LOCUS       NM_032514                964 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens microtubule associated protein 1 light chain 3 alpha
            (MAP1LC3A), transcript variant 1, mRNA.
ACCESSION   NM_032514
VERSION     NM_032514.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Luan,J., Zhang,Z., Wang,Q., Li,C., Zhang,H., Zhang,Y., Peng,X.,
            Zhao,G. and Lin,J.
  TITLE     The Role of LC3-Associated Phagocytosis Inhibits the Inflammatory
            Response in Aspergillus fumigatus Keratitis
  JOURNAL   Invest Ophthalmol Vis Sci 65 (8), 4 (2024)
   PUBMED   38953845
  REMARK    GeneRIF: The Role of LC3-Associated Phagocytosis Inhibits the
            Inflammatory Response in Aspergillus fumigatus Keratitis.
REFERENCE   3  (bases 1 to 964)
  AUTHORS   Ji,Y., Xiong,L., Zhang,G., Xu,M., Qiu,W., Xiu,C., Kuang,G. and
            Rui,Y.
  TITLE     Synovial fluid exosome-derived miR-182-5p alleviates osteoarthritis
            by downregulating TNFAIP8 and promoting autophagy through LC3
            signaling
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111177 (2023)
   PUBMED   37948986
  REMARK    GeneRIF: Synovial fluid exosome-derived miR-182-5p alleviates
            osteoarthritis by downregulating TNFAIP8 and promoting autophagy
            through LC3 signaling.
REFERENCE   4  (bases 1 to 964)
  AUTHORS   Chung,J., Park,J., Lai,Z.W., Lambert,T.J., Richards,R.C., Zhang,J.,
            Walther,T.C. and Farese,R.V. Jr.
  TITLE     The Troyer syndrome protein spartin mediates selective autophagy of
            lipid droplets
  JOURNAL   Nat Cell Biol 25 (8), 1101-1110 (2023)
   PUBMED   37443287
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Farnung,J., Muhar,M., Liang,J.R., Tolmachova,K.A., Benoit,R.M.,
            Corn,J.E. and Bode,J.W.
  TITLE     Semisynthetic LC3 Probes for Autophagy Pathways Reveal a
            Noncanonical LC3 Interacting Region Motif Crucial for the Enzymatic
            Activity of Human ATG3
  JOURNAL   ACS Cent Sci 9 (5), 1025-1034 (2023)
   PUBMED   37252361
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 964)
  AUTHORS   Bonnet,C., Boucher,D., Lazereg,S., Pedrotti,B., Islam,K.,
            Denoulet,P. and Larcher,J.C.
  TITLE     Differential binding regulation of microtubule-associated proteins
            MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation
  JOURNAL   J Biol Chem 276 (16), 12839-12848 (2001)
   PUBMED   11278895
REFERENCE   7  (bases 1 to 964)
  AUTHORS   Tanida,I., Tanida-Miyake,E., Ueno,T. and Kominami,E.
  TITLE     The human homolog of Saccharomyces cerevisiae Apg7p is a
            Protein-activating enzyme for multiple substrates including human
            Apg12p, GATE-16, GABARAP, and MAP-LC3
  JOURNAL   J Biol Chem 276 (3), 1701-1706 (2001)
   PUBMED   11096062
REFERENCE   8  (bases 1 to 964)
  AUTHORS   Mann,S.S. and Hammarback,J.A.
  TITLE     Gene localization and developmental expression of light chain 3: a
            common subunit of microtubule-associated protein 1A(MAP1A) and
            MAP1B
  JOURNAL   J Neurosci Res 43 (5), 535-544 (1996)
   PUBMED   8833088
REFERENCE   9  (bases 1 to 964)
  AUTHORS   Mann,S.S. and Hammarback,J.A.
  TITLE     Molecular characterization of light chain 3. A microtubule binding
            subunit of MAP1A and MAP1B
  JOURNAL   J Biol Chem 269 (15), 11492-11497 (1994)
   PUBMED   7908909
REFERENCE   10 (bases 1 to 964)
  AUTHORS   Schoenfeld,T.A., McKerracher,L., Obar,R. and Vallee,R.B.
  TITLE     MAP 1A and MAP 1B are structurally related microtubule associated
            proteins with distinct developmental patterns in the CNS
  JOURNAL   J Neurosci 9 (5), 1712-1730 (1989)
   PUBMED   2470876
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EL954540.1, BP212418.1 and
            AF276658.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032514.3.
            
            Summary: MAP1A and MAP1B are microtubule-associated proteins which
            mediate the physical interactions between microtubules and
            components of the cytoskeleton. MAP1A and MAP1B each consist of a
            heavy chain subunit and multiple light chain subunits. The protein
            encoded by this gene is one of the light chain subunits and can
            associate with either MAP1A or MAP1B. Two transcript variants
            encoding different isoforms have been found for this gene. The
            expression of variant 1 is suppressed in many tumor cell lines,
            suggesting that may be involved in carcinogenesis. [provided by
            RefSeq, Feb 2012].
            
            Transcript Variant: This variant (1) encodes the predominant
            isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276658.1, SRR1803612.440477.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360668.8/ ENSP00000353886.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-493               EL954540.1         86-578
            494-594             BP212418.1         458-558
            595-964             AF276658.1         598-967
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..964
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /note="microtubule associated protein 1 light chain 3
                     alpha"
                     /db_xref="GeneID:84557"
                     /db_xref="HGNC:HGNC:6838"
                     /db_xref="MIM:601242"
     exon            1..191
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            192..247
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            248..354
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /inference="alignment:Splign:2.1.0"
     exon            355..964
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /note="hexamer: AATAAA"
     polyA_site      964
                     /gene="MAP1LC3A"
                     /gene_synonym="ATG8E; LC3; LC3A; MAP1ALC3; MAP1BLC3"
                     /note="major polyA site"
ORIGIN      
        1 gggcgagtta cctcccgcag ccgcagccgc cgtgctcagc gcgagccccg gagcccttga
       61 gcgcgaggcg cggagccccc ggagccccca aaccgcagac acatccccgc gccccagagc
      121 cccggcctgc gcgcccagcc gggcccgcgc gatgccctca gaccggcctt tcaagcagcg
      181 gcggagcttc gccgaccgct gtaaggaggt acagcagatc cgcgaccagc accccagcaa
      241 aatcccggtg atcatcgagc gctacaaggg tgagaagcag ctgcccgtcc tggacaagac
      301 caagtttttg gtcccggacc atgtcaacat gagcgagttg gtcaagatca tccggcgccg
      361 cctgcagctg aaccccacgc aggccttctt cctgctggtg aaccagcaca gcatggtgag
      421 tgtgtccacg cccatcgcgg acatctacga gcaggagaaa gacgaggacg gcttcctcta
      481 tatggtctac gcctcccagg aaaccttcgg cttctgagcc agcagtaggg gggctcggcc
      541 tgggagtcgg gcggccccgg tcaggccctg cccagagagc tcctggttcc tgaactgagc
      601 tgcctctacc gtggtgggct gggcaggcat gtgcccccct agtcagaggg caccaaccca
      661 cctactctgc ccctgggtgg atcctgggcc ggtcgtgtta gggttgtccc tctgggtgct
      721 ggctggtggg atgggggagg gtggggagca gctcccagca cccctgctgt gtggttcatc
      781 ttttttttag gcccctgcct gtctgcccat ctgcccctca cccacccgag gctctgccca
      841 ccgcctggac ctgcccaccc ctgaaagact ggcccctggc tccccgcccc tcggtctcca
      901 cgtggtgtat ggatctgtgg tcattgtccc tctgcagaat aaagattgct caggcctgcc
      961 tggc
//
