LOCUS       NM_000898               2570 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens monoamine oxidase B (MAOB), mRNA.
ACCESSION   NM_000898
VERSION     NM_000898.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2570)
  AUTHORS   Qi,Y., Shao,W., Gao,J., Ni,N., Xue,F., Wang,T., Wang,Y., Fan,Y. and
            Yuan,H.
  TITLE     Monoamine oxidase B inhibits epithelial-mesenchymal transition and
            trigger apoptosis via targeting ERK1/2 signaling pathway in head
            and neck squamous cell carcinoma
  JOURNAL   Head Neck 46 (8), 2031-2041 (2024)
   PUBMED   38379404
  REMARK    GeneRIF: Monoamine oxidase B inhibits epithelial-mesenchymal
            transition and trigger apoptosis via targeting ERK1/2 signaling
            pathway in head and neck squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2570)
  AUTHORS   Huang,H.C., Hsieh,Y.H., Hsiao,C.H., Lin,C.Y., Wang,S.S., Ho,K.H.,
            Chang,L.C., Huang,H.M., Yang,S.F. and Chien,M.H.
  TITLE     MAOB expression correlates with a favourable prognosis in prostate
            cancer, and its genetic variants are associated with the metastasis
            of the disease
  JOURNAL   J Cell Mol Med 28 (8), e18229 (2024)
   PUBMED   38520217
  REMARK    GeneRIF: MAOB expression correlates with a favourable prognosis in
            prostate cancer, and its genetic variants are associated with the
            metastasis of the disease.
REFERENCE   3  (bases 1 to 2570)
  AUTHORS   Pu,T., Wang,J., Wei,J., Zeng,A., Zhang,J., Chen,J., Yin,L., Li,J.,
            Lin,T.P., Melamed,J., Corey,E., Gao,A.C. and Wu,B.J.
  TITLE     Stromal-derived MAOB promotes prostate cancer growth and
            progression
  JOURNAL   Sci Adv 10 (6), eadi4935 (2024)
   PUBMED   38335292
  REMARK    GeneRIF: Stromal-derived MAOB promotes prostate cancer growth and
            progression.
REFERENCE   4  (bases 1 to 2570)
  AUTHORS   Konjevod,M., Sreter,K.B., Popovic-Grle,S., Lampalo,M., Tudor,L.,
            Jukic,I., Nedic Erjavec,G., Bingulac-Popovic,J., Safic Stanic,H.,
            Nikolac Perkovic,M., Markeljevic,J., Samarzija,M., Pivac,N. and
            Svob Strac,D.
  TITLE     Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase
            B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in
            Asthma
  JOURNAL   Biomolecules 13 (5), 800 (2023)
   PUBMED   37238670
  REMARK    GeneRIF: Platelet Serotonin (5-HT) Concentration, Platelet
            Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB
            Gene Polymorphisms in Asthma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2570)
  AUTHORS   O'Higgins,M., Benito,A., Real-Lopez,M., Gil-Miravet,I., Ochoa,E.
            and Haro,G.
  TITLE     Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and
            antisocial personality disorders in polydrug users
  JOURNAL   Personal Ment Health 17 (1), 77-86 (2023)
   PUBMED   35961947
  REMARK    GeneRIF: Relationship of DRD5 and MAO-B VNTR polymorphisms with
            paranoid and antisocial personality disorders in polydrug users.
REFERENCE   6  (bases 1 to 2570)
  AUTHORS   Zhu,Q.S., Grimsby,J., Chen,K. and Shih,J.C.
  TITLE     Promoter organization and activity of human monoamine oxidase (MAO)
            A and B genes
  JOURNAL   J Neurosci 12 (11), 4437-4446 (1992)
   PUBMED   1432104
REFERENCE   7  (bases 1 to 2570)
  AUTHORS   Grimsby,J., Chen,K., Wang,L.J., Lan,N.C. and Shih,J.C.
  TITLE     Human monoamine oxidase A and B genes exhibit identical exon-intron
            organization
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3637-3641 (1991)
   PUBMED   2023912
REFERENCE   8  (bases 1 to 2570)
  AUTHORS   Bach,A.W., Lan,N.C., Johnson,D.L., Abell,C.W., Bembenek,M.E.,
            Kwan,S.W., Seeburg,P.H. and Shih,J.C.
  TITLE     cDNA cloning of human liver monoamine oxidase A and B: molecular
            basis of differences in enzymatic properties
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4934-4938 (1988)
   PUBMED   3387449
REFERENCE   9  (bases 1 to 2570)
  AUTHORS   Kochersperger,L.M., Parker,E.L., Siciliano,M., Darlington,G.J. and
            Denney,R.M.
  TITLE     Assignment of genes for human monoamine oxidases A and B to the X
            chromosome
  JOURNAL   J Neurosci Res 16 (4), 601-616 (1986)
   PUBMED   3540317
REFERENCE   10 (bases 1 to 2570)
  AUTHORS   Pearce,L.B. and Roth,J.A.
  TITLE     Human brain monoamine oxidase type B: mechanism of deamination as
            probed by steady-state methods
  JOURNAL   Biochemistry 24 (8), 1821-1826 (1985)
   PUBMED   4016087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC326844.1, M69177.1,
            BM726427.1 and AL133791.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000898.4.
            
            Summary: The protein encoded by this gene belongs to the flavin
            monoamine oxidase family. It is a enzyme located in the
            mitochondrial outer membrane. It catalyzes the oxidative
            deamination of biogenic and xenobiotic amines and plays an
            important role in the metabolism of neuroactive and vasoactive
            amines in the central nervous sysytem and peripheral tissues. This
            protein preferentially degrades benzylamine and phenylethylamine.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312679.1, BC022494.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000378069.5/
                                                  ENSP00000367309.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                DC326844.1         26-99
            75-1785             M69177.1           1-1711
            1786-2415           BM726427.1         35-664
            2416-2570           AL133791.1         277-431
FEATURES             Location/Qualifiers
     source          1..2570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..2570
                     /gene="MAOB"
                     /note="monoamine oxidase B"
                     /db_xref="GeneID:4129"
                     /db_xref="HGNC:HGNC:6834"
                     /db_xref="MIM:309860"
     exon            1..197
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1714
                     /gene="MAOB"
                     /EC_number="1.4.3.4"
                     /EC_number="1.4.3.21"
                     /note="MAO, platelet; MAO, brain; tyramine oxidase;
                     adrenalin oxidase; MAO-B; monoamine oxidase type B"
                     /codon_start=1
                     /product="amine oxidase [flavin-containing] B"
                     /protein_id="NP_000889.3"
                     /db_xref="CCDS:CCDS14261.1"
                     /db_xref="GeneID:4129"
                     /db_xref="HGNC:HGNC:6834"
                     /db_xref="MIM:309860"
                     /translation="MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTY
                     TLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGP
                     FPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTES
                     AKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVS
                     ERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNP
                     PLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPE
                     GNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQ
                     YSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREI
                     LHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALG
                     FLAHKRGLLVRV"
     exon            198..292
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            293..430
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            431..535
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            536..627
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            628..769
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            770..919
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1079
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1176
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1230
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1288
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1386
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1498
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1561
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..2570
                     /gene="MAOB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAOB"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="MAOB"
                     /note="major polyA site"
ORIGIN      
        1 aatatagcgg ctcgccgagg cgctggtgca cgggggcagc gcgcagcagg ccggcgggca
       61 ggcgggcggg ctggctggca ggcaggactg ggatcgaggc ccagaaaacg gagcagcggg
      121 caccagggag gcctggaacg gggcgagcgc catgagcaac aaatgcgacg tggtcgtggt
      181 ggggggcggc atctcaggta tggcagcagc caaacttctg catgactctg gactgaatgt
      241 ggttgttctg gaagcccggg accgtgtggg aggcaggact tacactctta ggaaccaaaa
      301 ggttaaatat gtggaccttg gaggatccta tgttggacca acccagaatc gtatcttgag
      361 attagccaag gagctaggat tggagaccta caaagtgaat gaggttgagc gtctgatcca
      421 ccatgtaaag ggcaaatcat accccttcag ggggccattc ccacctgtat ggaatccaat
      481 tacctactta gatcataaca acttttggag gacaatggat gacatggggc gagagattcc
      541 gagtgatgcc ccatggaagg ctccccttgc agaagagtgg gacaacatga caatgaagga
      601 gctactggac aagctctgct ggactgaatc tgcaaagcag cttgccactc tctttgtgaa
      661 cctgtgtgtc actgcagaga cccatgaggt ctctgctctc tggttcctgt ggtatgtgaa
      721 gcagtgtgga ggcacaacaa gaatcatctc gacaacaaat ggaggacagg agaggaaatt
      781 tgtgggcgga tctggtcaag tgagtgagcg gataatggac ctccttggag accgagtgaa
      841 gctggagagg cctgtgatct acattgacca gacaagagaa aatgtccttg tggagaccct
      901 aaaccatgag atgtatgagg ctaaatatgt gattagtgct attcctccta ctctgggcat
      961 gaagattcac ttcaatcccc ctctgccaat gatgagaaac cagatgatca ctcgtgtgcc
     1021 tttgggttca gtcatcaagt gtatagttta ttataaagag cctttctgga ggaaaaagga
     1081 ttactgtgga accatgatta ttgatggaga agaagctcca gttgcctaca cgttggatga
     1141 taccaaacct gaaggcaact atgctgccat aatgggattt atcctggccc acaaagccag
     1201 aaaactggca cgtcttacca aagaggaaag gttgaagaaa ctttgtgaac tctatgccaa
     1261 ggttctgggt tccctagaag ctctggagcc agtgcattat gaagaaaaga actggtgtga
     1321 ggagcagtac tctgggggct gctacacaac ttatttcccc cctgggatcc tgactcaata
     1381 tggaagggtt ctacgccagc cagtggacag gatttacttt gcaggcaccg agactgccac
     1441 acactggagc ggctacatgg agggggctgt agaggccggg gagagagcag cccgagagat
     1501 cctgcatgcc atggggaaga ttccagagga tgaaatctgg cagtcagaac cagagtctgt
     1561 ggatgtccct gcacagccca tcaccaccac ctttttggag agacatttgc cctccgtgcc
     1621 aggcctgctc aggctgattg gattgaccac catcttttca gcaacggctc ttggcttcct
     1681 ggcccacaaa agggggctac ttgtgagagt ctaaagagag agggtgtctg taatcacact
     1741 ctcttcttac tgtatttggg atatgagttt ggggaaagag ttgcagtaaa gttccatgaa
     1801 gacaaatagt gtggagtgag gcggggagca tgaagataaa tccaactctg actgtaaaat
     1861 acatggtatc tctttctccg ttgtggcccc tgcttagtgt cccttacctg gcttagcgtt
     1921 ctgtttcacc agtttccaag tttattgccc tcaaaatctt tagaatagtt aaattggctt
     1981 gtttaaggtt cttgctgccc cacaacacac cttgcccatg cacaaggaat gaattttttc
     2041 ctaccattat ggctttgtgc ttgttcttcc tcttacctgt aatagcctca ccttccctag
     2101 ttctttgcat tcgtccttag aatactgtat tgttacagct gaaagacagt aaagaccatt
     2161 tagtcctcac cttctgtttt agagttgagc aaactgaagc ccacagaggt ggaacttaat
     2221 tacctaagag ccacaataag ccactggtat ctgggggact agaacacaaa tccaacgctt
     2281 ttcccacctc tttggatgtt ttccccaatt atcctccttc actccctgtc atagttaccg
     2341 atggtgtccc gttgtgtggg tttactctgt gctaagttgt cttacacttc tcaaatgcta
     2401 ctcagtatat agccttaagt cttactgttt tgtgcggtgt gtctccagct gattttaact
     2461 tttttgatgg tagaaatttt atctcttctt ccttttgtat cctccattgt atcttcatac
     2521 aaaggacagt acacacttgg gtaattaaaa ataaaagttg attgaccata
//
