LOCUS       NM_001037225            1292 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens membrane anchored junction protein (MAJIN), transcript
            variant 1, mRNA.
ACCESSION   NM_001037225 XM_208524
VERSION     NM_001037225.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1292)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1292)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1292)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    GeneRIF: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to
            the nuclear envelope
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1292)
  AUTHORS   Dunce,J.M., Milburn,A.E., Gurusaran,M., da Cruz,I., Sen,L.T.,
            Benavente,R. and Davies,O.R.
  TITLE     Structural basis of meiotic telomere attachment to the nuclear
            envelope by MAJIN-TERB2-TERB1
  JOURNAL   Nat Commun 9 (1), 5355 (2018)
   PUBMED   30559341
  REMARK    GeneRIF: complementary structured illumination microscopy studies
            and biochemical findings reveal a telomere attachment mechanism in
            which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then
            displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind
            telomeric DNA and form a mature attachment plate.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1292)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1292)
  AUTHORS   Shibuya,H., Hernandez-Hernandez,A., Morimoto,A., Negishi,L.,
            Hoog,C. and Watanabe,Y.
  TITLE     MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging
            Telomere Cap
  JOURNAL   Cell 163 (5), 1252-1266 (2015)
   PUBMED   26548954
  REMARK    Erratum:[Cell. 2018 May 3;173(4):1058. doi:
            10.1016/j.cell.2018.04.025.. PMID: 29727665]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000436.5, DB445650.2, HY050994.1, BC106951.2 and BC033501.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001037225.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.108708.1, BC106951.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301896.6/ ENSP00000301896.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AP000436.5         29899-29915         c
            18-117              DB445650.2         2-101
            118-222             HY050994.1         94-198
            223-1068            BC106951.2         1-846
            1069-1292           BC033501.1         814-1037
FEATURES             Location/Qualifiers
     source          1..1292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1292
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /note="membrane anchored junction protein"
                     /db_xref="GeneID:283129"
                     /db_xref="HGNC:HGNC:27441"
                     /db_xref="MIM:617130"
     exon            1..232
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            233..279
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            280..397
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..947
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="membrane-anchored junction protein isoform 1"
                     /protein_id="NP_001032302.1"
                     /db_xref="CCDS:CCDS31603.1"
                     /db_xref="GeneID:283129"
                     /db_xref="HGNC:HGNC:27441"
                     /db_xref="MIM:617130"
                     /translation="MSLKPFTYPFPETRFLHAGPNVYKFKIRYGKSIRGEEIENKEVI
                     TQELEDSVRVVLGNLDNLQPFATEHFIVFPYKSKWERVSHLKFKHGEIILIPYPFVFT
                     LYVEMKWFHENLSPGKPISDSPLGLVPVEKKAVGAVMRKRKHMDEPSSPSRPGLDRIG
                     KEKPNKDCRRLWPLISLMSRNKILSGDTACQGELSHPCSTTHLHLRSEQPPASLGF"
     exon            398..443
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            444..519
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            520..645
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            646..677
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            678..769
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            770..842
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            843..948
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1292
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1270..1275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /note="hexamer: AATAAA"
     polyA_site      1292
                     /gene="MAJIN"
                     /gene_synonym="C11orf85"
                     /note="major polyA site"
ORIGIN      
        1 gcacttgcgc gtgcgcagaa ggcctggtgg gtgcgcggca cgagccccga agttgcttag
       61 gagctggcga gccagtccct caaaacgact tcgttcgagg ttggcgcccg cctttttcag
      121 agagcacttc ttagtgggta ttccgtccgg ggccactttt ctgaggccga aggaccccta
      181 gtcagtgtgt gagacatagc ctggccgagc ctgggaacca cctggggctg agagacgacc
      241 ttaagtggac agagattcta gaacaggaga aataaaacag ctatcgtttg ggagcaatga
      301 gtttaaaacc ctttacctac ccgtttccag agacgaggtt tcttcatgca ggacccaatg
      361 tgtataaatt caaaatcaga tatgggaaga gtatcagagg agaagagata gaaaataagg
      421 aagtcatcac ccaggagctg gaggattctg tccgcgtggt cttgggaaac ttggacaatc
      481 ttcagccctt tgctacagaa cacttcattg tatttcccta taaaagcaaa tgggagagag
      541 tttcccacct gaaattcaaa catggggaaa ttatcttgat cccctaccca tttgttttta
      601 ctctatatgt ggagatgaaa tggttccatg aaaacctgtc acctgggaaa ccaataagtg
      661 acagtcctct tgggttggtc ccagttgaga agaaagcagt aggagctgtg atgaggaaac
      721 gaaaacacat ggacgagccc agctccccca gcaggccagg gctggacaga atagggaaag
      781 aaaaacccaa caaggattgc aggagactct ggcctctgat atcactgatg tccagaaaca
      841 agattctgag tggggacaca gcctgccagg gcgaattgtc ccacccctgc agcacaactc
      901 acctccacct aaggagcgag cagccaccgg cttctttggg tttctaagct ctctcttccc
      961 gtttcgatat ttcttcagga agagcagcca ctcttgagcc ttccaaatgc agcgctggaa
     1021 agaggatcat ctcttgtagt gactcctccc gagccattct tcctccaact ctatcctttt
     1081 cttatgacac ttcagtcgtg gggaatgagg tccccatgct gagtcctctg tggttttatc
     1141 gtgtcctttg cccctttata atagattttt tcccccaatt taaaacatta agaatggaac
     1201 tttctaaaat gttcatgtcc tgagggccgg tttaggcctt ttgtcttcgg cacttaggat
     1261 cctaatgaca ataaattatt tatgaagagt ta
//
