LOCUS       NM_001142308            6850 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MAM and LDL receptor class A domain containing 1
            (MALRD1), mRNA.
ACCESSION   NM_001142308 XM_001715990 XM_001716836 XM_001718667 XM_003403619
            XM_005252651 XM_005276372
VERSION     NM_001142308.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6850)
  AUTHORS   Thibord,F., Chan,M.V., Chen,M.H. and Johnson,A.D.
  TITLE     A year of COVID-19 GWAS results from the GRASP portal reveals
            potential genetic risk factors
  JOURNAL   HGG Adv 3 (2), 100095 (2022)
   PUBMED   35224516
REFERENCE   2  (bases 1 to 6850)
  AUTHORS   Shelton,J.F., Shastri,A.J., Ye,C., Weldon,C.H.,
            Filshtein-Sonmez,T., Coker,D., Symons,A., Esparza-Gordillo,J.,
            Aslibekyan,S. and Auton,A.
  CONSRTM   23andMe COVID-19 Team
  TITLE     Trans-ancestry analysis reveals genetic and nongenetic associations
            with COVID-19 susceptibility and severity
  JOURNAL   Nat Genet 53 (6), 801-808 (2021)
   PUBMED   33888907
REFERENCE   3  (bases 1 to 6850)
  AUTHORS   Bataille,P., Michaud,V., Robert,M.P., Bekel,L., Leclerc-Mercier,S.,
            Harroche,A., Celerier,C., Lasseaux,E., Borgel,D.,
            Bremond-Gignac,D., Bodemer,C., Arveiler,B. and Hadj-Rabia,S.
  TITLE     Clinical variability and probable founder effect in oculocutaneous
            albinism type 7
  JOURNAL   Clin Genet 97 (3), 527-528 (2020)
   PUBMED   31694064
  REMARK    GeneRIF: Clinical variability and probable founder effect in
            oculocutaneous albinism type 7.
REFERENCE   4  (bases 1 to 6850)
  AUTHORS   Reue,K., Lee,J.M. and Vergnes,L.
  TITLE     Diet1 is a regulator of fibroblast growth factor 15/19-dependent
            bile acid synthesis
  JOURNAL   Dig Dis 33 (3), 307-313 (2015)
   PUBMED   26045262
  REMARK    GeneRIF: Diet1 appears to be a control point for the production of
            fibroblast growth factor 15/19 in enterocytes, and thus a regulator
            of bile acid and lipid homeostasis.
REFERENCE   5  (bases 1 to 6850)
  AUTHORS   Reue,K., Lee,J.M. and Vergnes,L.
  TITLE     Regulation of bile acid homeostasis by the intestinal
            Diet1-FGF15/19 axis
  JOURNAL   Curr Opin Lipidol 25 (2), 140-147 (2014)
   PUBMED   24535283
  REMARK    Review article
REFERENCE   6  (bases 1 to 6850)
  AUTHORS   Vergnes,L., Lee,J.M., Chin,R.G., Auwerx,J. and Reue,K.
  TITLE     Diet1 functions in the FGF15/19 enterohepatic signaling axis to
            modulate bile acid and lipid levels
  JOURNAL   Cell Metab 17 (6), 916-928 (2013)
   PUBMED   23747249
REFERENCE   7  (bases 1 to 6850)
  AUTHORS   Zubenko,G.S., Hughes,H.B. 3rd and Zubenko,W.N.
  TITLE     D10S1423 identifies a susceptibility locus for Alzheimer's disease
            (AD7) in a prospective, longitudinal, double-blind study of
            asymptomatic individuals: results at 14 years
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (2), 359-364 (2010)
   PUBMED   19591129
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6850)
  AUTHORS   Zubenko,G.S. and Hughes,H.B. 3rd.
  TITLE     Predicted gene sequence C10orf112 is transcribed, exhibits
            tissue-specific expression, and may correspond to AD7
  JOURNAL   Genomics 93 (4), 376-382 (2009)
   PUBMED   19103277
  REMARK    GeneRIF: Expression of these C10orf112 mRNA species was limited to
            a subset of brain regions and heart tissue
REFERENCE   9  (bases 1 to 6850)
  AUTHORS   Zubenko,G.S., Hughes,H.B. 3rd and Stiffler,J.S.
  TITLE     D10S1423 identifies a susceptibility locus for Alzheimer's disease
            in a prospective, longitudinal, double-blind study of asymptomatic
            individuals
  JOURNAL   Mol Psychiatry 6 (4), 413-419 (2001)
   PUBMED   11443525
REFERENCE   10 (bases 1 to 6850)
  AUTHORS   Majores,M., Bagli,M., Papassotiropoulos,A., Schwab,S.G., Jessen,F.,
            Rao,M.L., Maier,W. and Heun,R.
  TITLE     Allelic association between the D10S1423 marker and Alzheimer's
            disease in a German population
  JOURNAL   Neurosci Lett 289 (3), 224-226 (2000)
   PUBMED   10961670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from KC843478.1, AL391992.8,
            AL590378.5, AL589943.26, AL354695.12 and AL157895.8.
            
            On Nov 22, 2018 this sequence version replaced NM_001142308.2.
            
            Summary: This gene encodes a conserved protein that features
            multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR
            A2 (low density lipoprotein receptor A2) domains. Expression of
            this gene is enriched in the small intestine and is upregulated
            during differentiation of a human cell line that exhibits
            properties of intestinal epithelial cells. The encoded protein has
            been shown to modulate production of FGF19 in a human intestinal
            cell line and may regulate bile acid metabolism in the liver. A
            synergistic interaction between an allele of this gene and the APOE
            E4 allele is associated with an elevated risk of Alzheimer's
            disease in human patients. [provided by RefSeq, Jul 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: KC843478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: locus in the vicinity of
                                      disease-associated variant(s)
            MANE Ensembl match     :: ENST00000454679.7/ ENSP00000412763.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1112              KC843478.1         31-1142
            1113-1113           AL391992.8         64232-64232
            1114-2134           KC843478.1         1144-2164
            2135-2135           AL590378.5         44098-44098
            2136-2514           KC843478.1         2166-2544
            2515-2515           AL590378.5         45389-45389
            2516-2797           KC843478.1         2546-2827
            2798-2798           AL590378.5         49674-49674
            2799-3934           KC843478.1         2829-3964
            3935-3935           AL589943.26        22914-22914
            3936-4208           KC843478.1         3966-4238
            4209-4209           AL589943.26        39376-39376
            4210-4387           KC843478.1         4240-4417
            4388-4388           AL589943.26        43542-43542
            4389-4941           KC843478.1         4419-4971
            4942-4942           AL589943.26        81004-81004
            4943-5264           KC843478.1         4973-5294
            5265-5265           AL354695.12        45725-45725
            5266-6206           KC843478.1         5296-6236
            6207-6207           AL157895.8         38153-38153
            6208-6850           KC843478.1         6238-6880
FEATURES             Location/Qualifiers
     source          1..6850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.31"
     gene            1..6850
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /note="MAM and LDL receptor class A domain containing 1"
                     /db_xref="GeneID:340895"
                     /db_xref="HGNC:HGNC:24331"
                     /db_xref="MIM:617715"
     exon            1..337
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..6609
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /note="MAM and LDL-receptor class A domain-containing
                     protein C10orf112; novel MAM domain containing protein;
                     MAM and LDL-receptor class A domain-containing protein 1"
                     /codon_start=1
                     /product="MAM and LDL-receptor class A domain-containing
                     protein 1 precursor"
                     /protein_id="NP_001135780.2"
                     /db_xref="CCDS:CCDS73071.1"
                     /db_xref="GeneID:340895"
                     /db_xref="HGNC:HGNC:24331"
                     /db_xref="MIM:617715"
                     /translation="MLFFLDRMLAFPMNETFCCLWIACVFNSTLAQQGTESFQCDNGV
                     SLPPDSICDFTDQCGDSSDERHCLNYERCDFEDGLCHMTQDQSLQPSWTKRSGMIGLS
                     PPFYDHNGDVSAHFLSLVSRVDSISSSLRSRVFLPTNDQHDCQITFYYFSCQVSGKLM
                     VGLQTACGGPIQHLWQNTAALPNQWERNVIKIQSSQRFQVVFEGQMASTYEQDEVIAI
                     DDISFSSGCLPANDGILLCQEALNAERELCHPDTDLCRFDATDEELRLCQACGFEFDM
                     CEWTSEASAGQISWMRTKAREIPAFESTPQQDQGGDDEGYYVWVGAKHGFTLNHLDSR
                     AYLNSSVCHCLGKSCHLQFYYAMESSVLRVRLYNNKEEEIFWTYNISTHSQWVKADVL
                     IPEDLKTFKIIFEGTLLSQRSFIALDHLWVYACGQTQSRKLCSADEFPCTSGQCIAKE
                     SVCDSRQDCSDESDEDPATCSKHLTCDFESGFCGWEPFLTEDSHWKLMKGLNNGEHHF
                     PAADHTANINHGSFIYLEAQRSPGVAKLGSPVLTKLLTASTPCQVQFWYHLSQHSNLS
                     VFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIAEAGESTLPFQLILEATVLSSNATV
                     ALDDISVSQECEISYKSLPRTSTQSKFSKCDFEANSCDWFEAISGDHFDWIRSSQSEL
                     SADFEHQAPPRDHSLNASQGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYN
                     YGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLG
                     IYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDE
                     VNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPTPTLNTGPMKDNTLGTAKGHYLYI
                     ESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLL
                     WQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLP
                     ADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVME
                     VCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGW
                     YLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKL
                     WAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPER
                     KCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEK
                     DEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKR
                     SKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDF
                     QLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGK
                     CYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRP
                     PKDHTLGNENGHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKATGSI
                     QILIKTEKGLSKVWQESKQNPGNHWQKADILLGKLRNFEVIFQGIRTRDLGGGAAIDD
                     IEFKNCTTVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAHYTSTT
                     GSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNS
                     SGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSV
                     IGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQP
                     SPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDE
                     CIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQ
                     LDESSCSECPLNYCRNGGTCVVEKNGPMCRCRQGWKGNRCHIKFNPPATDFTYAQNNT
                     WTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTESS
                     VYSFSNPLYGTTSGSLETLSHHLK"
     exon            338..478
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            574..735
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..832
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..934
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1081
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1248
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1341
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1549
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1696
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1794
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1968
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2089
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2242
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2348
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2716
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..3129
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..3217
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3394
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3557
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3714
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            3715..3825
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            3826..4039
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4287
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4579
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            4580..4825
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            4826..4983
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            4984..5167
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            5168..5296
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            5297..5458
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            5459..5616
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            5617..5818
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            5819..6082
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            6083..6208
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            6209..6275
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            6276..6355
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            6356..6452
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            6453..6528
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     exon            6529..6850
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6829..6834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /note="hexamer: AATAAA"
     polyA_site      6850
                     /gene="MALRD1"
                     /gene_synonym="bA265G8.2; C10orf112; DIET1"
                     /note="major polyA site"
ORIGIN      
        1 agagttgcag atagttacca atagtatcca gttataagaa gcaaatctgg gaaaggaaga
       61 atagagaaat aaaagaatgt ttccaatgat ggacttactt attacaactg cttgatctct
      121 aatagacaat accaagtaat gctcttcttc ctggacagaa tgttggcatt ccccatgaat
      181 gaaacttttt gttgcctttg gattgcctgt gttttcaatt ctacactggc tcagcaaggg
      241 acagaaagct ttcagtgtga caatggagtc tccttgcctc ctgacagcat ttgtgacttc
      301 acagatcagt gtggggatag cagtgatgaa cggcactgtt tgaattatga aagatgtgat
      361 tttgaggatg gtctctgtca tatgactcaa gatcagagtc tgcaacctag ttggacaaag
      421 agaagtggga tgattggtct atcacctcca ttttatgatc acaatggtga tgtgtctgct
      481 cacttcctct cactggtttc cagagtggat tctatttcct caagtttaag aagcagagtt
      541 ttccttccaa caaatgatca acatgactgc cagattacat tttattactt ctcctgccaa
      601 gtgagtggca aattaatggt tgggcttcaa actgcatgtg gaggtcctat tcagcattta
      661 tggcaaaaca cagctgcact cccaaatcag tgggagagaa atgtcatcaa aatccagagt
      721 tcacagagat ttcaggttgt ttttgaaggt caaatggctt caacgtatga acaggatgaa
      781 gtcattgcta ttgatgatat atctttcagt tcaggctgct tgcctgccaa tgatggaatt
      841 ttactgtgtc aagaagcatt gaatgctgag cgggagctat gccatccaga tacagatctc
      901 tgcagatttg atgctacaga tgaagagttg agattgtgtc aggcctgtgg gtttgaattt
      961 gacatgtgtg agtggacgtc agaagcatct gctggccaaa tttcctggat gcgcacaaaa
     1021 gcgagagaga tccctgcatt cgaatccaca cctcagcagg atcaaggagg tgatgatgaa
     1081 ggttattatg tatgggtagg cgctaagcat ggtttcactc ttaaccattt agacagcagg
     1141 gcttacctaa atagctctgt gtgtcattgc ctgggcaaga gctgtcatct tcaattctat
     1201 tatgcaatgg aaagcagtgt cctgagagta agactgtata ataataagga agaagaaata
     1261 ttttggacat acaacatatc aactcacagc caatgggtga aagcagatgt gttaatacca
     1321 gaagatctga agacatttaa gattattttt gaagggactc ttttgagcca gagaagtttt
     1381 attgcccttg atcacctctg ggtctatgcc tgtggacaga cccaatccag aaagctttgc
     1441 tctgcagacg aattcccttg cactagtggc cagtgcatcg ccaaagaatc tgtctgtgac
     1501 tctcggcagg actgctccga tgagagtgat gaagacccag caacttgctc aaagcatctc
     1561 acctgtgact ttgagtcggg tttctgcggt tgggagccat ttctcacaga agattcacac
     1621 tggaagctga tgaaaggatt gaataatgga gagcaccact ttcctgcagc tgatcacaca
     1681 gcaaacataa atcatggatc gtttatttat ttggaggcac agcgctcccc cggggtggcc
     1741 aagcttggaa gtcctgttct tacaaaattg ctcactgcct ctaccccatg tcaggtgcag
     1801 ttttggtatc atttgtctca acattcaaat ctctcagttt ttacaagaac gtctctagat
     1861 ggaaacttgc aaaagcaggg caaaataatc agattctccg aatctcagtg gagccacgca
     1921 aaaattgatc tcattgcaga agcgggagaa tctactctac cttttcagtt aattttggaa
     1981 gctactgttt tgtcgtcaaa tgctaccgtt gctctagatg acatcagtgt gtcccaggaa
     2041 tgtgaaattt cctataaatc actaccaagg accagtacac aaagcaagtt ttccaagtgt
     2101 gactttgaag caaacagctg tgattggttt gaagcaatta gtggtgacca ttttgactgg
     2161 atacggagct ctcagagtga actttctgct gattttgagc accaggctcc acctcgggat
     2221 catagtctca acgcatctca agggcatttt atgttcattc tgaagaaaag cagcagcttg
     2281 tggcaagttg ctaagcttca gagcccaact ttcagccaga caggacctgg atgcatactt
     2341 tccttctggt tctataacta tggcctgtca gtgggagcag ctgagctgca gctacatatg
     2401 gaaaattctc atgactcaac agtgatttgg agagtattat acaatcaggg caaacaatgg
     2461 ttggaggcaa ccattcagct agggcgcctt tcgcagccct tccatttgtc actagataaa
     2521 gtcagtctgg gcatttatga tggggtctca gctattgatg acatccgatt tgaaaattgt
     2581 actctccctc ttcctgctga gagctgtgaa gggctggatc atttctggtg tcgccacacc
     2641 agggcttgca tagaaaagct tcggttatgt gatctggtgg atgactgtgg tgatcgtact
     2701 gatgaagtca actgtgcacc tgagctgcag tgtaactttg aaactggaat ctgtaactgg
     2761 gaacaagatg caaaagatga ctttgattgg accaggagcc agggtccaac tccaacactt
     2821 aacacagggc caatgaaaga taacactctg ggcacagcta aaggacacta tctctacata
     2881 gaatcttcag agccacaggc ttttcaagac agtgctgcct tactcagccc aatccttaat
     2941 gccactgata caaaaggctg caccttccgc ttctattacc acatgtttgg aaagcgcatt
     3001 tataggttgg caatctacca acgaatctgg agtgactcaa ggggacagct gctgtggcag
     3061 atatttggga atcaaggcaa cagatggatt aggaaacacc tcaacatttc cagcaggcag
     3121 ccctttcaga tattggtgga ggcttcagtg ggagatggct tcactggaga tattgcgatt
     3181 gatgatctgt catttatgga ctgcaccctc taccctggta atttgccagc agacctccca
     3241 actccaccag aaacgtcagt tcctgtaaca ttacctccac acaactgcac agacaatgaa
     3301 tttatctgca ggtctgatgg tcactgcatt gaaaaaatgc agaaatgtga ttttaaatat
     3361 gactgccctg acaaatcaga tgaagcatcc tgtgttatgg aagtttgcag ctttgagaaa
     3421 agaagcctgt gtaaatggta tcaaccaatc ccagtacatt tgcttcaaga ttcaaacaca
     3481 ttcaggtggg ggcttgggaa cgggatcagc attcatcatg gggaagaaaa ccacaggcca
     3541 tcagtggatc atacacaaaa taccactgat ggctggtacc tgtatgctga cagttctaat
     3601 gggaaatttg gtgacacggc tgacattctc actcctatca tttcactcac gggaccaaaa
     3661 tgtaccttgg tgttctggac acatatgaat ggggccaccg ttggttctct ccaggtgctc
     3721 atcaagaaag ataacgttac ttctaaattg tgggctcaaa ctggacagca aggtgcacag
     3781 tggaagagag cagaagtgtt tttaggcatt cgttcacata cacagattgt cttcagagcc
     3841 aaacgtggta tcagttacat aggagatgta gcagtggatg atatttcctt ccaagattgc
     3901 tcccctttgc ttagcccaga gagaaagtgt actgatcatg aattcatgtg tgctaataag
     3961 cactgcattg ccaaagacaa gctgtgtgat tttgtgaatg attgtgctga taattcagat
     4021 gagactactt tcatttgccg tacctccagt gggcgctgtg atttcgaatt tgatctttgt
     4081 tcctggaagc aggagaaaga tgaggacttt gactggaacc tgaaagctag cagcatccct
     4141 gcagcaggca cagagccagc agcagatcac actttgggaa attcatctgg tcattacatc
     4201 tttataaaga gtttgtttcc tcagcagccc atgagagctg ccagaatttc aagtccagtt
     4261 ataagtaaga gaagcaaaaa ctgcaagatt atttttcatt atcacatgta tggaaatggc
     4321 attggggcac tcaccttaat gcaggtgtca gtcacaaacc aaacgaaggt tctacttaac
     4381 ctcactgtag aacaaggcaa tttctggcgg agagaagaac tgtcactgtt tggtgatgaa
     4441 gacttccaac tcaaatttga aggtagagtt gggaaaggtc agcgtggaga cattgcactt
     4501 gatgacattg tgcttacaga aaattgtcta tcactccatg attccgtgca agaagaactg
     4561 gcagtgcctc ttccaacagg tttctgccca cttggctata gggaatgtca taatggaaaa
     4621 tgctataggc tggaacaaag ctgtaacttc gtagataact gtggagataa tactgatgaa
     4681 aatgagtgtg gtagctcctg tacttttgaa aaaggctggt gtggctggca aaactcccag
     4741 gctgacaact ttgattgggt tttaggggtt ggctctcatc aaagcttaag acctcccaaa
     4801 gaccacacac ttggaaatga aaatgggcac ttcatgtatc tggaagctac tgcagtgggc
     4861 cttcggggtg acaaagcaca cttcaggagt accatgtggc gagaatccag tgcagcctgc
     4921 accatgagct tctggtattt cgtatctgca aaggccacag gatccattca gattctcatc
     4981 aagacagaga aaggactatc aaaagtatgg caagaaagta agcagaaccc tggtaatcat
     5041 tggcaaaagg ctgacatcct gctaggaaag ttaaggaatt ttgaagtcat atttcaaggt
     5101 atcagaacaa gggacctggg aggaggagct gcaattgatg atattgaatt taaaaactgc
     5161 acaactgtgg gagagatctc tgagctttgt ccggaaatca ctgatttttt gtgccgggac
     5221 aagaagtgca ttgcatccca ccttctttgt gactataagc cagactgctc tgataggtct
     5281 gatgaagctc actgtgcaca ttatacaagc acaacaggaa gctgcaattt tgaaacaagt
     5341 tcaggaaact ggaccacagc ctgcagtctt actcaagact ctgaggatga cttggactgg
     5401 gccattggca gcagaattcc tgccaaagca ttaattccag actctgatca cacgccaggt
     5461 agtggtcagc acttcctgta cgtcaactca tctggctcca aggaaggatc cgttgccaga
     5521 attactactt ccaaatcctt cccagcaagc cttggaatgt gtactgttcg gttctggttc
     5581 tacatgattg atcccaggag tatgggaata ttaaaggtgt ataccattga agaatcgggg
     5641 ctaaacatcc tggtgtggtc agtgattgga aataaaagaa cgggatggac atatggctct
     5701 gtgcctctct ccagtaacag tccgtttaag gtggcatttg aagctgattt ggatggaaat
     5761 gaggacatct ttattgctct tgatgacatc tcttttaccc cagagtgtgt gactggaggt
     5821 cctgtcccag tgcagccatc accctgtgaa gctgatcagt tttcttgtat ctacacactc
     5881 caatgtgtcc ctctctcagg gaaatgtgat ggacatgaag actgcataga tggatctgat
     5941 gaaatggatt gtcctctcag ccccacccct ccactctgta gtaacatgga gttcccgtgc
     6001 tctacagacg agtgtatacc ttccctcctg ctatgcgatg gagtgcccga ctgccacttt
     6061 aatgaagatg agctcatctg ctccaacaaa agctgttcta atggagctct ggtgtgtgcc
     6121 tcctccaaca gctgtatccc agcccaccag cgctgtgatg gttttgccga ctgcatggat
     6181 ttccagcttg atgagtccag ctgctccgaa tgtccattaa attactgcag aaatggtggg
     6241 acttgtgtag tggagaaaaa tggtcctatg tgtcgatgta gacaaggctg gaaaggaaat
     6301 cgatgccata tcaagtttaa tcctcctgct acagacttca catacgctca gaataataca
     6361 tggactctcc tgggtattgg attagcattc ctgatgactc acatcacagt tgcagtcttg
     6421 tgttttcttg caaacagaaa ggtaccaata aggaaaaccg agggaagtgg taactgtgcc
     6481 tttgtcaatc cagtttacgg gaactggagc aacccagaga aaacagagag ttctgtctat
     6541 tccttctcaa acccattata tggcacaaca tcaggaagcc tggagaccct gtcacatcat
     6601 ctcaaatagc agcatcgaga ccaagtctga tccaacatgt gtagtttcta gaaaattgaa
     6661 gtctccacaa tctgatagaa actcatcttc tacaatggta aaaagagaaa ggattgtaaa
     6721 tgccagtgta attataacat ttatgaatga attttcttgc agaatataga gaatgtttat
     6781 atggaatcag aatcagtacc ttatcttcac tgaacatctg aatattttaa taaaatttct
     6841 atttaatcaa
//
