LOCUS       NM_145185               3375 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase 7 (MAP2K7),
            transcript variant 3, mRNA.
ACCESSION   NM_145185 NM_005043 NM_145329
VERSION     NM_145185.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3375)
  AUTHORS   Louveau,B., Reger De Moura,C., Jouenne,F., Sadoux,A., Allayous,C.,
            Da Meda,L., Bernard-Cacciarella,M., Baroudjian,B., Lebbe,C.,
            Mourah,S. and Dumaz,N.
  TITLE     Combined PDE4+MEK inhibition shows antiproliferative effects in
            NRASQ61 mutated melanoma preclinical models
  JOURNAL   Melanoma Res 34 (2), 186-192 (2024)
   PUBMED   38141200
  REMARK    GeneRIF: Combined PDE4+MEK inhibition shows antiproliferative
            effects in NRASQ61 mutated melanoma preclinical models.
REFERENCE   2  (bases 1 to 3375)
  AUTHORS   Kimura,T., Doolittle,W.K.L., Kruhlak,M., Zhao,L., Hwang,E., Zhu,X.,
            Tang,B., Wolcott,K.M. and Cheng,S.Y.
  TITLE     Inhibition of MEK Signaling Attenuates Cancer Stem Cell Activity in
            Anaplastic Thyroid Cancer
  JOURNAL   Thyroid 34 (4), 484-495 (2024)
   PUBMED   38115586
  REMARK    GeneRIF: Inhibition of MEK Signaling Attenuates Cancer Stem Cell
            Activity in Anaplastic Thyroid Cancer.
REFERENCE   3  (bases 1 to 3375)
  AUTHORS   Lee,K.T., Lin,C.Y., Liu,S.C., He,X.Y., Tsai,C.H., Ko,C.Y.,
            Tsai,Y.H., Chao,C.C., Chen,P.C. and Tang,C.H.
  TITLE     IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in
            osteoarthritis synovial fibroblasts
  JOURNAL   Aging (Albany NY) 16 (2), 1829-1844 (2024)
   PUBMED   38261743
  REMARK    GeneRIF: IL-17 promotes IL-18 production via the MEK/ERK/miR-4492
            axis in osteoarthritis synovial fibroblasts.
REFERENCE   4  (bases 1 to 3375)
  AUTHORS   Voigt,E. and Quelle,D.E.
  TITLE     FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve
            Sheath Tumor Therapy
  JOURNAL   Int J Mol Sci 24 (17), 13596 (2023)
   PUBMED   37686402
  REMARK    GeneRIF: FOXM1, MEK, and CDK4/6: New Targets for Malignant
            Peripheral Nerve Sheath Tumor Therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3375)
  AUTHORS   Sheppard,S.E., March,M.E., Seiler,C., Matsuoka,L.S., Kim,S.E.,
            Kao,C., Rubin,A.I., Battig,M.R., Khalek,N., Schindewolf,E.,
            O'Connor,N., Pinto,E., Priestley,J.R., Sanders,V.R., Niazi,R.,
            Ganguly,A., Hou,C., Slater,D., Frieden,I.J., Huynh,T., Shieh,J.T.,
            Krantz,I.D., Guerrero,J.C., Surrey,L.F., Biko,D.M., Laje,P.,
            Castelo-Soccio,L., Nakano,T.A., Snyder,K., Smith,C.L., Li,D.,
            Dori,Y. and Hakonarson,H.
  TITLE     Lymphatic disorders caused by mosaic, activating KRAS variants
            respond to MEK inhibition
  JOURNAL   JCI Insight 8 (9), e155888 (2023)
   PUBMED   37154160
  REMARK    GeneRIF: Lymphatic disorders caused by mosaic, activating KRAS
            variants respond to MEK inhibition.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3375)
  AUTHORS   Foltz,I.N., Gerl,R.E., Wieler,J.S., Luckach,M., Salmon,R.A. and
            Schrader,J.W.
  TITLE     Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly
            conserved c-Jun N-terminal kinase/stress-activated protein kinase
            (JNK/SAPK) activated by environmental stresses and physiological
            stimuli
  JOURNAL   J Biol Chem 273 (15), 9344-9351 (1998)
   PUBMED   9535930
REFERENCE   7  (bases 1 to 3375)
  AUTHORS   Wang,Y., Su,B., Sah,V.P., Brown,J.H., Han,J. and Chien,K.R.
  TITLE     Cardiac hypertrophy induced by mitogen-activated protein kinase
            kinase 7, a specific activator for c-Jun NH2-terminal kinase in
            ventricular muscle cells
  JOURNAL   J Biol Chem 273 (10), 5423-5426 (1998)
   PUBMED   9488659
REFERENCE   8  (bases 1 to 3375)
  AUTHORS   Wu,Z., Wu,J., Jacinto,E. and Karin,M.
  TITLE     Molecular cloning and characterization of human JNKK2, a novel Jun
            NH2-terminal kinase-specific kinase
  JOURNAL   Mol Cell Biol 17 (12), 7407-7416 (1997)
   PUBMED   9372971
REFERENCE   9  (bases 1 to 3375)
  AUTHORS   Lu,X., Nemoto,S. and Lin,A.
  TITLE     Identification of c-Jun NH2-terminal protein kinase
            (JNK)-activating kinase 2 as an activator of JNK but not p38
  JOURNAL   J Biol Chem 272 (40), 24751-24754 (1997)
   PUBMED   9312068
REFERENCE   10 (bases 1 to 3375)
  AUTHORS   Tournier,C., Whitmarsh,A.J., Cavanagh,J., Barrett,T. and Davis,R.J.
  TITLE     Mitogen-activated protein kinase kinase 7 is an activator of the
            c-Jun NH2-terminal kinase
  JOURNAL   Proc Natl Acad Sci U S A 94 (14), 7337-7342 (1997)
   PUBMED   9207092
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY063492.1, AF022805.1,
            BC038295.2, AK098807.1 and BF445461.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_145185.3.
            
            Summary: The protein encoded by this gene is a dual specificity
            protein kinase that belongs to the MAP kinase kinase family. This
            kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this
            kinase itself is phosphorylated and activated by MAP kinase kinase
            kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and
            MAP4K2/GCK. This kinase is involved in the signal transduction
            mediating the cell responses to proinflammatory cytokines, and
            environmental stresses. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1. It encodes
            isoform 3, which lacks an internal segment and is shorter, compared
            to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.71668.1,
                                           SRR7346977.1103218.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397979.4/ ENSP00000381066.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                HY063492.1         49-62
            15-1433             AF022805.1         7-1425
            1434-2441           BC038295.2         1491-2498
            2442-3373           AK098807.1         669-1600
            3374-3375           BF445461.1         8-9                 c
FEATURES             Location/Qualifiers
     source          1..3375
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..3375
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /note="mitogen-activated protein kinase kinase 7"
                     /db_xref="GeneID:5609"
                     /db_xref="HGNC:HGNC:6847"
                     /db_xref="MIM:603014"
     exon            1..192
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1328
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /EC_number="2.7.12.2"
                     /note="isoform 3 is encoded by transcript variant 3; MAP
                     kinase kinase 7; JNK-activating kinase 2; dual specificity
                     mitogen-activated protein kinase kinase 7; c-Jun
                     N-terminal kinase kinase 2; MAPK/ERK kinase 7; SAPK kinase
                     4; stress-activated protein kinase kinase 4"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 7 isoform 3"
                     /protein_id="NP_660186.1"
                     /db_xref="CCDS:CCDS42491.1"
                     /db_xref="GeneID:5609"
                     /db_xref="HGNC:HGNC:6847"
                     /db_xref="MIM:603014"
                     /translation="MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQ
                     LPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQ
                     TGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEEN
                     KRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERI
                     LGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTR
                     SAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTK
                     VLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVAS
                     WFKDVMAKTESPRTSGVLSQPHLPFFR"
     exon            193..334
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            335..401
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            402..515
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            516..635
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            636..743
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            744..923
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1004
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1147
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1193
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..3375
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3352..3357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /note="hexamer: AATAAA"
     polyA_site      3375
                     /gene="MAP2K7"
                     /gene_synonym="JNKK2; MAPKK7; MEK; MEK 7; MKK7; PRKMK7;
                     SAPKK-4; SAPKK4"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggtgt ttgtctgccg gactgacggg cggccgggcg gtgcgcggcg gcggtggcgg
       61 cggggaagat ggcggcgtcc tccctggaac agaagctgtc ccgcctggaa gcaaagctga
      121 agcaggagaa ccgggaggcc cggcggagga tcgacctcaa cctggatatc agcccccagc
      181 ggcccaggcc caccctgcag ctcccgctgg ccaacgatgg gggcagccgc tcgccatcct
      241 cagagagctc cccgcagcac cccacgcccc ccgcccggcc ccgccacatg ctggggctcc
      301 cgtcaaccct gttcacaccc cgcagcatgg agagcattga gattgaccag aagctgcagg
      361 agatcatgaa gcagacgggc tacctgacca tcgggggcca gcgctaccag gcagaaatca
      421 acgacctgga gaacttgggc gagatgggca gcggcacctg cggccaggtg tggaagatgc
      481 gcttccggaa gaccggccac gtcattgccg ttaagcaaat gcggcgctcc gggaacaagg
      541 aggagaacaa gcgcatcctc atggacctgg atgtggtgct gaagagccac gactgcccct
      601 acatcgtgca gtgctttggg acgttcatca ccaacacgga cgtcttcatc gccatggagc
      661 tcatgggcac ctgcgctgag aagctcaaga agcggatgca gggccccatc cccgagcgca
      721 ttctgggcaa gatgacagtg gcgattgtga aggcgctgta ctacctgaag gagaagcacg
      781 gtgtcatcca ccgcgacgtc aagccctcca acatcctgct ggacgagcgg ggccagatca
      841 agctctgcga cttcggcatc agcggccgcc tggtggactc caaagccaag acgcggagcg
      901 ccggctgtgc cgcctacatg gcacccgagc gcattgaccc cccagacccc accaagccgg
      961 actatgacat ccgggccgac gtatggagcc tgggcatctc gttggtggag ctggcaacag
     1021 gacagtttcc ctacaagaac tgcaagacgg actttgaggt cctcaccaaa gtcctacagg
     1081 aagagccccc gcttctgccc ggacacatgg gcttctcggg ggacttccag tccttcgtca
     1141 aagactgcct tactaaagat cacaggaaga gaccaaagta taataagcta cttgaacaca
     1201 gcttcatcaa gcgctacgag acgctggagg tggacgtggc gtcctggttc aaggatgtca
     1261 tggcgaagac tgagtcaccg cggactagcg gcgtcctgag ccagccccac ctgcccttct
     1321 tcaggtagct gcttggcggc ggccagcccc acagggggcc aggggcatgg ccacaggccc
     1381 ccctccccac ttggccaccc agctgcctgc caggggagac ctgggacctg gacggccacc
     1441 taggactgag gacagagagt ggggggtgcc cacccacccc ccccgccccg ggcctaccaa
     1501 gcccccgccc ttcccacccc ggggtcagcc ggccgtgtgc gtcccccgac agacactgtg
     1561 aacggaagac agcaggccgc gatcagagtc gctgttcatt cagccgcagc ctctgggccg
     1621 gggcggcccc caggggccag gagagagccc tggagtcccg cagccaccat gcacgctccc
     1681 agcgtgctgt gtccttcgcc actcccacgc gcccgttcct cttccgtcgc cctctgtccc
     1741 ctgctctacc tctctgtcct tgtctggctc tcccgtcacc ctccctgcct ctgtctctct
     1801 tctggcctga gcctgggccc agccacctcc tgacgggtcc cctgggtctg cataggtctc
     1861 ccatggcgca atgagtcagt ggcccccagc caggcagtgt gggcattgcc actgcggctg
     1921 gacggggctg cgcgctcgcg ctctctctct ctctctctct ctctctttga tctcaggggg
     1981 tcctttttgg agtttattgt attttattgt acttggtggg gtgtttgggg tgggggcgga
     2041 ggagagcttg ttctcgtggg gttgtcggta ccttcagaaa cttttaccaa agtcacgatt
     2101 agctgcttgt ggtggggccc caaccgccct cgggcactgg ggagctgggc tggggctgct
     2161 gctctggggt ctccgggggc cacagcttgg ggtgagttga agacctcagg ggatgtggag
     2221 gggtctgcgg ggccctggcc gcacaggatg gccttcaggg aaggtggtct tggggcatgg
     2281 tgcagagcag gtgaccggag ggaatcggtg acggagcggg gccaagggag gggtccggag
     2341 ggagtcaggg atggagggca gagggagtgg atgtgggggt ttgaggacgt gtgacaagct
     2401 ccagcagggg tgggggccgg gctgagggtg ggggtgcgag gtggtcactc ccatcgtgcc
     2461 cctggccgtc cctccactca cccacacctg gcccagtcca cgttgaggtc caggactggg
     2521 aaggaccggg tgagtgcacc ggggacccag gccaggtgcc ccccggagcc tgctggggtg
     2581 gccagagcag gagggggtgt gtttcctttt tgtgggtgtt gcatgcaaat caagtggaca
     2641 agaaaaaata acaaaacaaa aaacaagaaa aaaaaaacac aaaaccccgt aaaatcacaa
     2701 agaaaatcca acaccaaagg cgcagaagcc ggctggccgt ggtgggggca gcgtaggcgt
     2761 agcatccctc tcctctcact tagcctgttg actcttgtta ttatcatgat attcacaaaa
     2821 cgccgcatgt ttaaaaagtc atagatgtca tcttctctct gcccccaggg aggaaagcca
     2881 ccttctcttg ccccttggcc cctttgtcag gggccagggg tctgccgggt gggggtgcca
     2941 acaggcctgg ccctttcctc ccctgcatcc agccatgggg gcctctgcga ttgccggaag
     3001 gttgcatggc tggtcccagg gccagcacag gcccgaggcc gggctgcctg gttttatttt
     3061 tatttaactt tattttctgt tttatgagtg tgtgtccgcc cacccccacc cccttcagtg
     3121 ttaagtgggg agccctgggg gagtctctcc tgcctcccag cctctcccaa gacctccccc
     3181 ctcgtcacca gccatccctc tggaccaggc agagggcgga ccgggtgggc aggggcctga
     3241 gggtggctcg ggccagccca ccagccaatg gacccctcct caggccgcca gtgtcgccct
     3301 gccccttttt aaaacaaaat gccctcgttt gtaaaccctt agacgcttga gaataaaccc
     3361 cttccttttc ttcca
//
