LOCUS       NM_001004343            1207 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens microtubule associated protein 1 light chain 3 gamma
            (MAP1LC3C), mRNA.
ACCESSION   NM_001004343 XM_496447
VERSION     NM_001004343.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1207)
  AUTHORS   Sun,Y. and Wang,X.
  TITLE     Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis
  JOURNAL   Autophagy 20 (6), 1457-1458 (2024)
   PUBMED   38348842
  REMARK    GeneRIF: Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis.
REFERENCE   2  (bases 1 to 1207)
  AUTHORS   Chung,J., Park,J., Lai,Z.W., Lambert,T.J., Richards,R.C., Zhang,J.,
            Walther,T.C. and Farese,R.V. Jr.
  TITLE     The Troyer syndrome protein spartin mediates selective autophagy of
            lipid droplets
  JOURNAL   Nat Cell Biol 25 (8), 1101-1110 (2023)
   PUBMED   37443287
REFERENCE   3  (bases 1 to 1207)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   4  (bases 1 to 1207)
  AUTHORS   Judith,D., Versapuech,M., Bejjani,F., Palaric,M., Verlhac,P.,
            Kuster,A., Lepont,L., Gallois-Montbrun,S., Janvier,K. and
            Berlioz-Torrent,C.
  TITLE     ATG5 selectively engages virus-tethered BST2/tetherin in an
            LC3C-associated pathway
  JOURNAL   Proc Natl Acad Sci U S A 120 (20), e2217451120 (2023)
   PUBMED   37155854
  REMARK    GeneRIF: ATG5 selectively engages virus-tethered BST2/tetherin in
            an LC3C-associated pathway.
REFERENCE   5  (bases 1 to 1207)
  AUTHORS   Verma,R., Aggarwal,P., Bischoff,M.E., Reigle,J., Secic,D.,
            Wetzel,C., VandenHeuvel,K., Biesiada,J., Ehmer,B., Landero
            Figueroa,J.A., Plas,D.R., Medvedovic,M., Meller,J. and
            Czyzyk-Krzeska,M.F.
  TITLE     Microtubule-associated protein MAP1LC3C regulates lysosomal
            exocytosis and induces zinc reprogramming in renal cancer cells
  JOURNAL   J Biol Chem 299 (5), 104663 (2023)
   PUBMED   37003503
  REMARK    GeneRIF: Microtubule-associated protein MAP1LC3C regulates
            lysosomal exocytosis and induces zinc reprogramming in renal cancer
            cells.
REFERENCE   6  (bases 1 to 1207)
  AUTHORS   Popovic,D., Akutsu,M., Novak,I., Harper,J.W., Behrends,C. and
            Dikic,I.
  TITLE     Rab GTPase-activating proteins in autophagy: regulation of
            endocytic and autophagy pathways by direct binding to human ATG8
            modifiers
  JOURNAL   Mol Cell Biol 32 (9), 1733-1744 (2012)
   PUBMED   22354992
REFERENCE   7  (bases 1 to 1207)
  AUTHORS   Behrends,C., Sowa,M.E., Gygi,S.P. and Harper,J.W.
  TITLE     Network organization of the human autophagy system
  JOURNAL   Nature 466 (7302), 68-76 (2010)
   PUBMED   20562859
REFERENCE   8  (bases 1 to 1207)
  AUTHORS   Kirkin,V., Lamark,T., Sou,Y.S., Bjorkoy,G., Nunn,J.L., Bruun,J.A.,
            Shvets,E., McEwan,D.G., Clausen,T.H., Wild,P., Bilusic,I.,
            Theurillat,J.P., Overvatn,A., Ishii,T., Elazar,Z., Komatsu,M.,
            Dikic,I. and Johansen,T.
  TITLE     A role for NBR1 in autophagosomal degradation of ubiquitinated
            substrates
  JOURNAL   Mol Cell 33 (4), 505-516 (2009)
   PUBMED   19250911
REFERENCE   9  (bases 1 to 1207)
  AUTHORS   Tanida,I., Sou,Y.S., Ezaki,J., Minematsu-Ikeguchi,N., Ueno,T. and
            Kominami,E.
  TITLE     HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three
            human Atg8 homologues and delipidates microtubule-associated
            protein light chain 3- and GABAA receptor-associated
            protein-phospholipid conjugates
  JOURNAL   J Biol Chem 279 (35), 36268-36276 (2004)
   PUBMED   15187094
REFERENCE   10 (bases 1 to 1207)
  AUTHORS   He,H., Dang,Y., Dai,F., Guo,Z., Wu,J., She,X., Pei,Y., Chen,Y.,
            Ling,W., Wu,C., Zhao,S., Liu,J.O. and Yu,L.
  TITLE     Post-translational modifications of three members of the human
            MAP1LC3 family and detection of a novel type of modification for
            MAP1LC3B
  JOURNAL   J Biol Chem 278 (31), 29278-29287 (2003)
   PUBMED   12740394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX571673.8, CN260933.1, BC127722.1 and AF276659.1.
            
            On May 17, 2019 this sequence version replaced NM_001004343.2.
            
            Summary: Autophagy is a highly regulated bulk degradation process
            that plays an important role in cellular maintenance and
            development. MAP1LC3C is an ortholog of the yeast autophagosome
            protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM,
            Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276659.1, BC132988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357246.4/ ENSP00000349785.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BX571673.8         100888-100902       c
            16-24               CN260933.1         1-9
            25-561              BC127722.1         1-537
            562-1207            AF276659.1         536-1181
FEATURES             Location/Qualifiers
     source          1..1207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1207
                     /gene="MAP1LC3C"
                     /gene_synonym="ATG8J; LC3C"
                     /note="microtubule associated protein 1 light chain 3
                     gamma"
                     /db_xref="GeneID:440738"
                     /db_xref="HGNC:HGNC:13353"
                     /db_xref="MIM:609605"
     exon            1..148
                     /gene="MAP1LC3C"
                     /gene_synonym="ATG8J; LC3C"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..534
                     /gene="MAP1LC3C"
                     /gene_synonym="ATG8J; LC3C"
                     /note="MAP1 light chain 3-like protein 2;
                     microtubule-associated proteins 1A/1B light chain 3C;
                     LC3-like protein 2; MAP1A/MAP1B LC3 C; MAP1A/MAP1B light
                     chain 3 C; autophagy-related protein LC3 C; MAP1 light
                     chain 3-like protein 3; autophagy-related ubiquitin-like
                     modifier LC3 C"
                     /codon_start=1
                     /product="microtubule-associated protein 1 light chain 3
                     gamma"
                     /protein_id="NP_001004343.1"
                     /db_xref="CCDS:CCDS31074.1"
                     /db_xref="GeneID:440738"
                     /db_xref="HGNC:HGNC:13353"
                     /db_xref="MIM:609605"
                     /translation="MPPPQKIPSVRPFKQRKSLAIRQEEVAGIRAKFPNKIPVVVERY
                     PRETFLPPLDKTKFLVPQELTMTQFLSIIRSRMVLRATEAFYLLVNNKSLVSMSATMA
                     EIYRDYKDEDGFVYMTYASQETFGCLESAAPRDGSSLEDRPCNPL"
     exon            149..204
                     /gene="MAP1LC3C"
                     /gene_synonym="ATG8J; LC3C"
                     /inference="alignment:Splign:2.1.0"
     exon            205..311
                     /gene="MAP1LC3C"
                     /gene_synonym="ATG8J; LC3C"
                     /inference="alignment:Splign:2.1.0"
     exon            312..1207
                     /gene="MAP1LC3C"
                     /gene_synonym="ATG8J; LC3C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttggaag cagctggagg aatgagttag gttcccggtt gcgggacagt ttttttttct
       61 tttttaaaac agacacagct actgagtgca atgccgcctc cacagaaaat cccaagcgtc
      121 agacccttca agcagaggaa aagcttggca atcagacaag aggaagttgc tggaatccgg
      181 gcaaagttcc ccaacaaaat cccggtggta gtggagcgct accccaggga gacgttcctg
      241 cccccgctgg acaaaaccaa gttcctggtc ccgcaggagc tgaccatgac ccagttcctc
      301 agcatcatcc ggagccgcat ggtcctgaga gccacggaag ccttttactt gctggtgaac
      361 aacaagagcc tggtcagcat gagcgcaacc atggcagaga tctacagaga ctacaaggat
      421 gaggatggct tcgtgtacat gacctacgcc tcccaggaga catttggctg cctggagtca
      481 gcagccccca gggatgggag cagccttgag gacagaccct gcaatcctct ctagcccatg
      541 tcgggaagga tgtgtgctct gacagacgtg tcagatgctg gcagaaggga ttggttttct
      601 cctgtgtata cagtggagga gtctgagaag cagggatgcc tggggtgatc agctccaacc
      661 agtggcagca gagtggtggc tcttcctagt ttagtttttg tgctccgtgt tcttgtgtcc
      721 ttctaagaaa aatgtgggct gctcttgaaa gttatataat tatcattttt ttttttttga
      781 aacagggtct tgctctattg cctaggctgg agcacagtgg catgatcttg gctcactgca
      841 acctccgcct cctgggttca agtgattctt ctgcctccac cccccgagtg gctggtatta
      901 caagcacatg ccaccacacc aggctaattt ttgtattttt agtagagacg gggtttcacc
      961 atgttggcca ggctggtctc gaactcctga cctcaggtga tccacccacc tcggcctccc
     1021 aaagtgctgg gattacaggc gtgagccact gcatccagcc atataaccgt attctaaata
     1081 agaaatggtt ggcttgtgtg atggttttgt gtaatgagct agagataata ttttaagtgt
     1141 cttctgtggt atatgtggga gggccattaa ggagtgggtt tcactccctg catgtgggca
     1201 ggtgtcc
//
