LOCUS       NM_052886               2826 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens mal, T cell differentiation protein 2 (MAL2), mRNA.
ACCESSION   NM_052886
VERSION     NM_052886.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2826)
  AUTHORS   Zhang,C., Xu,L., Li,X., Chen,Y., Shi,T. and Wang,Q.
  TITLE     LINC00460 Facilitates Cell Proliferation and Inhibits Ferroptosis
            in Breast Cancer Through the miR-320a/MAL2 Axis
  JOURNAL   Technol Cancer Res Treat 22, 15330338231164359 (2023)
   PUBMED   36938678
  REMARK    GeneRIF: LINC00460 Facilitates Cell Proliferation and Inhibits
            Ferroptosis in Breast Cancer Through the miR-320a/MAL2 Axis.
REFERENCE   2  (bases 1 to 2826)
  AUTHORS   Chen,L., Li,H., Yao,D., Zou,Q., Yu,W. and Zhou,L.
  TITLE     The novel circ_0084904/miR-802/MAL2 axis promotes the development
            of cervical cancer
  JOURNAL   Reprod Biol 22 (1), 100600 (2022)
   PUBMED   35033901
  REMARK    GeneRIF: The novel circ_0084904/miR-802/MAL2 axis promotes the
            development of cervical cancer.
REFERENCE   3  (bases 1 to 2826)
  AUTHORS   Zhang,B., Xiao,J., Cheng,X. and Liu,T.
  TITLE     MAL2 interacts with IQGAP1 to promote pancreatic cancer progression
            by increasing ERK1/2 phosphorylation
  JOURNAL   Biochem Biophys Res Commun 554, 63-70 (2021)
   PUBMED   33780861
  REMARK    GeneRIF: MAL2 interacts with IQGAP1 to promote pancreatic cancer
            progression by increasing ERK1/2 phosphorylation.
REFERENCE   4  (bases 1 to 2826)
  AUTHORS   Fang,Y., Wang,L., Wan,C., Sun,Y., Van der Jeught,K., Zhou,Z.,
            Dong,T., So,K.M., Yu,T., Li,Y., Eyvani,H., Colter,A.B., Dong,E.,
            Cao,S., Wang,J., Schneider,B.P., Sandusky,G.E., Liu,Y., Zhang,C.,
            Lu,X. and Zhang,X.
  TITLE     MAL2 drives immune evasion in breast cancer by suppressing tumor
            antigen presentation
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   32990678
  REMARK    GeneRIF: MAL2 drives immune evasion in breast cancer by suppressing
            tumor antigen presentation.
REFERENCE   5  (bases 1 to 2826)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2826)
  AUTHORS   Marazuela,M., Acevedo,A., Garcia-Lopez,M.A., Adrados,M., de
            Marco,M.C. and Alonso,M.A.
  TITLE     Expression of MAL2, an integral protein component of the machinery
            for basolateral-to-apical transcytosis, in human epithelia
  JOURNAL   J Histochem Cytochem 52 (2), 243-252 (2004)
   PUBMED   14729876
REFERENCE   7  (bases 1 to 2826)
  AUTHORS   Marazuela,M., Martin-Belmonte,F., Garcia-Lopez,M.A., Aranda,J.F.,
            de Marco,M.C. and Alonso,M.A.
  TITLE     Expression and distribution of MAL2, an essential element of the
            machinery for basolateral-to-apical transcytosis, in human thyroid
            epithelial cells
  JOURNAL   Endocrinology 145 (2), 1011-1016 (2004)
   PUBMED   14576188
  REMARK    GeneRIF: MAL2 protein mRNA species were detected in the thyroid and
            immunohistochemical analysis of thyroid follicles indicated that
            MAL2 distributed to the apical membrane
REFERENCE   8  (bases 1 to 2826)
  AUTHORS   Boutros,R., Bailey,A.M., Wilson,S.H. and Byrne,J.A.
  TITLE     Alternative splicing as a mechanism for regulating 14-3-3 binding:
            interactions between hD53 (TPD52L1) and 14-3-3 proteins
  JOURNAL   J Mol Biol 332 (3), 675-687 (2003)
   PUBMED   12963375
REFERENCE   9  (bases 1 to 2826)
  AUTHORS   de Marco,M.C., Martin-Belmonte,F., Kremer,L., Albar,J.P.,
            Correas,I., Vaerman,J.P., Marazuela,M., Byrne,J.A. and Alonso,M.A.
  TITLE     MAL2, a novel raft protein of the MAL family, is an essential
            component of the machinery for transcytosis in hepatoma HepG2 cells
  JOURNAL   J Cell Biol 159 (1), 37-44 (2002)
   PUBMED   12370246
  REMARK    GeneRIF: Data show that MAL2 is essential for transcytosis in HepG2
            cells.
REFERENCE   10 (bases 1 to 2826)
  AUTHORS   Wilson,S.H., Bailey,A.M., Nourse,C.R., Mattei,M.G. and Byrne,J.A.
  TITLE     Identification of MAL2, a novel member of the mal proteolipid
            family, though interactions with TPD52-like proteins in the yeast
            two-hybrid system
  JOURNAL   Genomics 76 (1-3), 81-88 (2001)
   PUBMED   11549320
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC087856.6, CV574204.1 and
            AY007723.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052886.2.
            
            Summary: This gene encodes a multispan transmembrane protein
            belonging to the MAL proteolipid family. The protein is a component
            of lipid rafts and, in polarized cells, it primarily localizes to
            endosomal structures beneath the apical membrane. It is required
            for transcytosis, an intracellular transport pathway used to
            deliver membrane-bound proteins and exogenous cargos from the
            basolateral to the apical surface. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY007723.1, SRR1803613.258366.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614891.5/ ENSP00000479708.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC087856.6         112032-112039       c
            9-31                CV574204.1         1-23
            32-2826             AY007723.1         1-2795
FEATURES             Location/Qualifiers
     source          1..2826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..2826
                     /gene="MAL2"
                     /note="mal, T cell differentiation protein 2"
                     /db_xref="GeneID:114569"
                     /db_xref="HGNC:HGNC:13634"
                     /db_xref="MIM:609684"
     exon            1..242
                     /gene="MAL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..641
                     /gene="MAL2"
                     /note="MAL proteolipid protein 2; MAL2 proteolipid
                     protein; myelin and lymphocyte protein 2"
                     /codon_start=1
                     /product="protein MAL2"
                     /protein_id="NP_443118.1"
                     /db_xref="CCDS:CCDS75780.1"
                     /db_xref="GeneID:114569"
                     /db_xref="HGNC:HGNC:13634"
                     /db_xref="MIM:609684"
                     /translation="MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEI
                     LFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLD
                     FAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTT
                     ACYGCSLGLALRRWRP"
     exon            243..413
                     /gene="MAL2"
                     /inference="alignment:Splign:2.1.0"
     exon            414..569
                     /gene="MAL2"
                     /inference="alignment:Splign:2.1.0"
     exon            570..2826
                     /gene="MAL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAL2"
                     /note="hexamer: AATAAA"
     polyA_site      2826
                     /gene="MAL2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcccggag cccgcggagc tgagcggcgg cggcggcggc ggcaggagcc cgggaggcgg
       61 aggcgggagg cggcggcggc gcgcggagac gcagcagcgg cagcggcagc atgtcggccg
      121 gcggagcgtc agtcccgccg cccccgaacc ccgccgtgtc cttcccgccg ccccgggtca
      181 ccctgcccgc cggccccgac atcctgcgga cctactcggg cgccttcgtc tgcctggaga
      241 ttctgttcgg gggtcttgtc tggattttgg ttgcctcctc caatgttcct ctacctctac
      301 tacaaggatg ggtcatgttt gtgtccgtga cagcgttttt cttttcgctc ctctttctgg
      361 gcatgttcct ctctggcatg gtggctcaaa ttgatgctaa ctggaacttc ctggattttg
      421 cctaccattt tacagtattt gtcttctatt ttggagcctt tttattggaa gcagcagcca
      481 catccctgca tgatttgcat tgcaatacaa ccataaccgg gcagccactc ctgagtgata
      541 accagtataa cataaacgta gcagcctcaa tttttgcctt tatgacgaca gcttgttatg
      601 gttgcagttt gggtctggct ttacgaagat ggcgaccgta acactcctta gaaactggca
      661 gtcgtatgtt agtttcactt gtctacttta tatgtctgat caatttggat accattttgt
      721 ccagatgcaa aaacattcca aaagtaatgt gtttagtaga gagagactct aagctcaagt
      781 tctggtttat ttcatggatg gaatgttaat tttattatga tattaaagaa atggcctttt
      841 attttacatc tctccccttt ttccctttcc ccctttattt tcctcctttt ctttctgaaa
      901 gtttcctttt atgtccataa aatacaaata tattgttcat aaaaaattag tatccctttt
      961 gtttggttgc tgagtcacct gaaccttaat tttaattggt aattacagcc cctaaaaaaa
     1021 acacatttca aataggcttc ccactaaact ctatatttta gtgtaaacca ggaattggca
     1081 cacttttttt agaatgggcc agatggtaaa tatttatgct tcacggtcca tacagtctct
     1141 gtcacaacta ttcagttctg ctagtatagc gtgaaagcag ctatacacaa tacagaaatg
     1201 aatgagtgtg gttatgttct aataaaactt atttataaaa acaaggggag gctgggttta
     1261 gcctgtgggc catagtttgt caaccactgg tgtaaaacct tagttatata tgatctgcat
     1321 tttcttgaac tgatcattga aaacttataa acctaacaga aaagccacat aatatttagt
     1381 gtcattatgc aataatcaca ttgcctttgt gttaatagtc aaatacttac ctttggagaa
     1441 tacttacctt tggaggaatg tataaaattt ctcaggcaga gtcctggata taggaaaaag
     1501 taatttatga agtaaacttc agttgcttaa tcaaactaat gatagtctaa caactgagca
     1561 agatcctcat ctgagagtgc ttaaaatggg atccccagag accattaacc aatactggaa
     1621 ctggtatcta gctactgatg tcttactttg agtttattta tgcttcagaa tacagttgtt
     1681 tgccctgtgc atgaatatac ccatatttgt gtgtggatat gtgaagcttt tccaaataga
     1741 gctctcagaa gaattaagtt tttacttcta attattttgc attactttga gttaaatttg
     1801 aatagagtat taaatataaa gttgtagatt cttatgtgtt tttgtattag cccagacatc
     1861 tgtaatgttt ttgcactggt gacagacaaa atctgtttta aaatcatatc cagcacaaaa
     1921 actatttctg gctgaatagc acagaaaagt attttaacct acctgtagag atcctcgtca
     1981 tggaaaggtg ccaaactgtt ttgaatggaa ggacaagtaa gagtgaggcc acagttccca
     2041 ccacacgagg gcttttgtat tgttctactt tttcagccct ttactttctg gctgaagcat
     2101 ccccttggag tgccatgtat aagttgggct attagagttc atggaacata gaacaaccat
     2161 gaatgagtgg catgatccgt gcttaatgat caagtgttac ttatctaata atcctctaga
     2221 aagaaccctg ttagatcttg gtttgtgata aaaatataaa gacagaagac atgaggaaaa
     2281 acaaaaggtt tgaggaaatc aggcatatga ctttatactt aacatcagat cttttctata
     2341 atatcctact actttggttt tcctagctcc ataccacaca cctaaacctg tattatgaat
     2401 tacatattac aaagtcataa atgtgccata tggatataca gtacattcta gttggaatcg
     2461 tttactctgc tagaatttag gtgtgagatt ttttgtttcc caggtatagc aggcttatgt
     2521 ttggtggcat taaattggtt tctttaaaat gctttggtgg cacttttgta aacagattgc
     2581 ttctagattg ttacaaacca agcctaagac acatctgtga atacttagat ttgtagctta
     2641 atcacattct agacttgtga gttgaatgac aaagcagttg aacaaaaatt atggcattta
     2701 agaatttaac atgtcttagc tgtaaaaatg agaaagtgtt ggttggtttt aaaatctggt
     2761 aactccatga tgaaaagaaa tttattttat acgtgttatg tctctaataa agtattcatt
     2821 tgataa
//
