LOCUS       NM_001003897            1191 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens mannosidase beta like (MANBAL), transcript variant 2,
            mRNA.
ACCESSION   NM_001003897
VERSION     NM_001003897.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1191)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1191)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL034422.24.
            
            On Apr 17, 2019 this sequence version replaced NM_001003897.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.150239.1,
                                           SRR5189655.128956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373606.8/ ENSP00000362708.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL034422.24        29017-29048
            33-238              AL034422.24        40570-40775
            239-1191            AL034422.24        55670-56622
FEATURES             Location/Qualifiers
     source          1..1191
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1191
                     /gene="MANBAL"
                     /note="mannosidase beta like"
                     /db_xref="GeneID:63905"
                     /db_xref="HGNC:HGNC:15799"
     exon            1..32
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     exon            33..238
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..346
                     /gene="MANBAL"
                     /note="isoform a is encoded by transcript variant 2;
                     protein MANBAL; mannosidase, beta A, lysosomal-like;
                     mannosidase beta A like"
                     /codon_start=1
                     /product="protein MANBAL isoform a"
                     /protein_id="NP_001003897.1"
                     /db_xref="CCDS:CCDS13293.1"
                     /db_xref="GeneID:63905"
                     /db_xref="HGNC:HGNC:15799"
                     /translation="MASDLDFSPPEVPEPTFLENLLRYGLFLGAIFQLICVLAIIVPI
                     PKSHEAEAEPSEPRSAEVTRKPKAAVPSVNKRPKKETKKKR"
     exon            239..1191
                     /gene="MANBAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1166..1171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MANBAL"
                     /note="hexamer: AATAAA"
     polyA_site      1191
                     /gene="MANBAL"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggg gagcggcgcg gcggcgcggg agttggttct aaagagtggt gagtcagaag
       61 agacgtcagg cagcaagcga cttgggccat ggcctctgac ctagacttct cacctccgga
      121 ggtgcccgag cccactttcc tggagaacct gctacggtac ggactcttcc tgggagccat
      181 cttccagctc atctgtgtgc tggccatcat cgtacccatt cccaagtccc acgaggcgga
      241 ggctgaaccg tctgagccca gaagtgctga ggtgacgagg aagcccaagg ctgctgttcc
      301 ttctgtgaac aagaggccca agaaagagac taagaagaag cggtagaaga ggaggcctga
      361 ggagctgggc gggcagggag agggtcttgg ggacagccct cctgggaatc tacattgtgt
      421 tcccccgcat tccaggctca gggtctgagg aggctgtgac gccctatgac cgcagagatc
      481 tagacagtcg taacagtccc caggctccag ctgggcaatc caccacttcc tcttccttct
      541 gcttctgtga cggtttagag tcaagggggc tgaaacacac tgtgagcata gactgtatta
      601 ggtttgttca gaagccgggt cagctcacag agtcacattt tcttgcttag tcatgtgtcc
      661 ctccttgagt tgccccctcc ttgtgggttt acactacatt tgggagtcat tgtctaatgc
      721 tgacaagcac accctctccc attatttgtg cactacagat ctcctcctga tcagtcacct
      781 ttgttgctgc tgtgtagaca gagccaggcc tcacctgttt gtttaggcca agatgccatg
      841 gacatgcagc gttagtgatc ccactagctg tgacagccag gcccagaaaa tgcctggcgt
      901 gagagccagc agacagccag gccagggtag gcagtgcctg cttctgctcc atcaggtgca
      961 ggggatttgg ctgaaggcgt gcatatttcc tgggcacaaa cttcctgagc ctctgaaatg
     1021 ggaggctcgt caatttcaga ccaacctctt ttcaacccat catagcacgt tcaaggtgtg
     1081 ccttttactt ctacctgtac atcccccatc ccttcaattc tttcattccc tgaccagtga
     1141 gagggttcct gggggaagta tggtgaataa actgacatgc atgcttcaga a
//
