgcaggaa
     1741 gactggaagc tggagattca gcacatgttt gatgaccttc ggaccaagga gaaggagctt
     1801 cggagccgtg aggaggagct gctgcgggcg gcacaggagc agcgcttcca ggaggagcag
     1861 ctgcggcggc gggagcagga gctggcagaa cgtgagatgg acatcgtgga acgggagctg
     1921 cacctgctca tgtgccagct gagccaggag aagccccggg tccgcaagcg caagggcaac
     1981 ttcaagcgca gccgcctgct caagctgcgg gaaggcggca gccacatcag cctgccctct
     2041 ggctttgagc ataagatcac agtccaggcc tctccaactc tggataagcg gaaaggatcc
     2101 gatggggcca gcccccctgc aagccccagc atcatccccc ggctgagggc cattcgcctg
     2161 actcccgtgg actgtggtgg cagcagcagt ggcagcagca gtggaggaag tgggacatgg
     2221 agccgcggtg ggcccccaaa gaaggaagaa ctggtcgggg gcaagaagaa gggacgaacg
     2281 tgggggccca gctccaccct gcagaaggag cgggtgggag gagaggagag gctgaagggg
     2341 ctgggggaag gaagcaaaca gtggtcatca agtgccccca acctgggcaa gtcccccaaa
     2401 cacacaccca tcgcccctgg ctttgccagc ctcaatgaga tggaggagtt cgcggaggca
     2461 gaggatggag gcagcagcgt gcccccttcc ccctactcga ccccgtccta cctctcagtg
     2521 ccactgcctg ccgagccctc cccgggggcg cgggcgccgt gggagccgac gccgtccgcg
     2581 ccccccgctc ggtggggaca cggcgcccgg cggcgctgcg acctggcgct gctaggctgc
     2641 gccacgctgc tgggggctgt gggcctgggc gccgacgtgg ccgaggcgcg cgcggccgac
     2701 ggtgaggagc agcggcgctg gctcgacggc ctcttctttc cccgcgccgg ccgcttcccg
     2761 cggggcctca gcccacccgc gcgtccccac ggccgccgcg aagacgtggg ccccggcctg
     2821 ggcctggcgc cctcggccac cctcgtgtcg ctgtcgtccg tgtccgactg caactccacg
     2881 cgttcactgc tgcgctctga cagtgacgag gccgcaccgg ccgcgccctc cccaccaccc
     2941 tccccgcccg cgcccacacc cacgccctcg cccagcacca accccctggt ggacctggag
     3001 ctggagagct tcaagaagga cccccgccag tcgctcacgc ccacccacgt cacggctgca
     3061 tgcgctgtga gccgcgggca ccggcggacg ccatcggacg gggcgctggg gcagcggggg
     3121 ccgcccgagc ccgcgggcca tggccctggc cctcgtgacc ttctggactt cccccgcctg
     3181 cccgaccccc aggccctgtt cccagcccgc cgccggcccc ctgagttccc aggccgcccc
     3241 accaccctga cctttgcccc gagacctcgg ccggctgcca gtcgcccccg cttggacccc
     3301 tggaaactgg tctccttcgg ccggacactc accatctcgc ctcccagcag gccagacact
     3361 ccggagagcc ctgggccccc cagcgtgcag cccacactgc tggacatgga catggagggg
     3421 cagaaccaag acagcacagt gcccctgtgc ggggcccacg gctcccacta aggcctgccc
     3481 accaccgccc gcctgggcag ccatgaatgt agcgccccag gccctgcccc agcccgccat
     3541 gccacaaggt gggggaggcc ctgggcagga tgttcactct atttattggg gaaggaggga
     3601 ggggggggac acttaactta ttcctttgta ccccaggggg tggagccctg tgcccaccct
     3661 gcactggggg gagggtgggc agggatactc agggacaggg catcatgggg gatttggcac
     3721 aaaatggagc attaaaggta acccctgccc ccta
//
