LOCUS       NM_005907               5018 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mannosidase alpha class 1A member 1 (MAN1A1), mRNA.
ACCESSION   NM_005907
VERSION     NM_005907.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5018)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5018)
  AUTHORS   Suehara,Y., Kohsaka,S., Hayashi,T., Akaike,K., Kurisaki-Arakawa,A.,
            Sato,S., Kobayashi,E., Mizuno,S., Ueno,T., Morii,T., Okuma,T.,
            Kurihara,T., Hasegawa,N., Sano,K., Sasa,K., Okubo,T., Kim,Y.,
            Mano,H. and Saito,T.
  TITLE     Identification of a Novel MAN1A1-ROS1 Fusion Gene Through
            mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a
            Patient with Leiomyosarcoma
  JOURNAL   Clin Orthop Relat Res 479 (4), 838-852 (2021)
   PUBMED   33196586
  REMARK    GeneRIF: Identification of a Novel MAN1A1-ROS1 Fusion Gene Through
            mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a
            Patient with Leiomyosarcoma.
REFERENCE   3  (bases 1 to 5018)
  AUTHORS   Cheng,P.W., Davidson,S. and Bhat,G.
  TITLE     Markers of malignant prostate cancer cells: Golgi localization of
            alpha-mannosidase 1A at GM130-GRASP65 site and appearance of high
            mannose N-glycans on cell surface
  JOURNAL   Biochem Biophys Res Commun 527 (2), 406-410 (2020)
   PUBMED   32331836
  REMARK    GeneRIF: Markers of malignant prostate cancer cells: Golgi
            localization of alpha-mannosidase 1A at GM130-GRASP65 site and
            appearance of high mannose N-glycans on cell surface.
REFERENCE   4  (bases 1 to 5018)
  AUTHORS   Hamester,F., Legler,K., Wichert,B., Kelle,N., Eylmann,K.,
            Rossberg,M., Ding,Y., Kurti,S., Schmalfeldt,B., Milde-Langosch,K.
            and Oliveira-Ferrer,L.
  TITLE     Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian
            cancer: impact of N-glycosylation on tumour cell aggregation
  JOURNAL   Br J Cancer 121 (11), 944-953 (2019)
   PUBMED   31659304
  REMARK    GeneRIF: These results show an oncogenic role of the Golgi
            mannosidase MAN1A1 in ovarian cancer, where MAN1A1 expression
            levels significantly affects recurrence-free and overall survival .
            Mannosidase-mediated N-glycosylation has a strong impact on tumour
            cell aggregation and affects the prognostic impact of the adhesion
            molecule ALCAM.
REFERENCE   5  (bases 1 to 5018)
  AUTHORS   Tremblay,L.O. and Herscovics,A.
  TITLE     Cloning and expression of a specific human alpha 1,2-mannosidase
            that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan
            biosynthesis
  JOURNAL   Glycobiology 9 (10), 1073-1078 (1999)
   PUBMED   10521544
REFERENCE   6  (bases 1 to 5018)
  AUTHORS   Gonzalez,D.S., Karaveg,K., Vandersall-Nairn,A.S., Lal,A. and
            Moremen,K.W.
  TITLE     Identification, expression, and characterization of a cDNA encoding
            human endoplasmic reticulum mannosidase I, the enzyme that
            catalyzes the first mannose trimming step in mammalian Asn-linked
            oligosaccharide biosynthesis
  JOURNAL   J Biol Chem 274 (30), 21375-21386 (1999)
   PUBMED   10409699
REFERENCE   7  (bases 1 to 5018)
  AUTHORS   Tremblay,L.O., Campbell Dyke,N. and Herscovics,A.
  TITLE     Molecular cloning, chromosomal mapping and tissue-specific
            expression of a novel human alpha1,2-mannosidase gene involved in
            N-glycan maturation
  JOURNAL   Glycobiology 8 (6), 585-595 (1998)
   PUBMED   9592125
REFERENCE   8  (bases 1 to 5018)
  AUTHORS   Bieberich,E., Treml,K., Volker,C., Rolfs,A., Kalz-Fuller,B. and
            Bause,E.
  TITLE     Man9-mannosidase from pig liver is a type-II membrane protein that
            resides in the endoplasmic reticulum. cDNA cloning and expression
            of the enzyme in COS 1 cells
  JOURNAL   Eur J Biochem 246 (3), 681-689 (1997)
   PUBMED   9219526
REFERENCE   9  (bases 1 to 5018)
  AUTHORS   Bieberich,E. and Bause,E.
  TITLE     Man9-mannosidase from human kidney is expressed in COS cells as a
            Golgi-resident type II transmembrane N-glycoprotein
  JOURNAL   Eur J Biochem 233 (2), 644-649 (1995)
   PUBMED   7588811
REFERENCE   10 (bases 1 to 5018)
  AUTHORS   Bause,E., Bieberich,E., Rolfs,A., Volker,C. and Schmidt,B.
  TITLE     Molecular cloning and primary structure of Man9-mannosidase from
            human kidney
  JOURNAL   Eur J Biochem 217 (2), 535-540 (1993)
   PUBMED   8223597
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK025599.1, AL022722.1 and
            BQ008013.1.
            
            On Nov 24, 2018 this sequence version replaced NM_005907.3.
            
            Summary: This gene encodes a class I mammalian Golgi
            1,2-mannosidase which is a type II transmembrane protein. This
            protein catalyzes the hydrolysis of three terminal mannose residues
            from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to
            family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK025599.1, DRR138517.863810.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368468.4/ ENSP00000357453.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1875              AK025599.1         1-1875
            1876-1876           AL022722.1         32089-32089         c
            1877-2713           AK025599.1         1877-2713
            2714-4533           AL022722.1         20003-21822         c
            4534-5018           BQ008013.1         22-506              c
FEATURES             Location/Qualifiers
     source          1..5018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..5018
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /note="mannosidase alpha class 1A member 1"
                     /db_xref="GeneID:4121"
                     /db_xref="HGNC:HGNC:6821"
                     /db_xref="MIM:604344"
     exon            1..220
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            221..1045
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..2404
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /EC_number="3.2.1.113"
                     /note="alpha-1,2-mannosidase IA; Man9-mannosidase;
                     man(9)-alpha-mannosidase; processing alpha-1,2-mannosidase
                     IA"
                     /codon_start=1
                     /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase
                     IA"
                     /protein_id="NP_005898.2"
                     /db_xref="CCDS:CCDS5122.1"
                     /db_xref="GeneID:4121"
                     /db_xref="HGNC:HGNC:6821"
                     /db_xref="MIM:604344"
                     /translation="MPVGGLLPLFSSPAGGVLGGGLGGGGGRKGSGPAALRLTEKFVL
                     LLVFSAFITLCFGAIFFLPDSSKLLSGVLFHSSPALQPAADHKPGPGARAEDAAEGRA
                     RRREEGAPGDPEAALEDNLARIRENHERALREAKETLQKLPEEIQRDILLEKKKVAQD
                     QLRDKAPFRGLPPVDFVPPIGVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLN
                     ELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEI
                     SVFEVNIRFVGGLLSAYYLSGEEIFRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIG
                     RNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPN
                     YLNPSSGQWGQHHVSVGGLGDSFYEYLLKAWLMSDKTDLEAKKMYFDAVQAIETHLIR
                     KSSSGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEGMAQHYLELGAEIARTC
                     HESYNRTFMKLGPEAFRFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRK
                     WAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDDLL
                     PLEHWIFNSEAHLLPILPKDKKEVEIREE"
     exon            1046..1142
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1258
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1339
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1434
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1558
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1652
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1768
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1988
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2161
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2277
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..5018
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3354..3359
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /note="hexamer: AATAAA"
     polyA_site      3378
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /note="major polyA site"
     regulatory      4996..5001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
                     /note="hexamer: AATAAA"
     polyA_site      5018
                     /gene="MAN1A1"
                     /gene_synonym="HUMM3; HUMM9; MAN9"
ORIGIN      
        1 agtgctcgcg gggccgcggc ggagtgtacc gtgctgctct actcgctgcc attcgcccgc
       61 aggtcggcgc gctcgcccac ctgagccgcg ccggggctgc gggaccgtgg gacagcgcgc
      121 tcagcccagc ctaggaaaga ggcagcagtc tcagcgcgga gatggggagc gggcgaagtt
      181 gacgagtctc ccgcccacgc tgcgcccctc ctgcccagag gggctgcagc cagcggtctg
      241 tcgcgcgtgc ctgtgtgccc gaggagccgc cccggggaga agacccggcg cggagttgtt
      301 cccccaggga ggatccgcag cccagccgag ggggtcgggc ggcctggcta cgcaggaccc
      361 agccccgcag ccgcggactc ccagcggcgg cgaagtttgg ctgctgagcg gcgcggcgcc
      421 ggaccactgg acagcgggag cgatgcccgt ggggggcctg ttgccgctct tcagcagccc
      481 cgcgggcggc gtcctgggcg gggggctcgg cggcggcggt ggcaggaagg ggtcgggccc
      541 cgccgccctc cgcctgacgg agaagttcgt gctgctgctg gtattcagcg ccttcatcac
      601 gctctgcttc ggggcgatct tcttcctgcc agactcctcc aagctgctca gcggggtcct
      661 gttccactcc agccccgcct tgcagccggc cgccgaccac aagcccgggc ccggggcgcg
      721 cgccgaggac gcggccgagg ggcgagcccg gcgccgcgag gagggggcac ccggggaccc
      781 ggaggccgcc ctggaggaca acttggccag gatccgcgaa aaccacgagc gggctctcag
      841 ggaagccaag gagaccctgc agaagctgcc cgaggagatc caaagagaca tcctactgga
      901 gaagaagaag gtggcccagg accagctgcg tgacaaggcg ccgttcagag gcctgccccc
      961 ggtggacttc gtgcccccaa tcggggtgga gagccgggag cccgccgacg ccgccatccg
     1021 cgagaaaagg gcaaagatca aagagatgat gaaacatgct tggaataatt ataaaggtta
     1081 tgcctgggga ttaaatgaac tcaaacctat atcaaaagga ggccattcaa gcagtttgtt
     1141 tggtaacatc aaaggagcaa ctatagtaga tgccctggat acacttttta ttatggaaat
     1201 gaaacatgaa tttgaagaag caaaatcatg ggttgaagaa aatttagatt ttaatgtgaa
     1261 tgctgaaatt tctgtctttg aagtaaatat acgctttgtt ggtggactac tctcagccta
     1321 ctatctgtct ggagaagaga tttttcgaaa gaaagcagtg gaacttgggg taaaattgct
     1381 acctgcattt catactccct ctggaatacc ttgggcattg ctgaatatga aaagtggtat
     1441 tggaaggaac tggccctggg cctctggagg cagcagtatt ctggcagaat ttggaaccct
     1501 gcatttggag tttatgcact tgagccactt atcaggaaac cccatctttg ctgaaaaggt
     1561 aatgaatatt cgaacagtac tgaacaaact ggaaaaacca caaggccttt atcctaacta
     1621 tctgaatccc agtagtggac agtggggtca acatcatgta tcagttggag gacttggaga
     1681 cagcttctat gagtatttgc tgaaggcctg gttaatgtct gacaagacag atctggaagc
     1741 taagaagatg tattttgatg ctgttcaggc tatcgagact catttgatcc gcaagtctag
     1801 cagcggacta acttatatcg cagagtggaa agggggcctc ctggagcaca agatgggcca
     1861 cctgacctgc ttcgcggggg gcatgttcgc actcggggct gatgcagctc ccgaaggcat
     1921 ggcccaacac taccttgaac tcggggctga aattgcccgt acttgtcatg aatcatataa
     1981 tcgaacattt atgaaactgg gaccagaagc tttcagattt gatggtggtg ttgaagccat
     2041 cgctacaaga caaaatgaaa aatactacat cttacggcca gaagttatgg agacttacat
     2101 gtatatgtgg agactgactc atgatccaaa gtacaggaaa tgggcctggg aagccgtaga
     2161 ggccttggaa aaccattgca gagtgaatgg aggctattca ggcctaaggg atgtttacct
     2221 tcttcatgag agttatgatg atgtgcagca gagtttcttc ctggcagaga cattgaaata
     2281 tttgtaccta atattttctg acgacgatct tcttccactg gagcattgga tcttcaatag
     2341 cgaggcacat cttctcccta tcctccctaa agataaaaag gaagttgaaa tcagagagga
     2401 ataaaaagac attttatatt ttattctgct ccattccctt cactgtatac cttaataatt
     2461 ccttttctgg taatcaggca catgatgaac tttgattagt aggtctgtga ttaagttctt
     2521 aaattgtttt gcagtctttt atgtttatta tcataggtat aggtggacct aaattcctta
     2581 tcatatcctt tattaattca gccagtgtat ccaccagttt tttgtttatg tttttaagta
     2641 acctattatc tctggatttc atgaaggtgt aatatcgttt ttgttaaact gaatagaatt
     2701 gtatagcgat gacctcttaa ttataatttg atttgactgc aaaacttttt cctcctctaa
     2761 gaggagatga tgtctgcttt aagctgtaat gttttgccat gttgcaaaaa gccataataa
     2821 taagtataaa aaagcttttt cctttacaat ttcatgttaa tctggtttgt ctgtccacca
     2881 gagacagatc ttctgtgaca gcctccttat gcaggtctat cattatttga tagaatgtct
     2941 tctaaaatac ttcactcaca ttgtaattca aattagaaag tcattccaaa aggatcatgt
     3001 catgttgacc tcatttcatc ggaactgcag tatatttttg ttggttaatt atattagtgt
     3061 tttctatttt gtaaatgtgt cctttaattt tactttaaat gccctgtgtc atttctggat
     3121 tatatactag ttaatttctt ccattcccca ctacacagag aggtgagctt tcaaattttg
     3181 cagagctctg ctatcactga attacattta tctgaagaaa atagtacaac ttaatggatt
     3241 agcttttggg tttaactgaa tatatgaaga aattgggtct gtctaaagag agggtatttc
     3301 atatggcttt tagttcactt gtttgtattt catcttgatt tttttctttg gaaaataaag
     3361 cattctattt ggttcagatt tctcagattt gaaaaaggct ctatctcaga tgtagtaaat
     3421 tatttccttt cagtttgtga aagcaggatt tgactctgaa agaagctttg ccaattttac
     3481 ttattcgtga tcaatcaagg aaaatctaat aaattttagg ccaaataaga atatagcata
     3541 tttagtatgg ttatagtcaa cacagagatc acaacttaga agaaatataa agaaatggcc
     3601 actccccatc ccccacagtc ctggagtaaa tcaaaatcaa tatatgattc ttttaaacat
     3661 taagtttgaa ataggaatgg ttttctcaag aatagatttg gtgtgatacc ttgtgtttgc
     3721 ttacattggc ccactatata tacatatata tttatgtaga tatacttcca tgaaagggct
     3781 aatacgatgc atatactgaa gggcaaggac tttgaccatg tcaattttca gccgagaatg
     3841 gtcagaaaga tcagtacaac cccatggatt aggctgaaac atatgaaatt gctgcatttg
     3901 tagtttaaaa actgtcagca gtttcatatg gttccaccta atattattga agacaattat
     3961 tttcttagct atcaataggc ttaatagttt tagttatttt agcttttgaa agtgttttaa
     4021 aagatttcct ttatcggaca ggaccatctt tatgacctgc tttctgtttt tcaatatcat
     4081 acattggtgt atgtcaaaga ataaattagt aaaattagta aatgaaaaag actcttccgt
     4141 acatcattat ttccatgcta atgtgtgtct gtgatccaga ataacttctc ccactcatat
     4201 cttcagttca cctaatgaaa tgaatggata gcaagagccc tttgttccca ggactttaag
     4261 gcaaaatatt aaaaattatt gccaaaatta agaatataat gtttgtataa atgtccttga
     4321 atttgccatt taaattaact cattttcttt tcactttgat ttgaaagctg ataagtattt
     4381 ctgcagcaga tagaatatta aaatcaggtt gtgtgtacac actgcactat gaggtacctt
     4441 ggtgtcctgg tgtgaataga caagaagctg tactatatgt tgctctctca gtggcaacaa
     4501 tgaagttttt gcaattctag aacttggatt tttttttaac aaaagtccca aaacaccaaa
     4561 aatgtaaaca agataagaga ttaatattgt agtgatgtaa tttaattaaa gttatatttt
     4621 gggttaattt taacaactga agtcttattg ttgaaactta ttttcaacaa aactgtgcag
     4681 ttaaatttgt atacgtattc acatactgaa agatgaaccg ttaaaatagc acttaatttt
     4741 gtgtttcttc aatatgtctt gatatacttt gtgcaattaa tattacacat gtaagttgta
     4801 tggcagttta cagaactcaa tgacttgtca tgaggttttc atatgagcta cacattgtgt
     4861 acattgattg ttttttattt ttacataaat ccattctgtc attttcaact ttatatataa
     4921 atctccaatg ttatgggaaa caatagattg acacataatt tttaaaaatt atatttgtaa
     4981 aatttctcta ttgtgaataa agtcttttaa tatatctc
//
