LOCUS       NM_018717               6844 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens mastermind like transcriptional coactivator 3 (MAML3),
            mRNA.
ACCESSION   NM_018717 NM_005878
VERSION     NM_018717.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6844)
  AUTHORS   Na,L., Onishi,H., Morisaki,S., Ichimiya,S., Yamada,Y., Masuda,S.,
            Nagao,S., Koga,S., Nakayama,K., Imaizumi,A., Oda,Y. and Nakamura,M.
  TITLE     MAML3 Contributes to Induction of Malignant Phenotype of
            Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia
  JOURNAL   Anticancer Res 43 (7), 2909-2922 (2023)
   PUBMED   37351966
  REMARK    GeneRIF: MAML3 Contributes to Induction of Malignant Phenotype of
            Gallbladder Cancer Through Morphogenesis Signalling Under Hypoxia.
REFERENCE   2  (bases 1 to 6844)
  AUTHORS   Alzofon,N., Koc,K., Panwell,K., Pozdeyev,N., Marshall,C.B.,
            Albuja-Cruz,M., Raeburn,C.D., Nathanson,K.L., Cohen,D.L.,
            Wierman,M.E., Kiseljak-Vassiliades,K. and Fishbein,L.
  TITLE     Mastermind Like Transcriptional Coactivator 3 (MAML3) Drives
            Neuroendocrine Tumor Progression
  JOURNAL   Mol Cancer Res 19 (9), 1476-1485 (2021)
   PUBMED   33986121
  REMARK    GeneRIF: Mastermind Like Transcriptional Coactivator 3 (MAML3)
            Drives Neuroendocrine Tumor Progression.
REFERENCE   3  (bases 1 to 6844)
  AUTHORS   Onishi,H., Ichimiya,S., Yanai,K., Umebayashi,M., Nakamura,K.,
            Yamasaki,A., Imaizumi,A., Nagai,S., Murahashi,M., Ogata,H. and
            Morisaki,T.
  TITLE     RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung
            Cancer
  JOURNAL   Anticancer Res 38 (8), 4543-4547 (2018)
   PUBMED   30061220
  REMARK    GeneRIF: RBPJ and MAML3 could be new therapeutic targets for SCLC.
REFERENCE   4  (bases 1 to 6844)
  AUTHORS   Li,J., Li,T., Lu,Y., Shen,G., Guo,H., Wu,J., Lei,C., Du,F.,
            Zhou,F., Zhao,X., Nie,Y. and Fan,D.
  TITLE     MiR-2392 suppresses metastasis and epithelial-mesenchymal
            transition by targeting MAML3 and WHSC1 in gastric cancer
  JOURNAL   FASEB J 31 (9), 3774-3786 (2017)
   PUBMED   28512191
  REMARK    GeneRIF: These findings indicate that the
            miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical
            role in GC metastasis.
REFERENCE   5  (bases 1 to 6844)
  AUTHORS   Nieuwenhuis,M.A., Vonk,J.M., Himes,B.E., Sarnowski,C., Minelli,C.,
            Jarvis,D., Bouzigon,E., Nickle,D.C., Laviolette,M., Sin,D.,
            Weiss,S.T., van den Berge,M., Koppelman,G.H. and Postma,D.S.
  TITLE     PTTG1IP and MAML3, novel genomewide association study genes for
            severity of hyperresponsiveness in adult asthma
  JOURNAL   Allergy 72 (5), 792-801 (2017)
   PUBMED   27709636
  REMARK    GeneRIF: PTTG1IP and MAML3 are associated with BHR severity in
            adult asthma. The relevance of these genes is supported by the eQTL
            analyses and co-expression of PTTG1lP with vimentin and
            E-cadherin1, and MAML3 with MAML2.
REFERENCE   6  (bases 1 to 6844)
  AUTHORS   Hu,Z., Shi,Y., Mo,X., Xu,J., Zhao,B., Lin,Y., Yang,S., Xu,Z.,
            Dai,J., Pan,S., Da,M., Wang,X., Qian,B., Wen,Y., Wen,J., Xing,J.,
            Guo,X., Xia,Y., Ma,H., Jin,G., Yu,S., Liu,J., Zhou,Z., Wang,X.,
            Chen,Y., Sha,J. and Shen,H.
  TITLE     A genome-wide association study identifies two risk loci for
            congenital heart malformations in Han Chinese populations
  JOURNAL   Nat Genet 45 (7), 818-821 (2013)
   PUBMED   23708190
REFERENCE   7  (bases 1 to 6844)
  AUTHORS   Tonon,G., Modi,S., Wu,L., Kubo,A., Coxon,A.B., Komiya,T.,
            O'Neil,K., Stover,K., El-Naggar,A., Griffin,J.D., Kirsch,I.R. and
            Kaye,F.J.
  TITLE     t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates
            a novel fusion product that disrupts a Notch signaling pathway
  JOURNAL   Nat Genet 33 (2), 208-213 (2003)
   PUBMED   12539049
  REMARK    Erratum:[Nat Genet. 2003 Mar;33(3):430]
REFERENCE   8  (bases 1 to 6844)
  AUTHORS   Lin,S.E., Oyama,T., Nagase,T., Harigaya,K. and Kitagawa,M.
  TITLE     Identification of new human mastermind proteins defines a family
            that consists of positive regulators for notch signaling
  JOURNAL   J Biol Chem 277 (52), 50612-50620 (2002)
   PUBMED   12386158
  REMARK    GeneRIF: Identification of new human proteins defines a family that
            consists of positive regulators for notch signaling
REFERENCE   9  (bases 1 to 6844)
  AUTHORS   Wu,L., Sun,T., Kobayashi,K., Gao,P. and Griffin,J.D.
  TITLE     Identification of a family of mastermind-like transcriptional
            coactivators for mammalian notch receptors
  JOURNAL   Mol Cell Biol 22 (21), 7688-7700 (2002)
   PUBMED   12370315
REFERENCE   10 (bases 1 to 6844)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC131182.3, AC097464.3 and AC108053.3.
            
            On May 30, 2018 this sequence version replaced NM_018717.4.
            
            CCDS Note: The coding region was updated to make it identical to
            the current human reference genome sequence.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3372903.1,
                                           SRR18074969.2287964.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000509479.6/ ENSP00000421180.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1325              AC131182.3         59216-60540         c
            1326-2936           AC097464.3         98460-100070        c
            2937-3188           AC108053.3         31561-31812         c
            3189-3273           AC108053.3         26896-26980         c
            3274-6844           AC108053.3         17898-21468         c
FEATURES             Location/Qualifiers
     source          1..6844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..6844
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /note="mastermind like transcriptional coactivator 3"
                     /db_xref="GeneID:55534"
                     /db_xref="HGNC:HGNC:16272"
                     /db_xref="MIM:608991"
     exon            1..1325
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             858..4274
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /note="CAG repeat containing (glia-derived nexin I alpha);
                     expanded repeat domain, CAG/CTG 3; trinucleotide repeat
                     containing 3; polyglutamine rich"
                     /codon_start=1
                     /product="mastermind-like protein 3"
                     /protein_id="NP_061187.3"
                     /db_xref="CCDS:CCDS54805.1"
                     /db_xref="GeneID:55534"
                     /db_xref="HGNC:HGNC:16272"
                     /db_xref="MIM:608991"
                     /translation="MGDFAAPAAAANGSSICINSSLNSSLGGAGIGVNNTPNSTPAAP
                     SSNHPAAGGCGGSGGPGGGSAAVPKHSTVVERLRQRIEGCRRHHVNCENRYQQAQVEQ
                     LELERRDTVSLYQRTLEQRAKKSGAGTGKQQHPSKPQQDAEAASAEQRNHTLIMLQET
                     VKRKLEGARSPLNGDQQNGACDGNFSPTSKRIRKDISAGMEAINNLPSNMPLPSASPL
                     HQLDLKPSLPLQNSGTHTPGLLEDLSKNGRLPEIKLPVNGCSDLEDSFTILQSKDLKQ
                     EPLDDPTCIDTSETSLSNQNKLFSDINLNDQEWQELIDELANTVPEDDIQDLFNEDFE
                     EKKEPEFSQPATETPLSQESASVKSDPSHSPFAHVSMGSPQARPSSSGPPFSTVSTAT
                     SLPSVASTPAAPNPASSPANCAVQSPQTPNQAHTPGQAPPRPGNGYLLNPAAVTVAGS
                     ASGPVAVPSSDMSPAEQLKQMAAQQQQRAKLMQQKQQQQQQQQQQQQQQQQQQQQQQQ
                     QQHSNQTSNWSPLGPPSSPYGAAFTAEKPNSPMMYPQAFNNQNPIVPPMANNLQKTTM
                     NNYLPQNHMNMINQQPNNLGTNSLNKQHNILTYGNTKPLTHFNADLSQRMTPPVANPN
                     KNPLMPYIQQQQQQQQQQQQQQQQQQPPPPQLQAPRAHLSEDQKRLLLMKQKGVMNQP
                     MAYAALPSHGQEQHPVGLPRTTGPMQSSVPPGSGGMVSGASPAGPGFLGSQPQAAIMK
                     QMLIDQRAQLIEQQKQQFLREQRQQQQQQQQQILAEQQLQQSHLPRQHLQPQRNPYPV
                     QQVNQFQGSPQDIAAVRSQAALQSMRTSRLMAQNAGMMGIGPSQNPGTMATAAAQSEM
                     GLAPYSTTPTSQPGMYNMSTGMTQMLQHPNQSGMSITHNQAQGPRQPASGQGVGMVSG
                     FGQSMLVNSAITQQHPQMKGPVGQALPRPQAPPRLQSLMGTVQQGAQSWQQRSLQGMP
                     GRTSGELGPFNNGASYPLQAGQPRLTKQHFPQGLSQSVVDANTGTVRTLNPAAMGRQM
                     MPSLPGQQGTSQARPMVMSGLSQGVPGMPAFSQPPAQQQIPSGSFAPSSQSQAYERNA
                     PQDVSYNYSGDGAGGSFPGLPDGADLVDSIIKGGPGDEWMQELDELFGNP"
     exon            1326..2936
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3188
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3273
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3274..6844
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6823..6828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /note="hexamer: AATAAA"
     polyA_site      6844
                     /gene="MAML3"
                     /gene_synonym="CAGH3; ERDA3; GDN; MAM-2; mam-3; MAM2;
                     TNRC3"
                     /note="major polyA site"
ORIGIN      
        1 actccgctgg catggaggag gaggaggagg tggaggagcg agaggaggag gaggaggcgg
       61 cggcggcggc ggcggcgagc agttgatcat tgtgatggtg gcaggagcag cggcggcagc
      121 ggcagcccag ccgagcgtta ggtgctgctc tctgcgcggc gttttgcaaa ggacttcacc
      181 gatctacttt tgcagtcgcc tcggactgtc catgtgttta cttcccccag cccgaggatt
      241 cgatatctag gttcctgtga aatgcaactg agcagccaaa gtactttgag aacacggggc
      301 ggcataaaca ccaaaacttt tttgtggaag gaaaatgcaa taagcaagct tgccgttttc
      361 cgatgcggtg tggagtgagt gtgtgtcgcg cgtgtccgca ctggaggcat atgcttgtgt
      421 gtgtacatgg ggtgtgtttt tcggtatgta gggagaaaat gcttgccaac caccggaaat
      481 ctcctggaat ttattagaaa ataatggatt ataaaaagaa ggcaagcaag gagcggatct
      541 ccccttgagt tgcaacccga tttgctgctg gctcagtttg ttgtgattct ttttgttgat
      601 aggtgtctga tggtattccg ataacgttcc ccccttttct tccccttgag cttttacagt
      661 ttaaaaaaag gaaacaaaaa ccaccccaaa atctcccccc ccgttttttt cgccccgtcg
      721 ggatcgccgt ttccatccat gtgcttgcgt ctcccccgcg ttccacttaa actattttaa
      781 tccttggacc caaggaggag gctgataggg gggtggataa aaaaagttct tccaaaatag
      841 tgtgcccggg gagcaggatg ggggatttcg cagcccccgc tgctgccgcg aatggcagta
      901 gtatttgcat caacagtagc ctgaacagca gcctcggcgg ggccgggatc ggtgtgaata
      961 atactcccaa tagtactccc gctgctccga gtagcaatca cccggcagcc ggtggatgcg
     1021 gcggctccgg gggccccggc ggcggttcgg cggccgttcc caagcacagc accgtggtgg
     1081 agcggctccg ccagcgcatc gagggctgcc gtcggcacca cgtcaactgc gagaacaggt
     1141 accagcaggc tcaggtggag cagctggagc tggagcgccg ggacaccgtg agcctctacc
     1201 agcggaccct ggagcagagg gccaagaaat cgggcgccgg caccggcaaa cagcagcacc
     1261 cgagcaaacc ccagcaagat gcggaggctg cctcggcgga gcagaggaac cacacgctga
     1321 tcatgctaca agagactgtg aaaaggaagt tggaaggagc tcgatcacca cttaatggag
     1381 accagcagaa tggtgcttgt gatgggaatt tttctccgac tagcaaacga attcgaaagg
     1441 acatttctgc ggggatggaa gccatcaaca atttgcccag taacatgcca ctgccttcag
     1501 cttctcctct tcaccaactt gacctgaaac cttctttgcc cttgcagaac agtggaactc
     1561 acactcctgg gcttctagaa gatctaagta agaatggtag gctccctgag attaaacttc
     1621 ctgtcaacgg ttgcagtgac ctggaggata gcttcaccat cttgcagagc aaagacctca
     1681 aacaagaacc tctcgatgac cctacttgca tagacacatc agaaacatct ctttcaaatc
     1741 agaacaagct gttctcagac attaatctga atgatcagga gtggcaagaa ttaatagatg
     1801 aattggccaa cacggttcct gaggatgaca tacaggacct gttcaacgaa gactttgaag
     1861 agaagaagga gccagaattc tcgcagccag caactgagac ccctctctcc caggagagtg
     1921 cgagcgtgaa gagcgacccc tctcactctc ccttcgcaca tgtctccatg ggatctcccc
     1981 aggcgaggcc ttcttcttct ggtcctccct tttctactgt ctccacggcc actagtttac
     2041 cttctgttgc cagcactccc gcagctccaa accctgcaag ctcaccagca aactgtgctg
     2101 tccagtcccc tcaaactcca aaccaagccc acactccagg ccaagctcca cctcggcctg
     2161 gaaatggtta tctcctgaat ccggcagcag tgacagtggc cggttcagcg tcagggcctg
     2221 tggctgtgcc cagctctgac atgtctccag cagaacagct caaacagatg gctgcacagc
     2281 agcaacaaag ggccaaactc atgcagcaga aacagcaaca gcaacagcag cagcagcagc
     2341 agcagcagca gcagcagcag cagcagcagc agcagcagca gcaacagcac tcaaatcaga
     2401 cttcaaattg gtctccctta ggacctccct ctagtccata tggagcagct tttactgcag
     2461 aaaaaccaaa tagcccaatg atgtaccccc aagcctttaa caaccaaaac cctatagtgc
     2521 ctccaatggc aaacaacctg cagaagacaa caatgaataa ctacctccct cagaatcaca
     2581 tgaatatgat caatcagcag ccaaataact tgggtacaaa ctccttaaac aaacagcaca
     2641 atattctgac ttatggcaac actaaacccc tgacccactt caatgcagac ctgagtcaga
     2701 ggatgacacc accagtggcc aaccccaaca aaaacccctt gatgccgtat atccagcagc
     2761 agcaacagca gcagcaacag caacagcagc agcagcagca gcagcagccg ccacctccac
     2821 agctccaggc ccccagggca cacctgagcg aagaccagaa acgcctgctt ctcatgaagc
     2881 agaaaggagt gatgaatcag cccatggctt acgctgcact tccatcccac ggtcaggagc
     2941 agcatccagt tggacttccc cgaaccacag gccccatgca gtcctccgtg cccccaggct
     3001 caggtggcat ggtctcagga gccagtcccg caggccccgg cttcctgggc agccagcccc
     3061 aagcagccat catgaagcag atgctcattg atcagcgggc ccagttgata gagcagcaga
     3121 agcaacagtt cctgcgggag caaaggcagc agcagcagca gcagcagcag cagattttgg
     3181 cggaacagca gttgcagcaa tcacatctac cccggcagca cctccagcca cagcggaatc
     3241 catacccagt gcagcaggtc aatcagtttc aaggttctcc ccaggatata gcagccgtaa
     3301 gaagccaagc agccctccag agcatgcgaa cgtcacggct gatggcacag aacgcaggca
     3361 tgatgggaat aggaccctcc cagaaccctg ggacgatggc caccgcagct gcgcagtcgg
     3421 agatgggact ggccccttat agcaccacgc ctaccagcca accaggaatg tacaatatga
     3481 gcacaggcat gacccaaatg ttgcagcatc caaaccaaag tggcatgagc atcacacata
     3541 accaagccca gggaccgagg caacctgcct ctgggcaggg ggttggaatg gtgagtggct
     3601 ttggtcagag catgctggtg aactcagcca ttacccagca acatccacag atgaaagggc
     3661 cagtaggcca ggccttgcct aggccccaag cccctccaag gctgcagagc cttatgggaa
     3721 cagtccagca aggagcacaa agctggcaac agaggagctt gcagggcatg cctgggagga
     3781 ctagtggaga attgggacca ttcaacaatg gcgccagcta ccctcttcaa gctgggcagc
     3841 cgagactgac caagcagcac ttcccacagg gactgagcca gtcagtcgtg gatgctaaca
     3901 cgggcacagt gaggaccctc aacccagctg ccatgggtcg gcagatgatg ccatcgctcc
     3961 cggggcagca aggcaccagc caggcgaggc caatggtcat gtctggcctg agccagggag
     4021 tcccaggcat gccagcgttc agccagcccc cagcacagca gcagataccc agtggcagct
     4081 ttgctccaag cagccagagc caagcctatg agcggaatgc ccctcaggac gtgtcataca
     4141 attacagtgg cgacggagct gggggttcct tccctggcct cccggacggt gcagaccttg
     4201 tggactccat catcaaaggc gggccagggg acgagtggat gcaggagctt gatgaattgt
     4261 ttggtaaccc ctaatcaaga gaggccccaa gatccacaac tcgagtggtt aaagcttaaa
     4321 aagtgaaaaa gaaacaggat gttgacccat ccttgttttt tgtttttttg acccacgtaa
     4381 actgagcaaa actgcagctg gctgacaatg gaagatccag gtgccaatcc acagccccac
     4441 caggcctcat ttcacctgat tttcacacag caatcgagat gagacgccat gcagatcccg
     4501 gctgcgagag agggagacac ccggaggagc aggtgggaag atgaagccgg ccagagcccc
     4561 tctgcccagc atgccctgtg atcgcctggc ccagcaggag ctgcttcagc cgagagggac
     4621 tattacccaa gagaggtatc ctcagcccct cctgccccag gtcgggagac agcagctttg
     4681 gagacacaaa agagacagag cctcagccag ggagagtgag tcccccagaa gaggctgggt
     4741 ggttgcacag gccaggtgca caggttggaa atgcactgaa ctctgggtgc cgagagatgt
     4801 aaggctttga gacatgctac tgaatttgga gggcaggcac gaagaacagt gagattgtca
     4861 aaaggagaca accacagatc ctacaggact gtctgtctcc tgccccatga tgaccctcag
     4921 gaattgcaaa ggctctgctg tcacaaggag agcaggctga gtttggagca gggtccatcc
     4981 ggcagtcctg ggacggcttc cctctgctgg tgcccctggt ggcagtccct ccaggtgggg
     5041 ctggagcctg ctggcgccca atacaaaacc catacatcca ggtgggtcac atctacttct
     5101 ggcggccgca gggcagggaa acccctactg gaccctgtgt gtctgccagc ctggagcctt
     5161 tgtctccagc cctgccttta ttcctccttg cctccacacc agcctcccct tgcttctcct
     5221 tacagactat ccaagaagtg aagcttatgt ctttagggag ccttgggcag agtccacata
     5281 aatgcaggaa gaacttagac aatgcctgaa atgcaaaggc gacactggag tcttctttct
     5341 ctaacgtgta gcgttgaatg aatatctgcc tggaaccaag agggctgctc tgatgtttgg
     5401 gagtcggttt tttgtgagcc acatctgata tttctgatat ccccaggaag gagtggcctg
     5461 gaggtcactg gttcaggctc cctttgggcg aaatcctggg agtgatgctc taaaaatcca
     5521 cctttcccat catccctact catcagaaag acaaatataa aatcccagag aggtggagga
     5581 gctaaaaaag caattgctcc accttacaaa tttggataga aaggagatgt agtttatttc
     5641 atatgggcaa agtagtcctc ttccaaagtc ctgtacagtt gttctctgca attgacgcac
     5701 atctgcccta agcgaaatct gtcagaagga atcaacaagg ctccttgcct cccctcccaa
     5761 tccccctttt ggaggacttg tggcttcggt gtcgtcctaa gtgagagtgg cgtgtgcttt
     5821 tttcctgtcc cctcctccct ccgtgtccta gacgctggct gccttctgtg cactcccagg
     5881 cagatcacta cggaagagtc ggagcctgtg gggttggact ggccacactc agtcctgaga
     5941 aggcgagttg ccatggaaag ctgggggcag aggtgttttt ggagaggagg cggcaggcaa
     6001 acattgcctt tgacttgctc tccgcgtacc cggggttgta gagctgctca ggaaggggca
     6061 ggatgtaagg ccagaggtgc ctggtgggtg agaagcccag gcaggggctg ggcgccctct
     6121 ccgaagaggt ggcagcaggg tgaccctgaa ctccccaaat ggggagtgat gccactgggg
     6181 aaactgagtg gatcaaagag atgaaaccaa aaaaaagcaa acaaacaaat gagaagacac
     6241 aaaacataat taccttttcc tgaaaggtac aggaaataaa tatataagca atgatgagaa
     6301 actggaggtg gctaatggaa gtgagacaga caggggtggg gggctccatt atcttttaaa
     6361 agcttcctcc aaatgctcag tactgggacc aactaatagg tagattttaa tatggtggtt
     6421 ttgttttggt tttgttttta ctacggtgct gatgtatatg taatgtctaa aaaaagttat
     6481 ttgtacataa gtttttacaa tactgcagat atcactgggt ctactatctg taaaaaatat
     6541 acatataaat atatatatac tgtttgttta aaatagagta tttttatttc attccttaac
     6601 tcatcatcac agcagtggta ttgcacttca gatgacatct aattactaat ttgtactgta
     6661 tgacctctgg caacttgctc cattttattc agatttttct agttttctgt ttttactttg
     6721 tacattgagc attgcttatt tccttttaag aaatgtacag aacgctgaaa tgtagaaatg
     6781 aagtgatgtt gacataccac ttttaaagaa aacaaaaaca aaaataaaag attatctgaa
     6841 tcaa
//
