LOCUS       NM_032509               3561 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MAK16 homolog (MAK16), mRNA.
ACCESSION   NM_032509
VERSION     NM_032509.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Zhou,D., Zhu,X., Zheng,S., Tan,D., Dong,M.Q. and Ye,K.
  TITLE     Cryo-EM structure of an early precursor of large ribosomal subunit
            reveals a half-assembled intermediate
  JOURNAL   Protein Cell 10 (2), 120-130 (2019)
   PUBMED   29557065
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Kater,L., Thoms,M., Barrio-Garcia,C., Cheng,J., Ismail,S.,
            Ahmed,Y.L., Bange,G., Kressler,D., Berninghausen,O., Sinning,I.,
            Hurt,E. and Beckmann,R.
  TITLE     Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes
  JOURNAL   Cell 171 (7), 1599-1610 (2017)
   PUBMED   29245012
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Scherl,A., Coute,Y., Deon,C., Calle,A., Kindbeiter,K.,
            Sanchez,J.C., Greco,A., Hochstrasser,D. and Diaz,J.J.
  TITLE     Functional proteomic analysis of human nucleolus
  JOURNAL   Mol Biol Cell 13 (11), 4100-4109 (2002)
   PUBMED   12429849
REFERENCE   8  (bases 1 to 3561)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP281245.1, BC050528.1, AC091144.12 and BC039740.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032509.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.164468.1,
                                           SRR1803611.70066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360128.11/ ENSP00000353246.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BP281245.1         17-33
            18-985              BC050528.1         1-968
            986-988             AC091144.12        35273-35275         c
            989-2231            BC039740.1         983-2225
            2232-3559           BC039740.1         2227-3554
            3560-3561           AC091144.12        32700-32701         c
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p12"
     gene            1..3561
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /note="MAK16 homolog"
                     /db_xref="GeneID:84549"
                     /db_xref="HGNC:HGNC:13703"
     exon            1..40
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..928
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /note="RNA binding protein; RNA binding motif protein 13;
                     NNP78"
                     /codon_start=1
                     /product="protein MAK16 homolog"
                     /protein_id="NP_115898.2"
                     /db_xref="CCDS:CCDS6089.1"
                     /db_xref="GeneID:84549"
                     /db_xref="HGNC:HGNC:13703"
                     /translation="MQSDDVIWDTLGNKQFCSFKIRTKTQSFCRNEYSLTGLCNRSSC
                     PLANSQYATIKEEKGQCYLYMKVIERAAFPRRLWERVRLSKNYEKALEQIDENLIYWP
                     RFIRHKCKQRFTKITQYLIRIRKLTLKRQRKLVPLSKKVERREKRREEKALIAAQLDN
                     AIEKELLERLKQDTYGDIYNFPIHAFDKALEQQEAESDSSDTEEKDDDDDDEEDVGKR
                     EFVEDGEVDESDISDFEDMDKLDASSDEDQDGKSSSEEEEEKALSAKHKGKMPLRGPL
                     QRKRAYVEIEYEQETEPVAKAKTT"
     exon            41..90
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            91..200
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            201..265
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            266..417
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            418..472
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            473..547
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            548..664
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            665..730
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     exon            731..3561
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3459..3464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /note="hexamer: AACAAA"
     polyA_site      3478
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /note="major polyA site"
     regulatory      3539..3544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /note="hexamer: AATAAA"
     polyA_site      3561
                     /gene="MAK16"
                     /gene_synonym="MAK16L; RBM13"
                     /note="major polyA site"
ORIGIN      
        1 agttgcacgc tgagccgcgg acaccatgca gtcggatgat gttatctggg atacactagg
       61 aaacaagcaa ttttgttcct tcaaaataag aaccaagact cagagcttct gccgaaatga
      121 atatagcctg actggactgt gtaatcggtc atcctgtccc ctggcaaata gtcagtatgc
      181 cactattaaa gaagagaaag gacagtgcta cttgtatatg aaggttatag aacgagcggc
      241 ttttcctcgg cgtctctggg aacgggtccg gcttagtaaa aactatgaga aagcactgga
      301 gcaaatagat gaaaatctga tttactggcc ccgtttcatt cgacacaaat gtaagcagag
      361 attcaccaag atcacccaat acctaattcg aattagaaaa cttacactaa agcgacagag
      421 gaaacttgtt cctttgagta agaaggtgga gcgtagggag aaaagaagag aggaaaaggc
      481 attaatagct gctcagctgg acaatgccat tgagaaggaa ttactggaga gactgaaaca
      541 agatacgtat ggcgacatct acaacttccc cattcatgcc ttcgacaaag ccctggaaca
      601 acaggaggca gagagtgact cttcagatac tgaggaaaaa gatgatgatg atgatgatga
      661 ggaagatgtg gggaaaagag aatttgtcga agatggtgag gtagatgaga gtgacataag
      721 tgattttgag gatatggata aactggatgc cagcagtgat gaagatcagg atggtaaatc
      781 ctccagtgag gaggaggaag aaaaggccct tagtgcgaaa cacaaaggca aaatgccctt
      841 gagaggacca ctgcagagaa aacgagccta tgtggaaata gaatacgagc aggagacaga
      901 gcccgtggcc aaagccaaaa ccacgtgatt tccctttcag catttatacc caggactgaa
      961 catgcagaac tgtttttttt ttttttttat cttaaacaca tacacacctc cagtttttgc
     1021 tcttttgtgt tgtactgaac acaatatttg tgtttttatt atttatgcca cgtcagtggg
     1081 gcaagaaatc tggagtgagt gaagaaagct aagttgtgaa caagagtgtt tttatagcat
     1141 atgtgttgaa gtaacagctt gtgcccgaga aacttaacag atgagttctt gaatctggga
     1201 tgagatgacg gatgtaaata tttctaaatt ttaaatgcta cattacttgg tgtccttttt
     1261 tctcccaaac tttatttaga aatggaagga gttcaatttt ttcttgttct actttcccta
     1321 ttcttatgga ggtaaaagga aaggaaggaa ggaaaaagca gctttcactt acaaagtttc
     1381 gtgtaaaaat atcttttttt cttaaataac tccattcata caaattggga tgggaagaaa
     1441 atcctttcct cttgggaaag taatacaagt cttaagttcc attgtagggt gcgccttcag
     1501 aaacctgctg cacttttctg atatagttca ccacttttct gtcttcacag ctttggggaa
     1561 ttttggccag gagaccctga aacatgaaac caaacaggct ttgatatttt ttttttttta
     1621 attactttcc ccttttgctt gattcttctt ccttggtatc atattcaaag gaggaaagaa
     1681 tggatgacac ttagggacag gtcactaagc agaataggta ttagttggtt ttttattatt
     1741 tttaaattta tatagctctc atgtattgaa ggtgctactt taaaaactgt gttaatgtac
     1801 ttgcaaatct cctgctggct catgaaacag cagaattcca gccaaggcaa attcagttgg
     1861 atctagggct tgaaaactgc ccaagattaa agagctaaga tgaaatagtt tgaataaact
     1921 ggtaaaataa caattcatac tatctctaca tatttttagg atatgaattt ttttttcctg
     1981 ctgggtagat tgtccagtga cttatggcat gaatttcttt tcatgctacc ttcaatcttc
     2041 aactaaagat ttctaaaagg ggtaagaaat gaggcagtag tttattaaat acatagaagt
     2101 acacagctat tatatgctgt ggctttgaga agttaacttt tgtggaatat gaaaccaaag
     2161 gaagaatttc catgtagata aattaagaat agggaaaaac atctacctaa aagatggttg
     2221 tccctaaaaa actggaaaca tctgaaatgc tctatttatg ttattattcc tgggagctta
     2281 tagcccatta tttttacttt ttttttttaa ttcagaagac tagaacagaa cttaaatttt
     2341 acaaactttt gatcataatg cttttgccca tactgtctcg tccttagccc cagtgacatg
     2401 tgctgatcct cctgccttta gttctaaatg gttctgaata gctttaaaag atgaataaga
     2461 aaaaagatca agctcttttg aggctagagg gctcatatgg agatctaaaa ccctccatgt
     2521 tcatttccag acttggtcag gcacatacat agtaaattat aatcaatcat gggaattaca
     2581 taaggataat gaggcccaac tgaaaccaag tttcagtctg ccttaccttt acccgtcctt
     2641 gagaacagcg gtccaggaga atcaggcagt ctgtggcctc ctgtagcagg gcgctcttaa
     2701 cagactcagg tgtaaggttt ggatcccttg ctacatcaca aatcagtttc aagagggcct
     2761 tcagtaagac cacaagtctg caggaaactc tggaatcagg aagaaaagct atgttcatac
     2821 tctaaatctg gatattaaaa ttggaagaga cttcaaagac tgtcaagtgg aaagctatca
     2881 tttcctaaat taaggaactt aggtcaaagt taaatgaaaa agacctaaaa acagaaccaa
     2941 agacagcctc tagatttctt accctcaagt ctcctgttag catactgcct atacacacag
     3001 acacaccctc tgccacactg ctctcttcct tccagaagct tggttctact gtaagcaaca
     3061 gctccttcat gggctgagaa ggggaaacca ggatctcccc aaccaagggc ctatactttt
     3121 atttttcaac tctattaact gaactatgct tggagagagc cctgaatcct ttaactttaa
     3181 tgccatctta ggcctggaag ttagagtgag ggaaatgagc ttggcttctg ggactgtgtc
     3241 aagttgaatt ttctgtcatt taatttcaga tcctagctca tcatcagtga agtccagcct
     3301 acttacttgt aactattaac ctttctaaaa gttttcatcg ccttggtaaa gctccagaaa
     3361 tggacaatgc tagtgactgc acaatattgt gactgtactt aatgccactg aactgtacac
     3421 tttaaaatgg aaaatttata tgtattttta ccacaataaa caaaaaaccc taaaaaaact
     3481 ttaatgaaag gtggaaaata atttaactta caatgtgaaa atacaatgtg aaatgtacaa
     3541 taaatcatat ttatggacag a
//
