LOCUS       NM_032427               7121 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens mastermind like transcriptional coactivator 2 (MAML2),
            mRNA.
ACCESSION   NM_032427
VERSION     NM_032427.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7121)
  AUTHORS   Wu,F.Y., Yang,R.M., Zhang,H.Y., Zhan,M., Tu,P.H., Fang,Y.,
            Zhang,C.X., Song,S.Y., Dong,M., Cui,R.J., Liu,X.Y., Yang,L.,
            Yan,C.Y., Sun,F., Zhang,R.J., Wang,Z., Liang,J., Song,H.D.,
            Cheng,F. and Zhao,S.X.
  TITLE     Pathogenic variations in MAML2 and MAMLD1 contribute to congenital
            hypothyroidism due to dyshormonogenesis by regulating the Notch
            signalling pathway
  JOURNAL   J Med Genet 60 (9), 874-884 (2023)
   PUBMED   36898841
  REMARK    GeneRIF: Pathogenic variations in MAML2 and MAMLD1 contribute to
            congenital hypothyroidism due to dyshormonogenesis by regulating
            the Notch signalling pathway.
REFERENCE   2  (bases 1 to 7121)
  AUTHORS   Dermawan,J.K., DiNapoli,S.E., Sukhadia,P., Mullaney,K.A.,
            Gladdy,R., Healey,J.H., Agaimy,A., Cleven,A.H., Suurmeijer,A.J.H.,
            Dickson,B.C. and Antonescu,C.R.
  TITLE     Malignant undifferentiated epithelioid neoplasms with MAML2
            rearrangements: A clinicopathologic study of seven cases
            demonstrating a heterogenous entity
  JOURNAL   Genes Chromosomes Cancer 62 (4), 191-201 (2023)
   PUBMED   36344258
  REMARK    GeneRIF: Malignant undifferentiated epithelioid neoplasms with
            MAML2 rearrangements: A clinicopathologic study of seven cases
            demonstrating a heterogenous entity.
REFERENCE   3  (bases 1 to 7121)
  AUTHORS   Yamanaka,S., Suzuki,S., Ito,H., Sivasundaram,K., Hanamura,I.,
            Okubo,I., Yoshikawa,K., Ono,S., Takahara,T., Satou,A., Tsuzuki,T.,
            Ueda,R., Ogawa,T. and Fujimoto,Y.
  TITLE     Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical
            and Recurrence Biopsy Specimens
  JOURNAL   Int J Mol Sci 24 (2), 1722 (2023)
   PUBMED   36675234
  REMARK    GeneRIF: Establishment of Mucoepidermoid Carcinoma Cell Lines from
            Surgical and Recurrence Biopsy Specimens.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7121)
  AUTHORS   Wang,M., Xu,H., Han,Q. and Wang,L.
  TITLE     Significance of YAP1-MAML2 rearrangement and GTF2I mutation in the
            diagnosis and differential diagnosis of metaplastic thymoma
  JOURNAL   Ann Med 55 (2), 2237040 (2023)
   PUBMED   37489594
  REMARK    GeneRIF: Significance of YAP1-MAML2 rearrangement and GTF2I
            mutation in the diagnosis and differential diagnosis of metaplastic
            thymoma.
REFERENCE   5  (bases 1 to 7121)
  AUTHORS   Acunzo,M., Romano,G., Wernicke,D., Balatti,V., Rassenti,L.Z.,
            dell'Aquila,M., Kipps,T.J., Pekarsky,Y. and Croce,C.M.
  TITLE     Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion
            oncogene
  JOURNAL   Blood 124 (2), 259-262 (2014)
   PUBMED   24855209
  REMARK    GeneRIF: The rearrangement between MAML2 and CXCR4, created by a
            t(2;11)(q22.1;q21) translocation, results in a new fusion gene in
            which a portion of CXCR4 is linked to the MAML2 gene.
REFERENCE   6  (bases 1 to 7121)
  AUTHORS   Fehr,A., Roser,K., Heidorn,K., Hallas,C., Loning,T. and
            Bullerdiek,J.
  TITLE     A new type of MAML2 fusion in mucoepidermoid carcinoma
  JOURNAL   Genes Chromosomes Cancer 47 (3), 203-206 (2008)
   PUBMED   18050304
  REMARK    GeneRIF: study reports for the first time a CRTC3-MAML2 fusion gene
            in a mucoepidermoid carcinoma, as determined by RT-PCR and
            sequencing.
REFERENCE   7  (bases 1 to 7121)
  AUTHORS   Enlund,F., Behboudi,A., Andren,Y., Oberg,C., Lendahl,U., Mark,J.
            and Stenman,G.
  TITLE     Altered Notch signaling resulting from expression of a WAMTP1-MAML2
            gene fusion in mucoepidermoid carcinomas and benign Warthin's
            tumors
  JOURNAL   Exp Cell Res 292 (1), 21-28 (2004)
   PUBMED   14720503
  REMARK    GeneRIF: cloning of a novel fusion gene in mucoepidermoid
            carcinomas & benign Warthin's tumors; the fusion, which results
            from a translocation, creates a chimeric gene in which exon 1 of a
            novel gene designated WAMTP1 is linked to exons 2-5 of MAML2
            [WAMPT1]
REFERENCE   8  (bases 1 to 7121)
  AUTHORS   Tonon,G., Modi,S., Wu,L., Kubo,A., Coxon,A.B., Komiya,T.,
            O'Neil,K., Stover,K., El-Naggar,A., Griffin,J.D., Kirsch,I.R. and
            Kaye,F.J.
  TITLE     t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates
            a novel fusion product that disrupts a Notch signaling pathway
  JOURNAL   Nat Genet 33 (2), 208-213 (2003)
   PUBMED   12539049
  REMARK    GeneRIF: cloning and functional analyses of the t(11;19) fusion
            oncogene t(11;19)(q21;p13) translocation in mucoepidermoid
            carcinoma creates a novel fusion product that disrupts a Notch
            signaling pathway.
            Erratum:[Nat Genet. 2003 Mar;33(3):430]
REFERENCE   9  (bases 1 to 7121)
  AUTHORS   Lin,S.E., Oyama,T., Nagase,T., Harigaya,K. and Kitagawa,M.
  TITLE     Identification of new human mastermind proteins defines a family
            that consists of positive regulators for notch signaling
  JOURNAL   J Biol Chem 277 (52), 50612-50620 (2002)
   PUBMED   12386158
  REMARK    GeneRIF: Identification of new human proteins defines a family that
            consists of positive regulators for notch signaling
REFERENCE   10 (bases 1 to 7121)
  AUTHORS   Wu,L., Sun,T., Kobayashi,K., Gao,P. and Griffin,J.D.
  TITLE     Identification of a family of mastermind-like transcriptional
            coactivators for mammalian notch receptors
  JOURNAL   Mol Cell Biol 22 (21), 7688-7700 (2002)
   PUBMED   12370315
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000848.5, AB058722.1,
            AY186997.1, DA862475.1, BC152449.1 and CR627398.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032427.3.
            
            Summary: The protein encoded by this gene is a member of the
            Mastermind-like family of proteins. All family members are proline
            and glutamine-rich, and contain a conserved basic domain that binds
            the ankyrin repeat domain of the intracellular domain of the Notch
            receptors (ICN1-4) in their N-terminus, and a transcriptional
            activation domain in their C-terminus. This protein binds to an
            extended groove that is formed by the interaction of CBF1,
            Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively
            regulates Notch signaling. High levels of expression of this gene
            have been observed in several B cell-derived lymphomas.
            Translocations resulting in fusion proteins with both CRTC1 and
            CRTC3 have been implicated in the development of mucoepidermoid
            carcinomas, while a translocation event with CXCR4 has been linked
            with chronic lymphocytic leukemia (CLL). Copy number variation in
            the polyglutamine tract has been observed. [provided by RefSeq, Jan
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.233607.1, BC152449.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524717.6/ ENSP00000434552.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AP000848.5         165340-165354       c
            16-70               AB058722.1         1-55
            71-71               AP000848.5         165284-165284       c
            72-2697             AB058722.1         57-2682
            2698-3111           AY186997.1         1045-1458
            3112-3120           DA862475.1         4-12
            3121-5443           BC152449.1         3097-5419
            5444-7121           CR627398.1         4425-6102
FEATURES             Location/Qualifiers
     source          1..7121
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..7121
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /note="mastermind like transcriptional coactivator 2"
                     /db_xref="GeneID:84441"
                     /db_xref="HGNC:HGNC:16259"
                     /db_xref="MIM:607537"
     exon            1..1813
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /inference="alignment:Splign:2.1.0"
     CDS             1301..4771
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /note="mam-2; mastermind-like 2"
                     /codon_start=1
                     /product="mastermind-like protein 2"
                     /protein_id="NP_115803.1"
                     /db_xref="CCDS:CCDS44714.1"
                     /db_xref="GeneID:84441"
                     /db_xref="HGNC:HGNC:16259"
                     /db_xref="MIM:607537"
                     /translation="MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARI
                     AVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATT
                     TAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPAST
                     PGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGG
                     LQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCS
                     KHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATI
                     KQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFS
                     MANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQ
                     QHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSK
                     VMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQ
                     ANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSI
                     SAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRS
                     PLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSG
                     YMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPP
                     PDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTR
                     MPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTL
                     GPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGT
                     SKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMN
                     QMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFP
                     SPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDI
                     NLDEILGNNS"
     exon            1814..3439
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /inference="alignment:Splign:2.1.0"
     exon            3440..3643
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3755
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /inference="alignment:Splign:2.1.0"
     exon            3756..7121
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7100..7105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /note="hexamer: AATACA"
     polyA_site      7121
                     /gene="MAML2"
                     /gene_synonym="MAM-3; MAM2; MAM3; MLL-MAML2"
                     /note="major polyA site"
ORIGIN      
        1 actctctctc tttctctccc tctcctatcg gagcacaatg aaagcctgtg tatcgccgtg
       61 actccgggcg cgagccagtg tcagcaaagc ggctaacaac agacgagaaa gagaaaggaa
      121 aatacaagct actttttttt tccatctata aagcggagca aatacaggag atagaaccag
      181 attgcttatt gcgagtccag accctcagat ccactggccg gggatggaat gtacaaaagt
      241 ggacagaaaa gtggctggac atgactcggt gcaatttgct ggaagtttgt aagtttgacc
      301 atcgtttgta aattactctc ggaagagttt gtctctcttg atactgtatt agaatagagc
      361 cgggggtgag gaatagaaac gtaagcggga aagaaaaaaa tgtgttgaag gatctctctc
      421 agtggctagc gacttaagat tgcttttcat ttaaggctag gaaaccttag agggagtgag
      481 gattttaccg gtgattggat tagctgaaga aaaaagcatg gtccaaaagt ccaattactg
      541 acattgttaa cagttgaaaa gctgtctccc tcttttggga gaagacaaca tcctacagta
      601 ccccaaagag gagaaaacac cggagcgaaa ggaaagggag gaaaaattaa aagccaaaag
      661 acagtctccc ttgatttttg cacattttga acagtgactt aaacatcttc tgaaacagca
      721 ctgttttgtt ttgttttggt tttttattta acctgaggaa aagtcaaggc tgctggttac
      781 atagacatgg tagaaatgtg tttctctgca gaaacatccc cataaagaat tgtcggaaac
      841 aactaggtga gggggagtcc tctctattaa tacctctctc aatacctttt gctgtgtgtt
      901 tctgtctctt gctggacaat ccctgaattc ttgatctaac ccccagatcg tgtgtttaca
      961 aagtacctag tggctcttgt cagcttggtg gaggaaaaaa aatccaccaa ctctgtccaa
     1021 cttctccaga gctgtcaaat gcaattagag taagttaatc agggtttgtt tccaacttat
     1081 cctcccccca gttggtttct attctttctc cccaccctct ttttactaac tcccctcccc
     1141 cacaacttct ccacggctcc cccacaacct ctgaagacct ctattcatgt ggccctgaac
     1201 actgagctca cattgtcaaa aacagacttg cctgcaatag ccagcagtag cctctttcca
     1261 cctcaccatc ccagaggcag caatcattgt gtccggtaag atgggggaca cagcgccccc
     1321 gcaggccccc gcaggagggc tagggggggc ctctggggcg gggctccttg gagggggctc
     1381 agtcaccccg agagtgcaca gtgctatcgt ggagcgcctc cgggctcgga tcgctgtctg
     1441 ccgccaacac cacctgagct gtgaaggacg atatgaacga ggtagggccg agagctcaga
     1501 ccgggaaaga gaaagcacct tgcagctcct gagccttgta cagcatggcc agggggcaag
     1561 gaaagctggc aaacacacca aggccaccgc cactgctgcc accactacag cccctccacc
     1621 gccccctgct gcccctcctg cggcctccca agcagcagca acagcagccc caccgccccc
     1681 accagactat caccatcacc accagcagca cctgctgaac agtagcaata atggtggcag
     1741 tggtgggata aacggagagc agcagccgcc cgcttcaacc ccaggggacc agaggaactc
     1801 agccctgatt gcgctccagg gttccttgaa aagaaaacag gtagttaacc tatctcctgc
     1861 caacagcaag cgacccaatg gctttgtgga caactcattt cttgatatca aaagaattcg
     1921 tgttggggag aatctctctg caggacaagg tggcctccaa ataaacaatg gacaaagtca
     1981 gattatgtca gggaccttgc ctatgagcca agcacccctg cgaaagacta acactctgcc
     2041 atcccataca cattctcctg gcaatggcct gtttaacatg ggcttaaagg aggtaaagaa
     2101 ggagccagga gagactctgt cttgcagtaa gcacatggat ggccaaatga cccaagagaa
     2161 tatttttcct aataggtacg gagacgaccc tggagaacaa ctgatggatc ctgagctgca
     2221 ggaactgttc aatgaactga ccaacatatc tgtgcctccc atgagtgacc ttgaactgga
     2281 gaacatgatc aatgccacca taaagcagga tgacccattt aacattgact tgggtcagca
     2341 aagccagagg agcacaccta ggccctcctt acccatggag aaaatagtga tcaaaagtga
     2401 atactcaccg ggcttgactc agggcccctc aggctctcct cagctgaggc ccccatcagc
     2461 tggccccgca ttctccatgg ccaactctgc cctctccact tcgtctccaa tcccttcagt
     2521 ccctcagagc caggctcagc ctcagacagg ctccggagca agccgggcct tgccaagctg
     2581 gcaggaagta tcccatgccc agcagctcaa acagatagct gctaatcgtc agcagcatgc
     2641 ccggatgcag cagcaccagc agcagcacca gcctaccaac tggtcagcct tgccctcttc
     2701 tgctggacca tcaccaggtc catttgggca ggagaaaatc cccagccctt cttttggtca
     2761 gcagacattc agcccacaga gctcccccat gcctggggta gctggcggca gcggccagtc
     2821 gaaagtaatg gctaactaca tgtacaaggc cggcccctca gcccagggtg ggcacctaga
     2881 tgtcctcatg cagcaaaagc ctcaggatct cagtcgaagt tttattaaca acccgcaccc
     2941 agccatggag ccccgtcagg gcaacaccaa gcctttgttt cattttaact cagatcaagc
     3001 gaaccagcag atgccttctg ttttgccttc ccagaacaag ccttctctcc tacactacac
     3061 ccaacagcaa cagcagcaac agcagcagca gcagcagcag cagcagcagc agcagcagca
     3121 acagcagcag cagcagcaac agcaacagca acagcaacag cagagttcaa tttcagctca
     3181 acaacagcaa cagcagcaga gctcaatttc agcccaacag cagcagcagc agcaacaaca
     3241 gcagcagcag cagcaacaac aacagcaaca acagcagcag cagcagcagc aacaaccatc
     3301 ttctcagcct gcccaatctc taccaagcca gcctttgcta aggtcacctt tgccacttca
     3361 gcaaaagctc ctacttcagc aaatgcagaa tcagcccatt gcaggaatgg gataccaagt
     3421 ctcccaacaa cagagacagg atcaacactc tgtggtaggc cagaacacag gccccagtcc
     3481 aagtcctaac ccctgctcaa atccaaacac tggaagtggt tacatgaact cccagcaatc
     3541 actgttgaat cagcaattga tgggaaagaa gcagactcta cagaggcaga tcatggagca
     3601 gaaacagcaa cttcttctcc agcagcagat gctggctgac gcggagaaaa ttgctccaca
     3661 agatcagata aaccgacatt tgtcaaggcc acctccagat tataaagacc aaagaagaaa
     3721 tgtgggcaat atgcaaccaa ctgctcagta ttctggtggc tcatccacaa taagcttaaa
     3781 ctctaaccag gctttggcaa acccagtttc aacacacacc attttaactc ccaattccag
     3841 cctcctgtct acttctcacg ggacaagaat gccatcatta tctacagcag ttcagaatat
     3901 ggggatgtat ggaaatctgc cttgtaatca acctaacaca tacagtgtca cttcaggaat
     3961 gaatcaattg acccaacaga gaaacccaaa gcaattgtta gcaaatcaaa acaaccctat
     4021 gatgccacgg ccacctacct tagggccaag taataataac aatgtagcca cttttggagc
     4081 tggatctgtt ggtaattcac aacaattgag accaaattta acccatagta tggcaagcat
     4141 gccaccacag agaacatcaa acgtaatgat cacatccaac acaactgcac caaactgggc
     4201 ctctcaagaa ggaacaagca aacagcaaga agccctgacg tctgcaggag tccgcttccc
     4261 cacaggtaca cctgcagcct ataccccaaa tcagtcactg caacaggcag taggtagcca
     4321 gcaattttcc cagagggcag tggctcctcc taaccagtta acaccagcag tgcaaatgag
     4381 acccatgaac caaatgagcc aaacactaaa tgggcaaacc atgggtcccc tcaggggtct
     4441 gaatctcaga cccaatcagc taagcacaca gattttgcct aatttgaatc agtcaggaac
     4501 agggttgaat cagtcgagga cgggcatcaa ccagccacca tccctgacgc ccagcaattt
     4561 tccttcaccc aaccaaagtt ccagggcttt tcaaggaact gaccacagca gtgacttagc
     4621 ttttgacttc ctcagccaac aaaatgataa catgggccct gccctaaaca gtgatgctga
     4681 tttcattgat tctttattga agacagagcc tggtaatgat gactggatga aagacatcaa
     4741 tcttgatgaa atcttgggga acaattccta aagaagaaag ggaagacaat ttacaaactc
     4801 caagcactaa aaggcagtat attacagaaa ctctgtagag gctgaactgt tgatgttcag
     4861 gtggactaca tgaagataac atgcttaaaa atggaaagca gaaagtaact gcagtgatga
     4921 acattttggt ccaaattctt gttttaaatc ttacacctga aagtaaaata ttgggatcac
     4981 ttttccctgt ctaaactcca ggatacagta tccaatttat ccaaacagaa ctgtggtgtc
     5041 aatgtgtaat taattgtgta aaatagcctt cccaagtttc tttttccctg gaaaataaaa
     5101 aaggtaatag aacttgtagt ttatttaaac cccatgtcat gaggaggtac tagttccaag
     5161 caacaaactc cttaatttgc tctaatagat aggtatggtt taatctttcc attgtgtctt
     5221 ttcatttaat tttcctgaag cttgcaggat agattgaaat gttataggtt tgtttggagt
     5281 aaccaaacag tatgcaaatt aagaaaaagc cagagaacct agaaaacatc cagtggatta
     5341 cagaatttct tccccatatt cactcctcac ttttacaatt ttcccacaat cctctacttc
     5401 agtgggatgc tgtgtctagt gattaaacaa aaatatagag ctgtgcaatt tgattttggc
     5461 ttccacaacg aatatctgaa tccattccaa atgaaatttt agatataaca aagacttgtc
     5521 ctaatcatac tgaaatattg gtgcacacct ctctgcatta gatttcactt ttttaaaaaa
     5581 cccagtggac attgctataa ataagattta tttggctaca aataacctgg gatgttgctt
     5641 attatgattg atgcctgctg gtttgttccc aagctgagtg aaattgaacc tcgtcctccc
     5701 tactcatttt gatgactgag gctggtttat aagaaaagga agtttggaga agaaaaccga
     5761 gattagaaaa tatcatgttt tggttggaga taagaaccag ggatggcaag taccagtgtg
     5821 tacaaatgta tttcacggag tttgaaggaa cgcataatca agagggaaaa caatttgtcc
     5881 ttcattggac gtattatttg gatttgggtg agcaacaaaa tggaatgtgg tctgttagga
     5941 gcattctgtt tgttcttttg tccctgatgt gatgaatcat tgccacatgc tagatggact
     6001 cttcatatcc aggttttgtc cctcagggct gagcactgta ttaaagagtt tttgttgagt
     6061 catttaacct tagtgtccac atccagatca gctgtaaaat ggggaagacg tgtgctgatt
     6121 tggaatgaat gcaaaatatc actatcattt tcctaattac agaggagcaa aggttatctt
     6181 cagccctttc agttctatgc tcacatattc aaatatcaaa tgtaatttag ctgaagttat
     6241 ttaataatca agtctttcaa tatctgttca aagaaaaaga acacactttg aaaattctgc
     6301 aaagctgtct cccagtcttt aaaatgtctg gaagcactct ccttctttac aataccaaca
     6361 tcactggccc agaatcttcc ctgtgctagt ttgtaaatat aaataaatta cttgttttgt
     6421 aaacttttgt aaagaatatt ttggtagaaa tacttcaaac atattctttg ggttatattt
     6481 atacatatgt gaaataaata tactatcaaa aggttatatt ttatacaaaa agtaaattgc
     6541 taccttttgt atgctaatat gcaaagtttt gtataatatg atggtttatt tttagctcta
     6601 cacttaaacc ataggtggtt gagtgggaac ttttgaaaac tatcaagagg cttgttagac
     6661 aaatttatat tctgaaacct caataagaaa gcattccagg tttcaatcct tgttttttgt
     6721 cctgctccca aattcttttt taaacccata gttcttgtgt cttatttgat tcttctgctg
     6781 tgcacattgt attggtcctt gttgcatgta gtctactgtg tgttttccga ttttataagg
     6841 cagcatttct ccatacaaaa agaaaaaaaa tgatgtacat ataaacgctt ttgttgtatg
     6901 gctcctccat gttactgtat atatctgcca gcacttccca gttacactcc tgtgagtcag
     6961 cttattttta ccctaacata aatagtatgt tttgtagtag ttatcaaatt taagagataa
     7021 agcaatcaga atgtttggat tttcttctat cttaatgtga atttcataat taatgtctat
     7081 ttattcagct attcattaaa atacaggatt ctttgggaaa a
//
