LOCUS       NM_022818               2147 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens microtubule associated protein 1 light chain 3 beta
            (MAP1LC3B), mRNA.
ACCESSION   NM_022818
VERSION     NM_022818.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2147)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   2  (bases 1 to 2147)
  AUTHORS   Yoon,J., Hwang,Y., Yun,H., Chung,J.M., Kim,S., Kim,G., Lee,Y.,
            Lee,B.D. and Kang,H.C.
  TITLE     LC3B drives transcription-associated homologous recombination via
            direct interaction with R-loops
  JOURNAL   Nucleic Acids Res 52 (9), 5088-5106 (2024)
   PUBMED   38412240
  REMARK    GeneRIF: LC3B drives transcription-associated homologous
            recombination via direct interaction with R-loops.
REFERENCE   3  (bases 1 to 2147)
  AUTHORS   Ni,H., Tang,S., Lu,G., Niu,Y., Xu,J., Zhang,H., Hu,J., Shen,H.M.,
            Wu,Y. and Xia,D.
  TITLE     Linc00673-V3 positively regulates autophagy by promoting
            Smad3-mediated LC3B transcription in NSCLC
  JOURNAL   Life Sci Alliance 7 (6), e202302408 (2024)
   PUBMED   38527804
  REMARK    GeneRIF: Linc00673-V3 positively regulates autophagy by promoting
            Smad3-mediated LC3B transcription in NSCLC.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2147)
  AUTHORS   Qu,H., Liang,Y., Guo,Q., Lu,L., Yang,Y., Xu,W., Zhang,Y. and Qin,Y.
  TITLE     Identifying CTH and MAP1LC3B as ferroptosis biomarkers for
            prognostic indication in gastric cancer decoding
  JOURNAL   Sci Rep 14 (1), 4352 (2024)
   PUBMED   38388661
  REMARK    GeneRIF: Identifying CTH and MAP1LC3B as ferroptosis biomarkers for
            prognostic indication in gastric cancer decoding.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2147)
  AUTHORS   El-Deek,H.E.M., El-Naggar,M.S. and Sayed,S.G.
  TITLE     Immunohistochemical Expression of Autophagy-Related Marker (LC3B)
            and Stem Cell Marker (CD44) in Molecular Subtypes of Breast Cancer
  JOURNAL   Asian Pac J Cancer Prev 25 (1), 145-152 (2024)
   PUBMED   38285778
  REMARK    GeneRIF: Immunohistochemical Expression of Autophagy-Related Marker
            (LC3B) and Stem Cell Marker (CD44) in Molecular Subtypes of Breast
            Cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2147)
  AUTHORS   He,H., Dang,Y., Dai,F., Guo,Z., Wu,J., She,X., Pei,Y., Chen,Y.,
            Ling,W., Wu,C., Zhao,S., Liu,J.O. and Yu,L.
  TITLE     Post-translational modifications of three members of the human
            MAP1LC3 family and detection of a novel type of modification for
            MAP1LC3B
  JOURNAL   J Biol Chem 278 (31), 29278-29287 (2003)
   PUBMED   12740394
  REMARK    GeneRIF: the essential site for the distinct post-translation
            modification of microtubule-associated protein 1 light chain 3B is
            Lys-122 rather than the conserved Gly-120
REFERENCE   7  (bases 1 to 2147)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Komatsu,M., Ueno,T. and Kominami,E.
  TITLE     Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple
            substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the
            conjugation of hApg12p to hApg5p
  JOURNAL   J Biol Chem 277 (16), 13739-13744 (2002)
   PUBMED   11825910
  REMARK    GeneRIF: Human Apg3p/Aut1p homologue is an authentic E2 enzyme for
            multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates
            the conjugation of hApg12p to hApg5p
REFERENCE   8  (bases 1 to 2147)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Nishitani,T., Komatsu,M., Yamazaki,H.,
            Ueno,T. and Kominami,E.
  TITLE     Murine Apg12p has a substrate preference for murine Apg7p over
            three Apg8p homologs
  JOURNAL   Biochem Biophys Res Commun 292 (1), 256-262 (2002)
   PUBMED   11890701
REFERENCE   9  (bases 1 to 2147)
  AUTHORS   Kabeya,Y., Mizushima,N., Ueno,T., Yamamoto,A., Kirisako,T.,
            Noda,T., Kominami,E., Ohsumi,Y. and Yoshimori,T.
  TITLE     LC3, a mammalian homologue of yeast Apg8p, is localized in
            autophagosome membranes after processing
  JOURNAL   EMBO J 19 (21), 5720-5728 (2000)
   PUBMED   11060023
  REMARK    Erratum:[EMBO J. 2003 Sep 1;22(17):4577]
REFERENCE   10 (bases 1 to 2147)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010531.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022818.4.
            
            Summary:  The product of this gene is a subunit of neuronal
            microtubule-associated MAP1A and MAP1B proteins, which are involved
            in microtubule assembly and important for neurogenesis. Studies on
            the rat homolog implicate a role for this gene in autophagy, a
            process that involves the bulk degradation of cytoplasmic
            component. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF087871.1, BC048009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268607.10/ ENSP00000268607.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC010531.8         151942-152073
            133-188             AC010531.8         158421-158476
            189-295             AC010531.8         161781-161887
            296-2147            AC010531.8         162529-164380
FEATURES             Location/Qualifiers
     source          1..2147
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..2147
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /note="microtubule associated protein 1 light chain 3
                     beta"
                     /db_xref="GeneID:81631"
                     /db_xref="HGNC:HGNC:13352"
                     /db_xref="MIM:609604"
     exon            1..132
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..470
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /note="microtubule-associated proteins 1A/1B light chain
                     3B; MAP1A/MAP1B LC3 B; MAP1A/MAP1B light chain 3 B; MAP1
                     light chain 3-like protein 2; autophagy-related
                     ubiquitin-like modifier LC3 B"
                     /codon_start=1
                     /product="microtubule-associated protein 1 light chain 3
                     beta"
                     /protein_id="NP_073729.1"
                     /db_xref="CCDS:CCDS10960.1"
                     /db_xref="GeneID:81631"
                     /db_xref="HGNC:HGNC:13352"
                     /db_xref="MIM:609604"
                     /translation="MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQL
                     PVLDKTKFLVPDHVNMSELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESE
                     KDEDGFLYMVYASQETFGMKLSV"
     exon            133..188
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /inference="alignment:Splign:2.1.0"
     exon            189..295
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /inference="alignment:Splign:2.1.0"
     exon            296..2147
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /note="hexamer: AATAAA"
     polyA_site      2147
                     /gene="MAP1LC3B"
                     /gene_synonym="ATG8F; LC3B; MAP1A/1BLC3; MAP1LC3B-a"
                     /note="major polyA site"
ORIGIN      
        1 agagtcggat tcgccgccgc agcagccgcc gcccccggga gccgccggga ccctcgcgtc
       61 gtcgccgccg ccgccgccca gatccctgca ccatgccgtc ggagaagacc ttcaagcagc
      121 gccgcacctt cgaacaaaga gtagaagatg tccgacttat tcgagagcag catccaacca
      181 aaatcccggt gataatagaa cgatacaagg gtgagaagca gcttcctgtt ctggataaaa
      241 caaagttcct tgtacctgac catgtcaaca tgagtgagct catcaagata attagaaggc
      301 gcttacagct caatgctaat caggccttct tcctgttggt gaacggacac agcatggtca
      361 gcgtctccac accaatctca gaggtgtatg agagtgagaa agatgaagat ggattcctgt
      421 acatggtcta tgcctcccag gagacgttcg ggatgaaatt gtcagtgtaa aaccagaaaa
      481 aatgcagctc ttctagaatt gtttaaaccc ttaccaagga aaaaaaaggg atgttaccaa
      541 ctgagatcga tcagttcatc caatcacaga tcatgaaaca gtagtgttcc cacctaggag
      601 tgttaggaag ttgtgtttgt gtttcaagca gaaaaactga gctccaagtg agcacattca
      661 gctttggaaa ctatattatt taatgtaggc tagcttgttt tcaaatttta aaagtttaaa
      721 aataaaatac tttgcattct aagttgccaa taaaatagac cttcaagtta ttttaatgct
      781 cttttctcac taataggaac ttgtaattcc agcagtaatt taaaggcttt cagagagacc
      841 ctgagtcttc tcttcaggtt cacaaaaccc gccgcctttt tgggtagaag ttttctactc
      901 agctagagag atctccctaa gaggatcttt aggcctgagt tgtgaagcgc aacccccgca
      961 aaacgcattt gccatcacag ttggcacaaa cgcagggtaa acgggctgtg tgagaaaacg
     1021 gccctgactg taaactgctg aaggtccctg actcctaaga gaaccacacc caaagtcctc
     1081 actcttgcag gggtagacat ttctggtttg gtttgttctc tagatagtta cacacataaa
     1141 gacaccactc aaaaggaaac ttgaataatt tataattttg atcgagtttc ttaaaagacc
     1201 ctggagaaag agtggcattt cttctgtttc aggttttgtc tgagttcaaa ctagtgcctg
     1261 tgttgttacg gaaagcagca gtgtaccagt gtcactctgg agtacagcgg gagaaacaca
     1321 aaatagtata actgaaaaca ttaacattca gacacactcc cttctgcctt ccggcttaaa
     1381 gctgtggatg atccacgttt ttgttttttt aatgttaaat gtgtaactca gtattactga
     1441 aaaggtaccc acattttgaa tagtagttat cactcttagg tcagacagcc atcagaattc
     1501 tcccacacca agtgcatgtc agttgtggag aaaacatagc aaaaagagcc gtacgctctt
     1561 tacagatact aatgtcaaga gttaaacctc ctcaggttca acctgtgata aaagactagt
     1621 gcttcccagt acttgcatgg ggttcactat ttatagtttt cttgggagta tcacaggaaa
     1681 atcacaatta caccacttta gaccctatgt gtagcaggtc acaacttacc cttgtgtgtt
     1741 tagatgtgta tgaaatacct gtatacgtta gtgaaagctg tttactgtaa cggggaaaac
     1801 cagattcttt gcatctgggc cctctactga ttgttaaagg agttcctgtc acctgctccc
     1861 cccacccccg catgcgtctg tccacttggc taacttttaa tatgtgtatt tttacattat
     1921 gtatattctt aactggactg tctcgtttag actgtataca tcatatctga cattattgta
     1981 actaccgtgt gatcagtaag attcctgtaa gaaatactgc tttttaagaa aaaaaataac
     2041 atgctgaggg gtgacctata tcccatgtga gtggtcactt tatttatagg atctttaaaa
     2101 catttttaat gaactaagtt gaataaaggc acaattaaaa actgtca
//
