LOCUS       NM_024641               4578 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens mannosidase endo-alpha (MANEA), mRNA.
ACCESSION   NM_024641 XM_938989
VERSION     NM_024641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4578)
  AUTHORS   Jensen,K.P., Stein,M.B., Kranzler,H.R., Yang,B.Z., Farrer,L.A. and
            Gelernter,J.
  TITLE     The alpha-endomannosidase gene (MANEA) is associated with panic
            disorder and social anxiety disorder
  JOURNAL   Transl Psychiatry 4 (1), e353 (2014)
   PUBMED   24473444
  REMARK    GeneRIF: MANEA plays a role in anxiety disorders.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4578)
  AUTHORS   Farrer,L.A., Kranzler,H.R., Yu,Y., Weiss,R.D., Brady,K.T.,
            Anton,R., Cubells,J.F. and Gelernter,J.
  TITLE     Association of variants in MANEA with cocaine-related behaviors
  JOURNAL   Arch Gen Psychiatry 66 (3), 267-274 (2009)
   PUBMED   19255376
  REMARK    GeneRIF: Association of variants in MANEA with cocaine related
            behavior is established.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   3  (bases 1 to 4578)
  AUTHORS   Yu,Y., Kranzler,H.R., Panhuysen,C., Weiss,R.D., Poling,J.,
            Farrer,L.A. and Gelernter,J.
  TITLE     Substance dependence low-density whole genome association study in
            two distinct American populations
  JOURNAL   Hum Genet 123 (5), 495-506 (2008)
   PUBMED   18438686
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4578)
  AUTHORS   Hamilton,S.R., Li,H., Wischnewski,H., Prasad,A.,
            Kerley-Hamilton,J.S., Mitchell,T., Walling,A.J., Davidson,R.C.,
            Wildt,S. and Gerngross,T.U.
  TITLE     Intact {alpha}-1,2-endomannosidase is a typical type II membrane
            protein
  JOURNAL   Glycobiology 15 (6), 615-624 (2005)
   PUBMED   15677381
  REMARK    GeneRIF: We have cloned two novel endomannosidase sequences from
            rat and human cDNA libraries [and] confirm that endomannosidase is
            a type II membrane protein, like the majority of other secretory
            pathway glycosylation enzymes
REFERENCE   5  (bases 1 to 4578)
  AUTHORS   Hardt,B., Volker,C., Mundt,S., Salska-Navarro,M., Hauptmann,M. and
            Bause,E.
  TITLE     Human endo-alpha1,2-mannosidase is a Golgi-resident type II
            membrane protein
  JOURNAL   Biochimie 87 (2), 169-179 (2005)
   PUBMED   15760709
REFERENCE   6  (bases 1 to 4578)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 4578)
  AUTHORS   Spiro,M.J., Bhoyroo,V.D. and Spiro,R.G.
  TITLE     Molecular cloning and expression of rat liver
            endo-alpha-mannosidase, an N-linked oligosaccharide processing
            enzyme
  JOURNAL   J Biol Chem 272 (46), 29356-29363 (1997)
   PUBMED   9361017
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX481372.1, BC137014.1, BX537398.1 and BQ018032.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024641.3.
            
            Summary: N-glycosylation of proteins is initiated in the
            endoplasmic reticulum (ER) by the transfer of the preassembled
            oligosaccharide glucose-3-mannose-9-N-acetylglucosamine-2 from
            dolichyl pyrophosphate to acceptor sites on the target protein by
            an oligosaccharyltransferase complex. This core oligosaccharide is
            sequentially processed by several ER glycosidases and by an
            endomannosidase (E.C. 3.2.1.130), such as MANEA, in the Golgi.
            MANEA catalyzes the release of mono-, di-, and triglucosylmannose
            oligosaccharides by cleaving the alpha-1,2-mannosidic bond that
            links them to high-mannose glycans (Hamilton et al., 2005 [PubMed
            15677381]).[supplied by OMIM, Sep 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936827.1, SRR1660807.79940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358812.9/ ENSP00000351669.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               BX481372.1         43-198
            157-3833            BC137014.1         64-3740
            3834-4255           BX537398.1         3803-4224
            4256-4578           BQ018032.1         18-340              c
FEATURES             Location/Qualifiers
     source          1..4578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.1"
     gene            1..4578
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /note="mannosidase endo-alpha"
                     /db_xref="GeneID:79694"
                     /db_xref="HGNC:HGNC:21072"
                     /db_xref="MIM:612327"
     exon            1..104
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /inference="alignment:Splign:2.1.0"
     exon            105..686
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1531
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /EC_number="3.2.1.130"
                     /note="mandaselin; alpha 1,2-endomannosidase; endo-alpha
                     mannosidase"
                     /codon_start=1
                     /product="glycoprotein endo-alpha-1,2-mannosidase"
                     /protein_id="NP_078917.2"
                     /db_xref="CCDS:CCDS5032.1"
                     /db_xref="GeneID:79694"
                     /db_xref="HGNC:HGNC:21072"
                     /db_xref="MIM:612327"
                     /translation="MAKFRRRTCIILALFILFIFSLMMGLKMLRPNTATFGAPFGLDL
                     LPELHQRTIHLGKNFDFQKSDRINSETNTKNLKSVEITMKPSKASELNLDELPPLNNY
                     LHVFYYSWYGNPQFDGKYIHWNHPVLEHWDPRIAKNYPQGRHNPPDDIGSSFYPELGS
                     YSSRDPSVIETHMRQMRSASIGVLALSWYPPDVNDENGEPTDNLVPTILDKAHKYNLK
                     VTFHIEPYSNRDDQNMYKNVKYIIDKYGNHPAFYRYKTKTGNALPMFYVYDSYITKPE
                     KWANLLTTSGSRSIRNSPYDGLFIALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSS
                     HQNWASLKLFCDKYNLIFIPSVGPGYIDTSIRPWNTQNTRNRINGKYYEIGLSAALQT
                     RPSLISITSFNEWHEGTQIEKAVPKRTSNTVYLDYRPHKPGLYLELTRKWSEKYSKER
                     ATYALDRQLPVS"
     exon            687..796
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /inference="alignment:Splign:2.1.0"
     exon            797..873
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /inference="alignment:Splign:2.1.0"
     exon            874..4578
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4551..4556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /note="hexamer: AATAAA"
     polyA_site      4578
                     /gene="MANEA"
                     /gene_synonym="ENDO; hEndo"
                     /note="major polyA site"
ORIGIN      
        1 gaggggctgt ctgggctcgg ggcgcggcgg cagtcagctc tatgttcgcg gtcttaacct
       61 ctcctctggc cgagtccttg caagaagtga attacccgac cctgcaaaac acttactatt
      121 ttggagttta aagtatgtca tcatggcaaa gtttcggaga aggacttgca tcattttggc
      181 actttttatt ctatttattt tctctctgat gatgggttta aaaatgctga gaccaaatac
      241 agctactttt ggagctcctt ttggacttga ccttcttcca gaacttcatc aacgaactat
      301 tcatttgggg aaaaattttg atttccaaaa gagtgacaga atcaacagtg aaacaaatac
      361 caagaattta aaaagtgttg aaatcactat gaaaccttcc aaagcctctg aacttaactt
      421 ggatgaacta ccacctctga acaattatct acatgtattt tattacagtt ggtatggaaa
      481 tccacaattt gatggtaaat atatacattg gaatcatcca gtgttagagc attgggaccc
      541 tagaatagcc aagaattatc cacaagggag acacaaccct ccagatgaca ttggctccag
      601 cttttatcct gaattgggaa gttacagttc tcgggatcct tctgtcatag aaactcacat
      661 gagacaaatg cgctcagctt caattggtgt actagccctc tcttggtacc cacctgatgt
      721 aaatgatgaa aatggagaac ctactgataa cttggtaccc actattttgg ataaagctca
      781 taaatataac ctaaaggtta cttttcacat agaaccatat agcaatcgag atgatcaaaa
      841 catgtacaaa aatgtcaagt atattataga caaatatgga aatcatccgg ccttttacag
      901 gtacaagacg aagactggca atgctcttcc tatgttttat gtctatgatt cctatattac
      961 caagcctgaa aaatgggcca atctgttaac cacctcaggg tctcggagta ttcgcaattc
     1021 tccttatgat ggactgttta ttgcccttct ggtagaagaa aaacataagt atgatattct
     1081 tcaaagtggt tttgatggaa tttacacata ttttgccaca aatggcttta cttatggctc
     1141 atcacatcag aattgggcta gcctaaaatt attttgtgat aaatacaact taatatttat
     1201 cccaagtgtg ggcccaggat acatagatac cagcatccgt ccatggaaca cgcaaaacac
     1261 tcggaaccga atcaatggga agtattatga aattggtctg agtgccgcac ttcagacacg
     1321 ccccagctta atttctatca cctcttttaa tgagtggcat gaaggaactc agattgaaaa
     1381 agctgttccc aaaagaacca gtaatacagt gtacctagat taccgtcctc ataaaccagg
     1441 tctttaccta gaactgactc gcaagtggtc tgaaaaatac agtaaggaaa gagcaactta
     1501 tgcattagat cgccagctgc ctgtttctta atgcattgat taaagtttaa tagttatcaa
     1561 aatcacctaa tttttaaaaa tagctttcgt tttgagttct ggaaagaaaa ctgtcaaaat
     1621 cagtatatac tattagttat atttaaaaat atttttttaa attctttaca gataatatta
     1681 tacttgttac ccttcacaat accacatgag aaaatatctg agacaaaatg tatacaaata
     1741 tattccttat ggcataattt attgcatttc tgactgaaat caaaattctg atttgatggc
     1801 aattgaattt tcattttaca atagataaat gcttgtgcta cctaaagcac ttagcacaca
     1861 gttaaattat atttacatcc tagacccaaa taaataggat tgtgtgtata tttgggatat
     1921 ctattgaaga aaaaaagaaa accccttaaa gataatgtac atgcttcatg tcatgtcttt
     1981 aaaataattt aatcaacttt attgtcttag tatttagact ctggataact ctacaataat
     2041 gaggaaattc ttaagaataa caaaatcact gtaccttcct ctcaattttg ctgtgaacct
     2101 gaaatggctt taaattaata ctcttatttt ttatttaatt taattacata aattaaacct
     2161 taccatgacc aaattgtgtt aggacggcct gctatctaca gcacagtgtg tcatttgcag
     2221 atttgtggtt acctatacca cgctaggtgt tttgacatgt ttagtgtttc tgctttacag
     2281 tgctgaattc catattttag aagctatgaa agtcctttta tgaaaaagtt actgattgct
     2341 tctcagttat taggaaaaca gttgtttcac aattattatg tagatatgat gcccaaatat
     2401 catttttagt atatcttgtc gatctttaag ttgttactat tgtgttattc atgtctttaa
     2461 atcagatacc aaatattttt taggaaagaa aaatgttatt actgtcatta ggttgtcttt
     2521 taatacttta agttattttg acgaaaagta atagagaaaa tttacttagc attttagatt
     2581 ctagagacat ggaaatgaaa attattttat gtctagagta ggtcctgaag tttggcttta
     2641 cattaagttt agcactgtat cagaatgaag aaactaatat tttacataaa aactaatact
     2701 ttcaattttt tatatagtaa tatccccatt ttgtaaatgt tagactttta tcatacctgt
     2761 aagttaaaat acttgttatc aataacttgt catgttgtga caaattgatc acttgtgtac
     2821 gaaaaataaa tctccttaaa aactaaataa aatgcactgt attcttacag ttaatgttta
     2881 taactatagt aaaaaattaa tatatatcct attacataaa tgttatttct taggtgttcc
     2941 attaagaaga gcaatagaat aatgctaaaa aataatgcct ataaatcttc agagtataaa
     3001 gacatccatt cagaaacaaa aattagcact aaatttttta taaaatagac cagatgacaa
     3061 aatttatttt atttttaaac agtggttttg acacaaatta tgttattgaa aagcattatt
     3121 aatgtttaat ttatttaaaa ttttggaatt tgccatttct cagagaatga tcaggcctta
     3181 ggaaattaat acagtagtag taatcatttt ctaggggaaa ataaaagaat aaatcactat
     3241 actgatattt tgatacaagc aagcacttac atggtaatca ctatatagat ccaacctgtg
     3301 gattttcttc ttatgtccat ttaactagaa tatattattt taggtataat ttacaaatgt
     3361 cacacctaat aatcttttat aatataccat atttcattaa agttttgtta gagaagtatc
     3421 taccacagag gagtttttgt cattgtgtac gttgtgtatt tgaacccacc atgacagaaa
     3481 gtaaatttta ggaaatagtt atgagattaa gggaaaatct ataaaaacaa ggttagcata
     3541 ttctcaacac agataccacc actttctttt tcccattata gacatggtga atccacacag
     3601 catacttcat ctctgagctt tgttgtgatt cctcaacaca ttaccctaac cagccagcag
     3661 taacagattt cagagtaaga taaagcagat tctgtcttca ttgcaaaaag ttattctcaa
     3721 tggaagaatg gcatctgatc tcataattac tagtttatat taatatagtt tttttctccc
     3781 tttttaataa aataattaca gtcatccctc agtgtctgtg ggggattggt tccagttacc
     3841 cctatagata ccaaaatctg cagatgctca agtccctgat ataaactggc atagtagttg
     3901 catataatct atgcacatcc tcctgtatac attaagtcat ctctagatta tttataacac
     3961 ttaatacaat gtaaatgcta tgtagttgtt ataccatact ggttagtgaa taattacatg
     4021 aaaaaaaaga gtctgtacat cttcagagtt tcagtcggca atttcttggc catggatgta
     4081 gaacctacag ataaggtgag ccaactgcat taggaaataa ctctaataat tctgttaatt
     4141 cttagagagg aaaactttca aaatcttcct caggtattta ttacaactgc ctttaccatt
     4201 ttagttgtaa cacagtttaa attgttatga taacaagtaa ataagagcaa agaatgtatt
     4261 tcttaattca aaactatacg tttgaattca atatggtata acttaaagtg gtataataca
     4321 tacaatgcat gaatcataat ggattctttt ataagttatt aatttttatg gtttaatcag
     4381 tctaattgtt ttgactgtta tagaaaccaa atattttact gtttctttta aggactaata
     4441 ttgtcaaaaa ctgctgttat taacttcact tgagttgttt aacttccttc tgttttaaga
     4501 ttgtaattaa aaattactat tttgttatat ggaatggtta atttttacct aataaaaaca
     4561 tagatgaaat acattgta
//
