LOCUS       NM_006785               9289 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens MALT1 paracaspase (MALT1), transcript variant 1, mRNA.
ACCESSION   NM_006785
VERSION     NM_006785.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9289)
  AUTHORS   Kondreddy,V., Banerjee,R., Devi,B.L.A.P., Muralidharan,K. and
            Piramanayagam,S.
  TITLE     Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration
            and osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 189 (2024)
   PUBMED   38519981
  REMARK    GeneRIF: Inhibition of the MALT1-LPCAT3 axis protects cartilage
            degeneration and osteoarthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9289)
  AUTHORS   Iwamuro,M., Takenaka,R., Miyahara,K., Okanoue,S., Yoshioka,M.,
            Sakaguchi,C., Yamamoto,K., Kawai,Y., Toyokawa,T., Tanaka,T. and
            Otsuka,M.
  TITLE     Long-term monitoring of gastric mucosa-associated lymphoid tissue
            lymphoma in patients with extra copies of the MALT1 gene
  JOURNAL   Sci Rep 14 (1), 4953 (2024)
   PUBMED   38418651
  REMARK    GeneRIF: Long-term monitoring of gastric mucosa-associated lymphoid
            tissue lymphoma in patients with extra copies of the MALT1 gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9289)
  AUTHORS   Maghe,C., Trillet,K., Andre-Gregoire,G., Kerherve,M., Merlet,L.,
            Jacobs,K.A., Schauer,K., Bidere,N. and Gavard,J.
  TITLE     The paracaspase MALT1 controls cholesterol homeostasis in
            glioblastoma stem-like cells through lysosome proteome shaping
  JOURNAL   Cell Rep 43 (1), 113631 (2024)
   PUBMED   38183651
  REMARK    GeneRIF: The paracaspase MALT1 controls cholesterol homeostasis in
            glioblastoma stem-like cells through lysosome proteome shaping.
REFERENCE   4  (bases 1 to 9289)
  AUTHORS   Liu,C., Zhu,J., Zhao,L., Li,G., Sun,J., Zhang,S. and Liang,X.
  TITLE     Blood MALT1 reflects acute exacerbation risk and inflammation in
            elderly chronic obstructive pulmonary disease patients
  JOURNAL   Biomark Med 18 (10-12), 513-521 (2024)
   PUBMED   39136445
  REMARK    GeneRIF: Blood MALT1 reflects acute exacerbation risk and
            inflammation in elderly chronic obstructive pulmonary disease
            patients.
REFERENCE   5  (bases 1 to 9289)
  AUTHORS   Kowluru,A.
  TITLE     Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in islet
            beta-cell function in health and metabolic stress: Is there room
            for MALT1?
  JOURNAL   Biochem Pharmacol 218, 115889 (2023)
   PUBMED   37991197
  REMARK    GeneRIF: Regulatory roles of CARD9-BCL10-Rac1 (CBR) signalome in
            islet beta-cell function in health and metabolic stress: Is there
            room for MALT1?
            Review article
REFERENCE   6  (bases 1 to 9289)
  AUTHORS   Hulpiau,P., Driege,Y., Staal,J. and Beyaert,R.
  TITLE     MALT1 is not alone after all: identification of novel paracaspases
  JOURNAL   Cell Mol Life Sci 73 (5), 1103-1116 (2016)
   PUBMED   26377317
  REMARK    GeneRIF: Comparative analysis of the active site suggests that
            paracaspases constitute one of the several subclasses of
            metacaspases that have evolved several times independently.
REFERENCE   7  (bases 1 to 9289)
  AUTHORS   Suzuki,H., Motegi,M., Akagi,T., Hosokawa,Y. and Seto,M.
  TITLE     API1-MALT1-MLT is involved in mucosa-associated lymphoid tissue
            lymphoma with t(11;18)(q21;q21)
  JOURNAL   Blood 94 (9), 3270-3271 (1999)
   PUBMED   10610122
REFERENCE   8  (bases 1 to 9289)
  AUTHORS   Akagi,T., Motegi,M., Tamura,A., Suzuki,R., Hosokawa,Y., Suzuki,H.,
            Ota,H., Nakamura,S., Morishima,Y., Taniwaki,M. and Seto,M.
  TITLE     A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21)
            found in low-grade B-cell lymphoma of mucosa-associated lymphoid
            tissue
  JOURNAL   Oncogene 18 (42), 5785-5794 (1999)
   PUBMED   10523859
REFERENCE   9  (bases 1 to 9289)
  AUTHORS   Hosaka,S., Akamatsu,T., Nakamura,S., Kaneko,T., Kitano,K.,
            Kiyosawa,K., Ota,H., Hosaka,N., Miyabayashi,H. and Katsuyama,T.
  TITLE     Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum
            with chromosomal translocation of the t(11;18)(q21;q21) and an
            additional aberration of trisomy 3
  JOURNAL   Am J Gastroenterol 94 (7), 1951-1954 (1999)
   PUBMED   10406266
REFERENCE   10 (bases 1 to 9289)
  AUTHORS   Dierlamm,J., Baens,M., Wlodarska,I., Stefanova-Ouzounova,M.,
            Hernandez,J.M., Hossfeld,D.K., De Wolf-Peeters,C., Hagemeijer,A.,
            Van den Berghe,H. and Marynen,P.
  TITLE     The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are
            recurrently rearranged in the t(11;18)(q21;q21) associated with
            mucosa-associated lymphoid tissue lymphomas
  JOURNAL   Blood 93 (11), 3601-3609 (1999)
   PUBMED   10339464
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF316597.1, AC104365.4 and
            AK026459.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 29, 2018 this sequence version replaced NM_006785.3.
            
            Summary: This gene encodes a caspase-like protease that plays a
            role in BCL10-induced activation of NF-kappaB. The protein is a
            component of the CARMA1-BCL10-MALT1 (CBM) signalosome that triggers
            NF-kappaB signaling and lymphoctye activation following
            antigen-receptor stimulation. Mutations in this gene result in
            immunodeficiency 12 (IMD12). This gene has been found to be
            recurrently rearranged in chromosomal translocations with other
            genes in mucosa-associated lymphoid tissue lymphomas, including a
            t(11;18)(q21;q21) translocation with the baculoviral IAP
            repeat-containing protein 3 (also known as apoptosis inhibitor 2)
            locus [BIRC3(API2)-MALT1], and a t(14;18)(q32;q21) translocation
            with the immunoglobulin heavy chain locus (IGH-MALT1).
            Alternatively spliced transcript variants have been described for
            this gene. [provided by RefSeq, May 2018].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.156357.1,
                                           SRR1803612.156996.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649217.2/ ENSP00000497997.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2841              AF316597.1         80-2920
            2842-8475           AC104365.4         99162-104795        c
            8476-9289           AK026459.1         1517-2330
FEATURES             Location/Qualifiers
     source          1..9289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.32"
     gene            1..9289
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /note="MALT1 paracaspase"
                     /db_xref="GeneID:10892"
                     /db_xref="HGNC:HGNC:6819"
                     /db_xref="MIM:604860"
     exon            1..388
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2654
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /EC_number="3.4.22.-"
                     /note="isoform a is encoded by transcript variant 1;
                     caspase-like protein; paracaspase-1; mucosa-associated
                     lymphoid tissue lymphoma translocation protein 1; mucosa
                     associated lymphoid tissue lymphoma translocation gene 1;
                     MALT1 protease"
                     /codon_start=1
                     /product="mucosa-associated lymphoid tissue lymphoma
                     translocation protein 1 isoform a"
                     /protein_id="NP_006776.1"
                     /db_xref="CCDS:CCDS11967.1"
                     /db_xref="GeneID:10892"
                     /db_xref="HGNC:HGNC:6819"
                     /db_xref="MIM:604860"
                     /translation="MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSEL
                     LDQAPEGRGWRRLAELAGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCT
                     VTELSDFLQAMEHTEVLQLLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQW
                     FKMNKEIPNGNTSELIFNAVHVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRS
                     VDGVSESKLQICVEPTSQKLMPGSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYM
                     VPYVDLEHQGTYWCHVYNDRDSQDSKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQT
                     TDQPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMR
                     NAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQ
                     EKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLAN
                     GIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGKQALEIRSSLSEKRALTDPIQG
                     TEYSAESLVRNLQWAKAHELPESMCLKFDCGVQIQLGFAAEFSNVMIIYTSIVYKPPE
                     IIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHL
                     VFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRGLGRKTCFQTCLMSNGPYQSS
                     AATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCSRTPDAFISSFAHHASCHF
                     SRSNVPVETTDEIPFSFSDRLRISEK"
     exon            389..555
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..677
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..828
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..1007
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1104
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1137
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1164
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1197
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1401
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1579
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1654
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1782
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1932
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2090
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2216
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..9289
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4931..4936
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /note="hexamer: AATAAA"
     polyA_site      4950
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /note="major polyA site"
     regulatory      8687..8692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
                     /note="hexamer: AGTAAA"
     polyA_site      8710
                     /gene="MALT1"
                     /gene_synonym="IMD12; MLT; MLT1; PCASP1"
ORIGIN      
        1 aaacctgtct aattggggcg gggagcggag cttcctcctc tgagggccgt gccgcgctgc
       61 cagatttgtt cttccgcccc tgcctccgcg gctcggaggc gagcggaagg tgccccgggg
      121 ccgaggcccg tgacggggcg ggcgggagcc ccggcagtcc ggggtcgccg gcgagggcca
      181 tgtcgctgtt gggggacccg ctacaggccc tgccgccctc ggccgccccc acggggccgc
      241 tgctcgcccc tccggccggc gcgaccctca accgcctgcg ggagccgctg ctgcggaggc
      301 tcagcgagct cctggatcag gcgcccgagg gccggggctg gaggagactg gcggagctgg
      361 cggggagtcg cgggcgcctc cgcctcagtt gcctagacct ggagcagtgt tctcttaagg
      421 tactggagcc tgaaggaagc cccagcctgt gtctgctgaa gttaatgggt gaaaaaggtt
      481 gcacagtcac agaattgagt gatttcctgc aggctatgga acacactgaa gttcttcagc
      541 ttctcagccc cccaggaata aagattactg taaacccaga gtcaaaggca gtcttggctg
      601 gacagtttgt gaaactgtgt tgccgggcaa ctggacatcc ttttgttcaa tatcagtggt
      661 tcaaaatgaa taaagagatt ccaaatggaa atacatcaga gcttattttt aatgcagtgc
      721 atgtaaaaga tgcaggcttt tatgtctgtc gagttaataa caatttcacc tttgaattca
      781 gccagtggtc acagctggat gtttgcgaca tcccagagag cttccagaga agtgttgatg
      841 gcgtctctga atccaagttg caaatctgtg ttgaaccaac ttcccaaaag ctgatgccag
      901 gcagcacatt ggttttacag tgtgttgctg ttggaagccc tattcctcac taccagtggt
      961 tcaaaaatga attaccatta acacatgaga ccaaaaagct atacatggtg ccttatgtgg
     1021 atttggaaca ccaaggaacc tactggtgtc atgtatataa tgatcgagac agtcaagata
     1081 gcaagaaggt agaaatcatc ataggaagaa cagatgaggc agtggagtgc actgaagatg
     1141 aattaaataa tcttggtcat cctgataata aagagcaaac aactgaccag cctttggcga
     1201 aggacaaggt tgcccttttg ataggaaata tgaattaccg ggagcacccc aagctcaaag
     1261 ctcctttggt ggatgtgtac gaattgacta acttactgag acagctggac ttcaaagtgg
     1321 tttcactgtt ggatcttact gaatatgaga tgcgtaatgc tgtggatgag tttttactcc
     1381 ttttagacaa gggagtatat gggttattat attatgcagg acatggttat gaaaattttg
     1441 ggaacagctt catggtcccc gttgatgctc caaatccata taggtctgaa aattgtctgt
     1501 gtgtacaaaa tatactgaaa ttgatgcaag aaaaagaaac tggacttaat gtgttcttat
     1561 tggatatgtg taggaaaaga aatgactacg atgataccat tccaatcttg gatgcactaa
     1621 aagtcaccgc caatattgtg tttggatatg ccacgtgtca aggagcagaa gcttttgaaa
     1681 tccagcattc tggattggca aatggaatct ttatgaaatt tttaaaagac agattattag
     1741 aagataagaa aatcactgtg ttactggatg aagttgcaga agatatgggt aagtgtcacc
     1801 ttaccaaagg caaacaggct ctagagattc gaagtagttt atctgagaag agagcactta
     1861 ctgatccaat acagggaaca gaatattctg ctgaatctct tgtgcggaat ctacagtggg
     1921 ccaaggctca tgaacttcca gaaagtatgt gtcttaagtt tgactgtggt gttcagattc
     1981 aattaggatt tgcagctgag ttttccaatg tcatgatcat ctatacaagt atagtttaca
     2041 aaccaccgga gataataatg tgtgatgcct acgttactga ttttccactt gatctagata
     2101 ttgatccaaa agatgcaaat aaaggcacac ctgaagaaac tggcagctac ttggtatcaa
     2161 aggatcttcc caagcattgc ctctatacca gactcagttc actgcaaaaa ttaaaggaac
     2221 atctagtctt cacagtatgt ttatcatatc agtactcagg attggaagat actgtagagg
     2281 acaagcagga agtgaatgtt gggaaacctc tcattgctaa attagacatg catcgaggtt
     2341 tgggaaggaa gacttgcttt caaacttgtc ttatgtctaa tggtccttac cagagttctg
     2401 cagccacctc aggaggagca gggcattatc actcattgca agacccattc catggtgttt
     2461 accattcaca tcctggtaat ccaagtaatg ttacaccagc agatagctgt cattgcagcc
     2521 ggactccaga tgcatttatt tcaagtttcg ctcaccatgc ttcatgtcat tttagtagaa
     2581 gtaatgtgcc agtagagaca actgatgaaa taccatttag tttctctgac aggctcagaa
     2641 tttctgaaaa atgacctcct tgtttttgaa agttagcata attttagatg cctgtgaaat
     2701 agtactgcac ttacataaag tgagacattg tgaaaaggca aatttgtata tgtagagaaa
     2761 gaatagtagt aactgtttca tagcaaactt caggactttg agatgttgaa attacattat
     2821 ttaattacag acttcctctt tctaagattt tgtgaattgg ttgaatagtt ctatacaaat
     2881 gaagtatgga ggtgtgtatg tttatatgta tataacaaaa tattttcatt gtgaccactc
     2941 tgaagtaaga gcaatgggaa tggcattatt gtagaataag tcattgtatt tttaacacca
     3001 gaaagaacct tgccgatcac caggcataac ctaattttat ccatggaaga aacacagaaa
     3061 ggcatctaag ttagagctgg caccagaact gagacctcca gaaatctatt ccagtatttt
     3121 ttccactaca caactgcctt cctgacaggt tctgagataa gtgttatgtt tgtagataga
     3181 gtgaaatata tttatatata tataaatata tacagataca tatctgtgta ttatctcaag
     3241 gaatgtacaa actttagttt ttgattataa ggacttcact gcaagtttta gttaagaggt
     3301 ttgtatataa atctgttata gaacaggctg aaatttcttg ttcataagat tatgaaacca
     3361 catgagaagt gataaaatgt ttgttaaagc tagatagagg ttaagaatca agatataatg
     3421 gataattttc atagctgcct atcagaattt cccaaatatt tagcatcttc cttgataata
     3481 tgtattttct tcttgaattt cactggccta atgagataat actcttatct ttggctctac
     3541 ctaaaagttg gttaaaaatg caattggcat taacaaggaa aaatactgaa ttagtaattt
     3601 taaaagtctc acaaagaaaa tcccaggcct agatggctgc attgttgaat tctgccaaac
     3661 attaaaatta gcactaattt tttgcacact gtttctaaaa gtaggagagg aaagaacact
     3721 tcccaactta ctctaggtca gtattaccct gatactagac tagacatcac aagaaaacta
     3781 taagccaata ttccttatta atacaaacac aaaaatcatt aacaaaaata ttagcaaact
     3841 gaatccagca acctataaaa aggattctat atcatgacca agtggaattt atcccaggaa
     3901 ttcaaggttg gttcaacatc taaaaatcaa ataagctaat atacagtcag ttctcattat
     3961 tcacagtaat tatgttctac agaatattct cccataaaca ctgaattaaa tatggaacaa
     4021 ctgcttttag gagaaagtgt atttgtgtat atgtgtgtat acatatgttt atctcacaca
     4081 cattatgagc ttgaattctt aattcatcct agcaaattct accttatttt acagaagtga
     4141 aagtgaggta tcagaagtgt taagtgacat gcctgaggca cccccctaac aggtgtcaga
     4201 gctgaaattc aaaccccatc cagctggccc cggagccaga gcttcttgta ctacacagaa
     4261 ttgcccctgc catttccacc ctccagtcat ttctctatga gactgaagca ggaaggcaga
     4321 gcatcatctt gttcagcctc agctgggaac atgtgtactg ggtgactcaa atttttcacc
     4381 catttacaca tatccacaaa tgactgcaaa agtgccacgg atatcaattt gagggttata
     4441 aattttagca agttggtaaa ttcacaaata cataaccttg aataatgagg atcaactgta
     4501 ccatatttaa taaagcacaa aacccacaca gattgtctta ttacagcatt tgataaaatc
     4561 caaaactctt tcataaaaac actcaacaaa cttaggaata aaaggaatct tcctagatat
     4621 gataaatata acatctatga aaagcccaca cctaacatta tacttcatgg tgatagactg
     4681 aaggctgaat gttttcccct taagattggg aagaaggaca aggatgttca ctcggcacta
     4741 cttctattca gcattgtact tgaagttcta gccacagcag ttaggttagg aattcaaggt
     4801 ttgttcaaca tctaaaaatc aaataagcta ataaagaaaa gaggtttata ctgcaaaaga
     4861 agtgaaacta tatgtattca cagttgatac atagttgtat atagaaaatg ctaaagaatc
     4921 cataaaaagt aataaatgag ttcaacaggt tgcaggatac aagatcagtt ttatttctct
     4981 actaacagca aacattctga aaatgagaat aaagaaatcc tatatacagt agcatcaaga
     5041 ataaaactcc aacacgttta aagaaattaa gatccagata aatggaaaga catccatgtt
     5101 catggattgg aagactgaat attggtaaga tggcaatgct gcccaaatta gtctacatat
     5161 tcaacaattc ctatcaaaat cctagctgta ttttttgcag aaattgacaa actggtaaaa
     5221 ttggtaggga aacgcagggg acccagaata gccaaaaaac cttggaaaag aacaaagttg
     5281 gaagacgtac caatttcaaa aagtgctacc aagctacaat aagacagtgt aggcatatgg
     5341 atagacatat cgatcagagg aatggaactg aacatccaga aataaaccca tacatttctg
     5401 gtcaacttgt tttcaacaag gatgccaata ccatcaatag agaaggagtg gtcttttcaa
     5461 caaacggtgc tgggacaact aactggtagc tacgtgcaca gcaaaaggat ccctaccttc
     5521 ctaccacatt acaaattcta actcaaaatg gatcatagac ctcaatataa gagtttaaac
     5581 tcttagaaga aaacagaagt aaatctttgt gatgttgggc ttaggaatgg tttcttagac
     5641 ataataccaa aagcacaagc aacaaaggca aacagtagat aaatgggact tcatcaaaat
     5701 taactttagc gccttaaagg acaccattaa gaaagtgaag ttaaccctca gaatgggaga
     5761 aaaatttttg aaaaatcatg tatctgataa aaaaacaaac aaacatgcag gtgctcagct
     5821 gtggttacca ccgagcagca ctgtccagtg aacttgctgt gatgatggga tgcttggtat
     5881 ccgcactccc agtgtgatag cctttagcct catggggttg ttgagcagtt gaaataatag
     5941 ctagtgtgag gaactgaaca taaaatttta gttttaggat gggtgtggtg gctcacgcct
     6001 ataatctcag cactttggga ggccaatgaa ggcggatcac ttgagcccag gagttcaaga
     6061 ccagcttgac caagatggca aaaccctgtc tctattaaaa atacaaaaaa attagctggg
     6121 catggtggca cacacctgta atcccagcta ctagggaggc tgaggcagga gaatcgtact
     6181 tcccctttat actcttctgt atatttgatt tttttttttt taagacagag tcctggctct
     6241 gtcgcccagg ctggagtgca gcgacatagt ctcagctcac tgcagcatcc gtggaggctg
     6301 aaacaggaga atcgcatgaa ttttttaaaa aatctaaaca tgtaatttta aaacgggctt
     6361 aagaagaatg ataacagttt tggtcttctt ttttatcaac catgctttta ttttacttga
     6421 atctcgtgcc aattgctttg taatattaaa gtaggattta cacaagtgga atttagaaaa
     6481 gatgataatc tatcaaatct gtcaatacca attagaatgt aataaagaaa ttaggatagt
     6541 ggaggtttga gcaagtaaag gctcacccaa attcaaagcc aatacttgat gctgagaggg
     6601 gatattttct ggaaggtaat ttttaaaaat taaagtcaca attataaatt gtatatttcc
     6661 taataaaaga aatctcaact catgggacaa tttgaattta aaacactatt gttcctcatt
     6721 cagtgatgaa caagtcaaaa cgtttcagaa aagaaagcct ttaaagaaga atcctggcac
     6781 agaaaaggtc catttagaca ttgccttctt cccccatctc taatgcctct tttcaaatct
     6841 ctgacttgca catgaagtaa cagtgaggtg tcctgtgcag cagtcgcaat tttttgactt
     6901 gtcaaattga agaaattcaa ttatgtagcc agagcttaga tcactgacat gtatactggc
     6961 ataagctttt ttttgtttgt ttttaatttt attagaagtg ggatctcatt ttgttgccca
     7021 tgctggtctc aaacacctgt cttcaagtga tcctcctgcc tcagcagcat cagtttaata
     7081 tctagataaa atctgatgta tgtaatttta cttttaaggg tttttttcca aacagacgtc
     7141 ctgacaatgt tgtttcctat tccttgaaca ttcacctgac gcttatatac tgtcattact
     7201 tttatctgtc aactgatgtc agctactcaa tttacacatt acttttgtgc atttcatcct
     7261 gtttctcagt ttgacattgt cattcaaatt cagagtttga cactgaaacc ctgggcatgg
     7321 tggctcacac ctgtaatccc agcacttcgg gagactgcgg taagcagatc atttgaaccc
     7381 aggagtttga gactagcctt ggcaacatgg tgaaacccca tctctaccaa aaaaaaaaaa
     7441 aaaaaaaaag caaaaacaaa aattaactgg gcatagttgc acacacctgt agtcccagct
     7501 actcaggagg ctgaagtggg acgatcgctt gagcccagaa ggcagaggtt acggtgagta
     7561 gagattgtgc cactgcactc cagcctggac gacagggcaa gacgctgtct caaaaataaa
     7621 atattagtaa agaagagtac aatcagaata tgaaaatgtg taaatgtgca tattctcttt
     7681 ttttctaatt tggtagcatt aaaaatactt aagcatcaaa gtttggcttt atgaagaagg
     7741 agtctgagac acctcaggtt tcagccctta ctaatagcgt ggctcaaaga gcgttaactt
     7801 gcctgtgctt ctgtttcctt atctgtaaaa tggggatgat gctgtaacat caaagagctt
     7861 ataatacttt ccagagctgg cagtactaaa taagaccatt cctctaaagt gccagcattt
     7921 tgaaaagcat caacccatca accttgtgct ttaaatctgg cattcttaaa gctatacctg
     7981 taggcagtat agagtgtttt tttttatttg tttttttgtt gttgtctttt gagtctcact
     8041 ctgtctccca ggctgtagtg cagtggcacg tcttggttcg ccgcaacctc cgcctcccag
     8101 gttcaagcga ttctcgtgcc tcagcccccc gcatagctgg cattacaggc acacaccacc
     8161 acgcccagct aatttttgta gttttagtag tatctactaa aataaacagg gtttcaccat
     8221 gttggccagg ctggtctcaa actcctgacc tcaagtgatc tgcctgcctc ggcctcccaa
     8281 agtgctggga ttacaggcgt gagtcaccat gcccggccgg cagtgtatat cttctaaagt
     8341 tgcaattttt gttcactcca gaatcacttt tcaaaaagca tgcagattta atgccaccag
     8401 tttgtgttat gtatctatcc cgcaaaacag ctctaaaggt gatttactaa aagattaaca
     8461 gcatttatct ctggtgggat aatttttctt tgcttgttta cctgtgtctt gcagatttta
     8521 cacagtgaac aatgactgta taattttaaa atacagatat gcacaattgt gtaatgtaaa
     8581 tatgctcagc ttcaatacat ttaagaacac atttttaact tttcgtaagg agtcttcagt
     8641 ttaaaagtac agtgtcatta cagagtgctt attctgttac aaaattagta aagctgattc
     8701 tgcctctaaa tctgaagtaa ttcccacttt ttttcatgct tgagtttagt tgataaatag
     8761 cattttagat actaaaaatg attggatgag tatttctaca ttaataagtt gctaattagg
     8821 caccagggta gcagatagaa tgcctttctg tgtgctaggt ttaaacattt tacacacagt
     8881 cttatttaaa acagccttgc agtttataga tgaactgatt gttaggctaa ccagaggtgt
     8941 tactataccc tccaggataa cccagctagt aagggcagag ccaggatgat tcagacccag
     9001 accagagccg ggtgttttgt ccacagtact gctgctgctt ataccgtaac gggaaaagta
     9061 cacaacagtg tcttaatatt tcattcttcc atgaaaaaca cttttaaaat attgaaacat
     9121 tataggagca gaagtacatc tctaaatata cttttaggtc acattgaaaa catttccaaa
     9181 ggatttgacc tgaagttaat gttgctacat tatgctcaat acagcaggct gttctgctag
     9241 ggaaattgtt aatattttaa aaatattttc ctaagcttta gctttacca
//
