LOCUS       NM_000240               3931 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens monoamine oxidase A (MAOA), transcript variant 1,
            mRNA.
ACCESSION   NM_000240 XM_499175
VERSION     NM_000240.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3931)
  AUTHORS   Matsusue,A., Takayama,M., Tani,N., Waters,B., Kashiwagi,M.,
            Kubo,S.I. and Ishikawa,T.
  TITLE     Association between serum catecholamine levels and VNTR
            polymorphism in the promoter region of the monoamine oxidase A gene
            in forensic autopsy cases
  JOURNAL   Leg Med (Tokyo) 70, 102469 (2024)
   PUBMED   38870841
  REMARK    GeneRIF: Association between serum catecholamine levels and VNTR
            polymorphism in the promoter region of the monoamine oxidase A gene
            in forensic autopsy cases.
REFERENCE   2  (bases 1 to 3931)
  AUTHORS   Hung,C.C., Ko,Y.C., Chen,P.H. and Chung,C.M.
  TITLE     Impact of MAOA Gene Polymorphism on the Efficacy of Antidepressant
            Treatment and Craving Severity for Betel Quid Use Disorder
  JOURNAL   Int J Mol Sci 25 (17), 9221 (2024)
   PUBMED   39273170
  REMARK    GeneRIF: Impact of MAOA Gene Polymorphism on the Efficacy of
            Antidepressant Treatment and Craving Severity for Betel Quid Use
            Disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3931)
  AUTHORS   Nordquist,N. and Oreland,L.
  TITLE     Serotonin, genetic variability, behaviour, and psychiatric
            disorders--a review
  JOURNAL   Ups J Med Sci 115 (1), 2-10 (2010)
   PUBMED   20187845
  REMARK    Review article
REFERENCE   4  (bases 1 to 3931)
  AUTHORS   Brunner,H.G., Nelen,M., Breakefield,X.O., Ropers,H.H. and van
            Oost,B.A.
  TITLE     Abnormal behavior associated with a point mutation in the
            structural gene for monoamine oxidase A
  JOURNAL   Science 262 (5133), 578-580 (1993)
   PUBMED   8211186
REFERENCE   5  (bases 1 to 3931)
  AUTHORS   Zhu,Q.S., Grimsby,J., Chen,K. and Shih,J.C.
  TITLE     Promoter organization and activity of human monoamine oxidase (MAO)
            A and B genes
  JOURNAL   J Neurosci 12 (11), 4437-4446 (1992)
   PUBMED   1432104
REFERENCE   6  (bases 1 to 3931)
  AUTHORS   Chen,Z.Y., Hotamisligil,G.S., Huang,J.K., Wen,L., Ezzeddine,D.,
            Aydin-Muderrisoglu,N., Powell,J.F., Huang,R.H., Breakefield,X.O.,
            Craig,I. et al.
  TITLE     Structure of the human gene for monoamine oxidase type A
  JOURNAL   Nucleic Acids Res 19 (16), 4537-4541 (1991)
   PUBMED   1886775
REFERENCE   7  (bases 1 to 3931)
  AUTHORS   Grimsby,J., Chen,K., Wang,L.J., Lan,N.C. and Shih,J.C.
  TITLE     Human monoamine oxidase A and B genes exhibit identical exon-intron
            organization
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3637-3641 (1991)
   PUBMED   2023912
REFERENCE   8  (bases 1 to 3931)
  AUTHORS   Hsu,Y.P., Weyler,W., Chen,S., Sims,K.B., Rinehart,W.B.,
            Utterback,M.C., Powell,J.F. and Breakefield,X.O.
  TITLE     Structural features of human monoamine oxidase A elucidated from
            cDNA and peptide sequences
  JOURNAL   J Neurochem 51 (4), 1321-1324 (1988)
   PUBMED   3418353
REFERENCE   9  (bases 1 to 3931)
  AUTHORS   Bach,A.W., Lan,N.C., Johnson,D.L., Abell,C.W., Bembenek,M.E.,
            Kwan,S.W., Seeburg,P.H. and Shih,J.C.
  TITLE     cDNA cloning of human liver monoamine oxidase A and B: molecular
            basis of differences in enzymatic properties
  JOURNAL   Proc Natl Acad Sci U S A 85 (13), 4934-4938 (1988)
   PUBMED   3387449
REFERENCE   10 (bases 1 to 3931)
  AUTHORS   Ozelius,L., Hsu,Y.P., Bruns,G., Powell,J.F., Chen,S., Weyler,W.,
            Utterback,M., Zucker,D., Haines,J., Trofatter,J.A. et al.
  TITLE     Human monoamine oxidase gene (MAOA): chromosome position (Xp21-p11)
            and DNA polymorphism
  JOURNAL   Genomics 3 (1), 53-58 (1988)
   PUBMED   2906043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC044787.1, BC008064.2 and
            AL020990.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Dec 19, 2019 this sequence version replaced NM_000240.3.
            
            Summary: This gene is one of two neighboring gene family members
            that encode mitochondrial enzymes which catalyze the oxidative
            deamination of amines, such as dopamine, norepinephrine, and
            serotonin. Mutation of this gene results in Brunner syndrome. This
            gene has also been associated with a variety of other psychiatric
            disorders, including antisocial behavior. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3442180.1,
                                           SRR18074967.1397033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000338702.4/
                                                  ENSP00000340684.3
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               BC044787.1         1395-1543
            150-1926            BC008064.2         128-1904
            1927-3931           AL020990.2         13450-15454
FEATURES             Location/Qualifiers
     source          1..3931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..3931
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /note="monoamine oxidase A"
                     /db_xref="GeneID:4128"
                     /db_xref="HGNC:HGNC:6833"
                     /db_xref="MIM:309850"
     exon            1..116
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1627
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /EC_number="1.4.3.4"
                     /EC_number="1.4.3.21"
                     /note="isoform 1 is encoded by transcript variant 1; amine
                     oxidase [flavin-containing] A; monoamine oxidase type A"
                     /codon_start=1
                     /product="amine oxidase [flavin-containing] A isoform 1"
                     /protein_id="NP_000231.1"
                     /db_xref="CCDS:CCDS14260.1"
                     /db_xref="GeneID:4128"
                     /db_xref="HGNC:HGNC:6833"
                     /db_xref="MIM:309850"
                     /translation="MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEA
                     RDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVK
                     GKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKEL
                     IDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERK
                     FVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPT
                     LTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPIS
                     ITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHY
                     EEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVE
                     AGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFS
                     TSVTALGFVLYKYKLLPRS"
     exon            117..211
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            212..349
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            350..454
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            455..546
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            547..688
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            689..838
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            839..998
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1095
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1149
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1207
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1305
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1417
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1480
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..3931
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1926
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
     regulatory      3908..3913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /note="hexamer: AATAAA"
     polyA_site      3931
                     /gene="MAOA"
                     /gene_synonym="BRNRS; MAO-A"
                     /note="major polyA site"
ORIGIN      
        1 ccccactcct gtgcctacga cccaggagcg tgtcagccaa agcatggaga atcaagagaa
       61 ggcgagtatc gcgggccaca tgttcgacgt agtcgtgatc ggaggtggca tttcaggact
      121 atctgctgcc aaactcttga ctgaatatgg cgttagtgtt ttggttttag aagctcggga
      181 cagggttgga ggaagaacat atactataag gaatgagcat gttgattacg tagatgttgg
      241 tggagcttat gtgggaccaa cccaaaacag aatcttacgc ttgtctaagg agctgggcat
      301 agagacttac aaagtgaatg tcagtgagcg tctcgttcaa tatgtcaagg ggaaaacata
      361 tccatttcgg ggcgcctttc caccagtatg gaatcccatt gcatatttgg attacaataa
      421 tctgtggagg acaatagata acatggggaa ggagattcca actgatgcac cctgggaggc
      481 tcaacatgct gacaaatggg acaaaatgac catgaaagag ctcattgaca aaatctgctg
      541 gacaaagact gctaggcggt ttgcttatct ttttgtgaat atcaatgtga cctctgagcc
      601 tcacgaagtg tctgccctgt ggttcttgtg gtatgtgaag cagtgcgggg gcaccactcg
      661 gatattctct gtcaccaatg gtggccagga acggaagttt gtaggtggat ctggtcaagt
      721 gagcgaacgg ataatggacc tcctcggaga ccaagtgaag ctgaaccatc ctgtcactca
      781 cgttgaccag tcaagtgaca acatcatcat agagacgctg aaccatgaac attatgagtg
      841 caaatacgta attaatgcga tccctccgac cttgactgcc aagattcact tcagaccaga
      901 gcttccagca gagagaaacc agttaattca gcggcttcca atgggagctg tcattaagtg
      961 catgatgtat tacaaggagg ccttctggaa gaagaaggat tactgtggct gcatgatcat
     1021 tgaagatgaa gatgctccaa tttcaataac cttggatgac accaagccag atgggtcact
     1081 gcctgccatc atgggcttca ttcttgcccg gaaagctgat cgacttgcta agctacataa
     1141 ggaaataagg aagaagaaaa tctgtgagct ctatgccaaa gtgctgggat cccaagaagc
     1201 tttacatcca gtgcattatg aagagaagaa ctggtgtgag gagcagtact ctgggggctg
     1261 ctacacggcc tacttccctc ctgggatcat gactcaatat ggaagggtga ttcgtcaacc
     1321 cgtgggcagg attttctttg cgggcacaga gactgccaca aagtggagcg gctacatgga
     1381 aggggcagtt gaggctggag aacgagcagc tagggaggtc ttaaatggtc tcgggaaggt
     1441 gaccgagaaa gatatctggg tacaagaacc tgaatcaaag gacgttccag cggtagaaat
     1501 cacccacacc ttctgggaaa ggaacctgcc ctctgtttct ggcctgctga agatcattgg
     1561 attttccaca tcagtaactg ccctggggtt tgtgctgtac aaatacaagc tcctgccacg
     1621 gtcttgaagt tctgttctta tgctctctgc tcactggttt tcaataccac caagaggaaa
     1681 atattgacaa gtttaaaggc tgtgtcattg ggccatgttt aagtgtactg gatttaacta
     1741 cctttggctt aattccaatc attgttaaag taaaaacaat tcaaagaatc acctaattaa
     1801 tttcagtaag atcaagctcc atcttatttg tcagtgtaga tcaactcatg ttaattgata
     1861 gaataaagcc ttgtgatcac tttctgaaat tcacaaagtt aaacgtgatg tgctcatcag
     1921 aaacaatttc tgtgtcctgt ttttattccc ttcaatgcaa aatacatgat gatttcagaa
     1981 acaaagcatt tgactttctg tctgtggagg tggagtaggt gaaggcccag cctgtaactg
     2041 tcctttttct tcccttaggc aatggtgaac tgtcattaca gagcctagag gctcacagcc
     2101 tcctggagga agcagcctcc actttggatc aggaaatagt aaaggaaagc agtgttgggg
     2161 gtagcggcat gcagaccctc agaccagaat ggggacatct tgtggtctgc tgcctcagga
     2221 atctcctgac cacttgtagt ccctccgact tctctagaca tctagtctca gtgctagctt
     2281 atttgtattt ttcctctttc acttcttatg gaggagagtg tttaactgag ttagaatgtt
     2341 gaaactgact tgctgtgact tatgtgcagc tttccagttg agcagaggaa aatagtggca
     2401 ggactgtccc ccaggaggac tccctgctta gctctgtggg agaccaacta cgactggcat
     2461 cttctcttcc ccctggaagg cagctagaca ccaatggatc cttgtcagtt gtaacattct
     2521 atttcaactt caggaaagca gcagttttct tttaattttt cctatgacca taaaattaga
     2581 catacctctc aacttacata tgtcttcaac atggttacct ctgcataaat attagcaaag
     2641 catgccaatt tctcttaagt actgaaatac atatgataaa tttgactgtt atttgttgag
     2701 actatcaaac agaaaagaaa ttagggctct aatttcctta aagcaagctc acttgcttta
     2761 gttgttaagt tttataaaag acatgaaatt gagtcatttt atatatgaaa actaagttct
     2821 ctatcttagg agtaatgtcg gcccacaagg gtgcccacct cttgttttcc ccttttaaaa
     2881 actcagattt ttaaaagccc tttccaaagg tttcaactgt aaaatacttc tttttacaat
     2941 gtatcaacat atttttattt aaggggaatt aacaattgcc agggaaacca gccaacccaa
     3001 gtttattata tcattaacct tatcataaat tcaaacctaa gttgctggac cctggtgtga
     3061 ggacataaat cttccaaagt tttgcctatc ctaagagctg catttttcta ctgctcttta
     3121 ccttgcattt tagctaattt aggagttttg agaatgtatt ggatacgctc cagtacataa
     3181 ggagttgccg catattatat cagactgctt tgagaaatct catccctagt ctattgcagt
     3241 tgtttctatt agcttactga ttaactcagt cctgacacac cttttgggaa atgctgattt
     3301 aaacttctta actggcaaca gttggaacag taatcagttt gctaacatat ttaaagtctt
     3361 gaatgttgaa gaactcatgt gatttaccct tttcaacttt ttggaaaacg atttaattta
     3421 ttctaattag attaacccta ttaatctatg gattgggtat caaaatgaat gccagtccag
     3481 atgtgcctag acacgaaatt ggagctgagg actctcacga tatgcaagtt catccaacgt
     3541 gaagatacca taagcttttt ctctgaacca gagaaatgaa agtcagttta agaggctgat
     3601 agatcttggc cctgttaagg catccacttc acagttctga aggctgagtc agccccactc
     3661 cacagttagg ccaagaatta gattttaaaa cttcatctgt ctgtcccagt taactgttaa
     3721 ataaggcctc atcctccact gaagagtatg gattgaagga ttgtgaacta tgtttagtgt
     3781 gattgtgaac ttggtgccta atgttccatg tctgaagttt gccccagtgc tacacgttgg
     3841 agtataccta tgtgtgtgct ttgccactga agtaagattt tgcctgtatg gtactgtttt
     3901 gtttgttaat aaagtgcact gccaccccca a
//
