LOCUS       NM_020379               3561 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens mannosidase alpha class 1C member 1 (MAN1C1),
            transcript variant 1, mRNA.
ACCESSION   NM_020379
VERSION     NM_020379.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Batara,D.C., Kim,H.J., Phan,L.T., Kim,M., Son,Y.O., Lee,S.,
            Park,S.I., Choi,Y.S., Beck,S. and Kim,S.H.
  TITLE     Elevated alpha-1,2-mannosidase MAN1C1 in glioma stem cells and its
            implications for immunological changes and prognosis in glioma
            patients
  JOURNAL   Sci Rep 14 (1), 22159 (2024)
   PUBMED   39333557
  REMARK    GeneRIF: Elevated alpha-1,2-mannosidase MAN1C1 in glioma stem cells
            and its implications for immunological changes and prognosis in
            glioma patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Gonzalez-Andrades,M., Jalimarada,S.S., Rodriguez-Benavente,M.,
            Feeley,M.N., Woodward,A.M., AbuSamra,D.B. and Argueso,P.
  TITLE     Golgi alpha1,2-mannosidase I induces clustering and
            compartmentalization of CD147 during epithelial cell migration
  JOURNAL   Cell Adh Migr 14 (1), 96-105 (2020)
   PUBMED   32419574
  REMARK    GeneRIF: Golgi alpha1,2-mannosidase I induces clustering and
            compartmentalization of CD147 during epithelial cell migration.
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Hosokawa,N., You,Z., Tremblay,L.O., Nagata,K. and Herscovics,A.
  TITLE     Stimulation of ERAD of misfolded null Hong Kong alpha1-antitrypsin
            by Golgi alpha1,2-mannosidases
  JOURNAL   Biochem Biophys Res Commun 362 (3), 626-632 (2007)
   PUBMED   17727818
  REMARK    GeneRIF: overexpression of Golgi alpha1,2-mannosidase IA, IB, and
            IC also accelerates ERAD of terminally misfolded human
            alpha1-antitrypsin variant null (Hong Kong) (NHK), and mannose
            trimming from the N-glycans on NHK in 293 cells
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Tremblay,L.O. and Herscovics,A.
  TITLE     Characterization of a cDNA encoding a novel human Golgi alpha 1,
            2-mannosidase (IC) involved in N-glycan biosynthesis
  JOURNAL   J Biol Chem 275 (41), 31655-31660 (2000)
   PUBMED   10915796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031280.7 and AL020996.6.
            
            On Jul 10, 2020 this sequence version replaced NM_020379.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF261655.1, BC137017.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374332.9/ ENSP00000363452.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1547              AL031280.7         120955-122501       c
            1548-1644           AL031280.7         52756-52852         c
            1645-1760           AL020996.6         92709-92824         c
            1761-1841           AL020996.6         90157-90237         c
            1842-1936           AL020996.6         85914-86008         c
            1937-2054           AL020996.6         80783-80900         c
            2055-2148           AL020996.6         75525-75618         c
            2149-2264           AL020996.6         67720-67835         c
            2265-2484           AL020996.6         61168-61387         c
            2485-2657           AL020996.6         58380-58552         c
            2658-2773           AL020996.6         56792-56907         c
            2774-3561           AL020996.6         55042-55829         c
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..3561
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /note="mannosidase alpha class 1C member 1"
                     /db_xref="GeneID:57134"
                     /db_xref="HGNC:HGNC:19080"
                     /db_xref="MIM:616772"
     exon            1..1547
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     CDS             1008..2900
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /EC_number="3.2.1.113"
                     /note="isoform 1 is encoded by transcript variant 1;
                     1,2-alpha-mannosidase IC; mannosyl-oligosaccharide
                     1,2-alpha-mannosidase IC; processing alpha-1,2-mannosidase
                     IC"
                     /codon_start=1
                     /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase
                     IC isoform 1"
                     /protein_id="NP_065112.1"
                     /db_xref="CCDS:CCDS265.1"
                     /db_xref="GeneID:57134"
                     /db_xref="HGNC:HGNC:19080"
                     /db_xref="MIM:616772"
                     /translation="MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLP
                     HSSRLKRLFLAPRTQQPGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASP
                     RRRKGGLRRTRPTGPREEATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTR
                     ADESQEPQSQVRAQREKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGA
                     TVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTG
                     EEVFRIKAIRLGEKLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEF
                     LHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSF
                     YEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGH
                     LACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGRE
                     AVATQLSESYYILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQ
                     DVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDLLSLEDWVFNTEAHPLPVNHSDSSG
                     RAWGRH"
     exon            1548..1644
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1760
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1841
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1936
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2054
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2148
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2264
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            2265..2484
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2657
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2773
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..3561
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /note="hexamer: AATAAA"
     polyA_site      3561
                     /gene="MAN1C1"
                     /gene_synonym="HMIC; MAN1A3; MAN1C; pp6318"
                     /note="major polyA site"
ORIGIN      
        1 agtgaaagcc cgagcggcgg cggcggcggg gacggcggtg gaggcggccg ggtggctgtg
       61 cgcgcgtgtg gggcgcaggc tcggcggcag cggccggtct ggagcggccg ctgcgaggaa
      121 gacagctgca gcgggggagg cgcggccagg gctgcgcgct ccgcggagcc ggcggggccg
      181 ggaacaggtg atcccagtgg gagccccgcg ccctgccgag ttcgaggggc gggagcccgc
      241 gctcccgggc gcatctgcag ccgcccagcc gcggctccgg acccaggcat ccctgcgctg
      301 tctggggccc gggggaagcc ccctgccccc gcaggctcgg aagtgcctgc tcctgctccc
      361 tggccactcc ggctcccagc tcccggcgcc ctctccgcgg cggagaaagt tgtggacgtg
      421 tcccgatagt cgagcccggg cgctgtcgcg accgggccgg gtgtgcgcgc gctcggggcg
      481 gcgctgacac gccagccccc catcgcctcg gtcccctccg gaaactgctt ctgaagctga
      541 aactttgggc gcctaccagc gcgggcggga gcctaggggg cggagggcgg cttggtgcgg
      601 gcctgcgggc gcccctcggc gcggacagcc gggacgccgc ggacggcatg tgacggtccc
      661 ggcggccgca gcgcgggaag gcgcgggccc cggcgcggcg gggagggctc ggccggaggg
      721 gaggctgcgg cgcgcggccg gtcgctgcgg gcccgggccc caagccgtgc cgctccgctc
      781 gcccgggccc cgccgaggcc gctgcgcccc cgcctcctcg cgggaggact cgctccaaac
      841 tccctgaact tcggggacag tcccccgaag cggcgaaact ctcagggttg gcaaccctgc
      901 ccagggaccc ccatcccggg cggcgctccg gacgccctcc cctcaccgcg cccccgcaga
      961 cacgtgcctg gactccgagg gcttctggag ccaccggccg ggccacgatg ctcatgagga
     1021 aagtgcccgg cttcgtcccg gcctccccgt gggggctgcg gctgccgcag aagttcctct
     1081 tcctcctctt cctctcgggc ctggtcaccc tgtgcttcgg ggccctcttc ctgctgcccc
     1141 actcctctcg cctcaagcgc ctcttcctgg ccccccggac ccagcagcct ggtctggaag
     1201 tggtggctga aatcgccggc catgccccgg cccgcgagca ggagccgcct cccaacccgg
     1261 cccccgccgc gccggccccg ggcgaggatg accccagcag ctgggccagt ccccgccgca
     1321 ggaaaggggg gctgcggcgc acccgcccca ctggaccccg cgaggaggcc acggcggccc
     1381 ggggcaatag catcccggcc tccaggcccg gggacgaggg cgtccctttc cgctttgact
     1441 tcaacgcatt ccggagccgt ctccgccacc cggtcctggg aacgagggcc gatgagagtc
     1501 aggagcccca gagccaagtg cgagcccagc gggagaaaat caaggagatg atgcagtttg
     1561 cttggcagag ctataagcgt tatgcaatgg ggaaaaacga actccgtcca ctaacaaaag
     1621 atggctacga gggtaacatg ttcggaggcc tcagcggggc aacagtcatt gactccctcg
     1681 ataccctcta cctcatggag ctgaaggagg agttccagga ggccaaggcc tgggtgggag
     1741 agagcttcca cctgaacgtg agcggagaag catccttgtt tgaggtgaac atccgctaca
     1801 tcgggggact cctctcagcc ttctacctga caggagaaga ggtgttccga ataaaggcca
     1861 tcaggctggg agagaagctc ctgccggcgt tcaacacccc cacgggaatc ccaaagggcg
     1921 tggtgagctt caaaagtggg aactggggct gggccacagc cggcagcagc agcatcttgg
     1981 cggagtttgg atccctgcac ttggaattct tacacctcac tgaactctct ggcaaccagg
     2041 tcttcgctga aaaggtcagg aacatccgca aggtcctcag gaagatcgaa aagccctttg
     2101 gcctctaccc caacttcctc agcccagtga gtgggaactg ggtgcaacac catgtctcag
     2161 ttggaggact cggggacagt ttttatgaat atttgatcaa atcctggttg atgtcgggca
     2221 agacagatat ggaggctaaa aatatgtact acgaagcctt ggaggcgata gagacctact
     2281 tgctgaatgt ctctcccggg gggctgacct acattgccga gtggcgaggg gggattctgg
     2341 accacaagat ggggcacctg gcctgtttct ccgggggcat gatcgccctt ggcgccgagg
     2401 atgccaagga agaaaagagg gcccactacc gagagctcgc agcccagatc accaagacgt
     2461 gtcacgagtc atacgcccgc tcagacacca aacttgggcc tgaggccttc tggtttaact
     2521 ccggcagaga ggccgtggcc acccagctga gcgagagcta ctacatcctc cggccagagg
     2581 tggtggagag ctacatgtac ctgtggcgac agacccacaa ccccatctac agggagtggg
     2641 gctgggaggt ggtgctggcc ttggagaaat actgtcggac agaagccggt ttctctggga
     2701 tccaagacgt gtacagtagc acccccaacc acgacaacaa gcagcagagc ttctttctag
     2761 cggagacact aaagtatctc tatcttctgt tctctgaaga tgacttgctc tccctggaag
     2821 actgggtgtt caacaccgag gcccacccac tcccggtgaa ccactcagac agctccggca
     2881 gagcctgggg cagacactga ccccatctcc tgccgccgcc ctggggccgc cgcagggatg
     2941 ccttgccttt tcaggatttg agactgttct caaagggatt gggaacgaag gccccatctc
     3001 gggcagaccc ccagcagatg tgtcggacaa gcaacttctt ttcctctgtg aggagacaag
     3061 acttggagac tcagcgatgt caggccaggg ccatggccac actggcccac acattccttt
     3121 ctacagagaa tttctatgaa gcccactcac ttgccattcc agggccaaag gaccggaggt
     3181 ttgcatatcc gccccttgta tttgatttgc ttccttttgg tttcttggtt tttgtttttg
     3241 cttgattttg tcttttctct acagtttagt tttgtcacaa ttacacatat agttttcaaa
     3301 atcatgcact ttctaaaatg gtgtcatcct gaaaaacaaa acccagtgtt tgcacacaca
     3361 caaaatcttg accccgttat ctatatttta aatgcttttt gcccaacact gaccctatgt
     3421 tcaactttgt gtcatttacc ttataatttg aggaggggtt tccctttggg cctcagtgtt
     3481 acaaattact agtgctattt tcattattat tgtaatggaa aaatctgtgg actagaataa
     3541 aagagtttat tgaataagaa a
//
