LOCUS       NM_030662               1727 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2),
            mRNA.
ACCESSION   NM_030662
VERSION     NM_030662.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1727)
  AUTHORS   Wan,Y., Zhao,Y., Cao,M., Wang,J., Tran,S.V., Song,Z., Hsueh,B.W.
            and Wang,S.E.
  TITLE     Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular
            Vesicles Partially Through MEK2-dependent Macropinocytosis
  JOURNAL   Cancer Res Commun 4 (1), 170-181 (2024)
   PUBMED   38259097
  REMARK    GeneRIF: Lung Fibroblasts Take up Breast Cancer Cell-derived
            Extracellular Vesicles Partially Through MEK2-dependent
            Macropinocytosis.
REFERENCE   2  (bases 1 to 1727)
  AUTHORS   Gong,K.Q., Mikacenic,C., Long,M.E., Frevert,C.W., Birkland,T.P.,
            Charron,J., Gharib,S.A. and Manicone,A.M.
  TITLE     MAP2K2 Delays Recovery in Murine Models of Acute Lung Injury and
            Associates with Acute Respiratory Distress Syndrome Outcome
  JOURNAL   Am J Respir Cell Mol Biol 66 (5), 555-563 (2022)
   PUBMED   35157553
  REMARK    GeneRIF: MAP2K2 Delays Recovery in Murine Models of Acute Lung
            Injury and Associates with Acute Respiratory Distress Syndrome
            Outcome.
REFERENCE   3  (bases 1 to 1727)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 1727)
  AUTHORS   Hua,Z., Wei,R., Guo,M., Lin,Z., Yu,X., Li,X., Gu,C. and Yang,Y.
  TITLE     YTHDF2 promotes multiple myeloma cell proliferation via
            STAT5A/MAP2K2/p-ERK axis
  JOURNAL   Oncogene 41 (10), 1482-1491 (2022)
   PUBMED   35075244
  REMARK    GeneRIF: YTHDF2 promotes multiple myeloma cell proliferation via
            STAT5A/MAP2K2/p-ERK axis.
REFERENCE   5  (bases 1 to 1727)
  AUTHORS   Ye,T., Zhang,J.Y., Liu,X.Y., Zhou,Y.H., Yuan,S.Y., Yang,M.M.,
            Xie,W.Z., Gao,C., Chen,Y.X., Huang,M.L., Ye,C.Z. and Chen,J.
  TITLE     The Predictive Value of MAP2K1/2 Mutations on Efficiency of
            Immunotherapy in Melanoma
  JOURNAL   Front Immunol 12, 785526 (2022)
   PUBMED   35069558
  REMARK    GeneRIF: The Predictive Value of MAP2K1/2 Mutations on Efficiency
            of Immunotherapy in Melanoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1727)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   7  (bases 1 to 1727)
  AUTHORS   Derijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J.,
            Ulevitch,R.J. and Davis,R.J.
  TITLE     Independent human MAP-kinase signal transduction pathways defined
            by MEK and MKK isoforms
  JOURNAL   Science 267 (5198), 682-685 (1995)
   PUBMED   7839144
  REMARK    Erratum:[Science 1995 Jul 7;269(5220):17]
REFERENCE   8  (bases 1 to 1727)
  AUTHORS   Alessi,D.R., Saito,Y., Campbell,D.G., Cohen,P., Sithanandam,G.,
            Rapp,U., Ashworth,A., Marshall,C.J. and Cowley,S.
  TITLE     Identification of the sites in MAP kinase kinase-1 phosphorylated
            by p74raf-1
  JOURNAL   EMBO J 13 (7), 1610-1619 (1994)
   PUBMED   8157000
REFERENCE   9  (bases 1 to 1727)
  AUTHORS   Charest,D.L., Mordret,G., Harder,K.W., Jirik,F. and Pelech,S.L.
  TITLE     Molecular cloning, expression, and characterization of the human
            mitogen-activated protein kinase p44erk1
  JOURNAL   Mol Cell Biol 13 (8), 4679-4690 (1993)
   PUBMED   7687743
REFERENCE   10 (bases 1 to 1727)
  AUTHORS   Rauen,K.A.
  TITLE     Cardiofaciocutaneous Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301365
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000471.2 and AA312322.1.
            
            On Dec 4, 2019 this sequence version replaced NM_030662.3.
            
            Summary: The protein encoded by this gene is a dual specificity
            protein kinase that belongs to the MAP kinase kinase family. This
            kinase is known to play a critical role in mitogen growth factor
            signal transduction. It phosphorylates and thus activates
            MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is
            dependent on the Ser/Thr phosphorylation by MAP kinase kinase
            kinases. Mutations in this gene cause cardiofaciocutaneous syndrome
            (CFC syndrome), a disease characterized by heart defects, cognitive
            disability, and distinctive facial features similar to those found
            in Noonan syndrome. The inhibition or degradation of this kinase is
            also found to be involved in the pathogenesis of Yersinia and
            anthrax. A pseudogene, which is located on chromosome 7, has been
            identified for this gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000471.2, ERR279836.1707.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262948.10/ ENSP00000262948.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-906               BC000471.2         8-913
            907-1041            AA312322.1         358-492
            1042-1727           BC000471.2         1049-1734
FEATURES             Location/Qualifiers
     source          1..1727
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1727
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /note="mitogen-activated protein kinase kinase 2"
                     /db_xref="GeneID:5605"
                     /db_xref="HGNC:HGNC:6842"
                     /db_xref="MIM:601263"
     exon            1..339
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1450
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /EC_number="2.7.12.2"
                     /note="MAP kinase kinase 2; MAPK/ERK kinase 2; ERK
                     activator kinase 2; mitogen-activated protein kinase
                     kinase 2, p45"
                     /codon_start=1
                     /product="dual specificity mitogen-activated protein
                     kinase kinase 2"
                     /protein_id="NP_109587.1"
                     /db_xref="CCDS:CCDS12120.1"
                     /db_xref="GeneID:5605"
                     /db_xref="HGNC:HGNC:6842"
                     /db_xref="MIM:601263"
                     /translation="MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEEL
                     ELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKL
                     IHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK
                     EAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQ
                     LIDSMANSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELE
                     AIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLP
                     NGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQP
                     GTPTRTAV"
     exon            340..550
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..697
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..775
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..827
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            828..952
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1166
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1231
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1293
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1339
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1727
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1702..1707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /note="hexamer: AACAAA"
     polyA_site      1727
                     /gene="MAP2K2"
                     /gene_synonym="CFC4; MAPKK2; MEK2; MKK2; PRKMK2"
                     /note="major polyA site"
ORIGIN      
        1 ctctcggact cgggctgcgg cgtcagcctt cttcgggcct cggcagcggt agcggctcgc
       61 tcgcctcagc cccagcgccc ctcggctacc ctcggcccag gcccgcagcg ccgcccgccc
      121 tcggccgccc cgacgccggc ctgggccgcg gccgcagccc cgggctcgcg taggcgccga
      181 ccgctcccgg cccgccccct atgggccccg gctagaggcg ccgccgccgc cggcccgcgg
      241 agccccgatg ctggcccgga ggaagccggt gctgccggcg ctcaccatca accctaccat
      301 cgccgagggc ccatccccta ccagcgaggg cgcctccgag gcaaacctgg tggacctgca
      361 gaagaagctg gaggagctgg aacttgacga gcagcagaag aagcggctgg aagcctttct
      421 cacccagaaa gccaaggtcg gcgaactcaa agacgatgac ttcgaaagga tctcagagct
      481 gggcgcgggc aacggcgggg tggtcaccaa agtccagcac agaccctcgg gcctcatcat
      541 ggccaggaag ctgatccacc ttgagatcaa gccggccatc cggaaccaga tcatccgcga
      601 gctgcaggtc ctgcacgaat gcaactcgcc gtacatcgtg ggcttctacg gggccttcta
      661 cagtgacggg gagatcagca tttgcatgga acacatggac ggcggctccc tggaccaggt
      721 gctgaaagag gccaagagga ttcccgagga gatcctgggg aaagtcagca tcgcggttct
      781 ccggggcttg gcgtacctcc gagagaagca ccagatcatg caccgagatg tgaagccctc
      841 caacatcctc gtgaactcta gaggggagat caagctgtgt gacttcgggg tgagcggcca
      901 gctcatcgac tccatggcca actccttcgt gggcacgcgc tcctacatgg ctccggagcg
      961 gttgcagggc acacattact cggtgcagtc ggacatctgg agcatgggcc tgtccctggt
     1021 ggagctggcc gtcggaaggt accccatccc cccgcccgac gccaaagagc tggaggccat
     1081 ctttggccgg cccgtggtcg acggggaaga aggagagcct cacagcatct cgcctcggcc
     1141 gaggcccccc gggcgccccg tcagcggtca cgggatggat agccggcctg ccatggccat
     1201 ctttgaactc ctggactata ttgtgaacga gccacctcct aagctgccca acggtgtgtt
     1261 cacccccgac ttccaggagt ttgtcaataa atgcctcatc aagaacccag cggagcgggc
     1321 ggacctgaag atgctcacaa accacacctt catcaagcgg tccgaggtgg aagaagtgga
     1381 ttttgccggc tggttgtgta aaaccctgcg gctgaaccag cccggcacac ccacgcgcac
     1441 cgccgtgtga cagtggccgg gctccctgcg tcccgctggt gacctgccca ccgtccctgt
     1501 ccatgccccg cccttccagc tgaggacagg ctggcgcctc cacccaccct cctgcctcac
     1561 ccctgcggag agcaccgtgg cggggcgaca gcgcatgcag gaacgggggt ctcctctcct
     1621 gcccgtcctg gccggggtgc ctctggggac gggcgacgct gctgtgtgtg gtctcagagg
     1681 ctctgcttcc ttaggttaca aaacaaaaca gggagagaaa aagcaaa
//
