LOCUS       NM_002370                656 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mago homolog, exon junction complex subunit (MAGOH),
            mRNA.
ACCESSION   NM_002370
VERSION     NM_002370.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 656)
  AUTHORS   Yu,S., Chen,C., Chen,M., Liang,J., Jiang,K., Lou,B., Lu,J., Zhu,X.
            and Zhou,D.
  TITLE     MAGOH promotes gastric cancer progression via hnRNPA1 expression
            inhibition-mediated RONDelta160/PI3K/AKT signaling pathway
            activation
  JOURNAL   J Exp Clin Cancer Res 43 (1), 32 (2024)
   PUBMED   38268030
  REMARK    GeneRIF: MAGOH promotes gastric cancer progression via hnRNPA1
            expression inhibition-mediated RONDelta160/PI3K/AKT signaling
            pathway activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 656)
  AUTHORS   Xiao,F., Long,Z., Guo,Y., Zhu,H., Zhang,Z., Xiao,Y., Hu,G.,
            Yang,Q., Huang,K. and Guo,H.
  TITLE     MAGOH is correlated with poor prognosis and is essential for cell
            proliferation in lower-grade glioma
  JOURNAL   Aging (Albany NY) 15 (12), 5713-5733 (2023)
   PUBMED   37390121
  REMARK    GeneRIF: MAGOH is correlated with poor prognosis and is essential
            for cell proliferation in lower-grade glioma.
REFERENCE   3  (bases 1 to 656)
  AUTHORS   Soederberg,A., Meissgeier,T., Bosserhoff,A.K. and Linck-Paulus,L.
  TITLE     MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases
            Nonsense-Mediated Decay Activity and Promotes Apoptosis via
            Upregulation of GADD45A
  JOURNAL   Cells 11 (23), 3859 (2022)
   PUBMED   36497117
  REMARK    GeneRIF: MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases
            Nonsense-Mediated Decay Activity and Promotes Apoptosis via
            Upregulation of GADD45A.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 656)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 656)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 656)
  AUTHORS   Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J.
  TITLE     The exon-exon junction complex provides a binding platform for
            factors involved in mRNA export and nonsense-mediated mRNA decay
  JOURNAL   EMBO J 20 (17), 4987-4997 (2001)
   PUBMED   11532962
REFERENCE   7  (bases 1 to 656)
  AUTHORS   Mingot,J.M., Kostka,S., Kraft,R., Hartmann,E. and Gorlich,D.
  TITLE     Importin 13: a novel mediator of nuclear import and export
  JOURNAL   EMBO J 20 (14), 3685-3694 (2001)
   PUBMED   11447110
REFERENCE   8  (bases 1 to 656)
  AUTHORS   Zhao,X.F., Nowak,N.J., Shows,T.B. and Aplan,P.D.
  TITLE     MAGOH interacts with a novel RNA-binding protein
  JOURNAL   Genomics 63 (1), 145-148 (2000)
   PUBMED   10662555
REFERENCE   9  (bases 1 to 656)
  AUTHORS   Zhao,X.F., Colaizzo-Anas,T., Nowak,N.J., Shows,T.B., Elliott,R.W.
            and Aplan,P.D.
  TITLE     The mammalian homologue of mago nashi encodes a serum-inducible
            protein
  JOURNAL   Genomics 47 (2), 319-322 (1998)
   PUBMED   9479507
REFERENCE   10 (bases 1 to 656)
  AUTHORS   Newmark,P.A., Mohr,S.E., Gong,L. and Boswell,R.E.
  TITLE     mago nashi mediates the posterior follicle cell-to-oocyte signal to
            organize axis formation in Drosophila
  JOURNAL   Development 124 (16), 3197-3207 (1997)
   PUBMED   9272960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF067173.1 and AF035940.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002370.3.
            
            Summary: Drosophila that have mutations in their mago nashi
            (grandchildless) gene produce progeny with defects in germplasm
            assembly and germline development. This gene encodes the mammalian
            mago nashi homolog. In mammals, mRNA expression is not limited to
            the germ plasm, but is expressed ubiquitously in adult tissues and
            can be induced by serum stimulation of quiescent fibroblasts.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279835.4540.1, BU533022.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371470.8/ ENSP00000360525.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               AF067173.1         19-648
            631-656             AF035940.1         626-651
FEATURES             Location/Qualifiers
     source          1..656
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..656
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /note="mago homolog, exon junction complex subunit"
                     /db_xref="GeneID:4116"
                     /db_xref="HGNC:HGNC:6815"
                     /db_xref="MIM:602603"
     exon            1..158
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..511
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /note="mago-nashi homolog, proliferation-associated; mago
                     homolog, exon junction complex core component"
                     /codon_start=1
                     /product="protein mago nashi homolog"
                     /protein_id="NP_002361.1"
                     /db_xref="CCDS:CCDS577.1"
                     /db_xref="GeneID:4116"
                     /db_xref="HGNC:HGNC:6815"
                     /db_xref="MIM:602603"
                     /translation="MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDV
                     MIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTS
                     KIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI"
     exon            159..217
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /inference="alignment:Splign:2.1.0"
     exon            218..328
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /inference="alignment:Splign:2.1.0"
     exon            329..411
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /inference="alignment:Splign:2.1.0"
     exon            412..656
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      608..613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /note="hexamer: AATAAA"
     polyA_site      630
                     /gene="MAGOH"
                     /gene_synonym="MAGOH1; MAGOHA"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcgggc gcagacggcg gcagtgcggc ttgctcttgg aagttcaggc tcggttgtct
       61 tttgggagcc atggagagtg acttttatct gcgttactac gtggggcaca agggcaagtt
      121 cggccacgag ttcctggagt ttgagtttcg accggacggg aagttaagat atgccaacaa
      181 cagcaattac aagaatgatg tcatgatcag aaaagaggct tatgtacata aaagcgtgat
      241 ggaggaactg aagagaataa ttgacgacag tgaaattacc aaagaggatg atgcattgtg
      301 gcctcctcct gaccgagtgg gccggcagga gcttgaaatc gtcattggag atgaacacat
      361 ttcttttaca acatcaaaaa ttggttccct tattgatgtc aatcaatcca aggatccaga
      421 aggcttacga gtattttatt atcttgtcca ggacctgaag tgtttggtct tcagtcttat
      481 tggattacac ttcaagatta aaccaatcta gactgaatat tggtgtggac atggggggtg
      541 ggtgggagta gaaaattttg tgtatatcag ggcagtattt ttttatgaac tataaatgat
      601 tgtctttaat aaatatgtga taaaatccaa tttttattat tttataaaga cctgaa
//
