LOCUS       NM_018050               5532 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens MANSC domain containing 1 (MANSC1), transcript variant
            1, mRNA.
ACCESSION   NM_018050
VERSION     NM_018050.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5532)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5532)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007621.34 and AK023622.1.
            
            On Nov 24, 2018 this sequence version replaced NM_018050.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA733100.1, SRR1803613.15386.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000535902.6/ ENSP00000438205.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC007621.34        130588-130594       c
            8-2304              AK023622.1         1-2297
            2305-5532           AC007621.34        106408-109635       c
FEATURES             Location/Qualifiers
     source          1..5532
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.2"
     gene            1..5532
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /note="MANSC domain containing 1"
                     /db_xref="GeneID:54682"
                     /db_xref="HGNC:HGNC:25505"
     exon            1..165
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /inference="alignment:Splign:2.1.0"
     exon            166..488
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1561
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /EC_number="3.2.1.14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MANSC domain-containing protein 1; loss of
                     heterozygosity 12 chromosomal region 3 protein"
                     /codon_start=1
                     /product="MANSC domain-containing protein 1 isoform 1
                     precursor"
                     /protein_id="NP_060520.2"
                     /db_xref="CCDS:CCDS8648.1"
                     /db_xref="GeneID:54682"
                     /db_xref="HGNC:HGNC:25505"
                     /translation="MFFGGEGSLTYTLVIICFLTLRLSASQNCLKKSLEDVVIDIQSS
                     LSKGIRGNEPVYTSTQEDCINSCCSTKNISGDKACNLMIFDTRKTARQPNCYLFFCPN
                     EEACPLKPAKGLMSYRIITDFPSLTRNLPSQELPQEDSLLHGQFSQAVTPLAHHHTDY
                     SKPTDISWRDTLSQKFGSSDHLEKLFKMDEASAQLLAYKEKGHSQSSQFSSDQEIAHL
                     LPENVSALPATVAVASPHTTSATPKPATLLPTNASVTPSGTSQPQLATTAPPVTTVTS
                     QPPTTLISTVFTRAAATLQAMATTAVLTTTFQAPTDSKGSLETIPFTEISNLTLNTGN
                     VYNPTALSMSNVESSTMNKTASWEGREASPGSSSQGSVPENQYGLPFEKWLLIGSLLF
                     GVLFLVIGLVLLGRILSESLRRKRYSRLDYLINGIYVDI"
     exon            489..629
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /inference="alignment:Splign:2.1.0"
     exon            630..5532
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2305..2310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /note="hexamer: AATAAA"
     polyA_site      2339
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /note="major polyA site"
     regulatory      5503..5508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
                     /note="hexamer: AATAAA"
     polyA_site      5532
                     /gene="MANSC1"
                     /gene_synonym="9130403P13Rik; LOH12CR3"
ORIGIN      
        1 acttgctaac cacaaaaccc gccaggccgg tgcgggagct gcggagcatc cgctgcggtc
       61 ctcgccgaga cccccgcgcg gattcgccgg tccttcccgc gggcgcgaca gagctgtcct
      121 cgcacctgga tggcagcagg ggcgccgggg tcctctcgac gccagagaga aatctcatca
      181 tctgtgcagc cttcttaaag caaactaaga ccagagggag gattatcctt gacctttgaa
      241 gaccaaaact aaactgaaat ttaaaatgtt cttcggggga gaagggagct tgacttacac
      301 tttggtaata atttgcttcc tgacactaag gctgtctgct agtcagaatt gcctcaaaaa
      361 gagtctagaa gatgttgtca ttgacatcca gtcatctctt tctaagggaa tcagaggcaa
      421 tgagcccgta tatacttcaa ctcaagaaga ctgcattaat tcttgctgtt caacaaaaaa
      481 catatcaggg gacaaagcat gtaacttgat gatcttcgac actcgaaaaa cagctagaca
      541 acccaactgc tacctatttt tctgtcccaa cgaggaagcc tgtccattga aaccagcaaa
      601 aggacttatg agttacagga taattacaga ttttccatct ttgaccagaa atttgccaag
      661 ccaagagtta ccccaggaag attctctctt acatggccaa ttttcacaag cagtcactcc
      721 cctagcccat catcacacag attattcaaa gcccaccgat atctcatgga gagacacact
      781 ttctcagaag tttggatcct cagatcactt ggagaaacta tttaagatgg atgaagcaag
      841 tgcccagctc cttgcttata aggaaaaagg ccattctcag agttcacaat tttcctctga
      901 tcaagaaata gctcatctgc tgcctgaaaa tgtgagtgcg ctcccagcta cggtggcagt
      961 tgcttctcca cataccacct cggctactcc aaagcccgcc acccttctac ccaccaatgc
     1021 ttcagtgaca ccttctggga cttcccagcc acagctggcc accacagctc cacctgtaac
     1081 cactgtcact tctcagcctc ccacgaccct catttctaca gtttttacac gggctgcggc
     1141 tacactccaa gcaatggcta caacagcagt tctgactacc acctttcagg cacctacgga
     1201 ctcgaaaggc agcttagaaa ccataccgtt tacagaaatc tccaacctaa ctttgaacac
     1261 agggaatgtg tataacccta ctgcactttc tatgtcaaat gtggagtctt ccactatgaa
     1321 taaaactgct tcctgggaag gtagggaggc cagtccaggc agttcctccc agggcagtgt
     1381 tccagaaaat cagtacggcc ttccatttga aaaatggctt cttatcgggt ccctgctctt
     1441 tggtgtcctg ttcctggtga taggcctcgt cctcctgggt agaatcctct cggaatcact
     1501 ccgcaggaaa cgttactcaa gactggatta tttgatcaat gggatctatg tggacatcta
     1561 aggatggaac tcggtgtctc ttaattcatt tagtaaccag aagcccaaat gcaatgagtt
     1621 tctgctgact tgctagtctt agcaggaggt tgtattttga agacaggaaa atgccccctt
     1681 ctgctttcct tttttttttt tggagacaga gtcttgcttt gttgcccagg ctggagtgca
     1741 gtagcacgat ctcggctctc accgcaacct ccgtctcctg ggttcaagcg attctcctgc
     1801 ctcagcctcc taagtatctg ggattacagg catgtgccac cacacctggg tgatttttgt
     1861 atttttagta gagacggggt ttcaccatgt tggtcaggct ggtctcaaac tcctgaccta
     1921 gtgatccacc ctcctcggcc tcccaaagtg ctgggattac aggcatgagc caccacagct
     1981 ggcccccttc tgttttatgt ttggtttttg agaaggaatg aagtgggaac caaattaggt
     2041 aattttgggt aatctgtctc taaaatatta gctaaaaaca aagctctatg taaagtaata
     2101 aagtataatt gccatataaa tttcaaaatt caactggctt ttatgcaaag aaacaggtta
     2161 ggacatctag gttccaattc attcacattc ttggttccag ataaaatcaa ctgtttatat
     2221 caatttctaa tggatttgct tttcttttta tatggattcc tttaaaactt attccagatg
     2281 tagttccttc caattaaata tttgaataaa tcttttgtta ctcagtagtg ttctcataag
     2341 tagcatgtcc agctggataa ctttccattt atttccacta gcaaaatgat tatgtggtga
     2401 aaatatgcgt tccacgttaa aatgacaacc cccccttttt cccatcagtg agcaaagagc
     2461 ttcacttggg agaatctagc ggaatgttag cccacatgga gacaatgata agtcagttct
     2521 gataaatggc catatccact tgggatctgt tctagttaac ttgtgtgtgt gtgtgtgtgt
     2581 gtgtgtgtgt gtgtgtgtgt gtgacagagt cttgctctgt cacccaggct agagtgcagt
     2641 ggcgcgatct cggctcactg ccagctccgc ctcctgggtt cccgccattc tcctgcctca
     2701 gcctcccaag tagctgggac tacaggcgcc cgccaacacg cccagctaat tttttatatt
     2761 tttagtaaag acggggtttc actgtgttag tcaggatggt ctcgatctcc tgaccttgtg
     2821 atccgcccgc ctcggcctcc caaagtgctg ggattacagg cgtgagccac cgtgcccggc
     2881 ctctagttaa ctttttaaag aagtattata gacattttct aaacttgtac taagttaaaa
     2941 atgtaccact attattttat atccttactt aaattgacca gcaatcagtc taagcttaat
     3001 ttagaacaac attggaaata ataactagca caggccaggc gcggtggctc acgcctgtaa
     3061 tcccagcact ttgggaggcc gagatgggca aatcacgagg tcaggagatc gagaccatcc
     3121 tggctaacac ggtgaaaccc cgcctctact aaaaatacaa aaaattagcc gggcgtggtg
     3181 gcgggcgcct gtagttccag ctacttggga ggctgaggca ggagagtagt ttgaatccag
     3241 gaggcggagg ttgcggtgag ccagattgca ccattgcgct ccagcctggg caacagagcc
     3301 agactccgtc tcaaaaataa taataataat aactagcact aacatgatgc tacaattttt
     3361 actggttacc aattaaaatt tctgagaaag gcttttaata aagttttcca gacaagttat
     3421 aggtgaggta acaaagagtc cagaagtccc ctgggtcagt ttgatacctc tttcctctgg
     3481 acttcaattt gcttatctgc aaaacaggaa atttgatccc ttccaagtgt caccagagtt
     3541 tttaaagata aaaatggaat tcagatgcga acttaataca gtgagcacta gagggcagta
     3601 gctggttaat aagtacagca attaagacaa atgcaggaaa tgacagaaaa ggcttttctt
     3661 ctccttcctc ctcacctctt ccttcctcct cacctccttc ccctctgctc ttctggtacc
     3721 cctcccccat ttccctggtt tacactaagt tcataaagta cattaagagg aaagctggtc
     3781 tattgaaaat actacttttc ttatattttc caacttaaca gcttgacaca aatctccaag
     3841 gggtttacat aagctttaag taggctgaat aaataaaacc ttgagtcaat ttaacttaac
     3901 aagtatttat tgaatatcca catgtaggcc agaatcagat tagtaaccag gtgccttgga
     3961 attttaaaat ttctcctctc tttattaatg gatttagcga gtggaaatca ggctttctgt
     4021 gatggtttat aaaggtattt tcctggctct cttggagttc tctgtccacc ttgctgcagt
     4081 ctttgttgtg atggggagac cacatgggag cggtccagat gagtgatgct acgggcccaa
     4141 actgttagtg gccgtgagga tataggttgt aggggacatc tggagtggaa agagtgctct
     4201 tctcacacag ctctctctac ttactgcccc taggatggtg ggtgcaactg tggcaagggc
     4261 agtcagggta ggggaatccc ttagaggaat tcagcagtga ctagtctggt tagcctttcc
     4321 cacaaggccc attgagttat gagccccctc ctttggtttg tagaaagaga aggtagcagc
     4381 ctagaacagg tgagaagatg aggtaggtcc ttctgctcaa acatcctctc tccgtatttt
     4441 accaacacga tactgaccta ggttaaaaag ctactcttgg ccaggcgtgg tggctcacgc
     4501 ctgtaatccc agcactttgg gagtccaagg tgggtggatc acctgaggtc aggagttcta
     4561 gaccagcctg gccaacatgg tgaaacccca tctctacaga aatacaaaaa ttagccaggc
     4621 atggtggcag acacctgtaa tcccagctac ttgggaggct gaggtaggat aattgcttga
     4681 ggccgggagg gggcggttgc agtgagccaa gatcgctcca ttgcactcca gcctaggcga
     4741 cagagcaaga ctctatctca aaaaaataaa ataaaataaa ataaaaataa gctactctta
     4801 gccaggcaca tagtggctca catctgtaat ctcagccctt tgggagactg aggtgggagg
     4861 atcacttgag cccaggaggt cgaggctgca gtgagccatg atcacgccac tgcactccag
     4921 cctgggcgac agaacgagag cccatctcaa aaaaaaaaac aaaacaacaa caacaaaaaa
     4981 aaaactaaaa aactcttaaa aaacctgagg actcctggat gaatactgtt atgtgcctgt
     5041 ttctcaatta cccctggcct gagtgaggaa cttttggaac tctttggctc ccagactgtg
     5101 gtgggcacta ccggtcagct gcccagcagc cagccctagt cccacttctg cctcatttgt
     5161 tacaggttgg aagtgccagg ttcagggatg ggcctgtgac ccaagtttta gctgaaagga
     5221 aacctactag ggacttctag gagagatttt cttgcttgta aagggaaggc tgcacaagga
     5281 gaaaagccct ttctaaccac atccccttat ttcatgcttg ggatgctgac catgtgaaga
     5341 cttggttgtt ggagctgtgg tggcctccct gccatgatga ggggagaagg cactgccaca
     5401 ctgagcgtgg cagtgggtac aggaagagtc cagtctccgg gatgccttgg ttaattgaca
     5461 ggacaaaccc tggaactgcc aacttccatc ttgttctgta ataataaatc tctaatattt
     5521 gtaccacttt ca
//
