LOCUS       NM_001369743            1430 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens mannosidase beta like (MANBAL), transcript variant 4,
            mRNA.
ACCESSION   NM_001369743
VERSION     NM_001369743.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL034422.24.
            
            ##Evidence-Data-START##
            CDS exon combination :: BX399091.2, SRR7346977.168668.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL034422.24        29017-29048
            33-271              AL034422.24        36658-36896
            272-477             AL034422.24        40570-40775
            478-1430            AL034422.24        55670-56622
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1430
                     /gene="MANBAL"
                     /note="mannosidase beta like"
                     /db_xref="GeneID:63905"
                     /db_xref="HGNC:HGNC:15799"
     exon            1..32
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     exon            33..271
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     exon            272..477
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..585
                     /gene="MANBAL"
                     /note="isoform a is encoded by transcript variant 4;
                     protein MANBAL; mannosidase, beta A, lysosomal-like;
                     mannosidase beta A like"
                     /codon_start=1
                     /product="protein MANBAL isoform a"
                     /protein_id="NP_001356672.1"
                     /db_xref="CCDS:CCDS13293.1"
                     /db_xref="GeneID:63905"
                     /db_xref="HGNC:HGNC:15799"
                     /translation="MASDLDFSPPEVPEPTFLENLLRYGLFLGAIFQLICVLAIIVPI
                     PKSHEAEAEPSEPRSAEVTRKPKAAVPSVNKRPKKETKKKR"
     exon            478..1430
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1405..1410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MANBAL"
                     /note="hexamer: AATAAA"
     polyA_site      1430
                     /gene="MANBAL"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggg gagcggcgcg gcggcgcggg agtgccacct gattcactgc acttggaacc
       61 agatgatgtt gggctctttc cagaagtcaa atccttcctg ggaggatgaa gatctgccag
      121 ctctgaggat tctggctggg aagaaaaaga gcctcaagct ttgaaggcca ttcccatggt
      181 agacagagct gatgtgaaaa gtggccatcc tgttgcccca ggcacatgac cttctgaagt
      241 gaccaggctg aaagggaagc aatactcgtg tttggttcta aagagtggtg agtcagaaga
      301 gacgtcaggc agcaagcgac ttgggccatg gcctctgacc tagacttctc acctccggag
      361 gtgcccgagc ccactttcct ggagaacctg ctacggtacg gactcttcct gggagccatc
      421 ttccagctca tctgtgtgct ggccatcatc gtacccattc ccaagtccca cgaggcggag
      481 gctgaaccgt ctgagcccag aagtgctgag gtgacgagga agcccaaggc tgctgttcct
      541 tctgtgaaca agaggcccaa gaaagagact aagaagaagc ggtagaagag gaggcctgag
      601 gagctgggcg ggcagggaga gggtcttggg gacagccctc ctgggaatct acattgtgtt
      661 cccccgcatt ccaggctcag ggtctgagga ggctgtgacg ccctatgacc gcagagatct
      721 agacagtcgt aacagtcccc aggctccagc tgggcaatcc accacttcct cttccttctg
      781 cttctgtgac ggtttagagt caagggggct gaaacacact gtgagcatag actgtattag
      841 gtttgttcag aagccgggtc agctcacaga gtcacatttt cttgcttagt catgtgtccc
      901 tccttgagtt gccccctcct tgtgggttta cactacattt gggagtcatt gtctaatgct
      961 gacaagcaca ccctctccca ttatttgtgc actacagatc tcctcctgat cagtcacctt
     1021 tgttgctgct gtgtagacag agccaggcct cacctgtttg tttaggccaa gatgccatgg
     1081 acatgcagcg ttagtgatcc cactagctgt gacagccagg cccagaaaat gcctggcgtg
     1141 agagccagca gacagccagg ccagggtagg cagtgcctgc ttctgctcca tcaggtgcag
     1201 gggatttggc tgaaggcgtg catatttcct gggcacaaac ttcctgagcc tctgaaatgg
     1261 gaggctcgtc aatttcagac caacctcttt tcaacccatc atagcacgtt caaggtgtgc
     1321 cttttacttc tacctgtaca tcccccatcc cttcaattct ttcattccct gaccagtgag
     1381 agggttcctg ggggaagtat ggtgaataaa ctgacatgca tgcttcagaa
//
