LOCUS       NM_006122               6394 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mannosidase alpha class 2A member 2 (MAN2A2),
            transcript variant 1, mRNA.
ACCESSION   NM_006122 NM_018621
VERSION     NM_006122.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6394)
  AUTHORS   Mahajan,S., Ng,B.G., AlAbdi,L., Earnest,P.D.J., Sosicka,P.,
            Patel,N., Helaby,R., Abdulwahab,F., He,M., Alkuraya,F.S. and
            Freeze,H.H.
  TITLE     Homozygous truncating variant in MAN2A2 causes a novel congenital
            disorder of glycosylation with neurological involvement
  JOURNAL   J Med Genet 60 (7), 627-635 (2023)
   PUBMED   36357165
  REMARK    GeneRIF: Homozygous truncating variant in MAN2A2 causes a novel
            congenital disorder of glycosylation with neurological involvement.
REFERENCE   2  (bases 1 to 6394)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 6394)
  AUTHORS   Thonsri,U., Wongkham,S., Wongkham,C., Hino,S., Nakao,M.,
            Roytrakul,S., Koga,T. and Seubwai,W.
  TITLE     High glucose-ROS conditions enhance the progression in
            cholangiocarcinoma via upregulation of MAN2A2 and CHD8
  JOURNAL   Cancer Sci 112 (1), 254-264 (2021)
   PUBMED   33141432
  REMARK    GeneRIF: High glucose-ROS conditions enhance the progression in
            cholangiocarcinoma via upregulation of MAN2A2 and CHD8.
REFERENCE   4  (bases 1 to 6394)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   5  (bases 1 to 6394)
  AUTHORS   Lesch,K.P., Timmesfeld,N., Renner,T.J., Halperin,R., Roser,C.,
            Nguyen,T.T., Craig,D.W., Romanos,J., Heine,M., Meyer,J.,
            Freitag,C., Warnke,A., Romanos,M., Schafer,H., Walitza,S., Reif,A.,
            Stephan,D.A. and Jacob,C.
  TITLE     Molecular genetics of adult ADHD: converging evidence from
            genome-wide association and extended pedigree linkage studies
  JOURNAL   J Neural Transm (Vienna) 115 (11), 1573-1585 (2008)
   PUBMED   18839057
REFERENCE   6  (bases 1 to 6394)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 6394)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   8  (bases 1 to 6394)
  AUTHORS   Misago,M., Liao,Y.F., Kudo,S., Eto,S., Mattei,M.G., Moremen,K.W.
            and Fukuda,M.N.
  TITLE     Molecular cloning and expression of cDNAs encoding human
            alpha-mannosidase II and a previously unrecognized
            alpha-mannosidase IIx isozyme
  JOURNAL   Proc Natl Acad Sci U S A 92 (25), 11766-11770 (1995)
   PUBMED   8524845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC067986.24, AK289863.1, AC068831.17 and AI912006.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006122.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.52708.1, AK289863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000559717.6/ ENSP00000452948.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC067986.24        5583-5616
            35-2443             AK289863.1         1-2409
            2444-2444           AC067986.24        14509-14509
            2445-2980           AK289863.1         2411-2946
            2981-2981           AC067986.24        16008-16008
            2982-3656           AK289863.1         2948-3622
            3657-5910           AC068831.17        8681-10934
            5911-6394           AI912006.1         17-500              c
FEATURES             Location/Qualifiers
     source          1..6394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..6394
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /note="mannosidase alpha class 2A member 2"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
     exon            1..131
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            132..281
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..3602
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /EC_number="3.2.1.114"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-mannosidase IIx; MAN IIx; alpha-mannosidase 2x;
                     manosidase, alpha-, type II, isozyme X; mannosidase, alpha
                     type II-X; mannosyl-oligosaccharide
                     1,3-1,6-alpha-mannosidase"
                     /codon_start=1
                     /product="alpha-mannosidase 2x isoform 1"
                     /protein_id="NP_006113.2"
                     /db_xref="CCDS:CCDS32332.1"
                     /db_xref="GeneID:4122"
                     /db_xref="HGNC:HGNC:6825"
                     /db_xref="MIM:600988"
                     /translation="MKLKKQVTVCGAAIFCVAVFSLYLMLDRVQHDPTRHQNGGNFPR
                     SQISVLQNRIEQLEQLLEENHEIISHIKDSVLELTANAEGPPAMLPYYTVNGSWVVPP
                     EPRPSFFSISPQDCQFALGGRGQKPELQMLTVSEELPFDNVDGGVWRQGFDISYDPHD
                     WDAEDLQVFVVPHSHNDPGWIKTFDKYYTEQTQHILNSMVSKLQEDPRRRFLWAEVSF
                     FAKWWDNINVQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALIDQLIEGHQWLER
                     NLGATPRSGWAVDPFGYSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQ
                     TWDSDSSTDIFCHMMPFYSYDVPHTCGPDPKICCQFDFKRLPGGRINCPWKVPPRAIT
                     EANVAERAALLLDQYRKKSQLFRSNVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFFN
                     SRPNLHVQAQFGTLSDYFDALYKRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYY
                     TSRPFYKSLDRVLEAHLRGAEVLYSLAAAHARRSGLAGRYPLSDFTLLTEARRTLGLF
                     QHHDAITGTAKEAVVVDYGVRLLRSLVNLKQVIIHAAHYLVLGDKETYHFDPEAPFLQ
                     VDDTRLSHDALPERTVIQLDSSPRFVVLFNPLEQERFSMVSLLVNSPRVRVLSEEGQP
                     LAVQISAHWSSATEAVPDVYQVSVPVRLPALGLGVLQLQLGLDGHRTLPSSVRIYLHG
                     RQLSVSRHEAFPLRVIDSGTSDFALSNRYMQVWFSGLTGLLKSIRRVDEEHEQQVDMQ
                     VLVYGTRTSKDKSGAYLFLPDGEAKPYVPKEPPVLRVTEGPFFSEVVAYYEHIHQAVR
                     LYNLPGVEGLSLDISSLVDIRDYVNKELALHIHTDIDSQGIFFTDLNGFQVQPRRYLK
                     KLPLQANFYPMPVMAYIQDAQKRLTLHTAQALGVSSLKDGQLEVILDRRLMQDDNRGL
                     GQGLKDNKRTCNRFRLLLERRTVGSEVQDSHSTSYPSLLSHLTSMYLNAPALALPVAR
                     MQLPGPGLRSFHPLASSLPCDFHLLNLRTLQAEEDTLPSAETALILHRKGFDCGLEAK
                     NLGFNCTTSQGKVALGSLFHGLDVVFLQPTSLTLLYPLASPSNSTDVYLEPMEIATFR
                     LRLG"
     exon            282..539
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            540..684
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            685..856
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            857..984
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1158
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1345
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1523
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1726
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1909
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2024
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2092
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2258
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2495
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2618
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2733
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2867
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            2868..3009
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            3010..3143
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            3144..3338
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3449
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..6394
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4984..4989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /note="hexamer: AATAAA"
     polyA_site      5018
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /note="major polyA site"
     regulatory      6372..6377
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
                     /note="hexamer: AATAAA"
     polyA_site      6394
                     /gene="MAN2A2"
                     /gene_synonym="alpha-MIIx; MANA2X"
ORIGIN      
        1 agatcgcgct aagtagggca caacgcagag gcgacaaagc tcctcggccc cagggcccgc
       61 ggagcagact ccggagcgcg gtcccgccca cgctcggctc cgcagttagc gtcctccttc
      121 ctcctgagca ggtgtgtgtg gaggccagta tgaagctgaa aaagcaggtg acagtgtgtg
      181 gggctgccat cttctgtgtg gcagtcttct cgctctacct catgctggac cgagtgcaac
      241 acgatcccac ccgacaccag aatggtggga acttcccccg gagccaaatt tctgtgctgc
      301 agaaccgcat tgagcagctg gagcagcttt tggaggagaa ccatgagatt atcagccata
      361 tcaaggactc cgtgctggag ctgacagcca acgcagaggg cccgcccgcc atgctgccct
      421 actacacggt caatggctcc tgggtggtgc caccggagcc ccggcccagc ttcttctcca
      481 tctccccgca ggactgccag tttgctttgg ggggccgggg tcagaagcca gagctgcaga
      541 tgctcactgt gtcggaggag ctgccgtttg acaacgtgga tggtggtgtg tggaggcaag
      601 gcttcgacat ctcctacgac ccgcacgact gggatgctga agacctgcag gtgtttgtgg
      661 tgccccactc tcacaatgac ccaggctgga tcaagacctt tgacaagtac tacacagagc
      721 agacccaaca catcctcaat agcatggtgt ctaagctgca ggaggacccc cggcggcgct
      781 tcctctgggc agaggtctcc ttcttcgcca agtggtggga caacatcaat gtccaaaaga
      841 gagcggcagt ccgaaggctg gtgggaaacg ggcagctgga gattgcgaca ggaggctggg
      901 tgatgccaga tgaggccaat tcccactact ttgcattgat tgaccagctc atcgaaggac
      961 accagtggct ggagagaaat cttggtgcaa ccccccgctc tggctgggca gtggacccct
     1021 ttggatacag ctccaccatg ccttacctgc tgcgccgtgc caacctcacc agcatgctga
     1081 ttcagagagt gcactatgcc atcaagaagc actttgctgc cacccacagc ctagagttca
     1141 tgtggaggca gacatgggac tcggactcca gcacagacat cttctgtcac atgatgccct
     1201 tctacagcta tgacgtcccc catacctgtg gcccagatcc caagatctgc tgccaatttg
     1261 atttcaaacg cctgcctggt gggcgcatca actgcccttg gaaggtgcca ccccgggcca
     1321 tcacagaggc caacgtggca gagagggcag ccctgcttct ggaccaatac cggaagaagt
     1381 cccagctgtt ccgaagcaac gtcctcctgg tgcctcttgg agatgacttc cgatatgaca
     1441 agccccagga gtgggatgcc cagttcttca actaccaacg gctctttgac ttcttcaaca
     1501 gcaggcctaa cctccatgtg caggcccagt ttggcactct ttctgactat tttgatgccc
     1561 tgtacaagag gacaggggtg gagccagggg cccggcctcc agggtttcct gtgctgagcg
     1621 gggatttctt ctcctatgcg gaccgggagg atcattactg gacaggctat tacacttccc
     1681 ggcccttcta caagagctta gaccgagtcc tggaagccca cctgcggggg gcagaggttc
     1741 tgtacagcct ggctgcagct cacgctcgcc gctctggtct ggctggccgg tacccactgt
     1801 ctgatttcac cctcctgacg gaagctcggc gcacattggg gctcttccag catcacgatg
     1861 ccatcactgg cacggccaag gaggctgtgg tggtggacta tggggtcagg cttctgcgct
     1921 cccttgtcaa cctgaagcag gtcatcattc atgcagccca ctatctggtg ctgggggaca
     1981 aggagaccta ccactttgac cctgaggcgc ccttcctcca agtggatgac actcgcttaa
     2041 gtcacgacgc cctcccagag cgcacggtga tccagctgga ttcctcgccc aggtttgtgg
     2101 tcctattcaa cccactggaa caggagcgat tcagcatggt gtccctgctg gtcaactctc
     2161 cccgcgtgcg tgtcctttcg gaggagggtc agcccctggc cgtgcagatc agcgcacact
     2221 ggagctctgc caccgaggcg gtccctgacg tctaccaggt gtctgtgcct gtccgcctgc
     2281 cagccctggg cctgggcgtg ctgcagctac agctgggcct ggatgggcac cgcacgctgc
     2341 cctcctctgt gcgcatctac ctgcacggcc ggcagctgtc cgtcagcagg cacgaagcgt
     2401 ttcctctccg tgtcattgac tctggcacca gcgacttcgc cctcagcaac cgctacatgc
     2461 aggtctggtt ctcaggcctt actgggctcc tcaagagcat ccgaagggtg gatgaggagc
     2521 acgagcagca ggtggacatg caggtccttg tctatggcac ccgtacgtcc aaagacaaga
     2581 gtggagccta cctcttcctg cccgatggcg aggccaagcc ctacgtcccc aaggagcccc
     2641 ccgtgctgcg tgtcactgaa ggccctttct tctcagaggt ggttgcgtac tatgagcaca
     2701 ttcaccaggc ggtccggctt tacaatctgc caggggtgga ggggctgtct ctggacatat
     2761 catccctggt ggacatccgg gactacgtca acaaggagct ggccctgcac atccatacag
     2821 acatcgacag ccagggtatc ttcttcacag acctcaatgg ctttcaggtg cagccccgac
     2881 ggtatctgaa gaagctcccc ctccaggcca acttctaccc catgccagtc atggcctata
     2941 tccaggacgc acagaagcgc ctcacgctgc acactgccca ggccctgggt gtctctagcc
     3001 tcaaagatgg ccagctggag gtgatcttgg accggcggct gatgcaggat gacaaccggg
     3061 gcctaggcca agggctcaag gacaacaaga gaacctgcaa ccgtttccgc ctcctgctag
     3121 agcggcgaac cgtgggcagt gaggtccaag atagccactc taccagctac ccatccctcc
     3181 tcagccacct gacctccatg tacctgaacg ccccggcgct cgctctgcct gtagccagga
     3241 tgcagctccc aggccctggt ctgcgctcat ttcatcctct ggcttcctca ctgccctgtg
     3301 acttccacct gctcaaccta cgtacgctcc aggctgagga ggacacccta ccctcggcgg
     3361 agaccgcact catcttacac cgcaagggtt ttgactgcgg cctggaggcc aagaacttgg
     3421 gcttcaactg caccacaagc caaggcaagg tagccctggg cagccttttc catggcctgg
     3481 atgtggtatt ccttcagcca acctccttga cgttactgta ccctctggcc tccccgtcca
     3541 acagcactga cgtctatttg gagcccatgg agattgctac ctttcgcctc cgcttgggtt
     3601 agggcttctt gtggcctgaa gagaaagttc attcacagag actgcctctt aacatgaaga
     3661 tcattggaca agccacacgg gtatcccatc ccgatctgcc tcccagaact gtgacacact
     3721 gggctctgcc ctcattttct gtttattgct gctgctgtgt tttcggcgca acccacaaac
     3781 ccagtgatgg gtaaataggg cagacgccag tgagatcagg gagagaaggc ccttggtcag
     3841 agtgggcagt gccaggctct gctttgggtt gtgagtggac acccaactgg gcacaggctc
     3901 aggcacccat cctttttcca aacagggata tagaagtggt ggaagcagac agaagaggta
     3961 agggaggcta agtgggtaac agcccagcat cagggtcact gtggcaacag caggctctag
     4021 gggaatcctg tggttatgta gagactccat gtcctggtgt gatgagcagg atcagagtga
     4081 ctctgggagg acaggggtgg ggacccagag ttagcagtgg ggatggagca gtagaaggaa
     4141 tcactgtttc tcctaggagt ctgaaggcct cgctgctttc tgtgatggct ttgcagtaag
     4201 tgccgcctgg cctgcatgca ttggctaaca ggctgcagaa tggcaggaag gactcgctag
     4261 agattgtcat ggccagagat cataggtcac ttcaggtagc aagacccctg gcaaactggg
     4321 cacttggcct atgtactgat ttgtgggatg gtggcagggg tgtggggtcc ttcaccctgc
     4381 ctgaattctc tttggcttct gtgctctgta tgctgctgtc cccaagggct ctttcttatt
     4441 atggcaggga gtggggattg gtcctacttt ctttctctgg aaaggaaagc ctccaagact
     4501 ccatgtgctt gggcagcttg agaaggcgtt cagcaccacg cctagcaggc agaccttgaa
     4561 gcctcacctt tagtctatct gcagaggtat tcagttcctg gcacagggga ctaggggcat
     4621 gtagagtata tgaggaggca gtatggctgt gcaggagcct tcatttcagc ttcaattaat
     4681 agggaagaat ttatgatagc tctatagatg ctgaaaaggt atttcgtaag atttaaaatc
     4741 catcccttat taaaactctt agtaaattaa gtctggaaag aaacacccta atctagataa
     4801 aggtctgttt cagaaaccaa cagtgatggc attctaaaga gtcagacgcc acaggcattc
     4861 ccattaaagt cagaaactag ccaagggcaa gctattattc agcagtgtcc cggcactact
     4921 aacccctgca acaagccaga tgaggaacat aaggaagaat tataattgtc attatttgta
     4981 gacaataaaa ctgcctacct gtaaaaccta agaatcaact gaagacctgt taagagtatt
     5041 ctgtaagtca acccaatgat acacatcatg ttcctgtcca catactggtt ttccccaaat
     5101 cagctgataa attcagtgta attccaatga gattgaaact ttggaattga cagttctaaa
     5161 gtgcatttgg gagagtgaat gtgtgagaac actaagacca ctctgaacga tgataatgag
     5221 ttggggggtg gactgctcgg gggtgatcct gccagattcc cagaggattc tcacgccacc
     5281 attacctcac tcagtgtgac ctggaggggg tcagacagac gggagagtcc agaaacagac
     5341 ccagggctac aggaatttag tatatggtaa gagggatgtt ttaagtgggg aaaaaggtgg
     5401 attatttaat aaacagcact tttagacaac tagctatcaa agctagatct cagctgggtg
     5461 cgatggctca cgcctgtaat cccggcactt tgggaggcca aggtgggtgg atcacttgag
     5521 gtcaggagtt cgagaccagc ctggccaaga tggcgaaacc ctgtgtctac taaaaataca
     5581 aaaactagcc aggaatggtg gcgcgcgcct gtaatcccag ttacttagga ggctgaggca
     5641 ggagaatcac atcaacctgg gaggcggagg ttgcagtgag cttagatcat gccaccatgc
     5701 cactgcactc cagcctgggt gacacagcca aaaaaaaaac cactaagtta gatctctacc
     5761 tcacagtgtc catacaaatt agttccagag ggaagatata ccacaaaatt actcaaaaat
     5821 ttttatacct ctggtgtggg acggtctttt ctaaacttta acatgagact taaaagatat
     5881 aataagggaa aagataagca gatttcgcaa ccaaaaaata tcgaaagtct ctgtgtgatg
     5941 gaaaacatca aggttaaaac acaaatgaca gatatggaag aaaatatttg cagcacataa
     6001 aaaaatcaac gagtacaatt actttaggag aaaagcttgc ttcagggtcc ttagagaaag
     6061 tcactggggc ctgccaagct gccacctaaa gacaagagtg agagggctga gttcttccag
     6121 gtcatcagag ttgttgctgc ccgtattagg ccacacagtg gaaccccatt tatatcatag
     6181 cagaagaaat aggattatca atgtgaactg cttagcatgg tgcctggtat atacgagagc
     6241 tccacaaatg tgagctataa tcctactagt aaaggatgct aagcagttcc actgtggcag
     6301 gtgtcatttg ctagtagaat ttgtaatcaa acaataggag gggaatctgt gaacgcctag
     6361 aaaatgagca gaataaagga tattatcttt ggaa
//
