LOCUS       NM_001387336            1235 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens mannosidase beta like (MANBAL), transcript variant 11,
            mRNA.
ACCESSION   NM_001387336
VERSION     NM_001387336.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1235)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1235)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL034422.24.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF219139.1, SRR18074967.124067.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL034422.24        29017-29048
            33-238              AL034422.24        40570-40775
            239-282             AL034422.24        41642-41685
            283-1235            AL034422.24        55670-56622
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1235
                     /gene="MANBAL"
                     /note="mannosidase beta like"
                     /db_xref="GeneID:63905"
                     /db_xref="HGNC:HGNC:15799"
     exon            1..32
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     exon            33..238
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..259
                     /gene="MANBAL"
                     /note="isoform b is encoded by transcript variant 11;
                     protein MANBAL; mannosidase, beta A, lysosomal-like;
                     mannosidase beta A like"
                     /codon_start=1
                     /product="protein MANBAL isoform b"
                     /protein_id="NP_001374265.1"
                     /db_xref="CCDS:CCDS93036.1"
                     /db_xref="GeneID:63905"
                     /db_xref="HGNC:HGNC:15799"
                     /translation="MASDLDFSPPEVPEPTFLENLLRYGLFLGAIFQLICVLAIIVPI
                     PKSHEAEFHVEA"
     exon            239..282
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     exon            283..1235
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MANBAL"
                     /note="hexamer: AATAAA"
     polyA_site      1235
                     /gene="MANBAL"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggg gagcggcgcg gcggcgcggg agttggttct aaagagtggt gagtcagaag
       61 agacgtcagg cagcaagcga cttgggccat ggcctctgac ctagacttct cacctccgga
      121 ggtgcccgag cccactttcc tggagaacct gctacggtac ggactcttcc tgggagccat
      181 cttccagctc atctgtgtgc tggccatcat cgtacccatt cccaagtccc acgaggcgga
      241 gttccatgta gaggcctgat tccattccag tcaggttatt gggaggctga accgtctgag
      301 cccagaagtg ctgaggtgac gaggaagccc aaggctgctg ttccttctgt gaacaagagg
      361 cccaagaaag agactaagaa gaagcggtag aagaggaggc ctgaggagct gggcgggcag
      421 ggagagggtc ttggggacag ccctcctggg aatctacatt gtgttccccc gcattccagg
      481 ctcagggtct gaggaggctg tgacgcccta tgaccgcaga gatctagaca gtcgtaacag
      541 tccccaggct ccagctgggc aatccaccac ttcctcttcc ttctgcttct gtgacggttt
      601 agagtcaagg gggctgaaac acactgtgag catagactgt attaggtttg ttcagaagcc
      661 gggtcagctc acagagtcac attttcttgc ttagtcatgt gtccctcctt gagttgcccc
      721 ctccttgtgg gtttacacta catttgggag tcattgtcta atgctgacaa gcacaccctc
      781 tcccattatt tgtgcactac agatctcctc ctgatcagtc acctttgttg ctgctgtgta
      841 gacagagcca ggcctcacct gtttgtttag gccaagatgc catggacatg cagcgttagt
      901 gatcccacta gctgtgacag ccaggcccag aaaatgcctg gcgtgagagc cagcagacag
      961 ccaggccagg gtaggcagtg cctgcttctg ctccatcagg tgcaggggat ttggctgaag
     1021 gcgtgcatat ttcctgggca caaacttcct gagcctctga aatgggaggc tcgtcaattt
     1081 cagaccaacc tcttttcaac ccatcatagc acgttcaagg tgtgcctttt acttctacct
     1141 gtacatcccc catcccttca attctttcat tccctgacca gtgagagggt tcctggggga
     1201 agtatggtga ataaactgac atgcatgctt cagaa
//
