LOCUS       NM_018174               3288 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens microtubule associated protein 1S (MAP1S), transcript
            variant 1, mRNA.
ACCESSION   NM_018174
VERSION     NM_018174.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3288)
  AUTHORS   Shi,B., Wang,W., Ye,M., Liang,M., Yu,Z., Zhang,Y., Liu,Z.,
            Liang,X., Ao,J., Xu,F., Xu,G., Jiang,X., Zhou,X. and Liu,L.
  TITLE     Spermidine suppresses the activation of hepatic stellate cells to
            cure liver fibrosis through autophagy activator MAP1S
  JOURNAL   Liver Int 43 (6), 1307-1319 (2023)
   PUBMED   36892418
  REMARK    GeneRIF: Spermidine suppresses the activation of hepatic stellate
            cells to cure liver fibrosis through autophagy activator MAP1S.
REFERENCE   2  (bases 1 to 3288)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 3288)
  AUTHORS   Wang,J., Zhang,X., Yang,F., Yang,Y., Wang,T., Liu,W., Zhou,H. and
            Zhao,W.
  TITLE     RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating
            Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway
  JOURNAL   Drug Des Devel Ther 15, 21-35 (2021)
   PUBMED   33442234
  REMARK    GeneRIF: RASSF1A Enhances Chemosensitivity of NSCLC Cells Through
            Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2
            Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3288)
  AUTHORS   Bai,W., Bai,J., Li,Y., Tian,D. and Shi,R.
  TITLE     Microtubule-associated protein 1S-related autophagy inhibits
            apoptosis of intestinal epithelial cells via Wnt/beta-catenin
            signaling in Crohn's disease
  JOURNAL   Biochem Biophys Res Commun 485 (3), 635-642 (2017)
   PUBMED   28188784
  REMARK    GeneRIF: Results suggested that microtubule associated protein 1S
            (MAP1S) were up-regulated among Crohn's disease (CD) patients and
            MAP1S-related autophagy inhibits apoptosis of intestinal epithelial
            cells (IECs) through Wnt/beta-catenin signaling pathway which might
            play a vital role in the protection of intestinal mucosal barrier
            and inhibition the progression of CD.
REFERENCE   5  (bases 1 to 3288)
  AUTHORS   Xu,G., Jiang,Y., Xiao,Y., Liu,X.D., Yue,F., Li,W., Li,X., He,Y.,
            Jiang,X., Huang,H., Chen,Q., Jonasch,E. and Liu,L.
  TITLE     Fast clearance of lipid droplets through MAP1S-activated autophagy
            suppresses clear cell renal cell carcinomas and promotes patient
            survival
  JOURNAL   Oncotarget 7 (5), 6255-6265 (2016)
   PUBMED   26701856
  REMARK    GeneRIF: Autophagy defects in the degradation of lipid droplets
            triggered by the MAP1S deficiency may enhance the initiation and
            development of ccRCC and reduce the survival of ccRCC patients.
REFERENCE   6  (bases 1 to 3288)
  AUTHORS   Orban-Nemeth,Z., Simader,H., Badurek,S., Trancikova,A. and
            Propst,F.
  TITLE     Microtubule-associated protein 1S, a short and ubiquitously
            expressed member of the microtubule-associated protein 1 family
  JOURNAL   J Biol Chem 280 (3), 2257-2265 (2005)
   PUBMED   15528209
  REMARK    GeneRIF: is expressed in a wide range of tissues in addition to
            neurons and represents the non-neuronal counterpart of a cytolinker
            family
REFERENCE   7  (bases 1 to 3288)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 3288)
  AUTHORS   Wong,E.Y., Tse,J.Y., Yao,K.M., Lui,V.C., Tam,P.C. and Yeung,W.S.
  TITLE     Identification and characterization of human VCY2-interacting
            protein: VCY2IP-1, a microtubule-associated protein-like protein
  JOURNAL   Biol Reprod 70 (3), 775-784 (2004)
   PUBMED   14627543
  REMARK    GeneRIF: The amino acid sequence of VCY2IP-1 shows 59.3% and 41.9%
            homology to two human microtubule-associated proteins (MAPs), MAP1B
            and MAP1A, respectively. VCY2IP-1 has an extensive homology to the
            N-terminus and C-terminus regions of MAP1B and MAP1A
REFERENCE   9  (bases 1 to 3288)
  AUTHORS   Liu,L., Amy,V., Liu,G. and McKeehan,W.L.
  TITLE     Novel complex integrating mitochondria and the microtubular
            cytoskeleton with chromosome remodeling and tumor suppressor RASSF1
            deduced by in silico homology analysis, interaction cloning in
            yeast, and colocalization in cultured cells
  JOURNAL   In Vitro Cell Dev Biol Anim 38 (10), 582-594 (2002)
   PUBMED   12762840
REFERENCE   10 (bases 1 to 3288)
  AUTHORS   Liu,L. and McKeehan,W.L.
  TITLE     Sequence analysis of LRPPRC and its SEC1 domain interaction
            partners suggests roles in cytoskeletal organization, vesicular
            trafficking, nucleocytosolic shuttling, and chromosome activity
  JOURNAL   Genomics 79 (1), 124-136 (2002)
   PUBMED   11827465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB081409.1, BG771546.1, BC067115.1, BC007253.1 and AA905204.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018174.5.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292555.1, AL834233.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324096.9/ ENSP00000325313.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DB081409.1         29-42
            15-17               BG771546.1         6-8
            18-3284             BC067115.1         1-3267
            3285-3287           BC007253.1         1192-1194
            3288-3288           AA905204.1         11-11               c
FEATURES             Location/Qualifiers
     source          1..3288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3288
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /note="microtubule associated protein 1S"
                     /db_xref="GeneID:55201"
                     /db_xref="HGNC:HGNC:15715"
                     /db_xref="MIM:607573"
     exon            1..141
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3203
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     microtubule-associated protein 8; MAP-1S; BPY2-interacting
                     protein 1; VCY2-interacting protein 1; variable charge Y
                     chromosome 2-interacting protein 1"
                     /codon_start=1
                     /product="microtubule-associated protein 1S isoform 1"
                     /protein_id="NP_060644.4"
                     /db_xref="CCDS:CCDS32954.1"
                     /db_xref="GeneID:55201"
                     /db_xref="HGNC:HGNC:15715"
                     /db_xref="MIM:607573"
                     /translation="MAAVAGSGAAAAPSSLLLVVGSEFGSPGLLTYVLEELERGIRSW
                     DVDPGVCNLDEQLKVFVSRHSATFSSIVKGQRSLHHRGDNLETLVLLNPSDKSLYDEL
                     RNLLLDPASHKLLVLAGPCLEETGELLLQTGGFSPHHFLQVLKDREIRDILATTPPPV
                     QPPILTITCPTFGDWAQLAPAVPGLQGALRLQLRLNPPAQLPNSEGLCEFLEYVAESL
                     EPPSPFELLEPPTSGGFLRLGRPCCYIFPGGLGDAAFFAVNGFTVLVNGGSNPKSSFW
                     KLVRHLDRVDAVLVTHPGADSLPGLNSLLRRKLAERSEVAAGGGSWDDRLRRLISPNL
                     GVVFFNACEAASRLARGEDEAELALSLLAQLGITPLPLSRGPVPAKPTVLFEKMGVGR
                     LDMYVLHPPSAGAERTLASVCALLVWHPAGPGEKVVRVLFPGCTPPACLLDGLVRLQH
                     LRFLREPVVTPQDLEGPGRAESKESVGSRDSSKREGLLATHPRPGQERPGVARKEPAR
                     AEAPRKTEKEAKTPRELKKDPKPSVSRTQPREVRRAASSVPNLKKTNAQAAPKPRKAP
                     STSHSGFPPVANGPRSPPSLRCGEASPPSAACGSPASQLVATPSLELGPIPAGEEKAL
                     ELPLAASSIPRPRTPSPESHRSPAEGSERLSLSPLRGGEAGPDASPTVTTPTVTTPSL
                     PAEVGSPHSTEVDESLSVSFEQVLPPSAPTSEAGLSLPLRGPRARRSASPHDVDLCLV
                     SPCEFEHRKAVPMAPAPASPGSSNDSSARSQERAGGLGAEETPPTSVSESLPTLSDSD
                     PVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQT
                     ENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPL
                     SRKSSTPKTATRGPSGSASSRPGVSATPPKSPVYLDLAYLPSGSSAHLVDEEFFQRVR
                     ALCYVISGQDQRKEEGMRAVLDALLASKQHWDRDLQVTLIPTFDSVAMHTWYAETHAR
                     HQALGITVLGSNSMVSMQDDAFPACKVEF"
     exon            142..243
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..326
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            327..467
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..2811
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..3047
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3288
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3268..3273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /note="hexamer: AATAAA"
     polyA_site      3288
                     /gene="MAP1S"
                     /gene_synonym="BPY2IP1; C19orf5; MAP8; VCY2IP-1; VCY2IP1"
                     /note="major polyA site"
ORIGIN      
        1 gagaacgccg gggcggcccg aagatggcgg cggtggctgg atctggggct gccgcggctc
       61 cgagctcact gctcctcgtg gtgggcagcg agttcgggag cccggggctc ctcacctacg
      121 tcctggagga gctcgaaaga ggcatccggt cttgggatgt cgatcctggc gtctgcaacc
      181 ttgatgaaca gctcaaggtc tttgtgtccc gacactctgc caccttctcc agcattgtga
      241 aaggccagcg gagcctgcac caccgtggag acaacctgga gaccctggtc ctcctgaacc
      301 catcagacaa gtccctgtat gatgagctcc ggaaccttct gttggaccct gcctctcaca
      361 agctactggt gttggctggg ccctgcctgg aggagacggg ggagctgctg ctacagacag
      421 ggggcttctc gcctcaccac ttcctccagg tcctgaagga cagagagatc cgggacatcc
      481 tggccaccac gcccccacct gtgcagccgc ccatactcac catcacctgc cccaccttcg
      541 gtgactgggc tcagctggca cccgctgtgc ctggccttca gggggcgctc cggctccagc
      601 tgcggctgaa ccccccggcg cagctgccca actctgaggg cctgtgcgaa ttcctggagt
      661 acgtggctga gtctctggag ccaccgtccc ccttcgagct gctggagccc ccgacctccg
      721 ggggcttcct caggctgggc cggccctgct gctacatctt ccctggaggc ctcggggatg
      781 ccgccttctt cgccgtcaat ggcttcactg tgctggtcaa cggtggctca aaccccaagt
      841 ccagtttctg gaagctggtg cggcacctgg accgcgtgga tgccgtgctg gtgacccacc
      901 ctggcgccga cagcctcccc ggcctcaaca gcctgctgcg gcgcaaactg gcggagcgct
      961 ccgaggtggc tgctggtggg ggctcctggg acgacaggct gcgcaggctc atctccccca
     1021 acctgggggt cgtgttcttc aacgcctgcg aggccgcgtc gcggctggcg cgcggcgagg
     1081 atgaggcgga gctggcgctg agcctcctgg cgcagctggg catcacgcct ctgccactca
     1141 gccgcggccc cgtgccagcc aaacccaccg tgctcttcga gaagatgggc gtgggccggc
     1201 tggacatgta tgtgctgcac ccgccctccg ccggcgccga gcgcacgctg gcctctgtgt
     1261 gcgccctgct ggtgtggcac cccgccggcc ccggcgagaa ggtggtgcgc gtgctgttcc
     1321 ccggttgcac cccgcccgcc tgcctcctgg acggcctggt ccgcctgcag cacttgaggt
     1381 tcctgcgaga gcccgtggtg acgccccagg acctggaggg gccggggcga gccgagagca
     1441 aagagagcgt gggctcccgg gacagctcga agagagaggg cctcctggcc acccacccta
     1501 gacctggcca ggagcgccct ggggtggccc gcaaggagcc agcacgggct gaggccccac
     1561 gcaagactga gaaagaagcc aagacccccc gggagttgaa gaaagacccc aaaccgagtg
     1621 tctcccggac ccagccgcgg gaggtgcgcc gggcagcctc ttctgtgccc aacctcaaga
     1681 agacgaatgc ccaggcggca cccaagcccc gcaaagcgcc cagcacgtcc cactctggct
     1741 tcccgccggt ggcaaatgga ccccgcagcc cgcccagcct ccgatgtgga gaagccagcc
     1801 cccccagtgc agcctgcggc tctccggcct cccagctggt ggccacgccc agcctggagc
     1861 tggggccgat cccagccggg gaggagaagg cactggagct gcctttggcc gccagctcaa
     1921 tcccaaggcc acgcacaccc tcccctgagt cccaccggag ccccgcagag ggcagcgagc
     1981 ggctgtcgct gagcccactg cggggcgggg aggccgggcc agacgcctca cccacagtga
     2041 ccacacccac ggtgaccacg ccctcactac ccgcagaggt gggctccccg cactcgaccg
     2101 aggtggacga gtccctgtcg gtgtcctttg agcaggtgct gccgccatcc gcccccacca
     2161 gtgaggctgg gctgagcctc ccgctgcgtg gcccccgggc gcggcgctcg gcttccccac
     2221 acgatgtgga cctgtgcctg gtgtcaccct gtgaatttga gcatcgcaag gcggtgccaa
     2281 tggcaccggc acctgcgtcc cccggcagct cgaatgacag cagtgcccgg tcacaggaac
     2341 gggcaggtgg gctgggggcc gaggagacgc cacccacatc ggtcagcgag tccctgccca
     2401 ccctgtctga ctcggatccc gtgcccctgg cccccggtgc ggcagactca gacgaagaca
     2461 cagagggctt tggagtccct cgccacgacc ctttgcctga ccccctcaag gtccccccac
     2521 cactgcctga cccatccagc atctgcatgg tggaccccga gatgctgccc cccaagacag
     2581 cacggcaaac ggagaacgtc agccgcaccc ggaagcccct ggcccgcccc aactcacgcg
     2641 ctgccgcccc caaagccact ccagtggctg ctgccaaaac caaggggctt gctggtgggg
     2701 accgtgccag ccgaccactc agtgcccgga gtgagcccag tgagaaggga ggccgggcac
     2761 ccctgtccag aaagtcctca acccccaaga ctgccactcg aggcccgtcg gggtcagcca
     2821 gcagccggcc cggggtgtca gccaccccac ccaagtcccc ggtctacctg gacctggcct
     2881 acctgcccag cgggagcagc gcccacctgg tggatgagga gttcttccag cgcgtgcgcg
     2941 cgctctgcta cgtcatcagt ggccaggacc agcgcaagga ggaaggcatg cgggccgtcc
     3001 tggacgcgct actggccagc aagcagcatt gggaccgtga cctgcaggtg accctgatcc
     3061 ccactttcga ctcggtggcc atgcatacgt ggtacgcaga gacgcacgcc cggcaccagg
     3121 cgctgggcat cacggtgttg ggcagcaaca gcatggtgtc catgcaggat gacgccttcc
     3181 cggcctgcaa ggtggagttc tagccccatc gccgacacgc cccccactca gcccagcccg
     3241 cctgtcccta gattcagcca catcagaaat aaactgtgac tacacttg
//
