LOCUS       NM_005909              11790 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens microtubule associated protein 1B (MAP1B), transcript
            variant 1, mRNA.
ACCESSION   NM_005909
VERSION     NM_005909.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11790)
  AUTHORS   Inoue,H., Kanda,T., Hayashi,G., Munenaga,R., Yoshida,M.,
            Hasegawa,K., Miyagawa,T., Kurumada,Y., Hasegawa,J., Wada,T.,
            Horiuchi,M., Yoshimatsu,Y., Itoh,F., Maemoto,Y., Arasaki,K.,
            Wakana,Y., Watabe,T., Matsushita,H., Harada,H. and Tagaya,M.
  TITLE     A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis
  JOURNAL   J Cell Biol 223 (3) (2024)
   PUBMED   38353696
  REMARK    GeneRIF: A MAP1B-cortactin-Tks5 axis regulates TNBC invasion and
            tumorigenesis.
REFERENCE   2  (bases 1 to 11790)
  AUTHORS   Guo,Y., Shen,M., Dong,Q., Mendez-Albelo,N.M., Huang,S.X.,
            Sirois,C.L., Le,J., Li,M., Jarzembowski,E.D., Schoeller,K.A.,
            Stockton,M.E., Horner,V.L., Sousa,A.M.M., Gao,Y., Levine,J.E.,
            Wang,D., Chang,Q. and Zhao,X.
  CONSRTM   Birth Defects Research Laboratory
  TITLE     Elevated levels of FMRP-target MAP1B impair human and mouse
            neuronal development and mouse social behaviors via autophagy
            pathway
  JOURNAL   Nat Commun 14 (1), 3801 (2023)
   PUBMED   37365192
  REMARK    GeneRIF: Elevated levels of FMRP-target MAP1B impair human and
            mouse neuronal development and mouse social behaviors via autophagy
            pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11790)
  AUTHORS   Wang,Z., Zhang,Y., Zhao,C., Li,Y., Hu,X., Wu,L., Chen,M. and
            Tong,S.
  TITLE     The miR-223-3p/MAP1B axis aggravates TGF-beta-induced proliferation
            and migration of BPH-1 cells
  JOURNAL   Cell Signal 84, 110004 (2021)
   PUBMED   33839256
  REMARK    GeneRIF: The miR-223-3p/MAP1B axis aggravates TGF-beta-induced
            proliferation and migration of BPH-1 cells.
REFERENCE   4  (bases 1 to 11790)
  AUTHORS   Arya,R., Spaeth,C. and Zhang,W.
  TITLE     Epilepsy phenotypes associated with MAP1B-related brain
            malformations
  JOURNAL   Epileptic Disord 23 (2), 392-396 (2021)
   PUBMED   33772511
  REMARK    GeneRIF: Epilepsy phenotypes associated with MAP1B-related brain
            malformations.
REFERENCE   5  (bases 1 to 11790)
  AUTHORS   Cui,L., Zheng,J., Zhao,Q., Chen,J.R., Liu,H., Peng,G., Wu,Y.,
            Chen,C., He,Q., Shi,H., Yin,S., Friedman,R.A., Chen,Y. and
            Guan,M.X.
  TITLE     Mutations of MAP1B encoding a microtubule-associated phosphoprotein
            cause sensorineural hearing loss
  JOURNAL   JCI Insight 5 (23), 136046 (2020)
   PUBMED   33268592
  REMARK    GeneRIF: Mutations of MAP1B encoding a microtubule-associated
            phosphoprotein cause sensorineural hearing loss.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11790)
  AUTHORS   Lien,L.L., Feener,C.A., Fischbach,N. and Kunkel,L.M.
  TITLE     Cloning of human microtubule-associated protein 1B and the
            identification of a related gene on chromosome 15
  JOURNAL   Genomics 22 (2), 273-280 (1994)
   PUBMED   7806212
REFERENCE   7  (bases 1 to 11790)
  AUTHORS   Avila,J., Ulloa,L., Diez-Guerra,J. and Diaz-Nido,J.
  TITLE     Role of phosphorylated MAPlB in neuritogenesis
  JOURNAL   Cell Biol Int 18 (5), 309-314 (1994)
   PUBMED   7519512
REFERENCE   8  (bases 1 to 11790)
  AUTHORS   Lien,L.L., Boyce,F.M., Kleyn,P., Brzustowicz,L.M., Menninger,J.,
            Ward,D.C., Gilliam,T.C. and Kunkel,L.M.
  TITLE     Mapping of human microtubule-associated protein 1B in proximity to
            the spinal muscular atrophy locus at 5q13
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7873-7876 (1991)
   PUBMED   1881920
REFERENCE   9  (bases 1 to 11790)
  AUTHORS   Hammarback,J.A., Obar,R.A., Hughes,S.M. and Vallee,R.B.
  TITLE     MAP1B is encoded as a polyprotein that is processed to form a
            complex N-terminal microtubule-binding domain
  JOURNAL   Neuron 7 (1), 129-139 (1991)
   PUBMED   1712602
REFERENCE   10 (bases 1 to 11790)
  AUTHORS   Schoenfeld,T.A., McKerracher,L., Obar,R. and Vallee,R.B.
  TITLE     MAP 1A and MAP 1B are structurally related microtubule associated
            proteins with distinct developmental patterns in the CNS
  JOURNAL   J Neurosci 9 (5), 1712-1730 (1989)
   PUBMED   2470876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC017240.2, BN001084.2, BC046114.1, AC012609.7 and CA429544.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005909.4.
            
            Summary: This gene encodes a protein that belongs to the
            microtubule-associated protein family. The proteins of this family
            are thought to be involved in microtubule assembly, which is an
            essential step in neurogenesis. The product of this gene is a
            precursor polypeptide that presumably undergoes proteolytic
            processing to generate the final MAP1B heavy chain and LC1 light
            chain. Gene knockout studies of the mouse microtubule-associated
            protein 1B gene suggested an important role in development and
            function of the nervous system. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BN001084.2, SRR1803611.203936.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296755.12/ ENSP00000296755.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BC017240.2         185-188
            5-1836              BN001084.2         170-2001
            1837-2103           BC046114.1         1850-2116
            2104-9387           BN001084.2         2269-9552
            9388-11241          AC012609.7         98947-100800        c
            11242-11790         CA429544.1         23-571              c
FEATURES             Location/Qualifiers
     source          1..11790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..11790
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /note="microtubule associated protein 1B"
                     /db_xref="GeneID:4131"
                     /db_xref="HGNC:HGNC:6836"
                     /db_xref="MIM:157129"
     exon            1..241
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..7464
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein phosphatase 1, regulatory subunit 102"
                     /codon_start=1
                     /product="microtubule-associated protein 1B isoform 1"
                     /protein_id="NP_005900.2"
                     /db_xref="CCDS:CCDS4012.1"
                     /db_xref="GeneID:4131"
                     /db_xref="HGNC:HGNC:6836"
                     /db_xref="MIM:157129"
                     /translation="MATVVVEATEPEPSGSIANPAASTSPSLSHRFLDSKFYLLVVVG
                     EIVTEEHLRRAIGNIELGIRSWDTNLIECNLDQELKLFVSRHSARFSPEVPGQKILHH
                     RSDVLETVVLINPSDEAVSTEVRLMITDAARHKLLVLTGQCFENTGELILQSGSFSFQ
                     NFIEIFTDQEIGELLSTTHPANKASLTLFCPEEGDWKNSNLDRHNLQDFINIKLNSAS
                     ILPEMEGLSEFTEYLSESVEVPSPFDILEPPTSGGFLKLSKPCCYIFPGGRGDSALFA
                     VNGFNMLINGGSERKSCFWKLIRHLDRVDSILLTHIGDDNLPGINSMLQRKIAELEEE
                     QSQGSTTNSDWMKNLISPDLGVVFLNVPENLKNPEPNIKMKRSIEEACFTLQYLNKLS
                     MKPEPLFRSVGNTIDPVILFQKMGVGKLEMYVLNPVKSSKEMQYFMQQWTGTNKDKAE
                     FILPNGQEVDLPISYLTSVSSLIVWHPANPAEKIIRVLFPGNSTQYNILEGLEKLKHL
                     DFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETP
                     EVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQ
                     ATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKK
                     EVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAK
                     KSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAA
                     VGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKP
                     QLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEP
                     VEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKHSPT
                     EDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAR
                     EEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHDE
                     TLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDE
                     TNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPLNGFSEGSKTDATDGKDYNASA
                     STISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSISAVSSEKVSPSKSPSLSPS
                     PPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEV
                     VSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAVPVSFEFSDAKDENERASVS
                     PMDEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGAESPFEEKSGKQ
                     GSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPALALDE
                     RKLGDVSPTQIDVSQFGSFKEDTKMSISEGTVSDKSATPVDEGVAEDTYSHMEGVASV
                     STASVATSSFPEPTTDDVSPSLHAEVGSPHSTEVDDSLSVSVVQTPTTFQETEMSPSK
                     EECPRPMSISPPDFSPKTAKSRTPVQDHRSEQSSMSIEFGQESPEQSLAMDFSRQSPD
                     HPTVGAGVLHITENGPTEVDYSPSDMQDSSLSHKIPPMEEPSYTQDNDLSELISVSQV
                     EASPSTSSAHTPSQIASPLQEDTLSDVAPPRDMSLYASLTSEKVQSLEGEKLSPKSDI
                     SPLTPRESSPLYSPTFSDSTSAVKEKTATCHSSSSPPIDAASAEPYGFRASVLFDTMQ
                     HHLALNRDLSTPGLEKDSGGKTPGDFSYAYQKPEETTRSPDEEDYDYESYEKTTRTSD
                     VGGYYYEKIERTTKSPSDSGYSYETIGKTTKTPEDGDYSYEIIEKTTRTPEEGGYSYD
                     ISEKTTSPPEVSGYSYEKTERSRRLLDDISNGYDDSEDGGHTLGDPSYSYETTEKITS
                     FPESEGYSYETSTKTTRTPDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKKSPS
                     EARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPPP
                     PGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTD
                     KTVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKP
                     GTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTP
                     EVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVPPGLPVYLDLCYIP
                     NHSNSKNVDVEFFKRVRSSYYVVSGNDPAAEEPSRAVLDALLEGKAQWGSNMQVTLIP
                     THDSEVMREWYQETHEKQQDLNIMVLASSSTVVMQDESFPACKIEL"
     exon            242..343
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     exon            344..426
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     exon            427..567
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     exon            568..7069
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     exon            7070..7308
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     exon            7309..11790
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11773..11778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /note="hexamer: AATACA"
     polyA_site      11790
                     /gene="MAP1B"
                     /gene_synonym="DFNA83; FUTSCH; MAP5; PPP1R102; PVNH9"
                     /note="major polyA site"
ORIGIN      
        1 gcagtggaga ggagcggccg gagcgagaca cttcgccgag gcacagcagc cggcaggatg
       61 gcgaccgtgg tggtggaagc caccgagccg gagccgtccg gcagcatcgc caacccggcg
      121 gcgtccacct cgcctagcct gtcgcaccgc ttccttgaca gcaagttcta cttgctggtg
      181 gtcgtcggcg agatcgtgac cgaggagcac ctgcggcgtg ccatcggcaa catcgagctc
      241 ggaatccgat catgggacac aaacctgatt gaatgcaact tggaccaaga actcaaactt
      301 tttgtatctc gacactctgc aagattctct cctgaagtcc caggacaaaa gatccttcat
      361 caccgaagtg acgttttaga aacagtggtc ctgatcaacc cttctgatga agcagtcagc
      421 accgaggtgc gcttaatgat cactgatgct gcccgacaca agctgctcgt gctgaccggg
      481 cagtgctttg aaaataccgg agagctcatt ctccagtccg gctctttctc cttccagaac
      541 ttcatagaga ttttcaccga tcaagagatc ggggagttac taagcaccac ccatcctgcc
      601 aacaaagcca gcttaaccct gttctgtcct gaagaagggg actggaagaa ctccaatctt
      661 gacagacaca atctccaaga cttcatcaat attaaactca attcagcttc tatcttgcca
      721 gaaatggaag gactttctga gtttaccgag tatctctcag aatcagtgga agtcccatct
      781 ccctttgaca tcttggaacc tcccacatcg ggtggatttc tgaagctctc caagccctgc
      841 tgttatattt ttccaggagg gaggggcgat tctgccttgt ttgcagtgaa tggtttcaat
      901 atgctcatca atggcggatc agagagaaaa tcctgcttct ggaagctcat ccgacactta
      961 gaccgagtgg actccatcct gctcacccac attggggatg acaatttgcc tggaataaac
     1021 agcatgttac agcggaaaat tgcagagctc gaggaagaac agtcccaggg ctccaccaca
     1081 aatagtgact ggatgaaaaa cctcatctcc cctgacttag gagttgtatt tctcaatgta
     1141 cctgaaaatc tcaaaaatcc agagccaaac atcaagatga agagaagcat agaagaagcc
     1201 tgcttcactc tccagtacct aaacaaattg tccatgaaac cagaacctct gtttagaagt
     1261 gtaggcaata ctattgatcc tgtcattctt ttccaaaaaa tgggagtagg taaacttgag
     1321 atgtatgtgc ttaatccagt caagagcagc aaggaaatgc agtattttat gcagcagtgg
     1381 actggtacca acaaagacaa ggctgaattc attctgccta atggtcaaga agtagatctc
     1441 ccgatttcct acttaacttc agtctcatct ttgattgtgt ggcatccagc aaaccctgcg
     1501 gagaaaatca tccgagtcct gtttcctggg aacagcaccc agtacaacat cctggaaggg
     1561 ttggaaaagc tcaaacatct agactttctg aagcagccac tggccaccca aaaggatctc
     1621 actggccagg tgcccactcc tgtggtgaaa caaacaaaac tgaaacagag ggctgatagc
     1681 cgagaaagtc tgaagccagc cgcaaaacca cttcctagca aatccgtgcg caaggagtca
     1741 aaagaagaaa cccctgaggt cacaaaagtg aatcacgtgg aaaagccacc caaagttgaa
     1801 agcaaagaaa aggtaatggt gaaaaaagac aagccaataa aaacagagac caaaccttca
     1861 gtgactgaaa aggaggttcc cagcaaagaa gagccatctc cagtgaaagc cgaggtggct
     1921 gagaagcaag ccacagatgt caaacccaaa gctgccaagg agaagacggt gaaaaaggaa
     1981 acaaaggtaa agcctgaaga caagaaagag gagaaagaaa agccaaagaa agaagtggct
     2041 aaaaaggagg acaaaacacc tatcaagaag gaggaaaaac caaaaaagga agaggtgaaa
     2101 aaagaagtca aaaaagagat caagaaagaa gagaaaaaag aacccaagaa agaggttaag
     2161 aaagaaacac cgccaaagga agtcaagaag gaagttaaga aggaagagaa gaaggaagtg
     2221 aaaaaggaag aaaaggaacc caaaaaagaa attaagaagc tccctaaaga cgcaaagaaa
     2281 tcatctactc ctctgtctga agcaaaaaaa ccagctgctt taaaaccaaa agtacccaag
     2341 aaggaagagt ctgtcaagaa agattctgtt gctgccggaa agccaaagga gaaggggaaa
     2401 ataaaagtca ttaagaagga aggcaaggcc gcagaggctg tcgctgcagc tgtcggcact
     2461 ggagccacca cagcagctgt catggcggca gctggaatag cagccattgg ccctgccaaa
     2521 gaactcgaag ctgagaggtc ccttatgtca tctcctgagg atctaaccaa ggactttgaa
     2581 gagttaaagg ctgaagaggt cgatgtaaca aaggacatca agcctcagct ggagctaatc
     2641 gaagacgaag agaaactgaa ggaaactgag ccagtcgaag cctacgtcat ccagaaggag
     2701 agagaagtca ccaaaggtcc tgccgagtcc cctgatgagg gaatcactac cactgaaggg
     2761 gagggcgaat gtgaacagac acctgaggag ctggagcccg tcgagaagca gggagtagac
     2821 gacattgaaa aatttgaaga tgaaggagcc ggttttgaag aatcttcaga gactggagac
     2881 tatgaagaga aggcagaaac tgaggaggct gaggagccag aagaggatgg ggaggaacac
     2941 gtatgtgtga gcgcctccaa gcacagcccc actgaggatg aggaaagtgc caaggcggag
     3001 gctgatgcat acatcaggga gaagagggag tctgtggcca gtggggatga ccgagccgaa
     3061 gaagacatgg atgaggccat tgagaaagga gaggctgaac aatctgaaga ggaggctgat
     3121 gaggaggaca aagctgaaga tgccagagag gaggaatatg agccggaaaa aatggaagct
     3181 gaagactatg tgatggctgt ggtcgacaag gctgcagagg ctggtggtgc cgaggagcag
     3241 tatggattcc tcaccacacc aaccaagcaa ctaggagccc agtctcctgg ccgagaacct
     3301 gcatcttcaa ttcatgatga gactttacct ggaggctcag agagcgaggc caccgcttct
     3361 gatgaggaga atcgagaaga ccagcctgag gaattcactg ccacctctgg ctacactcag
     3421 tctactattg agatatccag tgagcccacc cccatggatg agatgtctac ccctcgagac
     3481 gtgatgagtg atgagaccaa caatgaagag acggagtccc cttctcagga attcgtaaat
     3541 atcaccaaat atgaatcttc attgtattct caggaatact ctaaacctgc tgatgttaca
     3601 ccgctcaacg gattttctga aggatcaaaa acagatgcca ctgatggcaa ggattacaat
     3661 gcttcagcct ctaccatatc accaccctct tccatggagg aagacaaatt cagcagatct
     3721 gctttacgtg atgcttactg ctctgaagtg aaagccagca ccactttgga catcaaagat
     3781 agcatctcag ctgtttcaag tgaaaaggtc agcccatcga agagcccgtc cctgagtcca
     3841 tctccaccat cacccttaga aaagaccccc ctgggtgaac gtagtgtgaa cttctctctg
     3901 acgcccaatg agattaaagt ctctgcagag gcagaagtag ccccggtgtc tcctgaggtg
     3961 acccaagaag tagttgaaga acattgtgct agtcctgagg acaagactct ggaagtggtg
     4021 tcaccatctc agtccgtgac tggcagtgct ggtcacacac cttactatca atctcctact
     4081 gacgagaaat ccagtcatct ccctacagaa gtcattgaaa aaccaccagc agttccagtg
     4141 agttttgaat tcagtgatgc caaagatgag aatgaaaggg cttcagtaag ccccatggat
     4201 gagcccgtgc ctgactcaga gtctcctatt gaaaaagttt tgtctccttt acgcagcccg
     4261 cccctcattg gatccgagtc tgcttatgaa agttttctaa gtgctgatga caaggcttct
     4321 ggcagaggtg ccgaaagtcc ttttgaagaa aagagtggaa aacaaggctc tccagaccaa
     4381 gtaagtccag tttctgaaat gacttctact agtctttacc aagacaaaca ggaagggaaa
     4441 agcacagact ttgcaccaat aaaagaagac tttggccaag aaaagaaaac tgatgatgtt
     4501 gaagccatga gttctcaacc agcactggct ctggatgaaa ggaaattagg agatgtttct
     4561 cccacacaaa tagatgtcag tcagtttgga tcttttaaag aagacactaa gatgtccatt
     4621 tctgaaggta ctgtctcaga caagtcagct actcctgttg atgagggcgt agcagaagac
     4681 acgtactctc atatggaggg tgtggcctca gtgtccacag cctcagtggc tacgagctca
     4741 tttccagagc caacaacaga tgatgtgtct ccatctctgc atgctgaggt tggctcccca
     4801 cattccacag aagtagatga ctccctttca gtgtctgttg tgcaaacacc taccacattc
     4861 caggaaacag aaatgtctcc atctaaagaa gaatgcccaa gaccgatgtc aatttctcca
     4921 ccagatttct cccctaaaac tgcaaagtcc aggacacccg ttcaagatca cagatctgaa
     4981 cagtcctcaa tgtctattga atttggccaa gaatctcctg agcaatccct tgctatggac
     5041 ttcagtcgac agtctccaga tcaccctaca gtgggtgcag gcgtgcttca catcactgaa
     5101 aatgggccaa ctgaagtgga ctacagtcct tctgacatgc aggactccag tttatcacat
     5161 aagataccac ctatggagga gccgtcctac acccaagata atgatctttc tgagctcatc
     5221 tcagtatctc aggtagaggc ctccccgtcc acctcttctg ctcatacccc ttctcagatc
     5281 gcttctcctc tccaagaaga tactctatcc gatgttgctc ctcccagaga tatgtcctta
     5341 tatgcctcac tcacctctga aaaagtgcaa agtctggaag gagagaagct ctctccaaaa
     5401 tctgatatct ctccactcac cccacgagag tcctctcctt tatattcacc tactttttca
     5461 gattctacct ctgcagtcaa agagaaaaca gcaacttgcc acagttcctc ttctccacca
     5521 atagatgcag catccgcaga gccctatggc ttccgtgcct cagtgttatt cgatacaatg
     5581 caacaccatc tagccttgaa tagagatttg tccacacctg gcctggagaa ggacagtgga
     5641 gggaagacac ctggtgactt tagctatgcc tatcaaaagc ctgaggaaac aaccaggtcc
     5701 ccagatgaag aagattatga ctatgagtct tatgagaaga ccacccggac ctcagatgtg
     5761 ggtggctatt actatgagaa gatagagaga accacaaaat ctccaagtga cagtggctac
     5821 tcctatgaga ccattgggaa aactaccaag acccctgaag atggtgacta ttcctatgaa
     5881 attattgaga agaccacacg gacccctgaa gagggtgggt actcatatga cataagtgaa
     5941 aagaccacca gcccccccga agtgagtggt tacagctatg aaaagactga gaggtctaga
     6001 aggcttctgg atgacatcag caatggctat gatgactctg aggatggtgg ccacacactt
     6061 ggggacccca gctactctta tgaaaccact gagaaaatta ccagtttccc tgagtctgaa
     6121 ggttattcct atgagacatc tacaaagaca acacgaaccc ctgatacttc cacatactgt
     6181 tacgagactg cagagaaaat cactagaacc cctcaggcat ccacatattc ctacgagact
     6241 tcagacctat gctacactgc agaaaagaag tccccctcag aagcccgtca ggatgtcgat
     6301 ttatgcctcg tgtcctcttg tgaatacaag caccccaaga cagagctttc accctctttc
     6361 attaatccca atcctcttga gtggtttgcc agtgaagaac ccactgaaga atctgaaaag
     6421 cccctcactc aatcaggggg agccccaccg cctccaggag gaaagcaaca gggccgacag
     6481 tgtgatgaaa cccctcccac ctcagtcagc gagtcagccc catcccagac cgactctgat
     6541 gttcccccgg agactgaaga gtgcccctcc atcacggccg atgccaatat cgactctgaa
     6601 gacgagtcgg aaaccatccc cacagacaaa actgtcacgt acaaacacat ggacccacct
     6661 ccagctcccg tgcaagaccg cagcccttcg ccacgccacc ctgatgtgtc catggtggac
     6721 ccagaggcct tggccattga gcagaacctg ggcaaagctc taaagaaaga tctgaaagag
     6781 aagaccaaaa ccaaaaagcc aggtacaaag accaagtcat cttcacctgt caaaaagagt
     6841 gatgggaagt ctaagccctt ggcagcttca ccaaaaccag cgggcttgaa agaatcctcg
     6901 gataaagtgt ccagggtggc ttctcctaag aagaaagaat ctgtggaaaa ggcagcaaaa
     6961 cccaccacca ctcctgaggt caaagctgca cgtggggaag agaaagacaa ggagaccaag
     7021 aatgctgcca atgcctctgc atccaagtcg gccaagaccg ccactgcagg accaggaact
     7081 accaagacga ccaagtcatc tgctgtgccc ccaggcctcc ctgtgtattt ggacctgtgc
     7141 tacattccta accacagcaa tagtaagaat gttgatgtgg aatttttcaa gagagtgcgg
     7201 tcttcctact acgtggtgag tgggaatgac cctgctgctg aggagcccag ccgggctgtc
     7261 ctggacgctt tgttggaagg aaaggctcag tggggcagca acatgcaggt gacactgatc
     7321 ccaactcatg actcagaagt gatgagggaa tggtaccagg agacccatga gaaacagcaa
     7381 gatctcaaca tcatggtttt agcaagcagc agcacagtgg ttatgcaaga tgaatccttc
     7441 cctgcatgca agattgaact gtaaaaacca aggccagcca caccacagga tctgaacttt
     7501 gtttccagaa attcttcaat ttgaaatcac cttttctaaa aagtcaattc atctagttaa
     7561 gtcgctgaac aattacctgc caaatgctat actgtgtcat ggtgatgcaa gtcactaaat
     7621 ttctcagttt ttgctgattg ctaagggaaa taacagtatt tccacaatag ggttcaaatt
     7681 cctgcaaaat tacctacccc agttcatctc tgctgaacat ttggaaacca tgcactagcc
     7741 aacccaactg acttctgcta ggtagaggca tttgtcttag agagagagag agcgcgggag
     7801 agagtgagag agagtgagag cacaaagata acgcaggaga gagagagaga aagaatgaga
     7861 aagaaaagga atgcaagaga aggagatgta atgacagaga gttctggtga gatacccaga
     7921 gagaaaaaga gagagcaggg tggggtaagg aggagaaaat aaaccaacaa ttaggtctgc
     7981 attttctcag gcagtaggca ttctttagtc tacataggca aagttttcca tttttgtcag
     8041 tctgagtcat caaaaagagt cttaattttc taaaacaagt tggctagaag aaagtaaaaa
     8101 gaacaacact tgttatgagg gcatgtgata ttttcacatc ttaattaagc tccttcagtt
     8161 tgaaggctgc acactgacat aatgtagtga gtgtagactg gccatgcaag tggtttgggc
     8221 cccattcaga actctcagac tctaaacaca caagtagatt gatctaaggc atgctcccag
     8281 catttgtcca cccacttagt ccactctgag tcgattaacc tgcatgcagc aacacccaag
     8341 tccaccccaa ttaactgaag caaataccaa agcagttggg agtacatatg gtagacaatt
     8401 tgccttagga agtgacttga atgtacaaag atacttgatg cacttatttt ttaatgtgag
     8461 acagcaagtt tataaaacat ccatatagga ttatagatac ttaaaggaac acgtgggtga
     8521 gcgtgtgtgg gggtactaga agctgatctg attggtccaa cagtttgatg ctgagtcatg
     8581 cgtgttgaat cccacttcag tgcacctgtg gcctctcagt caaacaagtt gtgcctttca
     8641 cagcttcttt actactgcaa gttcaagact gaaatggctt ctatgatcag aactgggaaa
     8701 acagtgaatc ttatggtgga agaggttctc agcaagtgta cagtatttac cttcctttgt
     8761 cttacattgg ctttttaaat tttccattaa tttcaacata attatgggaa caagtgtaca
     8821 gaagaatttt ttttttaaga tatgtgagaa cttttcatag atgaactttt taacaaatgt
     8881 tttcatttac aggaaattgc aaagaaaatt ctcaagtgat agtctttttt tttaagtgtt
     8941 tcgtaagaca aaaattgaat aatgtttttt gaagttctgg caagattgaa gtctgatatt
     9001 gcagtaatga tatttattaa aaacccataa ctaccaggaa taatgatacc tcccacccct
     9061 tgattcccat aacataaaag tgctacttga gagtggggga gaatggcatg gtaggctact
     9121 tttcagggcc ttgacaagta catcacccag tggtatccta catacttctt tcaagatctt
     9181 caaccatgag gtaaaagagc caagttcaaa gaaccctagc acaaatttgc tttgggattt
     9241 tcttttctgg aaaaaaaaaa taaaagaaat agtacattga aaacaaatga attctcaact
     9301 cctacggttc atgtagagtt tagagaaaat ttccatcatt gtcatcattg aactgtgaac
     9361 ctgggaagcc agatcatgat taacactgac atcaagtttc aagttgcaga tcaatgcacc
     9421 cagtgttcag atgaggcaaa cttctccgtg acaactgtgc tgtgctctgt cacattacat
     9481 ttcctgcaga ctctaagatc tacggagtag agaacaatga cctcatttta ttttctatgt
     9541 tagttattta tttcaaaatt aacattttag ttgatttttg tctgataagt ctatgttttg
     9601 cactgctaac tatgatgagg gtttaaaaaa atgcttcttc agggtccttt cactgaggac
     9661 ctatgcagtc tacttaatgc tgtgaattac atttttcaaa tgtttaattt tttaaagaaa
     9721 attaatattc tatttttgtt aggcttctct agaaatgcag cttttattta ttaccccatt
     9781 tctttcaagt ccttggaaaa taacatatta agggtacaag aaattaacac atgatggaaa
     9841 agtcattgtg acgccaatga atttcattga gtataaactc atctacttca aatttatttt
     9901 ataacacaac ctaagatact caagataatt atttaatggt tagctcttaa gttgaattgg
     9961 tctacataat gcgtgggaag aaaaccagat ttttagcctt cttgccaaat ccagacctct
    10021 ggttgatttt tctttgacag aagatgcaag ttattttcca atttcacaat taaatgtatt
    10081 taacctgaac attattttgc tttaaaaact ataaacattg taggagaatt atagccagtc
    10141 ttcagttata accactccac cctcctcact ttctctctct ctctctcttt tttttttttt
    10201 ttttttttgc tatgggattt aatgggaaaa atatgtaaaa actgtcacta gtcagctggc
    10261 tctttttcct atgaaatcta tcagtacctt tctccatccg ttgttctcaa tatgaccaca
    10321 gagcctgagt ataccaagaa aaccaatatt cgcattacag gttgctcctg tccttccaga
    10381 cacctttcct gcctgtgtga ctaacctaat tttgctagtt ccataaatac acgattagtt
    10441 tagtaacagc catcacaatg taccatgtac attcatggtg agagctaaag atcgacacag
    10501 acttctagga gctttgttca tactgattac ttaatccaat tgtatagatt gaatatttga
    10561 gtggaaggaa tttacactct gtttaaatga tgggattcta tcgagatagc actcatgatc
    10621 atgacctttt tggtagtatt cttaaacaaa attctacaga gactaaatgt tagcgatgat
    10681 cctccatttt caattttaac caattctgtc ccctttctca aaaccctgag ccctgtgcat
    10741 gctttctcag tcttgtggtg ggactggata caatgactaa cttcccctcc tcccctcttt
    10801 aaacaccatt ttccatggag ttcaaaaaaa ttttttttct taacgttaca tatcatagtg
    10861 aatggtttcc ccagtgtata tgaatgtttt aagtgtctcc aatagcttat gcagtctagg
    10921 agctttccaa tactcattta attaagattt aatcatttgc taatggaaat cttaccacct
    10981 ttcattttcc ctctgttacc aaatttcagc tcttaggagc tgctctacaa ttctgaattt
    11041 gcttttcttg cctctcttta gtcacctgtc acaggaggtt cctgctcagt aatgatattg
    11101 tgagttagga taataacttt ttttttttgt gcttcagatt tagaagaaaa gatcctgttt
    11161 ccatttgaaa ggaactgtaa gcttttatct tttaaccaac tgaacaatac accaaaagca
    11221 gcctagggat gagcatttct ttgaaagcaa ttaggttatt cacctggtat taaaactatt
    11281 tactgttaaa aaatctgtga cttcatgaag ttgattttta aaggcagcat caaaaactga
    11341 aaaggaaggg aaaaaatagg cagcttctct gcacttgttt ggagctcccc aaaacaggag
    11401 ccatggagaa gtggcatcaa gaccgggctg ccctttcgag aacaccctgt ggcagttcag
    11461 agacacgctt ttcctacact gcatgcagcc cctctttcca gcactggaaa gaagtggtct
    11521 tgagcccagc tgagaagcac ttcacactcc tctctcttgt tctgaatggt gtttgtgtca
    11581 gtctgcagct gtgtatggta ttatgtctta taatcctgca tcacttctat cctatccagt
    11641 catatctaat gtagaaaatt agtttccagt gaaagtaata tgtagtgctt ttatgatatt
    11701 tgtgtgcaat atcccctctt ccattgagga tatttgatgt aaaggaaaaa aaaaaactca
    11761 gttccacaat aaaatacaaa agtggcaaaa
//
