LOCUS       NM_002373              10266 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens microtubule associated protein 1A (MAP1A), transcript
            variant 1, mRNA.
ACCESSION   NM_002373
VERSION     NM_002373.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10266)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10266)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 10266)
  AUTHORS   Satterstrom,F.K., Walters,R.K., Singh,T., Wigdor,E.M., Lescai,F.,
            Demontis,D., Kosmicki,J.A., Grove,J., Stevens,C.,
            Bybjerg-Grauholm,J., Baekvad-Hansen,M., Palmer,D.S., Maller,J.B.,
            Nordentoft,M., Mors,O., Robinson,E.B., Hougaard,D.M., Werge,T.M.,
            Bo Mortensen,P., Neale,B.M., Borglum,A.D. and Daly,M.J.
  CONSRTM   iPSYCH-Broad Consortium
  TITLE     Autism spectrum disorder and attention deficit hyperactivity
            disorder have a similar burden of rare protein-truncating variants
  JOURNAL   Nat Neurosci 22 (12), 1961-1965 (2019)
   PUBMED   31768057
  REMARK    GeneRIF: analysis across Autism Spectrum Disorder and Attention
            Defecit Hyperactivity Disorder, identifyies microtubule-associated
            protein 1A (MAP1A) as a new exome-wide significant gene conferring
            risk for childhood psychiatric disorders.
REFERENCE   4  (bases 1 to 10266)
  AUTHORS   Guo,T., Noble,W. and Hanger,D.P.
  TITLE     Roles of tau protein in health and disease
  JOURNAL   Acta Neuropathol 133 (5), 665-704 (2017)
   PUBMED   28386764
  REMARK    Review article
REFERENCE   5  (bases 1 to 10266)
  AUTHORS   Takei,Y., Kikkawa,Y.S., Atapour,N., Hensch,T.K. and Hirokawa,N.
  TITLE     Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport,
            and Instability of Postsynaptic Density Proteins in Mice Lacking
            Microtubule-Associated Protein 1A
  JOURNAL   J Neurosci 35 (47), 15539-15554 (2015)
   PUBMED   26609151
REFERENCE   6  (bases 1 to 10266)
  AUTHORS   Fukuyama,R. and Rapoport,S.I.
  TITLE     Brain-specific expression of human microtubule-associated protein
            1A (MAP1A) gene and its assignment to human chromosome 15
  JOURNAL   J Neurosci Res 40 (6), 820-825 (1995)
   PUBMED   7629894
REFERENCE   7  (bases 1 to 10266)
  AUTHORS   Lien,L.L., Feener,C.A., Fischbach,N. and Kunkel,L.M.
  TITLE     Cloning of human microtubule-associated protein 1B and the
            identification of a related gene on chromosome 15
  JOURNAL   Genomics 22 (2), 273-280 (1994)
   PUBMED   7806212
REFERENCE   8  (bases 1 to 10266)
  AUTHORS   Pedrotti,B., Colombo,R. and Islam,K.
  TITLE     Microtubule associated protein MAP1A is an actin-binding and
            crosslinking protein
  JOURNAL   Cell Motil Cytoskeleton 29 (2), 110-116 (1994)
   PUBMED   7820861
REFERENCE   9  (bases 1 to 10266)
  AUTHORS   Schoenfeld,T.A., McKerracher,L., Obar,R. and Vallee,R.B.
  TITLE     MAP 1A and MAP 1B are structurally related microtubule associated
            proteins with distinct developmental patterns in the CNS
  JOURNAL   J Neurosci 9 (5), 1712-1730 (1989)
   PUBMED   2470876
REFERENCE   10 (bases 1 to 10266)
  AUTHORS   Bloom,G.S., Luca,F.C. and Vallee,R.B.
  TITLE     Widespread cellular distribution of MAP-1A (microtubule-associated
            protein 1A) in the mitotic spindle and on interphase microtubules
  JOURNAL   J Cell Biol 98 (1), 331-340 (1984)
   PUBMED   6142895
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP309709.1, BC094702.1,
            AC019011.7 and AI124707.1.
            
            On Nov 23, 2018 this sequence version replaced NM_002373.5.
            
            Summary: This gene encodes a protein that belongs to the
            microtubule-associated protein family. The proteins of this family
            are thought to be involved in microtubule assembly, which is an
            essential step in neurogenesis. The product of this gene is a
            precursor polypeptide that presumably undergoes proteolytic
            processing to generate the final MAP1A heavy chain and LC2 light
            chain. Expression of this gene is almost exclusively in the brain.
            Studies of the rat microtubule-associated protein 1A gene suggested
            a role in early events of spinal cord development. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300231.6/ ENSP00000300231.5
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BP309709.1         1-41
            42-2321             BC094702.1         1-2280
            2322-8413           AC019011.7         111847-117938
            8414-8850           AI124707.1         1-437
            8851-10266          AC019011.7         118715-120130
FEATURES             Location/Qualifiers
     source          1..10266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3"
     gene            1..10266
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /note="microtubule associated protein 1A"
                     /db_xref="GeneID:4130"
                     /db_xref="HGNC:HGNC:6835"
                     /db_xref="MIM:600178"
     exon            1..93
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            94..176
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            177..317
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            318..8502
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..8879
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAP-1A; proliferation-related protein p80"
                     /codon_start=1
                     /product="microtubule-associated protein 1A isoform 1"
                     /protein_id="NP_002364.5"
                     /db_xref="CCDS:CCDS42031.1"
                     /db_xref="GeneID:4130"
                     /db_xref="HGNC:HGNC:6835"
                     /db_xref="MIM:600178"
                     /translation="MDGVAEFSEYVSETVDVPSPFDLLEPPTSGGFLKLSKPCCYIFP
                     GGRGDSALFAVNGFNILVDGGSDRKSCFWKLVRHLDRIDSVLLTHIGADNLPGINGLL
                     QRKVAELEEEQSQGSSSYSDWVKNLISPELGVVFFNVPEKLRLPDASRKAKRSIEEAC
                     LTLQHLNRLGIQAEPLYRVVSNTIEPLTLFHKMGVGRLDMYVLNPVKDSKEMQFLMQK
                     WAGNSKAKTGIVLPNGKEAEISVPYLTSITALVVWLPANPTEKIVRVLFPGNAPQNKI
                     LEGLEKLRHLDFLRYPVATQKDLASGAVPTNLKPSKIKQRADSKESLKATTKTAVSKL
                     AKREEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEK
                     RKLIKDKVGKKHLKEKISKLEEKKDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKRK
                     DTKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIRGEKELSSEPQTPPAQ
                     KGTVPLPTISGHRELVLSSPEDLTQDFEEMKREERALLAEQRDTGLGDKPFPLDTAEE
                     GPPSTAIQGTPPSVPGLGQEEHVMKEKELVPEVPEEQGSKDRGLDSGAETEEEKDTWE
                     EKKQREAERLPDRTEAREESEPEVKEDVIEKAELEEMEEVHPSDEEEEDATKAEGFYQ
                     KHMQEPLKVTPRSREAFGGRELGLQGKAPEKETSLFLSSLTTPAGATEHVSYIQDETI
                     PGYSETEQTISDEEIHDEPEERPAPPRFHTSTYDLPGPEGAGPFEASQPADSAVPATS
                     GKVYGTPETELTYPTNIVAAPLAEEEHVSSATSITECDKLSSFATSVAEDQSVASLTA
                     PQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFKSPPCED
                     FSVTGESEKRGEIIGKGLSGERAVEEEEEETANVEMSEKLCSQYGTPVFSAPGHALHP
                     GEPALGEAEERCLSPDDSTVKMASPPPSGPPSATHTPFHQSPVEEKSEPQDFQEADSW
                     GDTKRTPGVGKEDAAEETVKPGPEEGTLEKEEKVPPPRSPQAQEAPVNIDEGLTGCTI
                     QLLPAQDKAIVFEIMEAGEPTGPILGAEALPGGLRTLPQEPGKPQKDEVLRYPDRSLS
                     PEDAESLSVLSVPSPDTANQEPTPKSPCGLTEQYLHKDRWPEVSPEDTQSLSLSEESP
                     SKETSLDVSSKQLSPESLGTLQFGELNLGKEEMGHLMQAEDTSHHTAPMSVPEPHAAT
                     ASPPTDGTTRYSAQTDITDDSLDRKSPASSFSHSTPSGNGKYLPGAITSPDEHILTPD
                     SSFSKSPESLPGPALEDIAIKWEDKVPGLKDRTSEQKKEPEPKDEVLQQKDKTLEHKE
                     VVEPKDTAIYQKDEALHVKNEAVKQQDKALEQKGRDLEQKDTALEQKDKALEPKDKDL
                     EEKDKALEQKDKIPEEKDKALEQKDTALEQKDKALEPKDKDLEQKDRVLEQKEKIPEE
                     KDKALDQKVRSVEHKAPEDTVAEMKDRDLEQTDKAPEQKHQAQEQKDKVSEKKDQALE
                     QKYWALGQKDEALEQNIQALEENHQTQEQESLVQEDKTRKPKMLEEKSPEKVKAMEEK
                     LEALLEKTKALGLEESLVQEGRAREQEEKYWRGQDVVQEWQETSPTREEPAGEQKELA
                     PAWEDTSPEQDNRYWRGREDVALEQDTYWRELSCERKVWFPHELDGQGARPHYTEERE
                     STFLDEGPDDEQEVPLREHATRSPWASDFKDFQESSPQKGLEVERWLAESPVGLPPEE
                     EDKLTRSPFEIISPPASPPEMVGQRVPSAPGQESPIPDPKLMPHMKNEPTTPSWLADI
                     PPWVPKDRPLPPAPLSPAPGPPTPAPESHTPAPFSWGTAEYDSVVAAVQEGAAELEGG
                     PYSPLGKDYRKAEGEREEEGRAEAPDKSSHSSKVPEASKSHATTEPEQTEPEQREPTP
                     YPDERSFQYADIYEQMMLTGLGPACPTREPPLGAAGDWPPCLSTKEAAAGRNTSAEKE
                     LSSPISPKSLQSDTPTFSYAALAGPTVPPRPEPGPSMEPSLTPPAVPPRAPILSKGPS
                     PPLNGNILSCSPDRRSPSPKESGRSHWDDSTSDSELEKGAREQPEKEAQSPSPPHPIP
                     MGSPTLWPETEAHVSPPLDSHLGPARPSLDFPASAFGFSSLQPAPPQLPSPAEPRSAP
                     CGSLAFSGDRALALAPGPPTRTRHDEYLEVTKAPSLDSSLPQLPSPSSPGAPLLSNLP
                     RPASPALSEGSSSEATTPVISSVAERFSPSLEAAEQESGELDPGMEPAAHSLWDLTPL
                     SPAPPASLDLALAPAPSLPGDMGDGILPCHLECSEAATEKPSPFQVPSEDCAANGPTE
                     TSPNPPGPAPAKAENEEAAACPAWERGAWPEGAERSSRPDTLLSPEQPVCPAGGSGGP
                     PSSASPEVEAGPQGCATEPRPHRGELSPSFLNPPLPPSIDDRDLSTEEVRLVGRGGRR
                     RVGGPGTTGGPCPVTDETPPTSASDSGSSQSDSDVPPETEECPSITAEAALDSDEDGD
                     FLPVDKAGGVSGTHHPRPGHDPPPLPQPDPRPSPPRPDVCMADPEGLSSESGRVERLR
                     EKEKVQGRVGRRAPGKAKPASPARRLDLRGKRSPTPGKGPADRASRAPPRPRSTTSQV
                     TPAEEKDGHSPMSKGLVNGLKAGPMALSSKGSSGAPVYVDLAYIPNHCSGKTADLDFF
                     RRVRASYYVVSGNDPANGEPSRAVLDALLEGKAQWGENLQVTLIPTHDTEVTREWYQQ
                     THEQQQQLNVLVLASSSTVVMQDESFPACKIEF"
     exon            8503..8723
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            8724..10266
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10247..10252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /note="hexamer: AATAAA"
     polyA_site      10266
                     /gene="MAP1A"
                     /gene_synonym="MAP1L; MTAP1A"
                     /note="major polyA site"
ORIGIN      
        1 actcccaccc taagtgctgc agactcttcc ctgaagctgc cggctgaggc cggagctgcc
       61 gcctccatga gaggcttcct cctacacccc agggccagag gaccctttgc caccagagtg
      121 agatcctaga gaccatcatc ctggtaaatc ccagtgcaga cagcatcagc tctgaggttc
      181 atcatcttct tagcagctca tcagcttata aactactaat cttgagtggg caaagtttag
      241 agcctggggg agacctcatc ctacagagtg gcacctactc atatgaaaac tttgcccagg
      301 tccttcacaa ccccgagatt tcccaattgc tcagcaatag agaccctggg atacaggcct
      361 tccttaccgt gtcctgctta ggggaaggtg attggagcca cctgggatta tccagttccc
      421 aagagaccct gcacctccgg ctaaaccctg agcccactct gcccaccatg gacggcgtgg
      481 ctgagttctc cgagtatgtc tctgagactg tggacgtgcc atccccattt gacctactag
      541 agccccccac ctcagggggc ttcctcaagc tctccaagcc ttgttgctac atcttcccag
      601 gtggtcgtgg ggactctgcc ctctttgctg tcaatggttt caacatcctg gtggatggtg
      661 gctctgatcg caagtcctgt ttttggaagc tggtacggca cttggaccgc attgactcgg
      721 tgctactcac acacattggg gcagacaacc tgccaggcat caatggacta ctgcagcgca
      781 aagtggcaga gctagaggag gagcagtccc agggctctag cagttacagc gactgggtga
      841 agaaccttat ctctcctgag cttggagttg tctttttcaa cgtgcctgag aagctgcggc
      901 ttcctgatgc ctcccggaaa gccaagcgta gcattgagga ggcctgcctc actctgcagc
      961 acttaaaccg cctgggcatc caggctgagc ctctatatcg tgtggtcagc aataccattg
     1021 agccactgac cctcttccac aaaatgggtg tgggccggct ggacatgtat gtcctcaacc
     1081 ctgtcaagga cagcaaggag atgcagttcc tcatgcaaaa gtgggcaggc aatagtaaag
     1141 ccaagacagg catcgtgctg cccaatggga aggaggctga gatctccgtg ccctacctta
     1201 cctctatcac tgctctggtg gtctggctac cagccaatcc cactgagaag attgtgcgtg
     1261 tgctttttcc aggaaatgct ccccaaaaca agatcttgga gggcctagaa aagcttcggc
     1321 atctggactt cctgcgttac cctgtggcca cgcagaagga cctggcttct ggggctgtgc
     1381 ctaccaacct caagcccagc aaaatcaaac agcgggctga tagcaaggag agcctcaaag
     1441 ccactaccaa gacggccgtg agcaagttgg ccaaacggga ggaggtggta gaagagggag
     1501 ccaaggaggc acgttcagag ctggccaagg agttagccaa gacagagaag aaggcaaaag
     1561 agtcatctga gaagccccca gagaagcctg ccaagcctga gagggtgaag acagagtcaa
     1621 gtgaggcact gaaggcagag aagcgaaagc tgatcaaaga caaggtaggg aaaaagcacc
     1681 ttaaagaaaa gatatcaaag ctggaagaaa aaaaagacaa ggagaaaaaa gagatcaaaa
     1741 aggagaggaa agagctcaag aaggatgaag gaaggaagga ggagaagaag gatgccaaga
     1801 aggaggagaa gaggaaagat accaaacctg agctcaagaa gatttccaag ccagacctaa
     1861 agccctttac tcctgaggta cgtaagaccc tctataaagc caaggtccct ggaagagtca
     1921 aaatagacag gagccgtgct atccgtgggg agaaggagct gtcttctgag ccccagacac
     1981 ccccagccca gaagggaact gtaccactcc caaccatcag tgggcacagg gagctggtcc
     2041 tatcctcacc agaggacctc acacaggact ttgaggagat gaagcgtgag gagagggctt
     2101 tgctggctga acaaagggac acaggactag gagataagcc attccctcta gacactgcag
     2161 aggagggacc cccaagtaca gctatccagg gaacaccacc ctctgttcca gggctgggac
     2221 aagaagaaca tgtgatgaag gagaaagagc ttgtcccaga ggtccctgag gaacaaggca
     2281 gcaaggacag aggcctagac tctggggctg aaacagagga agagaaagat acctgggagg
     2341 aaaagaagca gagggaagca gagaggctcc cagacagaac agaagccaga gaggaaagtg
     2401 aacctgaagt aaaggaggat gtgatagaaa aggctgagtt agaagaaatg gaggaggtac
     2461 acccttcaga tgaggaggaa gaggacgcga caaaagctga gggtttttac caaaaacata
     2521 tgcaggaacc cttgaaggta actccaagga gccgggaggc ttttgggggt cgggaattgg
     2581 gactccaggg caaggcccct gagaaggaga cctcgttatt cctaagcagc ctgaccacac
     2641 ctgcaggagc cactgagcat gtctcttaca tccaggatga gacaatccct ggctactcag
     2701 agactgagca gaccatctca gatgaggaga tccatgatga gccggaggag cgcccagctc
     2761 cacccagatt tcatacaagt acatatgacc tgcccgggcc tgaaggtgct ggcccattcg
     2821 aagccagcca acctgccgat agtgctgttc ctgctacctc tggcaaagtc tatggaacgc
     2881 cagagactga actcacctac cccactaaca tagtggctgc ccctttggct gaagaggaac
     2941 atgtgtcctc ggccacttca atcactgagt gtgacaaact ttcttccttt gccacatcag
     3001 tggctgagga ccaatctgtg gcctcactta cagctcccca gacagaggag acaggcaaga
     3061 gctccctgct gcttgacaca gtcacaagca tcccttcctc ccgtactgaa gctacgcagg
     3121 gcttggacta tgtgccatca gctggtacca tctcacccac ctcctcactg gaagaagaca
     3181 agggcttcaa atcaccaccc tgtgaggact tctctgtgac tggggagtca gagaagagag
     3241 gagagatcat agggaaaggc ttgtctggag agagagctgt ggaagaggaa gaggaggaga
     3301 cagcaaacgt agagatgtct gagaaacttt gcagtcaata tggaactcca gtgtttagtg
     3361 cccctgggca tgccctacat ccaggagaac cagcccttgg agaagcagag gagcggtgcc
     3421 ttagcccaga tgacagcaca gtgaagatgg cttctcctcc accatctggc ccacccagtg
     3481 ccacccacac accctttcat cagtccccag tggaagaaaa gtctgagccc caagactttc
     3541 aggaggcaga ctcctgggga gacactaagc gcacaccagg tgtgggcaaa gaagatgctg
     3601 ctgaggagac agtcaagcca gggcctgaag agggcacact agagaaggaa gagaaagttc
     3661 ctcctcccag gagcccccag gcccaggaag cacctgtcaa cattgatgag gggcttacag
     3721 gctgtaccat tcaactgttg ccagcacagg ataaagcaat agtctttgag attatggagg
     3781 caggagagcc cacaggccca attctgggag cagaagccct tcccggaggt ttgaggactt
     3841 taccccaaga acctggcaaa cctcagaaag atgaggtgct cagatatcct gaccgaagcc
     3901 tctctcctga agatgcagaa tccctctctg tcctcagcgt gccctcccca gacactgcca
     3961 accaagagcc tacccccaag tctccctgtg gcctgacaga acagtaccta cacaaagacc
     4021 gttggccaga ggtatctcca gaagacaccc agtcactttc tctgtcagaa gagagtccca
     4081 gcaaggagac ctccctggat gtctcttcta agcagctctc tccagaaagc cttggcaccc
     4141 tccagtttgg ggaactaaac cttgggaagg aagaaatggg gcatctgatg caggccgagg
     4201 atacctctca ccacacagct cccatgtctg ttccagagcc ccatgcagcc acagcgtcac
     4261 ctcccacaga tgggacaact cgatactctg cacagacaga catcacagat gacagccttg
     4321 acaggaagtc acctgccagc tcattctctc actctacacc ttcaggaaat gggaagtact
     4381 tacctggggc gatcacaagc cctgatgaac acattctgac acctgatagc tccttctcca
     4441 agagtcctga gtctttgcca ggccctgcct tggaggacat tgccataaag tgggaagata
     4501 aagttccagg gttgaaagac agaacctcag aacagaagaa ggaacctgag ccaaaggatg
     4561 aagttttaca gcagaaagac aaaactctgg agcacaagga ggtggtagag ccgaaggata
     4621 cagccatcta tcagaaagat gaggctctgc atgtaaagaa tgaggctgtg aaacagcagg
     4681 ataaggcttt agaacaaaag ggcagagact tagagcaaaa agacacagcc ctagaacaga
     4741 aggacaaggc cctggaacca aaagacaaag acttagaaga aaaagacaag gccctggaac
     4801 agaaggataa gattccagaa gagaaagaca aagccttaga acaaaaggat acagccctgg
     4861 aacagaagga caaggccctg gaaccaaaag ataaagactt ggaacaaaag gacagggtcc
     4921 tagaacagaa ggagaagatc ccagaagaga aagacaaagc cttagatcaa aaagtcagaa
     4981 gtgttgaaca taaggctccg gaggacacgg tcgctgaaat gaaggacaga gacctagaac
     5041 agacagacaa agcccctgaa cagaaacacc aggcccagga acaaaaggat aaagtctcag
     5101 aaaagaagga tcaggcctta gaacaaaaat actgggcttt gggacagaag gatgaagccc
     5161 tggaacaaaa cattcaggct ctggaagaga accaccaaac tcaggagcag gagagcctag
     5221 tgcaggagga taaaaccagg aaaccaaaga tgctagagga aaaatcccca gaaaaggtca
     5281 aggccatgga agagaagtta gaagctcttc tggagaagac caaagctctg ggcctggaag
     5341 agagcctagt gcaggagggc agggccagag agcaggaaga aaagtactgg agggggcagg
     5401 atgtggtcca ggagtggcaa gaaacatctc ctaccagaga ggagccggct ggagaacaga
     5461 aagagcttgc cccggcatgg gaggacacat ctcctgagca ggacaatagg tattggaggg
     5521 gcagagagga tgtggccttg gaacaggaca catactggag ggagctaagc tgtgagcgga
     5581 aggtctggtt ccctcacgag ctggatggcc agggggcccg cccacactac actgaggaac
     5641 gggaaagcac tttcctagat gagggcccag atgatgagca agaagtaccc ctgcgggaac
     5701 acgcaacccg gagcccctgg gcctcagact tcaaggattt ccaggaatcc tcaccacaga
     5761 aggggctaga ggtggagcgc tggcttgctg aatcaccagt tgggttgcca ccagaggaag
     5821 aggacaaact gacccgctct ccctttgaga tcatctcccc tccagcttcc ccacctgaga
     5881 tggttggaca aagggttcct tcagccccag gacaagagag tcctatccca gaccctaagc
     5941 tcatgccaca catgaagaat gaacccacta ctccctcatg gctggctgac atcccaccct
     6001 gggtgcccaa ggacagaccc ctcccccctg cacccctctc cccagctcct ggtcccccca
     6061 cacctgcccc ggaatcccat actcctgcac ccttctcttg gggcacagcc gagtatgaca
     6121 gtgtggtggc tgcagtgcag gagggggcag ctgagttgga aggtgggcca tactcccccc
     6181 tggggaagga ctaccgcaag gctgaagggg aaagggaaga agaaggtagg gctgaggctc
     6241 ctgacaaaag ctcacacagc tcaaaggtac cagaggccag caaaagccat gccaccacgg
     6301 agcctgagca gactgagccg gagcagagag agcccacacc ctatcctgat gagagaagct
     6361 ttcagtatgc agacatctat gagcagatga tgcttactgg gcttggccct gcatgcccca
     6421 ctagagagcc tccacttgga gcagctgggg attggccccc atgcctctca accaaggagg
     6481 cagctgccgg ccgaaacaca tctgcagaga aggagctttc atctcctatc tcacccaaga
     6541 gcctccagtc tgacactcca accttcagct atgcagccct ggcaggaccc actgtacccc
     6601 caaggccaga gccagggcca agtatggagc ccagcctcac cccacctgca gttccccccc
     6661 gtgctcctat cctgagcaaa ggcccaagcc cccctcttaa tggtaacatc ctgagctgca
     6721 gcccagatag gaggtcccca tcccccaagg aatcaggccg gagtcactgg gatgacagca
     6781 ctagtgactc agaactggag aagggggctc gggaacagcc agaaaaagag gcccaatccc
     6841 caagtcctcc tcaccccatt cctatggggt cccccacatt atggccagaa actgaggcac
     6901 atgttagccc tcccttggac tcacacctgg ggcctgcccg acccagtctg gacttccctg
     6961 cttcagcctt tggcttctcc tcattgcagc cagctccccc acagctgccc tctccagctg
     7021 aaccccgctc ggcaccctgt ggctcccttg ccttctctgg ggatcgagct ctggctctgg
     7081 ctccaggacc ccccaccaga acccggcatg atgaatacct ggaagtgacc aaggccccca
     7141 gcctggattc ctcactgccc cagctcccat cacccagttc tcctggggcc cctctcctct
     7201 ccaatctgcc acgacctgcc tcaccagccc tgtctgaggg ctcctcctct gaggctacca
     7261 cgcctgtgat ttcaagtgtg gcggagcgct tctctccaag ccttgaggct gcagaacagg
     7321 agtctggaga gctggaccca ggaatggaac cagctgccca cagcctctgg gacctcactc
     7381 ctctgagccc agcaccccca gcttcactgg acttggccct agctccagct ccaagcctgc
     7441 ctggagacat gggtgatggc atcctgccgt gccacctgga gtgctcagag gcagccacgg
     7501 agaagccaag ccccttccag gttccctctg aggattgtgc agccaatggc ccaactgaaa
     7561 ccagccctaa ccccccaggc cctgccccag ccaaggctga aaatgaagag gctgcggctt
     7621 gccctgcctg ggaacgtggg gcctggcctg aaggagctga gaggagctcc cggcctgaca
     7681 cattgctctc ccctgagcag ccagtgtgtc ctgcaggggg ctccgggggc ccacccagca
     7741 gtgcctctcc tgaggtcgaa gctgggcccc agggatgtgc cactgagcct cggccccatc
     7801 gtggggagct ctccccatcc ttcctgaacc cacctctgcc cccatccata gatgataggg
     7861 acctctcaac tgaggaagtt cggctagtag gaagaggggg gcggcgccgg gtaggggggc
     7921 cagggaccac tgggggccca tgccctgtga ctgatgagac accccctaca tcagccagtg
     7981 actcaggctc ctcacagtca gattctgatg tcccgccaga aactgaggag tgtccgtcca
     8041 tcacagctga ggcagccctc gactcagatg aagatggaga cttcctacct gtggacaaag
     8101 ctgggggtgt cagtggtact caccacccca ggcctggcca tgacccacct cctctcccac
     8161 agccagaccc ccgcccatcc cctccccgcc ctgatgtgtg catggctgac cccgaggggc
     8221 tcagctcaga gtctgggaga gtagagaggc tacgggagaa ggaaaaggtt caggggcgag
     8281 tagggcgcag ggccccaggc aaggccaagc cagcgtcccc tgcacggcgt ctggatcttc
     8341 ggggaaaacg ctcacccacc cctggtaaag ggcctgcaga tcgagcatcc cgggccccac
     8401 ctcgaccacg cagcaccaca agccaggtca ccccagcaga ggaaaaggat ggacacagcc
     8461 ccatgtccaa aggcctagtc aatggactca aggcaggacc aatggccttg agttccaagg
     8521 gcagctctgg tgcccctgta tatgtggatc tcgcctacat cccgaatcat tgcagtggca
     8581 agactgctga ccttgacttc ttccgtcgag tgcgtgcatc ctactatgtg gtcagtggga
     8641 atgaccctgc caatggcgag ccaagccggg ctgtgctgga tgccctgctg gagggcaagg
     8701 cccagtgggg ggagaatctt caggtgactc tgatccctac tcatgacacg gaggtgactc
     8761 gtgagtggta ccaacaaact catgagcagc agcaacaact gaatgtcctg gtcctggcta
     8821 gcagcagcac cgtggtgatg caggatgagt ccttccctgc ctgcaagatt gagttctgaa
     8881 agagccgccc tcccttcccc aaggatccac tcccccagct cctttagaga atggctactg
     8941 ctgagtcctt tggggttgag ggagatggga gctaggggga ggggagggag atgtcttgtt
     9001 gtggggactt gggctgggct aaatgggagg ggttgtccct ccccatcatc cattcctgtg
     9061 aggtgtctca aaccaaagtt aacagggaga ggatggggga ggggacaaat tagaatagga
     9121 tagcatctga tgcctgagaa ccctctccta gcactgtcaa atgctggtat tgaatgggga
     9181 ctgaggatgg gtctcagaga gcaacctcct ccctcgtaga gggagattat atccccaact
     9241 ccagggacct ctttatctca atctatttat ttggcatcct gggagggatt tccaatagta
     9301 atttatgtga cctggggcag gataccgtca gtgaggtgcc cagagctgca ccctttcctc
     9361 catttcccat cccccatctc ctcaaccacc agggtctgag ttctagcagg gtcctggggg
     9421 tatcccactg ctatactgtt ctactgcttc cctcagtatc tgaatgtctc aatttaaaac
     9481 ttgaagctct ttagaccaat agactggtga gaggagaaag gagcttatcc cccagaccct
     9541 gctttatacc attcacatcc cagggctgtg tccagacagc acaaaacggc aaggagagcc
     9601 caagccccaa tgccagaatt cttccaaact ccctgactct ttgaagtttt tactcacccc
     9661 atttcaatta tcctgatccc ttctcatccc ctgcttggct tctctgcatg tggtcatctg
     9721 ctgtggcttg gtgtttaatg ggttaaaaat aagccactgc ctgacatccc aacatttgac
     9781 accccagcaa tgtgtgactc ccccaacatt ccactatgcc atcctgcagc tgaaatggga
     9841 acactggctg cctctccaaa cccgctcttg gacagaggat ctgggaggtg gaagccaggc
     9901 cagaggactt ggggaaaatg agatggagga aggaaaaagg gagaagctga gccacagctt
     9961 aactcctaca gagtgaaatg aaaacgggct gaaaatacca ccccaggaga ggacctcgcc
    10021 ccaagcaagc cagtgagcag ccctgccaga ctactgccag actgagaaac ccagaagctg
    10081 gtagtcatgt gggcttgcct tctctgccaa acgactggga aaccaaaatg agcccacctt
    10141 gtgttcttcc tagctccacc ctccccgtgc tgctgtgttc tgctcctccc cacgcttccc
    10201 tgctatagtt cccagctgct gtaacggagc cacctccaac tctaacaata aaccaagttc
    10261 attgca
//
